Tnfaip3 (TNF alpha induced protein 3) - Rat Genome Database

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Pathways
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Gene: Tnfaip3 (TNF alpha induced protein 3) Chinchilla lanigera
Analyze
Symbol: Tnfaip3
Name: TNF alpha induced protein 3
RGD ID: 8974223
Description: ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); identical protein binding (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN B-1 B cell homeostasis (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to lipopolysaccharide (ortholog); PARTICIPATES IN nuclear factor kappa B signaling pathway; tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH autoimmune disease (ortholog); breast cancer (ortholog); cholangiocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tumor necrosis factor alpha-induced protein 3; tumor necrosis factor, alpha-induced protein 3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543621,566,423 - 21,578,469 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543621,566,591 - 21,581,551 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B-1 B cell homeostasis  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to lipopolysaccharide  (ISO)
establishment of protein localization to vacuole  (ISO)
negative regulation of B cell activation  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of CD40 signaling pathway  (ISO)
negative regulation of chronic inflammatory response  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of innate immune response  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  (ISO)
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of toll-like receptor 3 signaling pathway  (ISO)
negative regulation of toll-like receptor 5 signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of protein catabolic process  (ISO)
protein K48-linked ubiquitination  (ISO)
regulation of germinal center formation  (ISO)
response to molecule of bacterial origin  (ISO)
response to muramyl dipeptide  (ISO)
tolerance induction to lipopolysaccharide  (ISO)

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tnfaip3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543621,566,423 - 21,578,469 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543621,566,591 - 21,581,551 (-)NCBIChiLan1.0ChiLan1.0
TNFAIP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386137,866,349 - 137,883,312 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6137,867,214 - 137,883,314 (+)EnsemblGRCh38hg38GRCh38
GRCh376138,188,396 - 138,204,449 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366138,230,274 - 138,246,142 (+)NCBINCBI36Build 36hg18NCBI36
Build 346138,230,273 - 138,246,141NCBI
Celera6138,928,721 - 138,944,581 (+)NCBICelera
Cytogenetic Map6q23.3NCBI
HuRef6135,750,495 - 135,766,617 (+)NCBIHuRef
CHM1_16138,450,716 - 138,466,833 (+)NCBICHM1_1
T2T-CHM13v2.06139,054,729 - 139,071,725 (+)NCBIT2T-CHM13v2.0
Tnfaip3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391018,876,658 - 18,891,158 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1018,876,658 - 18,891,405 (-)EnsemblGRCm39 Ensembl
GRCm381019,000,910 - 19,015,410 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1019,000,910 - 19,015,657 (-)EnsemblGRCm38mm10GRCm38
MGSCv371018,720,716 - 18,735,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361018,690,332 - 18,704,783 (-)NCBIMGSCv36mm8
Celera1018,907,568 - 18,922,063 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map108.08NCBI
Tnfaip3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8115,528,921 - 15,543,993 (-)NCBIGRCr8
mRatBN7.2113,709,211 - 13,724,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl113,709,206 - 13,725,282 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0114,401,103 - 14,416,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl114,402,913 - 14,412,807 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0115,952,235 - 15,963,951 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera112,159,804 - 12,174,919 (-)NCBICelera
Cytogenetic Map1p12NCBI
TNFAIP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25157,824,380 - 157,840,522 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16155,721,970 - 155,737,920 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06135,617,465 - 135,634,085 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16139,705,255 - 139,721,264 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6139,705,255 - 139,720,819 (+)Ensemblpanpan1.1panPan2
TNFAIP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1130,247,432 - 30,262,992 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl130,251,059 - 30,261,001 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha131,130,692 - 31,146,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0130,415,149 - 30,430,593 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl130,415,167 - 30,428,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1130,293,899 - 30,309,336 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0130,175,668 - 30,191,127 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0130,484,573 - 30,499,998 (+)NCBIUU_Cfam_GSD_1.0
Tnfaip3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946125,345,739 - 125,359,816 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365605,128,843 - 5,138,345 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365605,124,955 - 5,138,988 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFAIP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,473,938 - 26,489,822 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,474,158 - 26,489,771 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2129,825,892 - 29,841,634 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFAIP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11335,537,103 - 35,553,396 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1335,537,102 - 35,549,197 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660407,722,304 - 7,738,445 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000012393   ⟹   ENSCLAP00000012251
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543621,566,423 - 21,578,469 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000012394   ⟹   ENSCLAP00000012252
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495543621,568,192 - 21,578,430 (-)Ensembl
RefSeq Acc Id: XM_005389278   ⟹   XP_005389335
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543621,566,591 - 21,578,873 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013516683   ⟹   XP_013372137
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543621,566,591 - 21,578,518 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013516684   ⟹   XP_013372138
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495543621,566,591 - 21,581,551 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005389335 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372137 (Get FASTA)   NCBI Sequence Viewer  
  XP_013372138 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000012251
  ENSCLAP00000012251.1
  ENSCLAP00000012252.1
Reference Protein Sequences
RefSeq Acc Id: XP_005389335   ⟸   XM_005389278
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YNT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013372138   ⟸   XM_013516684
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YNT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013372137   ⟸   XM_013516683
- Peptide Label: isoform X1
- UniProtKB: A0A8C2V9N1 (UniProtKB/TrEMBL),   A0A8C2YNT1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000012252   ⟸   ENSCLAT00000012394
RefSeq Acc Id: ENSCLAP00000012251   ⟸   ENSCLAT00000012393
Protein Domains
A20-type   OTU


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000008453 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000012393 ENTREZGENE
  ENSCLAT00000012393.1 UniProtKB/TrEMBL
  ENSCLAT00000012394.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.4770 UniProtKB/TrEMBL
  4.10.240.30 UniProtKB/TrEMBL
InterPro OTU_dom UniProtKB/TrEMBL
  Znf_A20 UniProtKB/TrEMBL
NCBI Gene Tnfaip3 ENTREZGENE
PANTHER PTHR13367:SF3 UniProtKB/TrEMBL
  UBIQUITIN THIOESTERASE UniProtKB/TrEMBL
Pfam OTU UniProtKB/TrEMBL
  zf-A20 UniProtKB/TrEMBL
PROSITE OTU UniProtKB/TrEMBL
  ZF_A20 UniProtKB/TrEMBL
SMART ZnF_A20 UniProtKB/TrEMBL
UniProt A0A8C2V9N1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YNT1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Tnfaip3  TNF alpha induced protein 3    tumor necrosis factor, alpha-induced protein 3  Symbol and/or name change 5135510 APPROVED