Polr2a (RNA polymerase II subunit A)

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Gene: Polr2a (RNA polymerase II subunit A) Rattus norvegicus

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Symbol:

Polr2a

Name:

RNA polymerase II subunit A

RGD ID:

1587326

Description:

Predicted to enable several functions, including 5'-3' RNA polymerase activity; enzyme binding activity; and metal ion binding activity. Predicted to contribute to RNA polymerase II activity. Involved in cellular response to oxygen levels and response to organic cyclic compound. Predicted to be located in euchromatin and nucleoplasm. Predicted to be part of Prp19 complex and RNA polymerase II, core complex. Orthologous to human POLR2A (RNA polymerase II subunit A); PARTICIPATES IN RNA polymerase II transcription pathway; Huntington's disease pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

DNA-directed RNA polymerase II subunit RPB1; Polr2a_mapped; Polymerase (RNA II (DNA directed), large polypeptide; polymerase (RNA) II (DNA directed) polypeptide A; polymerase (RNA) II (DNA directed) polypeptide A (mapped); polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; polymerase (RNA) II subunit A; Rpo2-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	POLR2A (RNA polymerase II subunit A)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Polr2a (polymerase (RNA) II (DNA directed) polypeptide A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Polr2a (RNA polymerase II subunit A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	POLR2A (RNA polymerase II subunit A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	POLR2A (RNA polymerase II subunit A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Polr2a (RNA polymerase II subunit A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	POLR2A (RNA polymerase II subunit A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	POLR2A (RNA polymerase II subunit A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Polr2a (RNA polymerase II subunit A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	POLR2A (RNA polymerase II subunit A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Polr2a (polymerase (RNA) II (DNA directed) polypeptide A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	polr2a (polymerase (RNA) II (DNA directed) polypeptide A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ama-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RPO21	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	RpII215	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	polr2a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	54,951,162 - 54,977,179 (-)	NCBI		GRCr8
mRatBN7.2	10	54,452,438 - 54,478,486 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	54,452,441 - 54,478,455 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	56,339,277 - 56,364,888 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	56,339,284 - 56,365,084 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	56,084,677 - 56,110,778 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	56,552,872 - 56,579,172 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	53,606,814 - 53,632,373 (-)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

common variable immunodeficiency (ISO)

congenital myasthenic syndrome 2A (ISO)

Developmental Disease (ISO)

dyskeratosis congenita (ISO)

genetic disease (ISO)

Huntington's disease (ISO)

Infarction (IEP)

intellectual disability (ISO)

Li-Fraumeni syndrome (ISO)

NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND VARIABLE INTELLECTUAL AND BEHAVIORAL ABNORMALITIES (ISO)

Neurodevelopmental Disorders (ISO)

very long chain acyl-CoA dehydrogenase deficiency (ISO)

Weissenbacher-Zweymuller syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1,2-naphthoquinone (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

3H-1,2-dithiole-3-thione (EXP)

4-phenylbutyric acid (ISO)

7,12-dimethyltetraphene (ISO)

acetylsalicylic acid (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

alpha-amanitin (ISO)

alvocidib (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (EXP,ISO)

Benzo[ghi]perylene (ISO)

bezafibrate (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

Brodifacoum (EXP)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

choline (ISO)

clobetasol (ISO)

coumarin (ISO)

decabromodiphenyl ether (ISO)

deferasirox (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

disodium selenite (ISO)

elemental selenium (ISO)

ethanol (ISO)

fenthion (ISO)

folic acid (ISO)

formaldehyde (EXP,ISO)

FR900359 (ISO)

gentamycin (EXP)

ivermectin (ISO)

L-methionine (ISO)

leflunomide (ISO)

methidathion (ISO)

methotrexate (ISO)

miconazole (ISO)

N(4)-hydroxycytidine (ISO)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel sulfate (ISO)

okadaic acid (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

temozolomide (ISO)

tetrachloromethane (EXP)

tetracycline (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

Triptolide (ISO)

triptonide (ISO)

tungsten (ISO)

urethane (ISO)

versicolorin A (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to oxygen levels (IEP)

DNA-templated transcription termination (ISO)

mitochondrial transcription (IEA)

plastid transcription (IEA)

positive regulation of RNA splicing (ISO)

response to organic cyclic compound (IEP)

RNA-templated transcription (IEA)

transcription by RNA polymerase I (IEA)

transcription by RNA polymerase II (ISO)

transcription by RNA polymerase III (IEA)

transcription by RNA polymerase IV (IEA)

transcription by RNA polymerase V (IEA)

Cellular Component

euchromatin (ISO)

nucleolus (ISO)

nucleoplasm (ISO)

nucleus (ISO)

Prp19 complex (ISO)

RNA polymerase II, core complex (IBA,ISO)

Molecular Function

core promoter sequence-specific DNA binding (ISO)

DNA binding (ISO)

DNA-directed 5'-3' RNA polymerase activity (ISO)

kinase binding (ISO)

magnesium ion binding (ISO)

microfibril binding (ISO)

mitochondrial single subunit type RNA polymerase activity (IEA)

plastid single subunit type RNA polymerase activity (IEA)

promoter-specific chromatin binding (ISO)

protein binding (ISO)

RNA polymerase I activity (IEA)

RNA polymerase II activity (IBA)

RNA polymerase III activity (IEA)

RNA polymerase IV activity (IEA)

RNA polymerase V activity (IEA)

RNA-dependent RNA polymerase activity (ISO)

ubiquitin protein ligase binding (ISO)

zinc ion binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Huntington's disease pathway (IEA)

purine metabolic pathway (IEA)

pyrimidine metabolic pathway (IEA)

RNA polymerase II transcription pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis.	Becanovic K, etal., Hum Mol Genet. 2010 Apr 15;19(8):1438-52. doi: 10.1093/hmg/ddq018. Epub 2010 Jan 20.
2.	The effect of aryl hydrocarbon receptor ligands on the expression of polymerase (DNA directed) kappa (Polkappa), polymerase RNA II (DNA directed) polypeptide A (PolR2a), CYP1B1 and CYP1A1 genes in rat liver.	Brauze D and Rawluszko AA, Environ Toxicol Pharmacol. 2012 Nov;34(3):819-25. doi: 10.1016/j.etap.2012.09.004. Epub 2012 Sep 16.
3.	Per-unit-living tissue normalization of real-time RT-PCR data in ischemic rat hearts.	Ellefsen S, etal., Physiol Genomics. 2012 Jun 15;44(12):651-6. doi: 10.1152/physiolgenomics.00004.2012. Epub 2012 Apr 24.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Intermittent hypoxia regulates RNA polymerase II in hippocampus and prefrontal cortex.	Ignacak ML, etal., Neuroscience. 2009 Feb 18;158(4):1436-45. doi: 10.1016/j.neuroscience.2008.11.025. Epub 2008 Nov 21.
6.	TFIIB-related factors in RNA polymerase I transcription.	Knutson BA and Hahn S, Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):265-73. doi: 10.1016/j.bbagrm.2012.08.003. Epub 2012 Aug 30.
7.	von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination.	Kuznetsova AV, etal., Proc Natl Acad Sci U S A 2003 Mar 4;100(5):2706-11. Epub 2003 Feb 25.
8.	RNA polymerase II large subunit is cleaved by caspases during DNA damage-induced apoptosis.	Lu Y, etal., Biochem Biophys Res Commun 2002 Aug 30;296(4):954-61.
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:9268387	PMID:9852112	PMID:14580349	PMID:15601870	PMID:15607978	PMID:15992770	PMID:16109376	PMID:17996703	PMID:21536736	PMID:22658674	PMID:22681889	PMID:22723415
PMID:24441171	PMID:26346254	PMID:26700805	PMID:28076779

Genomics

Comparative Map Data

Polr2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	54,951,162 - 54,977,179 (-)	NCBI		GRCr8
mRatBN7.2	10	54,452,438 - 54,478,486 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	54,452,441 - 54,478,455 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	56,339,277 - 56,364,888 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	56,339,284 - 56,365,084 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	56,084,677 - 56,110,778 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	56,552,872 - 56,579,172 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	53,606,814 - 53,632,373 (-)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

POLR2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	7,484,366 - 7,514,616 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	7,484,366 - 7,514,616 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	7,387,685 - 7,417,933 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	7,328,422 - 7,358,653 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	7,328,421 - 7,358,653	NCBI
Celera	17	7,414,117 - 7,444,201 (+)	NCBI		Celera
Cytogenetic Map	17	p13.1	NCBI
HuRef	17	7,281,725 - 7,311,963 (+)	NCBI		HuRef
CHM1_1	17	7,396,777 - 7,426,944 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	7,388,413 - 7,418,678 (+)	NCBI		T2T-CHM13v2.0

Polr2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	69,624,823 - 69,649,459 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	69,624,823 - 69,649,463 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	69,733,997 - 69,758,633 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	69,733,997 - 69,758,637 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	69,547,912 - 69,571,725 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	69,550,605 - 69,574,418 (-)	NCBI		MGSCv36	mm8
MGSCv36	11	70,318,517 - 70,342,330 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	11	B3	NCBI
cM Map	11	42.86	NCBI

Polr2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	9,421,256 - 9,447,530 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	9,423,540 - 9,447,530 (-)	NCBI	ChiLan1.0	ChiLan1.0

POLR2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	15,079,746 - 15,109,789 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	17,045,567 - 17,075,869 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	7,516,940 - 7,546,989 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	7,502,807 - 7,532,761 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	7,502,807 - 7,532,521 (+)	Ensembl	panpan1.1		panPan2

POLR2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	32,403,814 - 32,429,717 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	32,403,829 - 32,429,681 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	32,541,944 - 32,567,696 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	32,509,534 - 32,535,275 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	32,509,552 - 32,535,260 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	32,474,744 - 32,500,516 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	32,433,445 - 32,459,212 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	32,610,752 - 32,636,501 (+)	NCBI		UU_Cfam_GSD_1.0

Polr2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	47,281,387 - 47,307,489 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936595	755,535 - 781,783 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936595	755,585 - 781,692 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POLR2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	52,779,828 - 52,807,598 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	52,779,833 - 52,806,210 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	54,952,789 - 54,972,415 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POLR2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	6,860,487 - 6,889,054 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	6,860,677 - 6,888,618 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	14,516,279 - 14,548,527 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Polr2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624786	10,097,294 - 10,122,893 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624786	10,098,133 - 10,122,783 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Polr2a
58 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	150
Count of miRNA genes:	89
Interacting mature miRNAs:	95
Transcripts:	ENSRNOT00000048518, ENSRNOT00000068013
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35392457	63642539	Rat
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	50574707	95574707	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
152025229	Scl83	Serum cholesterol level QTL 83	4.33		blood cholesterol amount (VT:0000180)		10	35710580	68663659	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
152025227	Bw195	Body weight QTL 195	5.73		body mass (VT:0001259)		10	46989699	68663659	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
2293669	Bmd33	Bone mineral density QTL 33	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	10	49444551	81709989	Rat
152025224	Bw193	Body weight QTL 193	6.47		body mass (VT:0001259)		10	51663405	75085664	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	41142633	86142633	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
2293679	Bmd30	Bone mineral density QTL 30	3.5	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	49444551	81709989	Rat
1578762	Toxo1	Toxoplasma gondii resistance QTL 1			brain integrity trait (VT:0010579)	percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)	10	52200030	59378278	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	53797494	98952626	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41333258	86333258	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44441699	89441699	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45029650	95600334	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	53797385	107211142	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35392267	64155584	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42323132	87323132	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44441699	89441699	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
2293652	Bmd22	Bone mineral density QTL 22	4.9	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	49444551	81709989	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42323132	87323132	Rat
1359017	Hrtrt21	Heart rate QTL 21	2.4		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	10	51772940	96772940	Rat
2306787	Ean3	Experimental allergic neuritis QTL 3	3.1		nervous system integrity trait (VT:0010566)	body weight loss (CMO:0001399)	10	53797385	66979128	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	51770177	107211142	Rat
1354585	Eae18a	Experimental allergic encephalomyelitis QTL 18a	7.5	0.0004	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	10	53797385	58445852	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
2317043	Aia7	Adjuvant induced arthritis QTL 7	3.82		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	37565079	82565079	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
2317042	Aia20	Adjuvant induced arthritis QTL 20	3.38		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	37565079	82565079	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
70364	Bp72	Blood pressure QTL 72			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	51121100	96121100	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	51774612	95600334	Rat
631535	Cm51	Cardiac mass QTL 51	3		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	51786282	91669536	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
8552805	Bw145	Body weight QTL 145	2.2		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	10	41944526	78307017	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
2293705	Bmd25	Bone mineral density QTL 25	7.1	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	49444551	81709989	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40035094	102359817	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
7207811	Bmd90	Bone mineral density QTL 90	5.2		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	10	49444551	81709989	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44441699	89441699	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47369470	92369470	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
6893342	Cm78	Cardiac mass QTL 78	0.1	0.88	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	42876766	79813922	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat

Markers in Region

PMC56944P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	54,467,901 - 54,468,568 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	56,354,742 - 56,355,408	NCBI	Rnor6.0
Rnor_5.0	10	56,100,142 - 56,100,808	UniSTS	Rnor5.0
RGSC_v3.4	10	56,568,619 - 56,569,285	UniSTS	RGSC3.4
Celera	10	53,622,197 - 53,622,863	UniSTS
Cytogenetic Map	10	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001427041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001079162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087312	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063269519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000068013 ⟹ ENSRNOP00000061492

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	54,452,441 - 54,478,455 (-)	Ensembl
Rnor_6.0 Ensembl	10	56,339,284 - 56,365,084 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105702 ⟹ ENSRNOP00000097288

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	54,452,441 - 54,478,455 (-)	Ensembl

RefSeq Acc Id:

NM_001427041 ⟹ NP_001413970

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	54,951,162 - 54,977,179 (-)	NCBI

RefSeq Acc Id:

XM_039087312 ⟹ XP_038943240

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	54,951,168 - 54,976,471 (-)	NCBI
mRatBN7.2	10	54,452,438 - 54,477,945 (-)	NCBI

RefSeq Acc Id:

XM_063269519 ⟹ XP_063125589

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	54,951,168 - 54,976,816 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001413970	(Get FASTA)	NCBI Sequence Viewer
	XP_038943240	(Get FASTA)	NCBI Sequence Viewer
	XP_063125589	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000061492.1
	ENSRNOP00000097288.1

Ensembl Acc Id:

ENSRNOP00000061492 ⟸ ENSRNOT00000068013

RefSeq Acc Id:	XP_038943240 ⟸ XM_039087312
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000097288 ⟸ ENSRNOT00000105702

RefSeq Acc Id:	NP_001413970 ⟸ NM_001427041
- UniProtKB:	D4A5A6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063125589 ⟸ XM_063269519
- Peptide Label:	isoform X2

Protein Domains

RNA polymerase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A5A6-F1-model_v2	AlphaFold	D4A5A6	1-1970	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1587326	AgrOrtholog
BioCyc Gene	G2FUF-24520	BioCyc
Ensembl Genes	ENSRNOG00000028834	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000068013.4	UniProtKB/TrEMBL
	ENSRNOT00000105702.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.132.30	UniProtKB/TrEMBL
	1.10.150.390	UniProtKB/TrEMBL
	1.10.274.100	UniProtKB/TrEMBL
	2.40.40.20	UniProtKB/TrEMBL
	3.30.1360.140	UniProtKB/TrEMBL
	4.10.860.120	UniProtKB/TrEMBL
	6.10.250.2940	UniProtKB/TrEMBL
	6.20.50.80	UniProtKB/TrEMBL
	RNA polymerase ii	UniProtKB/TrEMBL
InterPro	DNA-dir_RpoC_beta_prime	UniProtKB/TrEMBL
	RNA_pol_asu	UniProtKB/TrEMBL
	RNA_pol_II_repeat_euk	UniProtKB/TrEMBL
	RNA_pol_N	UniProtKB/TrEMBL
	RNA_pol_Rpb1_1	UniProtKB/TrEMBL
	RNA_pol_Rpb1_3	UniProtKB/TrEMBL
	RNA_pol_Rpb1_3_sf	UniProtKB/TrEMBL
	RNA_pol_Rpb1_4	UniProtKB/TrEMBL
	RNA_pol_Rpb1_5	UniProtKB/TrEMBL
	RNA_pol_Rpb1_6	UniProtKB/TrEMBL
	RNA_pol_Rpb1_7	UniProtKB/TrEMBL
	RNA_pol_Rpb1_7_sf	UniProtKB/TrEMBL
	RNA_pol_Rpb1_clamp_domain	UniProtKB/TrEMBL
	Rpb1_funnel_sf	UniProtKB/TrEMBL
NCBI Gene	363633	ENTREZGENE
PANTHER	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1	UniProtKB/TrEMBL
	PTHR19376	UniProtKB/TrEMBL
Pfam	RNA_pol_Rpb1_1	UniProtKB/TrEMBL
	RNA_pol_Rpb1_2	UniProtKB/TrEMBL
	RNA_pol_Rpb1_3	UniProtKB/TrEMBL
	RNA_pol_Rpb1_4	UniProtKB/TrEMBL
	RNA_pol_Rpb1_5	UniProtKB/TrEMBL
	RNA_pol_Rpb1_6	UniProtKB/TrEMBL
	RNA_pol_Rpb1_7	UniProtKB/TrEMBL
	RNA_pol_Rpb1_R	UniProtKB/TrEMBL
PhenoGen	Polr2a	PhenoGen
PRINTS	PRICHEXTENSN	UniProtKB/TrEMBL
PROSITE	RNA_POL_II_REPEAT	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000028834	RatGTEx
SMART	RPOLA_N	UniProtKB/TrEMBL
Superfamily-SCOP	beta and beta-prime subunits of DNA dependent RNA-polymerase	UniProtKB/TrEMBL
UniProt	A0A8I6ASE2_RAT	UniProtKB/TrEMBL
	D4A5A6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-21	Polr2a	RNA polymerase II subunit A	Polr2a	polymerase (RNA) II subunit A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-16	Polr2a	polymerase (RNA) II subunit A	Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-10-22	Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	Polr2a	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Polr2a	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2007-04-13		polymerase (RNA) II (DNA directed) polypeptide A	Polr2a	polymerase (RNA) II (DNA directed) polypeptide A (mapped)	Name updated	737654	APPROVED
2007-04-11	Polr2a	polymerase (RNA) II (DNA directed) polypeptide A (mapped)	Polr2a_mapped	polymerase (RNA) II (DNA directed) polypeptide A (mapped)	Data merged from RGD:3365	737654	APPROVED
2006-11-19	Polr2a	polymerase (RNA) II (DNA directed) polypeptide A (mapped)			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-11-17	Polr2a_mapped	polymerase (RNA) II (DNA directed) polypeptide A (mapped)	Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	Symbol and Name updated	1556543	APPROVED
2003-04-09	Polr2a	polymerase (RNA) II (DNA directed) polypeptide A		Polymerase (RNA II (DNA directed), large polypeptide	Symbol and Name updated	629477	APPROVED
2002-06-10	Polr2a	Polymerase (RNA II (DNA directed), large polypeptide			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	binding to von Hippel_Lindau protein via UV radiation can lead to von Hippel-Lindau disease, a tumor-associated condition that can lead to cardiovascular pathologies	1299102
gene_function	large subunit of RNA pol II that catalyzes the transition from transcription initiation to elongation	1299102
gene_homology	human homologue POLR2A is cleaved by caspases during DNA damage-induced apoptosis	1303938
gene_physical_interaction	binds von Hippel-Lindau tumor suppressor protein for ubiquitination targeting, a process that is regulated by UV radiation	1299102
gene_process	this subunit is hyperphosphorylated during transcription elongation, which makes it a target for ubiquitination, particularly in response to UV radiation	1299102

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Annotations - KEGG (archival)