H1f2 (H1.2 linker histone, cluster member) - Rat Genome Database

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Gene: H1f2 (H1.2 linker histone, cluster member) Rattus norvegicus
Analyze
Symbol: H1f2
Name: H1.2 linker histone, cluster member
RGD ID: 1587893
Description: Predicted to enable double-stranded DNA binding activity; histone H3K27me3 reader activity; and nucleosomal DNA binding activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in chromosome condensation; facultative heterochromatin formation; and negative regulation of DNA recombination. Predicted to act upstream of or within chromatin organization and negative regulation of transcription by RNA polymerase II. Predicted to be located in chromosome. Predicted to be part of nucleosome. Predicted to be active in euchromatin and nucleus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human H1-2 (H1.2 linker histone, cluster member); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Hist1h1c; histone cluster 1 H1 family member c; histone cluster 1, H1c; histone H1.2; LOC684681; similar to Histone H1.2 (H1 VAR.1) (H1c)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81741,818,962 - 41,820,453 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1741,779,051 - 41,822,317 (-)EnsemblGRCr8
mRatBN7.21741,391,106 - 41,392,597 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1741,388,477 - 41,392,635 (-)EnsemblmRatBN7.2
Rnor_6.01743,638,938 - 43,640,445 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1743,639,749 - 43,640,387 (-)Ensemblrn6Rnor6.0
Rnor_5.01745,493,397 - 45,494,901 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1741,022,273 - 41,023,780 (-)NCBICelera
Cytogenetic Map17p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aminoglutethimide  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium silicate  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chrysene  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
fentin chloride  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
furan  (ISO)
genistein  (ISO)
glucose  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indirubin  (ISO)
iron dichloride  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
manganese(II) chloride  (EXP)
metformin  (ISO)
methylisothiazolinone  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
tremolite asbestos  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vandetanib  (ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
euchromatin  (IBA,ISO)
heterochromatin  (ISO)
nucleolus  (ISO)
nucleoplasm  (ISO)
nucleosome  (IEA)
nucleus  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. An extensive analysis of the hereditary hemochromatosis gene HFE and neighboring histone genes: associations with childhood leukemia. Davis CF and Dorak MT, Ann Hematol. 2010 Apr;89(4):375-84. doi: 10.1007/s00277-009-0839-y. Epub 2009 Oct 6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12808097   PMID:15562002   PMID:15911621   PMID:21383955   PMID:22083958   PMID:22658674   PMID:22681889   PMID:22701719   PMID:22720776   PMID:24625528  


Genomics

Comparative Map Data
H1f2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81741,818,962 - 41,820,453 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1741,779,051 - 41,822,317 (-)EnsemblGRCr8
mRatBN7.21741,391,106 - 41,392,597 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1741,388,477 - 41,392,635 (-)EnsemblmRatBN7.2
Rnor_6.01743,638,938 - 43,640,445 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1743,639,749 - 43,640,387 (-)Ensemblrn6Rnor6.0
Rnor_5.01745,493,397 - 45,494,901 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1741,022,273 - 41,023,780 (-)NCBICelera
Cytogenetic Map17p11NCBI
H1-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38626,055,740 - 26,056,470 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl626,054,760 - 26,056,470 (-)Ensemblhg38GRCh38
GRCh37626,055,968 - 26,056,698 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36626,163,894 - 26,164,678 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34626,163,946 - 26,164,678NCBI
Celera627,285,199 - 27,285,983 (-)NCBICelera
Cytogenetic Map6p22.2NCBI
HuRef625,999,033 - 25,999,764 (-)NCBIHuRef
CHM1_1626,058,241 - 26,058,972 (-)NCBICHM1_1
T2T-CHM13v2.0625,923,905 - 25,924,635 (-)NCBIT2T-CHM13v2.0
H1f2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391323,922,790 - 23,923,514 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1323,922,791 - 23,924,350 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381323,738,807 - 23,739,531 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1323,738,808 - 23,740,367 (+)Ensemblmm10GRCm38
MGSCv371323,830,676 - 23,832,236 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361323,746,272 - 23,747,831 (+)NCBIMGSCv36mm8
Celera1323,970,577 - 23,972,139 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map139.9NCBI
H1-2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955483961,343 - 961,984 (+)Ensembl
ChiLan1.0NW_004955483961,317 - 962,727 (+)NCBIChiLan1.0ChiLan1.0
H1-2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2540,703,548 - 40,704,343 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1636,704,988 - 36,705,767 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0625,891,079 - 25,891,859 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1626,548,932 - 26,549,698 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl626,549,016 - 26,549,657 (-)EnsemblpanPan2panpan1.1
H1-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13524,009,304 - 24,011,602 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3523,842,241 - 23,890,066 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03524,078,768 - 24,126,671 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3524,125,975 - 24,126,616 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13523,895,125 - 23,942,926 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03523,946,130 - 23,993,993 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03525,378,756 - 25,426,596 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
H1-2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049461,709,738 - 1,714,197 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366711,907,321 - 1,911,851 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366711,907,356 - 1,911,821 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
H1-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl720,743,716 - 20,744,356 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1720,743,716 - 20,744,356 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
H1-2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11746,199,245 - 46,200,970 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1746,199,304 - 46,199,942 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604425,990,365 - 25,992,087 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
H1-2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11442,732,674 - 42,734,152 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in H1f2
4 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001408767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001071565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000087731   ⟹   ENSRNOP00000073681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1743,639,749 - 43,640,387 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106787   ⟹   ENSRNOP00000077080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1741,817,062 - 41,820,464 (-)Ensembl
mRatBN7.2 Ensembl1741,388,477 - 41,392,635 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147710   ⟹   ENSRNOP00000102105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1741,779,051 - 41,822,317 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165737   ⟹   ENSRNOP00000103260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1741,784,318 - 41,820,491 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000168679   ⟹   ENSRNOP00000099275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1741,807,041 - 41,820,464 (-)Ensembl
RefSeq Acc Id: NM_001408767   ⟹   NP_001395696
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81741,818,962 - 41,820,453 (-)NCBI
mRatBN7.21741,391,106 - 41,392,597 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001395696 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86568 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077080.1
  ENSRNOP00000099275.1
  ENSRNOP00000102105.1
  ENSRNOP00000103260
  ENSRNOP00000103260.1
Ensembl Acc Id: ENSRNOP00000073681   ⟸   ENSRNOT00000087731
Ensembl Acc Id: ENSRNOP00000077080   ⟸   ENSRNOT00000106787
RefSeq Acc Id: NP_001395696   ⟸   NM_001408767
- UniProtKB: A0A0G2K654 (UniProtKB/TrEMBL),   A6KLM3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103260   ⟸   ENSRNOT00000165737
Ensembl Acc Id: ENSRNOP00000102105   ⟸   ENSRNOT00000147710
Ensembl Acc Id: ENSRNOP00000099275   ⟸   ENSRNOT00000168679
Protein Domains
H15

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K654-F1-model_v2 AlphaFold A0A0G2K654 1-212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700465
Promoter ID:EPDNEW_R10983
Type:multiple initiation site
Name:Hist1h1c_1
Description:histone cluster 1 H1 family member c
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01743,640,429 - 43,640,489EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587893 AgrOrtholog
BioCyc Gene G2FUF-9380 BioCyc
Ensembl Genes ENSRNOG00000054978 Ensembl
  ENSRNOG00000067441 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000106787.2 UniProtKB/TrEMBL
  ENSRNOT00000147710.1 UniProtKB/TrEMBL
  ENSRNOT00000165737 ENTREZGENE
  ENSRNOT00000165737.1 UniProtKB/TrEMBL
  ENSRNOT00000168679.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro Histone_H1/H5_H15 UniProtKB/TrEMBL
  Histone_H5 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene 684681 ENTREZGENE
Pfam Linker_histone UniProtKB/TrEMBL
PhenoGen H1f2 PhenoGen
PRINTS HISTONEH5 UniProtKB/TrEMBL
PROSITE H15 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054978 RatGTEx
  ENSRNOG00000067441 RatGTEx
SMART H15 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A0A0G2K654 ENTREZGENE, UniProtKB/TrEMBL
  A6KLM3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 H1f2  H1.2 linker histone, cluster member  H1f2  H1.2 linker histone, cluster member  Data merged from RGD:149736122 737654 PROVISIONAL
2021-08-09 H1f2  H1.2 linker histone, cluster member      Symbol and Name status set to provisional 45752 PROVISIONAL
2019-09-13 H1f2  H1.2 linker histone, cluster member  H1f2  H1.2 linker histone, cluster member  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-09-13 H1f2  H1.2 linker histone, cluster member  Hist1h1c  histone cluster 1 H1 family member c  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-10-12 Hist1h1c  histone cluster 1 H1 family member c  Hist1h1c  histone cluster 1, H1c  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-11 Hist1h1c  histone cluster 1, H1c  LOC684681  similar to Histone H1.2 (H1 VAR.1) (H1c)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC684681  similar to Histone H1.2 (H1 VAR.1) (H1c)      Symbol and Name status set to provisional 70820 PROVISIONAL