Rbpj (recombination signal binding protein for immunoglobulin kappa J region) - Rat Genome Database

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Gene: Rbpj (recombination signal binding protein for immunoglobulin kappa J region) Rattus norvegicus
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Symbol: Rbpj
Name: recombination signal binding protein for immunoglobulin kappa J region
RGD ID: 1593096
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including negative regulation of smooth muscle cell apoptotic process; negative regulation of smooth muscle cell migration; and positive regulation of smooth muscle cell proliferation. Part of protein-DNA complex. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-methylfuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC679028; recombining binding protein suppressor of hairless; similar to Recombining binding protein suppressor of hairless (J kappa-recombination signal binding protein) (RBP-J kappa)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Rbpjl2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81461,551,366 - 61,736,220 (-)NCBIGRCr8
mRatBN7.21457,338,493 - 57,523,330 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1457,338,507 - 57,523,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1461,746,363 - 61,809,045 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01463,048,700 - 63,111,484 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01459,445,481 - 59,508,257 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01459,657,738 - 59,865,427 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1459,658,935 - 59,735,450 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01459,785,053 - 59,859,229 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1456,447,546 - 56,510,235 (-)NCBICelera
Cytogenetic Map14q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
3-methylcholanthrene  (ISO)
3-methylfuran  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
alpha-phellandrene  (ISO)
amitrole  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cycloheximide  (ISO)
DAPT  (EXP,ISO)
decabromodiphenyl ether  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
galactose  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP)
menadione  (ISO)
methimazole  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (EXP)
rimonabant  (ISO)
SB 203580  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
aortic valve development  (ISO)
arterial endothelial cell fate commitment  (ISO)
artery morphogenesis  (ISO)
atrioventricular canal development  (ISO)
auditory receptor cell fate commitment  (ISO)
B cell differentiation  (ISO)
blood vessel endothelial cell fate specification  (ISO)
blood vessel lumenization  (ISO)
blood vessel remodeling  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cardiac muscle cell myoblast differentiation  (ISO)
cell differentiation  (ISO)
cell fate commitment  (ISO)
cell population proliferation  (ISO)
club cell differentiation  (ISO)
defense response to bacterium  (ISO)
dorsal aorta morphogenesis  (ISO)
endocardium development  (ISO)
endocardium morphogenesis  (ISO)
epidermal cell fate specification  (ISO)
epithelial cell proliferation  (ISO)
epithelial to mesenchymal transition  (ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
hair follicle maturation  (ISO)
heart development  (ISO)
hemopoiesis  (ISO)
humoral immune response  (ISO)
inflammatory response to antigenic stimulus  (ISO)
keratinocyte differentiation  (ISO)
labyrinthine layer blood vessel development  (ISO)
myeloid dendritic cell differentiation  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of neuron projection development  (IMP)
negative regulation of ossification  (ISO)
negative regulation of smooth muscle cell apoptotic process  (IMP)
negative regulation of smooth muscle cell migration  (IMP)
negative regulation of stem cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron differentiation  (ISO)
Notch signaling pathway  (IBA,ISO)
outflow tract morphogenesis  (ISO)
pituitary gland development  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell proliferation involved in heart morphogenesis  (ISO)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of ephrin receptor signaling pathway  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERBB signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription of Notch receptor target  (ISO)
pulmonary valve development  (ISO)
regulation of cell adhesion involved in heart morphogenesis  (ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of gene expression  (ISO)
regulation of generation of precursor metabolites and energy  (ISO)
regulation of timing of cell differentiation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
sebaceous gland development  (ISO)
secondary heart field specification  (ISO)
somatic stem cell population maintenance  (ISO)
somitogenesis  (ISO)
stem cell proliferation  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Notch signaling pathway  (IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Bi P, etal., Nat Med. 2014 Aug;20(8):911-8. doi: 10.1038/nm.3615. Epub 2014 Jul 20.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Genetic elements regulating HES-1 induction in Wnt-1-transformed PC12 cells. Issack PS and Ziff EB, Cell Growth Differ. 1998 Oct;9(10):827-36.
4. Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. Jeffries S, etal., Mol Cell Biol. 2002 Jun;22(11):3927-41.
5. Functional interactions between an atypical NF-kappaB site from the rat CYP2B1 promoter and the transcriptional repressor RBP-Jkappa/CBF1. Lee SH, etal., Nucleic Acids Res. 2000 May 15;28(10):2091-8.
6. Notch signaling inhibits PC12 cell neurite outgrowth via RBP-J-dependent and -independent mechanisms. Levy OA, etal., Dev Neurosci. 2002;24(1):79-88.
7. Enhanced expression and autoimmunity of recombination signal binding protein-jkappa in human dilated cardiomyopathy. Nickenig G, etal., Biochem Biophys Res Commun. 1999 Dec 20;266(2):432-6.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. Sweeney C, etal., FASEB J. 2004 Sep;18(12):1421-3. Epub 2004 Jul 9.
Additional References at PubMed
PMID:9102301   PMID:9111338   PMID:9874765   PMID:10476967   PMID:10713164   PMID:11967543   PMID:12730124   PMID:12794108   PMID:14701881   PMID:15466160   PMID:15509736   PMID:15632090  
PMID:15689374   PMID:16287852   PMID:16510869   PMID:16691198   PMID:17015435   PMID:17079689   PMID:17283045   PMID:17336907   PMID:17392792   PMID:17658278   PMID:17658279   PMID:17685488  
PMID:17938243   PMID:18663143   PMID:19124651   PMID:19154718   PMID:19779553   PMID:20890042   PMID:21102556   PMID:21311046   PMID:21402740   PMID:21493891   PMID:22711842   PMID:22797898  
PMID:23117660   PMID:23303788   PMID:23571214   PMID:23639443   PMID:23913046   PMID:25406395   PMID:26491108   PMID:26951801  


Genomics

Comparative Map Data
Rbpj
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81461,551,366 - 61,736,220 (-)NCBIGRCr8
mRatBN7.21457,338,493 - 57,523,330 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1457,338,507 - 57,523,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1461,746,363 - 61,809,045 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01463,048,700 - 63,111,484 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01459,445,481 - 59,508,257 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01459,657,738 - 59,865,427 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1459,658,935 - 59,735,450 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01459,785,053 - 59,859,229 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1456,447,546 - 56,510,235 (-)NCBICelera
Cytogenetic Map14q11NCBI
RBPJ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38426,105,449 - 26,435,131 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl426,163,455 - 26,435,131 (+)EnsemblGRCh38hg38GRCh38
GRCh37426,165,080 - 26,436,753 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36425,930,430 - 26,042,376 (+)NCBINCBI36Build 36hg18NCBI36
Celera426,771,681 - 26,884,040 (+)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef425,659,979 - 25,775,063 (+)NCBIHuRef
CHM1_1426,322,549 - 26,437,875 (+)NCBICHM1_1
T2T-CHM13v2.0426,087,631 - 26,420,111 (+)NCBIT2T-CHM13v2.0
Rbpj
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39553,713,121 - 53,814,787 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl553,623,494 - 53,814,704 (+)EnsemblGRCm39 Ensembl
GRCm38553,555,779 - 53,657,445 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl553,466,152 - 53,657,362 (+)EnsemblGRCm38mm10GRCm38
MGSCv37553,947,018 - 54,048,684 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36553,878,593 - 53,944,281 (+)NCBIMGSCv36mm8
Celera550,938,216 - 51,041,035 (+)NCBICelera
Cytogenetic Map5C1NCBI
cM Map529.37NCBI
Rbpj
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544318,783,061 - 18,910,228 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544318,783,061 - 19,029,441 (-)NCBIChiLan1.0ChiLan1.0
RBPJ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2326,573,771 - 26,689,708 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1426,766,523 - 26,881,531 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0420,719,548 - 20,835,439 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1425,996,223 - 26,107,683 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl425,995,263 - 26,107,683 (+)Ensemblpanpan1.1panPan2
RBPJ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1384,060,417 - 84,286,008 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl384,064,440 - 84,286,360 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha386,572,469 - 86,797,897 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0385,030,006 - 85,255,529 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl385,034,041 - 85,255,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1384,151,949 - 84,377,265 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0384,271,690 - 84,496,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0384,656,440 - 84,881,337 (-)NCBIUU_Cfam_GSD_1.0
Rbpj
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528549,648,938 - 49,859,262 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364773,349,627 - 3,461,797 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364773,354,336 - 3,445,248 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBPJ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl819,922,779 - 20,166,754 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1819,933,035 - 20,166,746 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2820,306,820 - 20,540,623 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RBPJ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12723,911,084 - 24,023,856 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604770,424,032 - 70,537,613 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbpj
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247556,176,497 - 6,298,225 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247556,176,497 - 6,298,034 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rbpj
640 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:378
Count of miRNA genes:217
Interacting mature miRNAs:273
Transcripts:ENSRNOT00000071929
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142216796767167967Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat

Markers in Region
D14Got163  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21457,378,908 - 57,379,048 (+)MAPPERmRatBN7.2
Rnor_6.01459,712,144 - 59,712,283NCBIRnor6.0
Rnor_5.01459,836,103 - 59,836,242UniSTSRnor5.0
RGSC_v3.41462,296,273 - 62,296,412UniSTSRGSC3.4
Celera1456,486,697 - 56,486,835UniSTS
Cytogenetic Map14 RGD
Rbpsuh-rs3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.255,465,228 - 5,465,852 (+)MAPPERmRatBN7.2
Rnor_6.054,878,500 - 4,879,123NCBIRnor6.0
Rnor_5.054,847,450 - 4,848,073UniSTSRnor5.0
RGSC_v3.454,664,368 - 4,664,991UniSTSRGSC3.4
Celera55,053,895 - 5,054,518UniSTS
Cytogenetic Map5q11UniSTS
X17459  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21457,342,105 - 57,342,263 (+)MAPPERmRatBN7.2
Rnor_6.01459,661,351 - 59,661,508NCBIRnor6.0
Rnor_5.01459,787,469 - 59,787,626UniSTSRnor5.0
Celera1456,449,963 - 56,450,120UniSTS
UniSTS:465469  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21457,342,788 - 57,343,333 (+)MAPPERmRatBN7.2
Rnor_6.01459,662,034 - 59,662,578NCBIRnor6.0
Rnor_5.01459,788,152 - 59,788,696UniSTSRnor5.0
Celera1456,450,646 - 56,451,190UniSTS
Rbpj  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.255,465,633 - 5,466,132 (+)MAPPERmRatBN7.2
Rnor_6.054,878,905 - 4,879,403NCBIRnor6.0
Rnor_5.054,847,855 - 4,848,353UniSTSRnor5.0
RGSC_v3.454,664,773 - 4,665,271UniSTSRGSC3.4
Celera55,054,300 - 5,054,798UniSTS
Cytogenetic Map5q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001414973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000071929   ⟹   ENSRNOP00000065485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1457,338,511 - 57,402,233 (-)Ensembl
Rnor_6.0 Ensembl1459,658,935 - 59,735,450 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103399   ⟹   ENSRNOP00000095583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1457,338,507 - 57,523,353 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106059   ⟹   ENSRNOP00000093992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1457,338,507 - 57,385,814 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117966   ⟹   ENSRNOP00000081140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1457,338,507 - 57,402,684 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118409   ⟹   ENSRNOP00000093252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1457,338,507 - 57,434,555 (-)Ensembl
RefSeq Acc Id: NM_001106631   ⟹   NP_001100101
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81461,552,560 - 61,615,438 (-)NCBI
mRatBN7.21457,339,690 - 57,402,574 (-)NCBI
Rnor_6.01459,658,935 - 59,735,450 (-)NCBI
Rnor_5.01459,785,053 - 59,859,229 (-)NCBI
Celera1456,447,546 - 56,510,235 (-)RGD
Sequence:
RefSeq Acc Id: NM_001414973   ⟹   NP_001401902
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81461,551,366 - 61,615,260 (-)NCBI
mRatBN7.21457,338,496 - 57,402,396 (-)NCBI
RefSeq Acc Id: XM_039092403   ⟹   XP_038948331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81461,551,375 - 61,736,220 (-)NCBI
mRatBN7.21457,340,056 - 57,523,329 (-)NCBI
RefSeq Acc Id: XM_039092405   ⟹   XP_038948333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81461,551,375 - 61,615,238 (-)NCBI
mRatBN7.21457,340,056 - 57,402,324 (-)NCBI
RefSeq Acc Id: XM_039092406   ⟹   XP_038948334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81461,551,375 - 61,736,218 (-)NCBI
mRatBN7.21457,340,056 - 57,523,330 (-)NCBI
RefSeq Acc Id: XM_039092407   ⟹   XP_038948335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81461,551,375 - 61,615,014 (-)NCBI
mRatBN7.21457,339,813 - 57,402,148 (-)NCBI
RefSeq Acc Id: XM_039092408   ⟹   XP_038948336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81461,551,375 - 61,616,484 (-)NCBI
mRatBN7.21457,340,056 - 57,403,621 (-)NCBI
RefSeq Acc Id: XM_063273584   ⟹   XP_063129654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81461,551,375 - 61,616,408 (-)NCBI
RefSeq Acc Id: XM_063273585   ⟹   XP_063129655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81461,551,375 - 61,592,371 (-)NCBI
RefSeq Acc Id: NP_001100101   ⟸   NM_001106631
- Peptide Label: isoform 1
- UniProtKB: A6IJF7 (UniProtKB/TrEMBL),   A0A8I6AFG7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065485   ⟸   ENSRNOT00000071929
RefSeq Acc Id: XP_038948335   ⟸   XM_039092407
- Peptide Label: isoform X4
- UniProtKB: A6IJF7 (UniProtKB/TrEMBL),   A0A8I6AFG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948334   ⟸   XM_039092406
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AL64 (UniProtKB/TrEMBL),   A0A8I6AFG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948331   ⟸   XM_039092403
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AN87 (UniProtKB/TrEMBL),   A0A8I6AFG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948336   ⟸   XM_039092408
- Peptide Label: isoform X4
- UniProtKB: A6IJF7 (UniProtKB/TrEMBL),   A0A8I6AFG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948333   ⟸   XM_039092405
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AL64 (UniProtKB/TrEMBL),   A0A8I6AFG7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093992   ⟸   ENSRNOT00000106059
Ensembl Acc Id: ENSRNOP00000093252   ⟸   ENSRNOT00000118409
Ensembl Acc Id: ENSRNOP00000081140   ⟸   ENSRNOT00000117966
Ensembl Acc Id: ENSRNOP00000095583   ⟸   ENSRNOT00000103399
RefSeq Acc Id: NP_001401902   ⟸   NM_001414973
- Peptide Label: isoform 2
- UniProtKB: M0R7Q3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129654   ⟸   XM_063273584
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZUF4 (UniProtKB/TrEMBL),   A6IJF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129655   ⟸   XM_063273585
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AL64 (UniProtKB/TrEMBL)
Protein Domains
Beta-trefoil DNA-binding   RBP-J/Cbf11/Cbf12 DNA binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7Q3-F1-model_v2 AlphaFold M0R7Q3 1-465 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593096 AgrOrtholog
BioCyc Gene G2FUF-15611 BioCyc
Ensembl Genes ENSRNOG00000046327 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071929.3 UniProtKB/TrEMBL
  ENSRNOT00000103399.1 UniProtKB/TrEMBL
  ENSRNOT00000106059.1 UniProtKB/TrEMBL
  ENSRNOT00000117966.1 UniProtKB/TrEMBL
  ENSRNOT00000118409.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.1450 UniProtKB/TrEMBL
  2.80.10.50 UniProtKB/TrEMBL
InterPro Beta-trefoil_DNA-bd_dom UniProtKB/TrEMBL
  BTD_sf UniProtKB/TrEMBL
  CLS_fam UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  LAG1_DNA-bd UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RBP-J/Cbf11/Cbf12_DNA-bd_sf UniProtKB/TrEMBL
  RBP-Jkappa_IPT UniProtKB/TrEMBL
KEGG Report rno:679028 UniProtKB/TrEMBL
NCBI Gene 679028 ENTREZGENE
PANTHER PTHR10665 UniProtKB/TrEMBL
  RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS UniProtKB/TrEMBL
Pfam BTD UniProtKB/TrEMBL
  LAG1-DNAbind UniProtKB/TrEMBL
  TIG_SUH UniProtKB/TrEMBL
PhenoGen Rbpj PhenoGen
RatGTEx ENSRNOG00000046327 RatGTEx
SMART BTD UniProtKB/TrEMBL
  LAG1_DNAbind UniProtKB/TrEMBL
Superfamily-SCOP Beta-trefoil UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  P53_like_DNA_bnd UniProtKB/TrEMBL
UniProt A0A8I5ZUF4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFG7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AL64 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AN87 ENTREZGENE, UniProtKB/TrEMBL
  A6IJF6 ENTREZGENE, UniProtKB/TrEMBL
  A6IJF7 ENTREZGENE, UniProtKB/TrEMBL
  M0R7Q3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-04-14 Rbpj  recombination signal binding protein for immunoglobulin kappa J region  LOC679028  similar to Recombining binding protein suppressor of hairless (J kappa-recombination signal binding protein) (RBP-J kappa)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC679028  similar to Recombining binding protein suppressor of hairless (J kappa-recombination signal binding protein) (RBP-J kappa)      Symbol and Name status set to provisional 70820 PROVISIONAL