Med12 (mediator complex subunit 12) - Rat Genome Database

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Gene: Med12 (mediator complex subunit 12) Rattus norvegicus
Analyze
Symbol: Med12
Name: mediator complex subunit 12
RGD ID: 1585896
Description: Contributes to ubiquitin protein ligase activity. Involved in protein ubiquitination. Part of ubiquitin ligase complex. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disorder Lujan-Fryns-type. Orthologous to human MED12 (mediator complex subunit 12); PARTICIPATES IN RNA polymerase II transcription pathway; INTERACTS WITH 6-propyl-2-thiouracil; amitrole; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC679693; mediator of RNA polymerase II transcription subunit 12; similar to Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing pr...
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,444,615 - 70,467,780 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX70,444,705 - 70,467,708 (+)EnsemblGRCr8
mRatBN7.2X66,404,807 - 66,427,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,404,760 - 66,428,387 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX67,888,182 - 67,911,125 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,388,570 - 71,411,513 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,949,477 - 68,972,420 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X71,174,653 - 71,197,812 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,174,699 - 71,197,812 (+)Ensemblrn6Rnor6.0
Rnor_5.0X72,027,135 - 72,050,293 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X89,351,546 - 89,374,489 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX66,760,730 - 66,783,673 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
CKM complex  (IEA,ISO)
mediator complex  (IBA,IEA,ISO)
nucleus  (IEA,ISO)
ubiquitin ligase complex  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Brower CS, etal., Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10353-8. Epub 2002 Jul 29.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Clinical and neurocognitive characterization of a family with a novel MED12 gene frameshift mutation. Lesca G, etal., Am J Med Genet A. 2013 Dec;161A(12):3063-71. doi: 10.1002/ajmg.a.36162. Epub 2013 Aug 16.
4. Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12. Makinen N, etal., PLoS Genet. 2016 Feb 18;12(2):e1005850. doi: 10.1371/journal.pgen.1005850. eCollection 2016 Feb.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. The association of a HOPA polymorphism with major depression and phobia. Philibert R, etal., Compr Psychiatry 2002 Sep-Oct;43(5):404-10.
7. The Mediator complex and transcription regulation. Poss ZC, etal., Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome. Risheg H, etal., Nat Genet. 2007 Apr;39(4):451-3. Epub 2007 Mar 4.
12. A novel mutation in MED12 causes FG syndrome (Opitz-Kaveggia syndrome). Rump P, etal., Clin Genet. 2011 Feb;79(2):183-8. doi: 10.1111/j.1399-0004.2010.01449.x.
13. The original Lujan syndrome family has a novel missense mutation (p.N1007S) in the MED12 gene. Schwartz CE, etal., J Med Genet. 2007 Jul;44(7):472-7. Epub 2007 Mar 16.
14. Mutations in MED12 cause X-linked Ohdo syndrome. Vulto-van Silfhout AT, etal., Am J Hum Genet. 2013 Mar 7;92(3):401-6. doi: 10.1016/j.ajhg.2013.01.007. Epub 2013 Feb 7.
Additional References at PubMed
PMID:10198638   PMID:10235267   PMID:11867769   PMID:11984006   PMID:12037571   PMID:12218053   PMID:15340084   PMID:17000779   PMID:19946888   PMID:20508642   PMID:20589884   PMID:20630950  
PMID:20720539   PMID:23575864   PMID:30361391  


Genomics

Comparative Map Data
Med12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X70,444,615 - 70,467,780 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX70,444,705 - 70,467,708 (+)EnsemblGRCr8
mRatBN7.2X66,404,807 - 66,427,775 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX66,404,760 - 66,428,387 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX67,888,182 - 67,911,125 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X71,388,570 - 71,411,513 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,949,477 - 68,972,420 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X71,174,653 - 71,197,812 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX71,174,699 - 71,197,812 (+)Ensemblrn6Rnor6.0
Rnor_5.0X72,027,135 - 72,050,293 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X89,351,546 - 89,374,489 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX66,760,730 - 66,783,673 (+)NCBICelera
Cytogenetic MapXq22NCBI
MED12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X71,118,596 - 71,142,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX71,118,543 - 71,144,103 (+)Ensemblhg38GRCh38
GRCh37X70,338,446 - 70,362,300 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,255,131 - 70,279,029 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X70,121,593 - 70,145,168NCBI
CeleraX70,692,310 - 70,716,179 (+)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX64,157,722 - 64,181,176 (+)NCBIHuRef
CHM1_1X70,231,161 - 70,255,024 (+)NCBICHM1_1
T2T-CHM13v2.0X69,551,517 - 69,576,535 (+)NCBIT2T-CHM13v2.0
Med12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,317,697 - 100,342,540 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX100,317,636 - 100,341,071 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X101,274,091 - 101,298,934 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,274,030 - 101,297,465 (+)Ensemblmm10GRCm38
MGSCv37X98,469,430 - 98,494,273 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X97,477,613 - 97,499,990 (+)NCBIMGSCv36mm8
CeleraX88,190,265 - 88,214,981 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX43.91NCBI
Med12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547510,687,367 - 10,710,053 (+)Ensembl
ChiLan1.0NW_00495547510,687,168 - 10,710,286 (+)NCBIChiLan1.0ChiLan1.0
MED12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X70,795,965 - 70,819,857 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X70,799,572 - 70,823,460 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X60,386,820 - 60,410,730 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X70,443,467 - 70,467,178 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,443,667 - 70,466,942 (+)EnsemblpanPan2panpan1.1
MED12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,487,629 - 55,508,941 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,482,013 - 55,509,992 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX46,314,714 - 46,337,057 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X56,456,534 - 56,465,517 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1X54,424,767 - 54,447,085 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X55,756,191 - 55,778,506 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X55,683,336 - 55,705,668 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Med12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X46,697,933 - 46,721,139 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936762460,342 - 483,195 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936762460,342 - 483,264 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX57,150,919 - 57,175,333 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X57,150,884 - 57,174,367 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X64,681,038 - 64,704,523 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MED12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,915,796 - 60,939,220 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX60,915,703 - 60,937,677 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660652,776,278 - 2,799,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249031,412,474 - 1,436,474 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249031,412,346 - 1,436,474 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Med12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X59,245,992 - 59,269,018 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Med12
30 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:58
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000040334
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X4493088389930883Rat

Markers in Region
RH79662  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,427,531 - 66,427,714 (+)MAPPERmRatBN7.2
Rnor_6.0X71,197,572 - 71,197,754NCBIRnor6.0
Rnor_5.0X72,050,050 - 72,050,232UniSTSRnor5.0
RGSC_v3.4X89,374,249 - 89,374,431UniSTSRGSC3.4
CeleraX66,783,433 - 66,783,615UniSTS
Cytogenetic MapXq31UniSTS
px-6d9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,420,599 - 66,420,727 (+)MAPPERmRatBN7.2
Rnor_6.0X71,190,640 - 71,190,767NCBIRnor6.0
Rnor_5.0X72,043,118 - 72,043,245UniSTSRnor5.0
RGSC_v3.4X89,367,317 - 89,367,444UniSTSRGSC3.4
CeleraX66,776,501 - 66,776,628UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000040334   ⟹   ENSRNOP00000048013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX70,444,705 - 70,467,031 (+)Ensembl
mRatBN7.2 EnsemblX66,404,760 - 66,427,086 (+)Ensembl
Rnor_6.0 EnsemblX71,174,869 - 71,197,812 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX71,183,887 - 71,187,623 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076957   ⟹   ENSRNOP00000068498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX70,444,705 - 70,467,708 (+)Ensembl
mRatBN7.2 EnsemblX66,404,760 - 66,427,704 (+)Ensembl
Rnor_6.0 EnsemblX71,174,699 - 71,197,736 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090192   ⟹   ENSRNOP00000073197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX70,444,705 - 70,467,708 (+)Ensembl
mRatBN7.2 EnsemblX66,404,760 - 66,427,704 (+)Ensembl
Rnor_6.0 EnsemblX71,174,803 - 71,197,802 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111218   ⟹   ENSRNOP00000084779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX70,444,705 - 70,467,708 (+)Ensembl
mRatBN7.2 EnsemblX66,404,760 - 66,428,387 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000140120   ⟹   ENSRNOP00000111737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX70,444,793 - 70,467,304 (+)Ensembl
RefSeq Acc Id: NM_001193292   ⟹   NP_001180221
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,444,810 - 70,467,777 (+)NCBI
mRatBN7.2X66,404,807 - 66,427,775 (+)NCBI
Rnor_6.0X71,174,869 - 71,197,812 (+)NCBI
Rnor_5.0X72,027,135 - 72,050,293 (+)NCBI
CeleraX66,760,730 - 66,783,673 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001414735   ⟹   NP_001401664
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,444,810 - 70,467,777 (+)NCBI
mRatBN7.2X66,404,807 - 66,427,775 (+)NCBI
RefSeq Acc Id: XM_063280295   ⟹   XP_063136365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,444,615 - 70,467,780 (+)NCBI
RefSeq Acc Id: XM_063280296   ⟹   XP_063136366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,444,615 - 70,467,780 (+)NCBI
RefSeq Acc Id: XM_063280297   ⟹   XP_063136367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,444,615 - 70,467,780 (+)NCBI
RefSeq Acc Id: XM_063280298   ⟹   XP_063136368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X70,444,615 - 70,467,780 (+)NCBI
RefSeq Acc Id: NP_001180221   ⟸   NM_001193292
- Peptide Label: isoform 2
- UniProtKB: A0A8I6A1Z4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073197   ⟸   ENSRNOT00000090192
Ensembl Acc Id: ENSRNOP00000068498   ⟸   ENSRNOT00000076957
Ensembl Acc Id: ENSRNOP00000048013   ⟸   ENSRNOT00000040334
Ensembl Acc Id: ENSRNOP00000084779   ⟸   ENSRNOT00000111218
RefSeq Acc Id: NP_001401664   ⟸   NM_001414735
- Peptide Label: isoform 1
- UniProtKB: A0A096MKF8 (UniProtKB/TrEMBL),   A0A8I6A1Z4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136367   ⟸   XM_063280297
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A1Z4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136365   ⟸   XM_063280295
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A1Z4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136368   ⟸   XM_063280298
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A1Z4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136366   ⟸   XM_063280296
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A1Z4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111737   ⟸   ENSRNOT00000140120
Protein Domains
Mediator complex subunit Med12

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MKF8-F1-model_v2 AlphaFold A0A096MKF8 1-2190 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701875
Promoter ID:EPDNEW_R12397
Type:multiple initiation site
Name:Med12_2
Description:mediator complex subunit 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12398  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X71,174,736 - 71,174,796EPDNEW
RGD ID:13701880
Promoter ID:EPDNEW_R12398
Type:multiple initiation site
Name:Med12_1
Description:mediator complex subunit 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12397  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X71,174,848 - 71,174,908EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585896 AgrOrtholog
BioCyc Gene G2FUF-2103 BioCyc
Ensembl Genes ENSRNOG00000003848 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040334.6 UniProtKB/TrEMBL
  ENSRNOT00000076957 ENTREZGENE
  ENSRNOT00000076957.4 UniProtKB/TrEMBL
  ENSRNOT00000090192 ENTREZGENE
  ENSRNOT00000090192.3 UniProtKB/TrEMBL
  ENSRNOT00000111218.2 UniProtKB/TrEMBL
  ENSRNOT00000140120 ENTREZGENE
  ENSRNOT00000140120.1 UniProtKB/TrEMBL
InterPro Med12-LCEWAV UniProtKB/TrEMBL
  Med12-PQL UniProtKB/TrEMBL
  Mediator_comp_sub12 UniProtKB/TrEMBL
  Mediator_Med12 UniProtKB/TrEMBL
NCBI Gene 679693 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 UniProtKB/TrEMBL
  MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12 UniProtKB/TrEMBL
Pfam Med12 UniProtKB/TrEMBL
  Med12-LCEWAV UniProtKB/TrEMBL
  Med12-PQL UniProtKB/TrEMBL
PhenoGen Med12 PhenoGen
RatGTEx ENSRNOG00000003848 RatGTEx
SMART Med12 UniProtKB/TrEMBL
UniProt A0A096MKF8 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K4W3_RAT UniProtKB/TrEMBL
  A0A8I6A1Z4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LYL7_RAT UniProtKB/TrEMBL
  D3ZDE6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-03-16 Med12  mediator complex subunit 12  LOC679693  similar to Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing pr...  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC679693  similar to Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing pr...  LOC683401  similar to Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing pr...  Data merged from RGD:1586889 1643240 APPROVED
2006-11-19 LOC679693  similar to Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing pr...      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683401  similar to Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing pr...      Symbol and Name status set to provisional 70820 PROVISIONAL