Ndufa10l1 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1) - Rat Genome Database

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Gene: Ndufa10l1 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ndufa10l1
Name: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1
RGD ID: 1589745
Description: Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial matrix. Predicted to be part of respiratory chain complex I. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 22. Orthologous to human NDUFA10 (NADH:ubiquinone oxidoreductase subunit A10); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CI-42kD; Complex I-42kD; LOC316632; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like; NADH dehydrogenase 1 alpha subcomplex 10-like protein; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; NADH-ubiquinone oxidoreductase 42 kDa subunit; Ndufa10
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: The correct placement for Ndufa10l is on Rno6 with a single exon structure. The highly similar paralog Ndufa10 (geneID:678759) was incorrectly placed at the same location on the reference assembly for NCBI Build 4.1. The correct placement for Ndufa10 is on Rno9. [17 Jun 2014]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8665,606,866 - 65,608,299 (-)NCBIGRCr8
mRatBN7.2659,879,819 - 59,881,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl659,879,312 - 59,881,241 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx660,183,032 - 60,184,465 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0660,498,001 - 60,499,434 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
Rnor_6.0662,796,951 - 62,798,384 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl662,796,456 - 62,798,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0672,382,515 - 72,383,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4662,280,832 - 62,282,265 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera658,896,526 - 58,897,959 (-)NCBICelera
Cytogenetic Map6q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ndufa10l1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of NDUFA10L1 mRNACTDPMID:33387578
Ndufa10l1Rataflatoxin B1 increases expressionEXP 6480464Aflatoxin B1 results in increased expression of NDUFA10L1 mRNACTDPMID:33354967
Ndufa10l1Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of NDUFA10L1 mRNACTDPMID:16483693
Ndufa10l1Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of NDUFA10L1 mRNACTDPMID:30816183
Ndufa10l1Ratgentamycin decreases expressionEXP 6480464Gentamicins results in decreased expression of NDUFA10L1 proteinCTDPMID:22061828
Ndufa10l1Ratglyphosate decreases methylationEXP 6480464Glyphosate results in decreased methylation of NDUFA10L1 geneCTDPMID:31011160
Ndufa10l1Ratisoprenaline multiple interactionsEXP 6480464[Isoproterenol co-treated with POSTN protein] results in decreased expression of NDUFA10L1 mRNACTDPMID:30303030
Ndufa10l1RatN-nitrosodiethylamine multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NDUFA10L1 mRNACTDPMID:20360939
Ndufa10l1Ratparaquat increases expressionEXP 6480464Paraquat results in increased expression of NDUFA10L1 mRNACTDPMID:32680482
Ndufa10l1RatPCB138 decreases expressionEXP 64804642 more ...CTDPMID:21673325
Ndufa10l1Ratphenethyl caffeate multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of NDUFA10L1 mRNACTDPMID:20360939

1 to 11 of 11 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ndufa10l1Ratmitochondrial electron transport, NADH to ubiquinone involved_inIBAMGI:1914523 and PANTHER:PTN0008282011600115GO_REF:0000033GO_CentralGO_REF:0000033
Ndufa10l1Ratmitochondrial electron transport, NADH to ubiquinone involved_inIEAInterPro:IPR0158281600115GO_REF:0000002InterProGO_REF:0000002
Ndufa10l1Ratproton transmembrane transport involved_inIEAGO:00081371600115GO_REF:0000108GOCGO_REF:0000108

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ndufa10l1Ratcytoplasm is_active_inIBAFB:FBgn0019957 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ndufa10l1Ratmitochondrial matrix located_inIEAUniProtKB-SubCell:SL-01701600115GO_REF:0000044UniProtGO_REF:0000044
Ndufa10l1Ratmitochondrial matrix located_inIEAUniRule:UR0003293181600115GO_REF:0000104UniProtGO_REF:0000104
Ndufa10l1Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
Ndufa10l1Ratrespiratory chain complex I part_ofISSUniProtKB:O952991600115GO_REF:0000024UniProtGO_REF:0000024
Ndufa10l1Ratrespiratory chain complex I part_ofIBAFB:FBgn0019957 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ndufa10l1RatAlzheimer's disease pathway   IEA 6907045 KEGGrno:05010
Ndufa10l1RatHuntington's disease pathway   IEA 6907045 KEGGrno:05016
Ndufa10l1Ratoxidative phosphorylation pathway  IEA 6907045 KEGGrno:00190
Ndufa10l1RatParkinson's disease pathway   IEA 6907045 KEGGrno:05012

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:9125149  



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Variants in Ndufa10l1
6 total Variants

1 to 10 of 23 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat

1 to 10 of 23 rows
RH129838  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2993,007,111 - 93,007,291 (+)MAPPERmRatBN7.2
mRatBN7.2659,879,390 - 59,879,571 (+)MAPPERmRatBN7.2
Rnor_6.0662,796,523 - 62,796,703NCBIRnor6.0
Rnor_6.0999,617,129 - 99,617,308NCBIRnor6.0
Rnor_5.0672,382,087 - 72,382,267UniSTSRnor5.0
Rnor_5.0999,282,243 - 99,282,422UniSTSRnor5.0
RGSC_v3.4662,280,404 - 62,280,584UniSTSRGSC3.4
Celera990,544,465 - 90,544,644UniSTS
Celera658,896,098 - 58,896,278UniSTS
Cytogenetic Map9q36UniSTS
Cytogenetic Map6q21UniSTS
Ndufa10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2659,880,174 - 59,881,074 (+)MAPPERmRatBN7.2
Rnor_6.0662,797,307 - 62,798,206NCBIRnor6.0
Rnor_5.0672,382,871 - 72,383,770UniSTSRnor5.0
RGSC_v3.4662,281,188 - 62,282,087UniSTSRGSC3.4
Celera658,896,882 - 58,897,781UniSTS
Cytogenetic Map9q36UniSTS
Cytogenetic Map6q21UniSTS




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 12 38 34 30 18 6 18 6 65 30 26 11 25 12



Ensembl Acc Id: ENSRNOT00000093200   ⟹   ENSRNOP00000076258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl659,879,312 - 59,881,241 (-)Ensembl
Rnor_6.0 Ensembl662,796,456 - 62,798,384 (-)Ensembl
RefSeq Acc Id: NM_182671   ⟹   NP_872612
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8665,606,866 - 65,608,299 (-)NCBI
mRatBN7.2659,879,819 - 59,881,252 (-)NCBI
Rnor_6.0662,796,951 - 62,798,384 (-)NCBI
Rnor_5.0672,382,515 - 72,383,948 (-)NCBI
RGSC_v3.4662,280,832 - 62,282,265 (-)RGD
Celera658,896,526 - 58,897,959 (-)RGD
Sequence:
Protein RefSeqs NP_872612 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP20092 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076258
RefSeq Acc Id: NP_872612   ⟸   NM_182671
- UniProtKB: A0A1W2Q6F8 (UniProtKB/TrEMBL),   A0A8L2QBL2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000076258   ⟸   ENSRNOT00000093200
Deoxynucleoside kinase

Name Modeler Protein Id AA Range Protein Structure
AF-A0A1W2Q6F8-F1-model_v2 AlphaFold A0A1W2Q6F8 1-355 view protein structure
AF-Q561S0-F1-model_v2 AlphaFold Q561S0 1-355 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694574
Promoter ID:EPDNEW_R5099
Type:multiple initiation site
Name:Ndufa10l1_2
Description:NADH dehydrogenase 1 alpha subcomplex 10-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7390  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0662,798,386 - 62,798,446EPDNEW


1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-37717 BioCyc
Ensembl Genes ENSRNOG00000062245 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000093200 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro Deoxyribonucleoside_kinase UniProtKB/Swiss-Prot
  DNK_dom UniProtKB/Swiss-Prot
  NDUFA10 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:316632 UniProtKB/Swiss-Prot
  rno:678759 UniProtKB/Swiss-Prot
NCBI Gene 316632 ENTREZGENE
PANTHER DEOXYNUCLEOSIDE KINASE UniProtKB/Swiss-Prot
  NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam dNK UniProtKB/Swiss-Prot
PhenoGen Ndufa10l1 PhenoGen
PIRSF NADH_UQ_42KD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000062245 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A1W2Q6F8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QBL2 ENTREZGENE, UniProtKB/TrEMBL
  NDUAA_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q80WE0 UniProtKB/Swiss-Prot
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-01 Ndufa10l1  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1  Ndufa10  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10  Symbol and Name updated 1299863 APPROVED
2008-06-27     Ndufa10  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-12 Ndufa10  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10  Ndufa10l1  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2008-03-18 Ndufa10l1  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1  Ndufa10  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-13 Ndufa10  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10  LOC316632  NADH dehydrogenase 1 alpha subcomplex 10-like protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC316632  NADH dehydrogenase 1 alpha subcomplex 10-like protein      Symbol and Name status set to provisional 70820 PROVISIONAL