Gys1 Rat (+)-catechin multiple interactions ISO GYS1 (Homo sapiens) 6480464 [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of GYS1 mRNA CTD PMID:24763279 Gys1 Rat (+)-catechin multiple interactions EXP 6480464 Catechin inhibits the reaction [Glucose results in increased phosphorylation of GYS1 protein] CTD PMID:29981789 Gys1 Rat (+)-catechin decreases phosphorylation EXP 6480464 Catechin results in decreased phosphorylation of GYS1 protein CTD PMID:29981789 Gys1 Rat (-)-alpha-phellandrene increases expression ISO GYS1 (Homo sapiens) 6480464 alpha phellandrene results in increased expression of GYS1 mRNA CTD PMID:25075043 Gys1 Rat (3,4-dihydroxyphenyl)acetic acid multiple interactions EXP 6480464 3,4-Dihydroxyphenylacetic Acid inhibits the reaction [Glucose results in increased phosphorylation of GYS1 protein] CTD PMID:29981789 Gys1 Rat (3,4-dihydroxyphenyl)acetic acid decreases phosphorylation EXP 6480464 3,4-Dihydroxyphenylacetic Acid results in decreased phosphorylation of GYS1 protein CTD PMID:29981789 Gys1 Rat 1,2-dimethylhydrazine increases expression ISO Gys1 (Mus musculus) 6480464 1,2-Dimethylhydrazine results in increased expression of GYS1 mRNA CTD PMID:22206623 Gys1 Rat 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of GYS1 mRNA CTD PMID:32145629 Gys1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Gys1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of GYS1 mRNA CTD PMID:21570461 Gys1 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO GYS1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of GYS1 mRNA CTD PMID:29704546 Gys1 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Gys1 (Mus musculus) 6480464 [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression more ... CTD PMID:25975270 Gys1 Rat 3-methyladenine multiple interactions ISO GYS1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GYS1 protein] CTD PMID:30362509 Gys1 Rat 4,4'-sulfonyldiphenol increases expression ISO GYS1 (Homo sapiens) 6480464 bisphenol S results in increased expression of GYS1 mRNA; bisphenol S results in increased expression more ... CTD PMID:31121516|PMID:34186270 Gys1 Rat 4,4'-sulfonyldiphenol affects methylation ISO Gys1 (Mus musculus) 6480464 bisphenol S affects the methylation of GYS1 gene CTD PMID:31683443 Gys1 Rat acrolein multiple interactions ISO GYS1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ... CTD PMID:32699268 Gys1 Rat acrylamide affects expression EXP 6480464 Acrylamide affects the expression of GYS1 mRNA CTD PMID:28959563 Gys1 Rat aflatoxin B1 increases methylation ISO GYS1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of GYS1 gene CTD PMID:27153756 Gys1 Rat aldehydo-D-glucose multiple interactions EXP 6480464 3,4-Dihydroxyphenylacetic Acid inhibits the reaction [Glucose results in increased phosphorylation of GYS1 protein]; Catechin inhibits more ... CTD PMID:29981789 Gys1 Rat aldehydo-D-glucose increases phosphorylation EXP 6480464 Glucose results in increased phosphorylation of GYS1 protein CTD PMID:29981789 Gys1 Rat all-trans-retinoic acid increases expression ISO GYS1 (Homo sapiens) 6480464 Tretinoin results in increased expression of GYS1 mRNA CTD PMID:33167477 Gys1 Rat alpha-phellandrene increases expression ISO GYS1 (Homo sapiens) 6480464 alpha phellandrene results in increased expression of GYS1 mRNA CTD PMID:25075043 Gys1 Rat alpha-pinene multiple interactions ISO GYS1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ... CTD PMID:32699268 Gys1 Rat amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of GYS1 mRNA CTD PMID:30779732 Gys1 Rat aristolochic acid A decreases expression ISO GYS1 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of GYS1 mRNA; aristolochic acid I results in more ... CTD PMID:33212167 Gys1 Rat arsane multiple interactions ISO GYS1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Gys1 Rat arsenic atom multiple interactions ISO GYS1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Gys1 Rat arsenous acid decreases phosphorylation ISO GYS1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased phosphorylation of GYS1 protein CTD PMID:30362509 Gys1 Rat arsenous acid multiple interactions ISO GYS1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GYS1 protein]; Palmitic Acid more ... CTD PMID:30362509 Gys1 Rat arsenous acid decreases phosphorylation ISO Gys1 (Mus musculus) 6480464 Arsenic Trioxide results in decreased phosphorylation of GYS1 protein CTD PMID:30362509 Gys1 Rat arsenous acid multiple interactions ISO Gys1 (Mus musculus) 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GYS1 protein] CTD PMID:30362509 Gys1 Rat benzatropine multiple interactions ISO GYS1 (Homo sapiens) 6480464 [Cuprizone co-treated with Benztropine] results in decreased expression of GYS1 protein CTD PMID:34122009 Gys1 Rat benzo[a]pyrene multiple interactions ISO Gys1 (Mus musculus) 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of GYS1 mRNA] CTD PMID:22228805 Gys1 Rat benzo[a]pyrene increases methylation ISO GYS1 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of GYS1 3' UTR CTD PMID:27901495 Gys1 Rat benzo[a]pyrene decreases expression ISO Gys1 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of GYS1 mRNA CTD PMID:22228805 Gys1 Rat bisphenol A decreases expression ISO Gys1 (Mus musculus) 6480464 bisphenol A results in decreased expression of GYS1 protein CTD PMID:26146954 Gys1 Rat bisphenol A decreases expression ISO GYS1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of GYS1 protein CTD PMID:34186270 Gys1 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of GYS1 mRNA CTD PMID:32145629|PMID:34947998 Gys1 Rat bisphenol A affects expression ISO GYS1 (Homo sapiens) 6480464 bisphenol A affects the expression of GYS1 mRNA CTD PMID:30903817 Gys1 Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of GYS1 mRNA CTD PMID:25181051|PMID:39307384 Gys1 Rat bisphenol AF increases expression ISO GYS1 (Homo sapiens) 6480464 bisphenol AF results in increased expression of GYS1 protein CTD PMID:34186270 Gys1 Rat Bisphenol B increases expression ISO GYS1 (Homo sapiens) 6480464 bisphenol B results in increased expression of GYS1 protein CTD PMID:34186270 Gys1 Rat bisphenol F decreases expression ISO Gys1 (Mus musculus) 6480464 bisphenol F results in decreased expression of GYS1 mRNA CTD PMID:38685157 Gys1 Rat bisphenol F increases expression ISO GYS1 (Homo sapiens) 6480464 bisphenol F results in increased expression of GYS1 protein CTD PMID:34186270 Gys1 Rat C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of GYS1 mRNA CTD PMID:19167457 Gys1 Rat caffeine increases phosphorylation ISO GYS1 (Homo sapiens) 6480464 Caffeine results in increased phosphorylation of GYS1 protein CTD PMID:35688186 Gys1 Rat cannabidiol multiple interactions ISO GYS1 (Homo sapiens) 6480464 [Cannabidiol co-treated with moringin] results in increased expression of GYS1 mRNA CTD PMID:30096889 Gys1 Rat cisplatin decreases expression ISO GYS1 (Homo sapiens) 6480464 Cisplatin results in decreased expression of GYS1 mRNA CTD PMID:27594783 Gys1 Rat cobalt dichloride multiple interactions ISO GYS1 (Homo sapiens) 6480464 zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of GYS1 mRNA] CTD PMID:22202117 Gys1 Rat cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of GYS1 mRNA CTD PMID:24386269 Gys1 Rat cobalt dichloride increases expression ISO GYS1 (Homo sapiens) 6480464 cobaltous chloride results in increased expression of GYS1 mRNA CTD PMID:22202117 Gys1 Rat copper atom multiple interactions EXP 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of GYS1 mRNA CTD PMID:26033743 Gys1 Rat copper atom multiple interactions ISO GYS1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of GYS1 mRNA CTD PMID:30911355 Gys1 Rat copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of GYS1 mRNA CTD PMID:26033743 Gys1 Rat copper(0) multiple interactions EXP 6480464 [Copper co-treated with Dietary Sucrose] results in increased expression of GYS1 mRNA CTD PMID:26033743 Gys1 Rat copper(0) multiple interactions ISO GYS1 (Homo sapiens) 6480464 [Chelating Agents binds to Copper] which results in increased expression of GYS1 mRNA CTD PMID:30911355 Gys1 Rat copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of GYS1 mRNA CTD PMID:26033743 Gys1 Rat Cuprizon multiple interactions ISO GYS1 (Homo sapiens) 6480464 [Cuprizone co-treated with Benztropine] results in decreased expression of GYS1 protein CTD PMID:34122009 Gys1 Rat cyclosporin A decreases expression ISO GYS1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of GYS1 mRNA CTD PMID:20106945|PMID:25562108|PMID:27989131 Gys1 Rat D-glucose multiple interactions EXP 6480464 3,4-Dihydroxyphenylacetic Acid inhibits the reaction [Glucose results in increased phosphorylation of GYS1 protein]; Catechin inhibits more ... CTD PMID:29981789 Gys1 Rat D-glucose increases phosphorylation EXP 6480464 Glucose results in increased phosphorylation of GYS1 protein CTD PMID:29981789 Gys1 Rat dexamethasone affects phosphorylation EXP 6480464 Dexamethasone affects the phosphorylation of GYS1 protein CTD PMID:18328801 Gys1 Rat diarsenic trioxide decreases phosphorylation ISO GYS1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased phosphorylation of GYS1 protein CTD PMID:30362509 Gys1 Rat diarsenic trioxide multiple interactions ISO Gys1 (Mus musculus) 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GYS1 protein] CTD PMID:30362509 Gys1 Rat diarsenic trioxide multiple interactions ISO GYS1 (Homo sapiens) 6480464 3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GYS1 protein]; Palmitic Acid more ... CTD PMID:30362509 Gys1 Rat diarsenic trioxide decreases phosphorylation ISO Gys1 (Mus musculus) 6480464 Arsenic Trioxide results in decreased phosphorylation of GYS1 protein CTD PMID:30362509 Gys1 Rat Dibutyl phosphate affects expression ISO GYS1 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of GYS1 mRNA CTD PMID:37042841 Gys1 Rat dicrotophos increases expression ISO GYS1 (Homo sapiens) 6480464 dicrotophos results in increased expression of GYS1 mRNA CTD PMID:28302478 Gys1 Rat dimethyl sulfoxide increases expression ISO GYS1 (Homo sapiens) 6480464 Dimethyl Sulfoxide results in increased expression of GYS1 mRNA CTD PMID:39709020 Gys1 Rat dioxygen increases expression ISO Gys1 (Mus musculus) 6480464 Oxygen deficiency results in increased expression of GYS1 mRNA CTD PMID:20880076 Gys1 Rat fluoranthene multiple interactions ISO Gys1 (Mus musculus) 6480464 [1-methylanthracene co-treated with fluoranthene] results in decreased expression of GYS1 mRNA CTD PMID:28329830 Gys1 Rat fluoranthene decreases expression ISO Gys1 (Mus musculus) 6480464 fluoranthene results in decreased expression of GYS1 mRNA CTD PMID:28329830 Gys1 Rat gallic acid decreases expression ISO GYS1 (Homo sapiens) 6480464 Gallic Acid results in decreased expression of GYS1 mRNA CTD PMID:34408198 Gys1 Rat glucose multiple interactions EXP 6480464 3,4-Dihydroxyphenylacetic Acid inhibits the reaction [Glucose results in increased phosphorylation of GYS1 protein]; Catechin inhibits more ... CTD PMID:29981789 Gys1 Rat glucose increases phosphorylation EXP 6480464 Glucose results in increased phosphorylation of GYS1 protein CTD PMID:29981789 Gys1 Rat glyphosate decreases expression ISO GYS1 (Homo sapiens) 6480464 Glyphosate results in decreased expression of GYS1 mRNA CTD PMID:31295307 Gys1 Rat glyphosate increases methylation EXP 6480464 Glyphosate results in increased methylation of GYS1 gene CTD PMID:31011160 Gys1 Rat GSK-J4 decreases expression ISO GYS1 (Homo sapiens) 6480464 GSK-J4 results in decreased expression of GYS1 mRNA CTD PMID:29301935 Gys1 Rat hexadecanoic acid multiple interactions ISO GYS1 (Homo sapiens) 6480464 Palmitic Acid inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GYS1 protein] CTD PMID:30362509 Gys1 Rat ivermectin decreases expression ISO GYS1 (Homo sapiens) 6480464 Ivermectin results in decreased expression of GYS1 protein CTD PMID:32959892 Gys1 Rat lead diacetate increases expression ISO Gys1 (Mus musculus) 6480464 lead acetate results in increased expression of GYS1 mRNA CTD PMID:25270620 Gys1 Rat lead diacetate decreases expression EXP 6480464 lead acetate results in decreased expression of GYS1 mRNA; lead acetate results in decreased expression more ... CTD PMID:28916327 Gys1 Rat manganese atom multiple interactions ISO GYS1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Gys1 Rat manganese(0) multiple interactions ISO GYS1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Gys1 Rat manganese(II) chloride multiple interactions ISO GYS1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Gys1 Rat metformin multiple interactions ISO GYS1 (Homo sapiens) 6480464 Metformin inhibits the reaction [INS protein results in decreased expression of GYS1 protein] CTD PMID:33651899 Gys1 Rat microcystin-LR multiple interactions ISO Gys1 (Mus musculus) 6480464 cyanoginosin LR results in increased expression of and results in increased phosphorylation of and results more ... CTD PMID:28984034 Gys1 Rat microcystin-LR multiple interactions ISO GYS1 (Homo sapiens) 6480464 cyanoginosin LR inhibits the reaction [INS protein results in decreased phosphorylation of and results in more ... CTD PMID:28984034 Gys1 Rat mono(2-ethylhexyl) phthalate increases phosphorylation ISO GYS1 (Homo sapiens) 6480464 mono-(2-ethylhexyl)phthalate results in increased phosphorylation of GYS1 protein CTD PMID:31228551 Gys1 Rat Muraglitazar increases expression EXP 6480464 muraglitazar results in increased expression of GYS1 mRNA CTD PMID:21515302 Gys1 Rat nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of GYS1 mRNA CTD PMID:22110744 Gys1 Rat okadaic acid increases expression ISO GYS1 (Homo sapiens) 6480464 Okadaic Acid results in increased expression of GYS1 mRNA CTD PMID:38832940 Gys1 Rat ozone multiple interactions ISO GYS1 (Homo sapiens) 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ... CTD PMID:32699268 Gys1 Rat ozone increases expression EXP 6480464 Ozone results in increased expression of GYS1 mRNA CTD PMID:35737395 Gys1 Rat paracetamol multiple interactions ISO Gys1 (Mus musculus) 6480464 [Acetaminophen co-treated with PRKN gene mutant form] results in decreased phosphorylation of GYS1 protein CTD PMID:25752611 Gys1 Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of GYS1 mRNA CTD PMID:33387578 Gys1 Rat Pf-06840003 multiple interactions ISO Gys1 (Mus musculus) 6480464 PF-06840003 inhibits the reaction [[amyloid beta-protein (1-42) binds to MAPT protein] which results in decreased more ... CTD PMID:39172838 Gys1 Rat Pf-06840003 multiple interactions ISO GYS1 (Homo sapiens) 6480464 PF-06840003 inhibits the reaction [MAPT protein mutant form results in decreased expression of GYS1 mRNA] CTD PMID:39172838 Gys1 Rat quercetin increases expression ISO GYS1 (Homo sapiens) 6480464 Quercetin results in increased expression of GYS1 mRNA CTD PMID:15309432 Gys1 Rat quercetin decreases phosphorylation ISO GYS1 (Homo sapiens) 6480464 Quercetin results in decreased phosphorylation of GYS1 protein CTD PMID:35688186 Gys1 Rat resveratrol multiple interactions ISO GYS1 (Homo sapiens) 6480464 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol results in increased phosphorylation of GYS1 protein]; TSC2 mutant form more ... CTD PMID:23292070 Gys1 Rat SB 415286 multiple interactions ISO GYS1 (Homo sapiens) 6480464 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol results in increased phosphorylation of GYS1 protein] CTD PMID:23292070 Gys1 Rat sodium arsenate decreases expression ISO Gys1 (Mus musculus) 6480464 sodium arsenate results in decreased expression of GYS1 mRNA CTD PMID:39847705 Gys1 Rat sodium arsenite decreases expression ISO GYS1 (Homo sapiens) 6480464 sodium arsenite results in decreased expression of GYS1 mRNA CTD PMID:38568856 Gys1 Rat sodium arsenite multiple interactions ISO GYS1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Gys1 Rat sodium arsenite increases expression ISO GYS1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of GYS1 mRNA CTD PMID:34032870 Gys1 Rat sodium fluoride increases expression ISO Gys1 (Mus musculus) 6480464 Sodium Fluoride results in increased expression of GYS1 mRNA CTD PMID:27862939 Gys1 Rat streptozocin decreases expression EXP 6480464 Streptozocin results in decreased expression of GYS1 mRNA CTD PMID:27038876 Gys1 Rat streptozocin increases phosphorylation EXP 6480464 Streptozocin results in increased phosphorylation of GYS1 protein CTD PMID:36627075 Gys1 Rat streptozocin multiple interactions EXP 6480464 Plant Extracts inhibits the reaction [Streptozocin results in decreased expression of GYS1 mRNA]; Tribulus extract more ... CTD PMID:27038876|PMID:36627075 Gys1 Rat taurine multiple interactions ISO GYS1 (Homo sapiens) 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GYS1 protein] CTD PMID:30362509 Gys1 Rat taurine multiple interactions ISO Gys1 (Mus musculus) 6480464 Taurine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GYS1 protein] CTD PMID:30362509 Gys1 Rat tert-butyl hydroperoxide increases expression ISO Gys1 (Mus musculus) 6480464 tert-Butylhydroperoxide results in increased expression of GYS1 mRNA CTD PMID:15003993 Gys1 Rat Tesaglitazar increases expression EXP 6480464 tesaglitazar results in increased expression of GYS1 mRNA CTD PMID:21515302 Gys1 Rat testosterone increases expression ISO GYS1 (Homo sapiens) 6480464 Testosterone results in increased expression of GYS1 mRNA CTD PMID:21632903 Gys1 Rat thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of GYS1 mRNA CTD PMID:34492290 Gys1 Rat thiram decreases expression ISO GYS1 (Homo sapiens) 6480464 Thiram results in decreased expression of GYS1 mRNA CTD PMID:38568856 Gys1 Rat titanium dioxide decreases methylation ISO Gys1 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of GYS1 promoter alternative form CTD PMID:35295148 Gys1 Rat triclosan decreases expression ISO GYS1 (Homo sapiens) 6480464 Triclosan results in decreased expression of GYS1 mRNA CTD PMID:30510588 Gys1 Rat valproic acid decreases expression ISO GYS1 (Homo sapiens) 6480464 Valproic Acid results in decreased expression of GYS1 mRNA CTD PMID:29154799 Gys1 Rat valproic acid affects expression ISO Gys1 (Mus musculus) 6480464 Valproic Acid affects the expression of GYS1 mRNA CTD PMID:17963808 Gys1 Rat valproic acid increases methylation ISO GYS1 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of GYS1 gene CTD PMID:29154799 Gys1 Rat vanillic acid multiple interactions ISO GYS1 (Homo sapiens) 6480464 Vanillic Acid inhibits the reaction [INS protein results in decreased expression of GYS1 protein] CTD PMID:33651899 Gys1 Rat xanthosine multiple interactions EXP 6480464 xanthosine inhibits the reaction [Palmitates results in increased phosphorylation of GYS1 protein] CTD PMID:36627075 Gys1 Rat zinc dichloride multiple interactions ISO GYS1 (Homo sapiens) 6480464 zinc chloride inhibits the reaction [cobaltous chloride results in increased expression of GYS1 mRNA] CTD PMID:22202117