Ndufa10l1 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1) - Rat Genome Database

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Gene: Ndufa10l1 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ndufa10l1
Name: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1
RGD ID: 1589745
Description: Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial matrix. Predicted to be part of mitochondrial respiratory chain complex I. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 22. Orthologous to human NDUFA10 (NADH:ubiquinone oxidoreductase subunit A10); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CI-42kD; Complex I-42kD; LOC316632; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like; NADH dehydrogenase 1 alpha subcomplex 10-like protein; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; NADH-ubiquinone oxidoreductase 42 kDa subunit; Ndufa10
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: The correct placement for Ndufa10l is on Rno6 with a single exon structure. The highly similar paralog Ndufa10 (geneID:678759) was incorrectly placed at the same location on the reference assembly for NCBI Build 4.1. The correct placement for Ndufa10 is on Rno9. [17 Jun 2014]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8665,606,866 - 65,608,299 (-)NCBIGRCr8
mRatBN7.2659,879,819 - 59,881,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl659,879,312 - 59,881,241 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx660,183,032 - 60,184,465 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0660,498,001 - 60,499,434 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
Rnor_6.0662,796,951 - 62,798,384 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl662,796,456 - 62,798,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0672,382,515 - 72,383,948 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4662,280,832 - 62,282,265 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera658,896,526 - 58,897,959 (-)NCBICelera
Cytogenetic Map6q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9125149  


Genomics

Variants

.
Variants in Ndufa10l1
6 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat

Markers in Region
RH129838  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2993,007,111 - 93,007,291 (+)MAPPERmRatBN7.2
mRatBN7.2659,879,390 - 59,879,571 (+)MAPPERmRatBN7.2
Rnor_6.0662,796,523 - 62,796,703NCBIRnor6.0
Rnor_6.0999,617,129 - 99,617,308NCBIRnor6.0
Rnor_5.0672,382,087 - 72,382,267UniSTSRnor5.0
Rnor_5.0999,282,243 - 99,282,422UniSTSRnor5.0
RGSC_v3.4662,280,404 - 62,280,584UniSTSRGSC3.4
Celera990,544,465 - 90,544,644UniSTS
Celera658,896,098 - 58,896,278UniSTS
Cytogenetic Map9q36UniSTS
Cytogenetic Map6q21UniSTS
Ndufa10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2659,880,174 - 59,881,074 (+)MAPPERmRatBN7.2
Rnor_6.0662,797,307 - 62,798,206NCBIRnor6.0
Rnor_5.0672,382,871 - 72,383,770UniSTSRnor5.0
RGSC_v3.4662,281,188 - 62,282,087UniSTSRGSC3.4
Celera658,896,882 - 58,897,781UniSTS
Cytogenetic Map9q36UniSTS
Cytogenetic Map6q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system
High
Medium
Low
Below cutoff 6 2 2 2 8 2 12

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000093200   ⟹   ENSRNOP00000076258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl659,879,312 - 59,881,241 (-)Ensembl
Rnor_6.0 Ensembl662,796,456 - 62,798,384 (-)Ensembl
RefSeq Acc Id: NM_182671   ⟹   NP_872612
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8665,606,866 - 65,608,299 (-)NCBI
mRatBN7.2659,879,819 - 59,881,252 (-)NCBI
Rnor_6.0662,796,951 - 62,798,384 (-)NCBI
Rnor_5.0672,382,515 - 72,383,948 (-)NCBI
RGSC_v3.4662,280,832 - 62,282,265 (-)RGD
Celera658,896,526 - 58,897,959 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_872612 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP20092 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022089.6
  ENSRNOP00000076258
  ENSRNOP00000076258.1
  ENSRNOP00065028857
Reference Protein Sequences
RefSeq Acc Id: NP_872612   ⟸   NM_182671
- UniProtKB: A0A1W2Q6F8 (UniProtKB/TrEMBL),   A0A8L2QBL2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000076258   ⟸   ENSRNOT00000093200
Protein Domains
Deoxynucleoside kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A1W2Q6F8-F1-model_v2 AlphaFold A0A1W2Q6F8 1-355 view protein structure
AF-Q561S0-F1-model_v2 AlphaFold Q561S0 1-355 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694574
Promoter ID:EPDNEW_R5099
Type:multiple initiation site
Name:Ndufa10l1_2
Description:NADH dehydrogenase 1 alpha subcomplex 10-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7390  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0662,798,386 - 62,798,446EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589745 AgrOrtholog
BioCyc Gene G2FUF-37717 BioCyc
Ensembl Genes ENSRNOG00000016470 UniProtKB/TrEMBL
  ENSRNOG00000062245 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00065021041 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022089.7 UniProtKB/TrEMBL
  ENSRNOT00000093200 ENTREZGENE
  ENSRNOT00000093200.2 UniProtKB/TrEMBL
  ENSRNOT00065035796 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DNK_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NDUFA10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:316632 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  rno:678759 UniProtKB/Swiss-Prot
NCBI Gene 316632 ENTREZGENE
PANTHER DEOXYNUCLEOSIDE KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam dNK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ndufa10l1 PhenoGen
PIRSF NADH_UQ_42KD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016470 RatGTEx
  ENSRNOG00000062245 RatGTEx
  ENSRNOG00065021041 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2Q6F8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QBL2 ENTREZGENE, UniProtKB/TrEMBL
  NDUAA_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q80WE0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-01 Ndufa10l1  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1  Ndufa10  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10  Symbol and Name updated 1299863 APPROVED
2008-06-27     Ndufa10  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-12 Ndufa10  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10  Ndufa10l1  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2008-03-18 Ndufa10l1  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1  Ndufa10  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-13 Ndufa10  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10  LOC316632  NADH dehydrogenase 1 alpha subcomplex 10-like protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC316632  NADH dehydrogenase 1 alpha subcomplex 10-like protein      Symbol and Name status set to provisional 70820 PROVISIONAL