Tnfaip3 (TNF alpha induced protein 3) - Rat Genome Database

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Gene: Tnfaip3 (TNF alpha induced protein 3) Rattus norvegicus
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Symbol: Tnfaip3
Name: TNF alpha induced protein 3
RGD ID: 1589275
Description: Predicted to enable several functions, including deubiquitinase activity; enzyme binding activity; and ubiquitin binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of signal transduction; and protein modification by small protein conjugation or removal. Predicted to act upstream of or within several processes, including negative regulation of interleukin-1 beta production; positive regulation of protein catabolic process; and protein K63-linked deubiquitination. Predicted to be located in lysosome. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; esophageal cancer; and familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3); PARTICIPATES IN nuclear factor kappa B signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC683206; similar to Tumor necrosis factor, alpha-induced protein 3 (Putative DNA binding protein A20) (Zinc finger protein A20); tumor necrosis factor alpha-induced protein 3; tumor necrosis factor, alpha-induced protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8115,528,921 - 15,543,993 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl115,528,921 - 15,543,979 (-)EnsemblGRCr8
mRatBN7.2113,709,211 - 13,724,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl113,709,206 - 13,725,282 (-)EnsemblmRatBN7.2
Dahl_SR_JrHsd115,087,174 - 15,102,236 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive114,400,428 - 14,415,484 (-)NCBILyon_Normotensive
Lyon_Hypertensive115,566,452 - 15,581,508 (-)NCBILyon_Hypertensive
F344_StmMcwi113,917,702 - 13,932,760 (-)NCBIF344_StmMcwi
Rnor_6.0114,401,103 - 14,416,369 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl114,402,913 - 14,412,807 (-)Ensemblrn6Rnor6.0
Rnor_5.0115,952,235 - 15,963,951 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera112,159,804 - 12,174,919 (-)NCBICelera
Cytogenetic Map1p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-amphetamine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
adenosine  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
andrographolide  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Bardoxolone methyl  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Berbamine  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boron nitride  (ISO)
bortezomib  (ISO)
Botulinum toxin type A  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
cholate  (EXP)
choline  (ISO)
chromium atom  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt atom  (ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-mannitol  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
eriodictyol  (ISO)
erythromycin estolate  (EXP)
etacrynic acid  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
eugenol  (ISO)
fenthion  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
galactose  (ISO)
gallic acid  (ISO)
gemcitabine  (ISO)
gentamycin  (EXP)
gliclazide  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GSK-J4  (ISO)
Heptachlor epoxide  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
ibrutinib  (ISO)
isobutanol  (ISO)
kaempferol  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
LY294002  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nifedipine  (ISO)
o-anisidine  (ISO)
o-xylene  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pemetrexed  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
pevonedistat  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenol  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolbutamide  (ISO)
toluene  (ISO)
Tributyltin oxide  (ISO)
tricetin  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vincristine  (ISO)
withaferin A  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
B-1 B cell homeostasis  (IEA,ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to oxygen-containing compound  (IEA)
establishment of protein localization to vacuole  (ISO)
immune system process  (IEA)
inflammatory response  (IEA)
negative regulation of B cell activation  (IEA,ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
negative regulation of CD40 signaling pathway  (IEA,ISO)
negative regulation of chronic inflammatory response  (IEA,ISO)
negative regulation of cytoplasmic pattern recognition receptor signaling pathway  (IEA)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of innate immune response  (IEA,ISO)
negative regulation of interleukin-1 beta production  (IEA,ISO)
negative regulation of interleukin-2 production  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA,ISO)
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  (IEA,ISO)
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (IEA,ISO)
negative regulation of protein ubiquitination  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (IEA,ISO)
negative regulation of toll-like receptor 3 signaling pathway  (IEA,ISO)
negative regulation of toll-like receptor 5 signaling pathway  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of hepatocyte proliferation  (IEA,ISO)
positive regulation of protein catabolic process  (IEA,ISO)
protein deubiquitination  (IEA,ISO)
protein K11-linked deubiquitination  (IEA,ISO)
protein K48-linked deubiquitination  (IEA,ISO)
protein K48-linked ubiquitination  (IEA,ISO)
protein K63-linked deubiquitination  (IEA,ISO)
proteolysis  (IEA)
regulation of cell population proliferation  (IEA)
regulation of germinal center formation  (IEA,ISO)
response to molecule of bacterial origin  (IEA,ISO)
response to muramyl dipeptide  (IEA,ISO)
tolerance induction to lipopolysaccharide  (IEA,ISO)

Cellular Component
cytoplasm  (IEA,ISO)
lysosome  (IEA)
nucleus  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death. Catrysse L, etal., Cell Death Dis. 2016 Jun 2;7(6):e2250. doi: 10.1038/cddis.2016.154.
2. A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression. Chen H, etal., Mol Cancer. 2015 Nov 4;14:186. doi: 10.1186/s12943-015-0454-6.
3. Regulation of NF-kappaB by ubiquitination. Chen J and Chen ZJ, Curr Opin Immunol. 2013 Feb;25(1):4-12. doi: 10.1016/j.coi.2012.12.005. Epub 2013 Jan 8.
4. Expressions of Tumor Necrosis Factor alpha-induced Protein 3 and Mammary Serine Protease Inhibitor in Radiotherapy of Nasopharyngeal Carcinoma. Deng XQ, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2015 Jun;37(3):279-84. doi: 10.3881/j.issn.1000-503X.2015.03.006.
5. The potential role of TNFAIP3 in malignant transformation of gastric carcinoma. Du B, etal., Pathol Res Pract. 2019 Aug;215(8):152471. doi: 10.1016/j.prp.2019.152471. Epub 2019 May 24.
6. A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma. Feng Y, etal., Cell Death Dis. 2020 Feb 3;11(2):89. doi: 10.1038/s41419-020-2278-6.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Evaluation of the germline single nucleotide polymorphism rs583522 in the TNFAIP3 gene as a prognostic marker in esophageal cancer. Ghadban T, etal., Cancer Genet. 2015 Dec;208(12):595-601. doi: 10.1016/j.cancergen.2015.09.008. Epub 2015 Oct 9.
9. An A/C germline single-nucleotide polymorphism in the TNFAIP3 gene is associated with advanced disease stage and survival in only surgically treated esophageal cancer. Ghadban T, etal., J Hum Genet. 2014 Dec;59(12):661-6. doi: 10.1038/jhg.2014.90. Epub 2014 Oct 30.
10. TNFAIP3 overexpression is an independent factor for poor survival in esophageal squamous cell carcinoma. Hadisaputri YE, etal., Int J Oncol. 2017 Mar;50(3):1002-1010. doi: 10.3892/ijo.2017.3869. Epub 2017 Feb 9.
11. Deubiquitinases in the regulation of NF-kappaB signaling. Harhaj EW and Dixit VM, Cell Res. 2011 Jan;21(1):22-39. doi: 10.1038/cr.2010.166. Epub 2010 Nov 30.
12. A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1. Lee JH, etal., Nat Cell Biol. 2017 Oct;19(10):1260-1273. doi: 10.1038/ncb3609. Epub 2017 Sep 11.
13. Association of the tandem polymorphisms (rs148314165, rs200820567) in TNFAIP3 with chronic hepatitis B virus infection in Chinese Han population. Li N, etal., Virol J. 2017 Aug 7;14(1):148. doi: 10.1186/s12985-017-0814-5.
14. Ubiquitin ligase A20 regulates p53 protein in human colon epithelial cells. Liu J, etal., J Biomed Sci. 2013 Oct 7;20:74. doi: 10.1186/1423-0127-20-74.
15. A20 enhances the radiosensitivity of hepatocellular carcinoma cells to 60Co-γ ionizing radiation. Liu R, etal., Oncotarget. 2017 Oct 16;8(54):93103-93116. doi: 10.18632/oncotarget.21860. eCollection 2017 Nov 3.
16. Altered expression of Tumor Necrosis Factor Alpha -Induced Protein 3 correlates with disease severity in Ulcerative Colitis. Majumdar I, etal., Sci Rep. 2017 Aug 25;7(1):9420. doi: 10.1038/s41598-017-09796-9.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Genetic variation and alterations of genes involved in NFκB/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer. Ungerbäck J, etal., Carcinogenesis. 2012 Nov;33(11):2126-34. doi: 10.1093/carcin/bgs256. Epub 2012 Jul 28.
21. miR-19a promotes colitis-associated colorectal cancer by regulating tumor necrosis factor alpha-induced protein 3-NF-κB feedback loops. Wang T, etal., Oncogene. 2017 Jun 8;36(23):3240-3251. doi: 10.1038/onc.2016.468. Epub 2016 Dec 19.
22. The Prognostic Role of SOCS3 and A20 in Human Cholangiocarcinoma. Wang Y, etal., PLoS One. 2015 Oct 20;10(10):e0141165. doi: 10.1371/journal.pone.0141165. eCollection 2015.
Additional References at PubMed
PMID:8797804   PMID:10385526   PMID:11009421   PMID:11389905   PMID:11463333   PMID:12167698   PMID:12885753   PMID:14748687   PMID:15258597   PMID:15474016   PMID:15962316   PMID:16816117  
PMID:18006655   PMID:18223652   PMID:18342009   PMID:18952128   PMID:19285159   PMID:19912257   PMID:20392859   PMID:20430393   PMID:20458337   PMID:21088135   PMID:21127049   PMID:21220427  
PMID:21923101   PMID:23609450   PMID:23827681   PMID:24012418   PMID:25416956   PMID:25502805   PMID:26231971   PMID:26991692   PMID:28094437   PMID:30561431   PMID:31515488   PMID:34481142  
PMID:37995648  


Genomics

Comparative Map Data
Tnfaip3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8115,528,921 - 15,543,993 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl115,528,921 - 15,543,979 (-)EnsemblGRCr8
mRatBN7.2113,709,211 - 13,724,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl113,709,206 - 13,725,282 (-)EnsemblmRatBN7.2
Dahl_SR_JrHsd115,087,174 - 15,102,236 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive114,400,428 - 14,415,484 (-)NCBILyon_Normotensive
Lyon_Hypertensive115,566,452 - 15,581,508 (-)NCBILyon_Hypertensive
F344_StmMcwi113,917,702 - 13,932,760 (-)NCBIF344_StmMcwi
Rnor_6.0114,401,103 - 14,416,369 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl114,402,913 - 14,412,807 (-)Ensemblrn6Rnor6.0
Rnor_5.0115,952,235 - 15,963,951 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera112,159,804 - 12,174,919 (-)NCBICelera
Cytogenetic Map1p12NCBI
TNFAIP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386137,866,349 - 137,883,312 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6137,866,383 - 137,885,836 (+)Ensemblhg38GRCh38
GRCh376138,188,396 - 138,204,449 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366138,230,274 - 138,246,142 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346138,230,273 - 138,246,141NCBI
Celera6138,928,721 - 138,944,581 (+)NCBICelera
Cytogenetic Map6q23.3NCBI
HuRef6135,750,495 - 135,766,617 (+)NCBIHuRef
CHM1_16138,450,716 - 138,466,833 (+)NCBICHM1_1
T2T-CHM13v2.06139,054,729 - 139,071,725 (+)NCBIT2T-CHM13v2.0
Tnfaip3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391018,876,658 - 18,891,158 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1018,876,658 - 18,891,405 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381019,000,910 - 19,015,410 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1019,000,910 - 19,015,657 (-)Ensemblmm10GRCm38
MGSCv371018,720,716 - 18,735,216 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361018,690,332 - 18,704,783 (-)NCBIMGSCv36mm8
Celera1018,907,568 - 18,922,063 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map108.08NCBI
Tnfaip3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543621,566,423 - 21,578,469 (-)Ensembl
ChiLan1.0NW_00495543621,566,591 - 21,581,551 (-)NCBIChiLan1.0ChiLan1.0
TNFAIP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25157,824,380 - 157,840,522 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16155,721,970 - 155,737,920 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06135,617,465 - 135,634,085 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16139,705,255 - 139,721,264 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6139,705,255 - 139,720,819 (+)EnsemblpanPan2panpan1.1
TNFAIP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1130,247,432 - 30,262,992 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl130,251,059 - 30,261,001 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha131,130,692 - 31,146,131 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0130,415,149 - 30,430,593 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl130,415,167 - 30,428,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1130,293,899 - 30,309,336 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0130,175,668 - 30,191,127 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0130,484,573 - 30,499,998 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tnfaip3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946125,345,739 - 125,359,816 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365605,128,843 - 5,138,345 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365605,124,955 - 5,138,988 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFAIP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,473,938 - 26,489,822 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1126,474,158 - 26,489,771 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2129,825,892 - 29,841,634 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFAIP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11335,537,103 - 35,553,396 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1335,537,102 - 35,549,197 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660407,722,304 - 7,738,445 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfaip3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12217,827,167 - 217,840,707 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tnfaip3
38 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:72
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000074583
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1128483164Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat

Markers in Region
D1Rat250  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2113,717,158 - 13,717,273 (+)MAPPERmRatBN7.2
Rnor_6.0114,409,169 - 14,409,285NCBIRnor6.0
Rnor_5.0115,960,301 - 15,960,417UniSTSRnor5.0
Celera112,167,753 - 12,167,867UniSTS
RH 3.4 Map1143.6UniSTS
RH 3.4 Map1143.6RGD
RH 2.0 Map157.6RGD
SHRSP x BN Map110.34RGD


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001060914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003748656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006222836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000074583   ⟹   ENSRNOP00000065542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl115,528,921 - 15,543,979 (-)Ensembl
mRatBN7.2 Ensembl113,709,206 - 13,725,282 (-)Ensembl
Rnor_6.0 Ensembl114,402,913 - 14,412,807 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095738   ⟹   ENSRNOP00000093412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl113,709,206 - 13,723,498 (-)Ensembl
RefSeq Acc Id: NM_001427106   ⟹   NP_001414035
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8115,528,921 - 15,543,979 (-)NCBI
Dahl_SR_JrHsd115,087,174 - 15,102,236 (-)NCBI
Lyon_Normotensive114,400,428 - 14,415,484 (-)NCBI
Lyon_Hypertensive115,566,452 - 15,581,508 (-)NCBI
F344_StmMcwi113,917,702 - 13,932,760 (-)NCBI
RefSeq Acc Id: XM_039098825   ⟹   XP_038954753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8115,528,921 - 15,542,630 (-)NCBI
mRatBN7.2113,709,211 - 13,722,918 (-)NCBI
RefSeq Acc Id: XM_039098833   ⟹   XP_038954761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8115,528,921 - 15,543,211 (-)NCBI
mRatBN7.2113,709,211 - 13,723,500 (-)NCBI
RefSeq Acc Id: XM_039098843   ⟹   XP_038954771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8115,528,921 - 15,543,993 (-)NCBI
mRatBN7.2113,709,211 - 13,724,290 (-)NCBI
RefSeq Acc Id: XR_005497282
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8115,528,921 - 15,542,630 (-)NCBI
mRatBN7.2113,709,211 - 13,722,918 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414035 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954753 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954761 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954771 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93780 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065542
  ENSRNOP00000065542.2
Ensembl Acc Id: ENSRNOP00000065542   ⟸   ENSRNOT00000074583
RefSeq Acc Id: XP_038954771   ⟸   XM_039098843
- Peptide Label: isoform X2
- UniProtKB: M0R7V5 (UniProtKB/TrEMBL),   A6JPA8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954761   ⟸   XM_039098833
- Peptide Label: isoform X2
- UniProtKB: M0R7V5 (UniProtKB/TrEMBL),   A6JPA8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954753   ⟸   XM_039098825
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AL23 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093412   ⟸   ENSRNOT00000095738
RefSeq Acc Id: NP_001414035   ⟸   NM_001427106
- UniProtKB: A6JPA8 (UniProtKB/TrEMBL),   M0R7V5 (UniProtKB/TrEMBL)
Protein Domains
A20-type   OTU

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7V5-F1-model_v2 AlphaFold M0R7V5 1-814 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689519
Promoter ID:EPDNEW_R34
Type:single initiation site
Name:Tnfaip3_1
Description:TNF alpha induced protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0114,412,891 - 14,412,951EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589275 AgrOrtholog
BioCyc Gene G2FUF-62250 BioCyc
Ensembl Genes ENSRNOG00000049517 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074583 ENTREZGENE
  ENSRNOT00000074583.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.4770 UniProtKB/TrEMBL
  3.90.70.80 UniProtKB/TrEMBL
  4.10.240.30 UniProtKB/TrEMBL
InterPro OTU UniProtKB/TrEMBL
  OTU_Deubiquitinase UniProtKB/TrEMBL
  Znf_A20 UniProtKB/TrEMBL
NCBI Gene 683206 ENTREZGENE
PANTHER PTHR13367:SF3 UniProtKB/TrEMBL
  UBIQUITIN THIOESTERASE UniProtKB/TrEMBL
Pfam OTU UniProtKB/TrEMBL
  zf-A20 UniProtKB/TrEMBL
PhenoGen Tnfaip3 PhenoGen
PROSITE OTU UniProtKB/TrEMBL
  ZF_A20 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049517 RatGTEx
SMART ZnF_A20 UniProtKB/TrEMBL
UniProt A0A8I6AL23 ENTREZGENE
  A6JPA8 ENTREZGENE, UniProtKB/TrEMBL
  M0R7V5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Tnfaip3  TNF alpha induced protein 3  Tnfaip3  tumor necrosis factor, alpha-induced protein 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-13 Tnfaip3  tumor necrosis factor, alpha-induced protein 3  LOC683206  similar to Tumor necrosis factor, alpha-induced protein 3 (Putative DNA binding protein A20) (Zinc finger protein A20)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC683206  similar to Tumor necrosis factor, alpha-induced protein 3 (Putative DNA binding protein A20) (Zinc finger protein A20)      Symbol and Name status set to provisional 70820 PROVISIONAL