Prkg1 (protein kinase cGMP-dependent 1) - Rat Genome Database

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Gene: Prkg1 (protein kinase cGMP-dependent 1) Rattus norvegicus
Analyze
Symbol: Prkg1
Name: protein kinase cGMP-dependent 1
RGD ID: 1587390
Description: Enables identical protein binding activity and mitogen-activated protein kinase p38 binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; positive regulation of large conductance calcium-activated potassium channel activity; and regulation of small molecule metabolic process. Located in acrosomal vesicle; nucleoplasm; and sarcolemma. Biomarker of allergic rhinitis; hypertension; hypogonadism; impotence; and obesity. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1); PARTICIPATES IN eicosanoid signaling pathway; long term depression; INTERACTS WITH 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one; 3,4-methylenedioxymethamphetamine; 4-hydroxy-TEMPO.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cAMP-dependent protein kinase catalytic subunit PRKX-like; cGk1; cGMP dependent protein kinase type 1; cGMP dependent protein kinase type1; cGMP-dependent protein kinase 1; LOC100912084; LOC365449; Pkgi; Prkg1_mapped; protein kinase, cGMP-dependent, type 1; protein kinase, cGMP-dependent, type 1 (mapped); Protein kinase, cGMP-dependent, type I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Lnnr2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,818,950 - 239,052,184 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1237,823,053 - 239,103,005 (-)EnsemblGRCr8
mRatBN7.21228,409,605 - 229,638,794 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1228,408,947 - 229,639,080 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1236,778,127 - 238,005,258 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,707,829 - 244,934,964 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,538,254 - 237,776,527 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1237,122,273 - 238,352,430 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1242,041,111 - 243,271,250 (-)NCBILyon_Normotensive
Lyon_Hypertensive1238,790,311 - 240,020,462 (-)NCBILyon_Hypertensive
F344_StmMcwi1237,027,772 - 238,257,917 (-)NCBIF344_StmMcwi
Rnor_6.01248,982,039 - 250,300,952 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01256,221,067 - 257,537,289 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41234,420,597 - 235,765,375 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1225,545,145 - 226,760,176 (-)NCBICelera
RGSC_v3.11235,515,049 - 235,845,833 (-)NCBI
Cytogenetic Map1q52NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-cotinine  (ISO)
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (EXP)
5-methoxypsoralen  (ISO)
7-nitroindazole  (EXP)
8-(4-chlorophenylthio)-cGMP  (EXP,ISO)
8-bromo-3',5'-cyclic GMP  (EXP,ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonia  (EXP)
apocynin  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
calyculin A  (ISO)
captan  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP)
D-glucose  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenziodolium  (EXP)
diethyl malate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
Evodiamine  (ISO)
fluoxetine  (EXP)
folpet  (ISO)
formaldehyde  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
glucose  (EXP)
hydralazine  (ISO)
indometacin  (ISO)
KT 5823  (ISO)
lead diacetate  (EXP)
menadione  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
mevinphos  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nitroglycerin  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
SB 431542  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sucrose  (EXP)
sulindac sulfone  (ISO)
tadalafil  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP)
testosterone enanthate  (EXP,ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptorelin  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vorinostat  (ISO)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
acrosomal vesicle  (IDA)
cytoplasm  (IEA,ISO)
Golgi apparatus  (IEA,ISO)
nucleoplasm  (IDA)
plasma membrane  (IEA,ISO)
sarcolemma  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction. Airhart N, etal., J Biol Chem. 2003 Oct 3;278(40):38693-8. Epub 2003 Jul 10.
2. Testosterone-induced modulation of nitric oxide-cGMP signaling pathway and androgenesis in the rat Leydig cells. Andric SA, etal., Biol Reprod. 2010 Sep;83(3):434-42. doi: 10.1095/biolreprod.110.083626. Epub 2010 May 12.
3. Dysregulation of cGMP-dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: influence of in vivo gene therapy of PKG1alpha. Bivalacqua TJ, etal., BJU Int. 2007 Jun;99(6):1488-94. Epub 2007 Mar 12.
4. Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS. Butt E, etal., Br J Pharmacol. 1995 Dec;116(8):3110-6.
5. Nitric oxide modulation of agonist-evoked intracellular Ca2+ release in neurosecretory PC-12 cells: inhibition of phospholipase C activity via cyclic GMP-dependent protein kinase I. Clementi E, etal., Mol Pharmacol. 1995 Mar;47(3):517-24.
6. Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages. Coffey MJ, etal., Biochim Biophys Acta. 2008 Jun-Jul;1781(6-7):299-305. doi: 10.1016/j.bbalip.2008.04.005. Epub 2008 Apr 24.
7. cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes. Fiedler B, etal., J Biol Chem. 2006 Oct 27;281(43):32831-40. Epub 2006 Aug 29.
8. Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression. Gambaryan S, etal., J Clin Invest 1996 Aug 1;98(3):662-70.
9. Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle. Gerzanich V, etal., Circ Res. 2003 Oct 31;93(9):805-12. Epub 2003 Sep 25.
10. Hyperlipidaemia induced by a high-cholesterol diet leads to the deterioration of guanosine-3',5'-cyclic monophosphate/protein kinase G-dependent cardioprotection in rats. Giricz Z, etal., Br J Pharmacol. 2009 Nov;158(6):1495-502. doi: 10.1111/j.1476-5381.2009.00424.x. Epub 2009 Oct 20.
11. Transient rise of serum testosterone level after single sildenafil treatment of adult male rats. Janjic MM, etal., J Sex Med. 2012 Oct;9(10):2534-43. doi: 10.1111/j.1743-6109.2012.02674.x. Epub 2012 Mar 16.
12. cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Jaumann M, etal., Nat Med. 2012 Jan 22;18(2):252-9. doi: 10.1038/nm.2634.
13. Cyclic GMP potentiates phenylephrine but not cyclic ADP-ribose-evoked calcium release from rat lacrimal acinar cells. Jorgensen TD, etal., FEBS Lett. 1996 Aug 5;391(1-2):117-20.
14. Expression of cGMP-dependent protein kinases (I and II) and neuronal nitric oxide synthase in the developing rat cerebellum. Jurado S, etal., Brain Res Bull. 2005 Mar 15;65(2):111-5. Epub 2005 Jan 8.
15. Specific phosphorylation sites underlie the stimulation of a large conductance, Ca(2+)-activated K(+) channel by cGMP-dependent protein kinase. Kyle BD, etal., FASEB J. 2013 May;27(5):2027-38. doi: 10.1096/fj.12-223669. Epub 2013 Feb 13.
16. Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG. Maas O, etal., Br J Pharmacol. 2008 May;154(1):25-31. doi: 10.1038/bjp.2008.71. Epub 2008 Mar 10.
17. Cyclic GMP signaling in rat urinary bladder, prostate, and epididymis: tissue-specific changes with aging and in response to Leydig cell depletion. Muller D, etal., Reproduction. 2011 Aug;142(2):333-43. doi: 10.1530/REP-10-0517. Epub 2011 Apr 21.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Nitrite exerts potent negative inotropy in the isolated heart via eNOS-independent nitric oxide generation and cGMP-PKG pathway activation. Pellegrino D, etal., Biochim Biophys Acta. 2009 Jul;1787(7):818-27. doi: 10.1016/j.bbabio.2009.02.007. Epub 2009 Feb 24.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. Insulin increases glomerular filtration barrier permeability through dimerization of protein kinase G type Ialpha subunits. Piwkowska A, etal., Biochim Biophys Acta. 2013 Jun;1832(6):791-804. doi: 10.1016/j.bbadis.2013.02.011. Epub 2013 Feb 21.
23. Expression, purification, and characterization of the cGMP-dependent protein kinases I beta and II using the baculovirus system. Pohler D, etal., FEBS Lett. 1995 Nov 6;374(3):419-25.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Elevated guanylate cyclase and cyclic-guanosine monophosphate-dependent protein kinase levels in nasal mucosae of antigen-challenged rats. Sakai H, etal., Microvasc Res. 2013 Nov;90:150-3. doi: 10.1016/j.mvr.2013.08.009. Epub 2013 Sep 5.
28. Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat. Sandberg M, etal., FEBS Lett. 1989 Sep 25;255(2):321-9.
29. Both protein kinase G dependent and independent mechanisms are involved in the modulation of glutamate release by nitric oxide in rat hippocampal nerve terminals. Sequeira SM, etal., Neurosci Lett. 1999 Feb 12;261(1-2):29-32.
30. Stage- and cell-specific expression of soluble guanylyl cyclase alpha and beta subunits, cGMP-dependent protein kinase I alpha and beta, and cyclic nucleotide-gated channel subunit 1 in the rat testis. Shi F, etal., J Androl. 2005 Mar-Apr;26(2):258-63.
31. Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase. Soro-Paavonen A, etal., J Hypertens. 2010 Apr;28(4):780-8. doi: 10.1097/HJH.0b013e328335043e.
32. Proteolytic processing of cGMP-dependent protein kinase I mediates nuclear cGMP signaling in vascular smooth muscle cells. Sugiura T, etal., Circ Res. 2008 Jul 3;103(1):53-60. doi: 10.1161/CIRCRESAHA.108.176321. Epub 2008 Jun 5.
33. Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Tegeder I, etal., Neurosci Lett. 2002 Oct 31;332(2):146-50.
34. Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I. Tegeder I, etal., Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3253-7. Epub 2004 Feb 18.
35. Circadian clock-controlled regulation of cGMP-protein kinase G in the nocturnal domain. Tischkau SA, etal., J Neurosci. 2003 Aug 20;23(20):7543-50.
36. Endogenous type II cGMP-dependent protein kinase exists as a dimer in membranes and can Be functionally distinguished from the type I isoforms. Vaandrager AB, etal., J Biol Chem. 1997 May 2;272(18):11816-23.
37. Dysregulation of the endothelial nitric oxide synthase-soluble guanylate cyclase pathway is normalized by insulin in the aorta of diabetic rat. Zanetti M, etal., Atherosclerosis. 2005 Jul;181(1):69-73. Epub 2005 Feb 12.
38. Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway. Zhou Y, etal., Cardiovasc Res. 2009 Oct 1;84(1):54-63. doi: 10.1093/cvr/cvp178. Epub 2009 Jun 19.
39. Essential role of protein kinase G and decreased cytoplasmic Ca2+ levels in NO-induced inhibition of rat aortic smooth muscle cell motility. Zhuang D, etal., Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1859-66. Epub 2004 Dec 2.
Additional References at PubMed
PMID:10671526   PMID:11799084   PMID:12177418   PMID:14608379   PMID:14609817   PMID:14960318   PMID:15184388   PMID:15465019   PMID:15483626   PMID:15564589   PMID:15905169   PMID:16055922  
PMID:16154207   PMID:16632465   PMID:16870832   PMID:16990611   PMID:17182580   PMID:17717153   PMID:17878170   PMID:18280805   PMID:18723505   PMID:19127022   PMID:19168131   PMID:19244401  
PMID:19656393   PMID:19961855   PMID:20023176   PMID:20039971   PMID:20349314   PMID:20826808   PMID:21402151   PMID:21520075   PMID:22433666   PMID:22479572   PMID:22498562   PMID:22922339  
PMID:23686857   PMID:23770744   PMID:24041960   PMID:24602613   PMID:24911927   PMID:24921837   PMID:25447536   PMID:25855081   PMID:26440524   PMID:26527422   PMID:27066748   PMID:27230807  
PMID:29196237   PMID:34830353   PMID:37301747  


Genomics

Comparative Map Data
Prkg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,818,950 - 239,052,184 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1237,823,053 - 239,103,005 (-)EnsemblGRCr8
mRatBN7.21228,409,605 - 229,638,794 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1228,408,947 - 229,639,080 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1236,778,127 - 238,005,258 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,707,829 - 244,934,964 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,538,254 - 237,776,527 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1237,122,273 - 238,352,430 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1242,041,111 - 243,271,250 (-)NCBILyon_Normotensive
Lyon_Hypertensive1238,790,311 - 240,020,462 (-)NCBILyon_Hypertensive
F344_StmMcwi1237,027,772 - 238,257,917 (-)NCBIF344_StmMcwi
Rnor_6.01248,982,039 - 250,300,952 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01256,221,067 - 257,537,289 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41234,420,597 - 235,765,375 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1225,545,145 - 226,760,176 (-)NCBICelera
RGSC_v3.11235,515,049 - 235,845,833 (-)NCBI
Cytogenetic Map1q52NCBI
PRKG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381050,990,888 - 52,298,350 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1050,990,888 - 52,298,423 (+)Ensemblhg38GRCh38
GRCh371052,750,648 - 54,058,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361052,420,951 - 53,725,280 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341052,504,298 - 53,725,280NCBI
Celera1046,013,603 - 47,318,321 (+)NCBICelera
Cytogenetic Map10q11.23-q21.1NCBI
HuRef1046,729,527 - 48,036,312 (+)NCBIHuRef
CHM1_11053,032,644 - 54,339,928 (+)NCBICHM1_1
T2T-CHM13v2.01051,839,480 - 53,144,930 (+)NCBIT2T-CHM13v2.0
Prkg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391930,541,887 - 31,742,675 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1930,541,889 - 31,742,433 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381930,564,487 - 31,765,268 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1930,564,489 - 31,765,033 (-)Ensemblmm10GRCm38
MGSCv371930,642,041 - 31,839,523 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361930,633,548 - 31,831,030 (-)NCBIMGSCv36mm8
Celera1931,351,778 - 32,553,439 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1925.17NCBI
Prkg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554256,176,432 - 7,331,446 (+)Ensembl
ChiLan1.0NW_0049554256,176,335 - 7,335,867 (+)NCBIChiLan1.0ChiLan1.0
PRKG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2863,299,984 - 64,595,221 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11063,306,357 - 64,600,543 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01047,642,312 - 48,935,188 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11049,778,821 - 51,069,314 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1049,779,211 - 51,064,882 (+)EnsemblpanPan2panpan1.1
PRKG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12635,732,974 - 36,932,744 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2635,737,242 - 36,932,729 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2635,620,229 - 36,818,502 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02637,271,288 - 38,465,630 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2637,275,477 - 38,465,591 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12635,169,158 - 36,367,548 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02634,756,074 - 35,955,695 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02635,996,645 - 37,196,072 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prkg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721375,309,475 - 76,469,932 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936787332,342 - 1,491,285 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936787330,390 - 1,491,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1497,558,533 - 98,793,010 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11497,558,531 - 98,793,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214106,256,149 - 107,028,245 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.214107,499,623 - 107,663,552 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1978,858,269 - 80,188,163 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604839,812,502 - 40,750,048 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479111,338,510 - 12,654,812 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479111,334,146 - 12,656,480 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prkg1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1230,872,391 - 31,757,664 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prkg1
7148 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:83
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000041080
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
D1Mgh25  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81238,963,877 - 238,964,073 (+)Marker Load Pipeline
mRatBN7.21229,550,480 - 229,550,676 (+)MAPPERmRatBN7.2
Rnor_6.01250,195,095 - 250,195,290NCBIRnor6.0
Rnor_5.01257,430,524 - 257,430,719UniSTSRnor5.0
RGSC_v3.41235,677,488 - 235,677,683UniSTSRGSC3.4
RGSC_v3.41235,677,487 - 235,677,683RGDRGSC3.4
Celera1226,671,919 - 226,672,114UniSTS
RGSC_v3.11235,841,510 - 235,841,706RGD
Cytogenetic Map1q52UniSTS
D1Rat75  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81238,398,865 - 238,399,043 (+)Marker Load Pipeline
mRatBN7.21228,985,440 - 228,985,618 (+)MAPPERmRatBN7.2
Rnor_6.01249,607,907 - 249,608,084NCBIRnor6.0
Rnor_5.01256,846,704 - 256,846,881UniSTSRnor5.0
RGSC_v3.41235,098,616 - 235,098,949RGDRGSC3.4
RGSC_v3.41235,098,674 - 235,098,851UniSTSRGSC3.4
Celera1226,110,015 - 226,110,192UniSTS
RGSC_v3.11235,262,639 - 235,262,972RGD
SHRSP x BN Map1126.57RGD
SHRSP x BN Map1126.57UniSTS
FHH x ACI Map1116.87RGD
Cytogenetic Map1q52UniSTS
D1Rat301  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81237,995,023 - 237,995,199 (+)Marker Load Pipeline
mRatBN7.21228,581,588 - 228,581,766 (+)MAPPERmRatBN7.2
Rnor_6.01249,206,242 - 249,206,417NCBIRnor6.0
Rnor_5.01256,444,932 - 256,445,107UniSTSRnor5.0
Rnor_5.01262,883,614 - 262,883,789UniSTSRnor5.0
RGSC_v3.41234,595,190 - 234,595,366RGDRGSC3.4
RGSC_v3.41234,595,191 - 234,595,366UniSTSRGSC3.4
Celera1225,716,310 - 225,716,485UniSTS
RGSC_v3.11234,759,214 - 234,759,389RGD
RH 3.4 Map11618.9RGD
RH 3.4 Map11618.9UniSTS
RH 2.0 Map11185.7RGD
SHRSP x BN Map1126.57RGD
Cytogenetic Map1q52UniSTS
D1Rat371  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81238,031,317 - 238,031,609 (+)Marker Load Pipeline
mRatBN7.21228,617,884 - 228,618,176 (+)MAPPERmRatBN7.2
Rnor_6.01249,242,639 - 249,242,930NCBIRnor6.0
Rnor_5.01256,481,329 - 256,481,620UniSTSRnor5.0
RGSC_v3.41234,631,432 - 234,631,857RGDRGSC3.4
RGSC_v3.41234,631,485 - 234,631,776UniSTSRGSC3.4
Celera1225,752,215 - 225,752,506UniSTS
RGSC_v3.11234,795,508 - 234,795,799RGD
RH 3.4 Map11618.0UniSTS
RH 3.4 Map11618.0RGD
RH 2.0 Map11185.8RGD
SHRSP x BN Map1126.57RGD
Cytogenetic Map1q52UniSTS
D1Got245  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,602,908 - 228,603,109 (+)MAPPERmRatBN7.2
Rnor_6.01249,227,664 - 249,227,864NCBIRnor6.0
Rnor_5.01256,466,354 - 256,466,554UniSTSRnor5.0
Rnor_5.01262,862,271 - 262,862,471UniSTSRnor5.0
RGSC_v3.41234,616,508 - 234,616,709RGDRGSC3.4
RGSC_v3.41234,616,509 - 234,616,709UniSTSRGSC3.4
Celera1225,737,504 - 225,737,704UniSTS
RGSC_v3.11234,780,532 - 234,780,732RGD
RH 3.4 Map11619.0RGD
RH 3.4 Map11619.0UniSTS
RH 2.0 Map11197.5RGD
Cytogenetic Map1q52UniSTS
D1Uia16  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81238,385,475 - 238,385,744 (+)Marker Load Pipeline
mRatBN7.21228,972,050 - 228,972,319 (+)MAPPERmRatBN7.2
Rnor_6.01249,594,421 - 249,594,689NCBIRnor6.0
Rnor_5.01256,833,218 - 256,833,486UniSTSRnor5.0
RGSC_v3.41235,079,922 - 235,080,191RGDRGSC3.4
RGSC_v3.41235,079,923 - 235,080,191UniSTSRGSC3.4
Celera1226,096,894 - 226,097,162UniSTS
RGSC_v3.11235,243,945 - 235,244,214RGD
Cytogenetic Map1q52UniSTS
RH133105  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81238,971,725 - 238,971,923 (+)Marker Load Pipeline
mRatBN7.21229,558,329 - 229,558,526 (+)MAPPERmRatBN7.2
Rnor_6.01250,202,943 - 250,203,139NCBIRnor6.0
Rnor_6.01250,207,927 - 250,208,123NCBIRnor6.0
Rnor_5.01257,443,356 - 257,443,552UniSTSRnor5.0
Rnor_5.01257,438,372 - 257,438,568UniSTSRnor5.0
RGSC_v3.41235,685,336 - 235,685,532UniSTSRGSC3.4
Celera1226,679,768 - 226,679,964UniSTS
Cytogenetic Map1q52UniSTS
BF392245  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,323,292 - 229,323,471 (+)MAPPERmRatBN7.2
Rnor_6.01249,954,285 - 249,954,463NCBIRnor6.0
Rnor_5.01257,190,780 - 257,190,958UniSTSRnor5.0
RGSC_v3.41235,447,302 - 235,447,480UniSTSRGSC3.4
Celera1226,444,839 - 226,445,017UniSTS
RH 3.4 Map11619.2UniSTS
Cytogenetic Map1q52UniSTS
BF396337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,989,146 - 228,989,340 (+)MAPPERmRatBN7.2
Rnor_6.01249,611,611 - 249,611,804NCBIRnor6.0
Rnor_5.01256,850,408 - 256,850,601UniSTSRnor5.0
RGSC_v3.41235,102,378 - 235,102,571UniSTSRGSC3.4
Celera1226,113,717 - 226,113,910UniSTS
RH 3.4 Map11619.5UniSTS
Cytogenetic Map1q52UniSTS
BF404353  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,024,644 - 229,024,844 (+)MAPPERmRatBN7.2
Rnor_6.01249,647,106 - 249,647,305NCBIRnor6.0
Rnor_5.01256,885,547 - 256,885,746UniSTSRnor5.0
RGSC_v3.41237,138,936 - 237,139,135UniSTSRGSC3.4
Celera1226,148,793 - 226,148,992UniSTS
RH 3.4 Map11647.02UniSTS
Cytogenetic Map1q52UniSTS
AU048249  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21228,839,017 - 228,839,199 (+)MAPPERmRatBN7.2
Rnor_6.01249,461,588 - 249,461,769NCBIRnor6.0
Rnor_5.01256,700,441 - 256,700,622UniSTSRnor5.0
RGSC_v3.41234,857,973 - 234,858,154UniSTSRGSC3.4
Celera1225,969,235 - 225,969,416UniSTS
Cytogenetic Map1q52UniSTS
RH138063  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,432,243 - 229,432,391 (+)MAPPERmRatBN7.2
Rnor_6.01250,064,397 - 250,064,544NCBIRnor6.0
Rnor_5.01257,300,391 - 257,300,538UniSTSRnor5.0
RGSC_v3.41235,556,813 - 235,556,960UniSTSRGSC3.4
Celera1226,553,757 - 226,553,904UniSTS
Cytogenetic Map1q52UniSTS
Prkg1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,638,525 - 229,638,798 (+)MAPPERmRatBN7.2
Rnor_6.01250,300,684 - 250,300,956NCBIRnor6.0
Rnor_5.01257,537,021 - 257,537,293UniSTSRnor5.0
RGSC_v3.41235,765,107 - 235,765,379UniSTSRGSC3.4
Celera1226,759,908 - 226,760,180UniSTS
Cytogenetic Map1q52UniSTS
D19Dcr84  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,174,789 - 229,174,869 (+)MAPPERmRatBN7.2
Rnor_6.01249,812,118 - 249,812,197NCBIRnor6.0
Rnor_5.01257,049,182 - 257,049,261UniSTSRnor5.0
Celera1226,297,609 - 226,297,688UniSTS
Cytogenetic Map1q52UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
exocrine system
hemolymphoid system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
10 1 101 115 6 30 16 162 149 9 113 22 32 17 17

Sequence


RefSeq Acc Id: NM_001105731   ⟹   NP_001099201
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,823,053 - 239,052,184 (-)NCBI
mRatBN7.21228,409,605 - 229,638,794 (-)NCBI
Dahl_SR_JrHsd1237,122,273 - 238,352,430 (-)NCBI
Lyon_Normotensive1242,041,111 - 243,271,250 (-)NCBI
Lyon_Hypertensive1238,790,311 - 240,020,462 (-)NCBI
F344_StmMcwi1237,027,772 - 238,257,917 (-)NCBI
Rnor_6.01248,982,039 - 250,300,952 (-)NCBI
Rnor_5.01256,221,067 - 257,537,289 (-)NCBI
RGSC_v3.41234,420,597 - 235,765,375 (-)RGD
Celera1225,545,145 - 226,760,176 (-)RGD
Sequence:
RefSeq Acc Id: XM_063271952   ⟹   XP_063128022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,818,950 - 238,970,243 (-)NCBI
RefSeq Acc Id: XM_063271955   ⟹   XP_063128025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,818,950 - 237,965,761 (-)NCBI
RefSeq Acc Id: NP_001099201   ⟸   NM_001105731
- UniProtKB: A0A8I6ATM1 (UniProtKB/TrEMBL),   A9LNM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_063128022   ⟸   XM_063271952
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A9E8 (UniProtKB/TrEMBL),   A9LNM8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128025   ⟸   XM_063271955
- Peptide Label: isoform X2
- UniProtKB: A0A8I6B3H1 (UniProtKB/TrEMBL)
Protein Domains
AGC-kinase C-terminal   Cyclic nucleotide-binding   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587390 AgrOrtholog
BioCyc Gene G2FUF-55937 BioCyc
Ensembl Genes ENSRNOG00000053728 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091108 ENTREZGENE
  ENSRNOT00000091108.3 UniProtKB/TrEMBL
  ENSRNOT00000107140 ENTREZGENE
  ENSRNOT00000107140.2 UniProtKB/TrEMBL
  ENSRNOT00000119088.2 UniProtKB/TrEMBL
  ENSRNOT00000162200.1 UniProtKB/TrEMBL
  ENSRNOT00000166788 ENTREZGENE
  ENSRNOT00000166788.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  cGMP_dep_kinase UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PKcGMP_CC UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  STKc_cGK UniProtKB/TrEMBL
KEGG Report rno:54286 UniProtKB/TrEMBL
NCBI Gene 54286 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE UniProtKB/TrEMBL
  PTHR24353:SF68 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  PKcGMP_CC UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Prkg1 PhenoGen
PIRSF cGMP-dep_kinase UniProtKB/TrEMBL
PRINTS CGMPKINASE UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  CNMP_BINDING_1 UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053728 RatGTEx
SMART cNMP UniProtKB/TrEMBL
  S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8I6A9E8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATM1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B3H1 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LK44_RAT UniProtKB/TrEMBL
  A0ABK0M8L4_RAT UniProtKB/TrEMBL
  A6I0Z1_RAT UniProtKB/TrEMBL
  A6I0Z2_RAT UniProtKB/TrEMBL
  A9LNM8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Prkg1  protein kinase cGMP-dependent 1  LOC100912084  cAMP-dependent protein kinase catalytic subunit PRKX-like  Data merged from RGD:6489110 737654 PROVISIONAL
2019-04-03 Prkg1  protein kinase cGMP-dependent 1  Prkg1  protein kinase, cGMP-dependent, type 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100912084  cAMP-dependent protein kinase catalytic subunit PRKX-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Prkg1  protein kinase, cGMP-dependent, type 1  Prkg1_predicted  protein kinase, cGMP-dependent, type 1  'predicted' is removed 2292626 APPROVED
2007-04-13   protein kinase, cGMP-dependent, type 1  Prkg1_predicted  protein kinase, cGMP-dependent, type 1 (predicted)  Name updated 737654 APPROVED
2007-04-12 Prkg1_predicted  protein kinase, cGMP-dependent, type 1 (predicted)  Prkg1  protein kinase, cGMP-dependent, type 1 (mapped)  Nomenclature changed to reflect predicted status 1299863 APPROVED
2007-04-12 Prkg1  protein kinase, cGMP-dependent, type 1 (mapped)  Prkg1_predicted_retired  protein kinase, cGMP-dependent, type I (RETIRED predicted)  Data merged from RGD:1311140 737654 APPROVED
2006-11-19 Prkg1  protein kinase, cGMP-dependent, type 1 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Prkg1_mapped  protein kinase, cGMP-dependent, type 1 (mapped)  Prkg1  protein kinase, cGMP-dependent, type 1  Symbol and Name updated 1556543 APPROVED
2005-01-20 Prkg1  protein kinase, cGMP-dependent, type 1    cGMP dependent protein kinase type1  Name updated 1299863 APPROVED
2005-01-12 Prkg1_predicted  protein kinase, cGMP-dependent, type I (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-06-10 Prkg1  cGMP dependent protein kinase type1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at high levels in cerebellar Purkinje cells and human platelets, moderately in vascular smooth muscle cells, and at a lower levels in cardiac myocytes 61502
gene_mapping maps between D1Mit6 and D1Mit7 on rat chr 1 61022
gene_process lowers intracellular Ca2+, and inhibits vascular smooth muscle contraction, platelet activation and endothelial cell permeability, thereby opposing events leading to hypertension, thrombosis, and atherosclerosis 61502