Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | type 2 diabetes mellitus | | ISO | KCNU1 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:28869590 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | type 2 diabetes mellitus | | ISO | KCNU1 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:28869590 | |
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# | Reference Title | Reference Citation |
1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
3. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
4. | Cloning and characterization of the rat Slo3 (KCa 5.1) channel: From biophysics to pharmacology. | Wang GM, etal., Br J Pharmacol. 2020 Aug;177(15):3552-3567. doi: 10.1111/bph.15078. Epub 2020 May 14. |
PMID:16567053 | PMID:18295190 | PMID:19359368 | PMID:19363492 | PMID:19457113 | PMID:19731297 | PMID:19911462 | PMID:25675513 |
Kcnu1 (Rattus norvegicus - Norway rat) |
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KCNU1 (Homo sapiens - human) |
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Kcnu1 (Mus musculus - house mouse) |
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KCNU1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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KCNU1 (Canis lupus familiaris - dog) |
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Kcnu1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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KCNU1 (Sus scrofa - pig) |
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LOC103215616 (Chlorocebus sabaeus - green monkey) |
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Kcnu1 (Heterocephalus glaber - naked mole-rat) |
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Variants in Kcnu1
448 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
endocrine system | hemolymphoid system | integumental system | musculoskeletal system | nervous system | reproductive system | respiratory system | appendage | |
High | ||||||||
Medium | 7 | |||||||
Low | 3 | |||||||
Below cutoff | 8 | 7 | 2 | 2 | 9 | 12 | 1 | 2 |
RefSeq Acc Id: | ENSRNOT00000019935 ⟹ ENSRNOP00000019935 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000105941 ⟹ ENSRNOP00000092925 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_039094935 ⟹ XP_038950863 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_063275977 ⟹ XP_063132047 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063275978 ⟹ XP_063132048 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063275979 ⟹ XP_063132049 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063275980 ⟹ XP_063132050 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063275981 ⟹ XP_063132051 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063275982 ⟹ XP_063132052 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XR_005494752 | ||||||||||||
Type: | NON-CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XR_005494753 | ||||||||||||
Type: | NON-CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XR_005494755 | ||||||||||||
Type: | NON-CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOP00000019935 ⟸ ENSRNOT00000019935 |
RefSeq Acc Id: | XP_038950863 ⟸ XM_039094935 |
- Peptide Label: | isoform X6 |
- UniProtKB: | A0A8I6AEU3 (UniProtKB/TrEMBL), A6IW00 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | ENSRNOP00000092925 ⟸ ENSRNOT00000105941 |
RefSeq Acc Id: | XP_063132049 ⟸ XM_063275979 |
- Peptide Label: | isoform X3 |
RefSeq Acc Id: | XP_063132047 ⟸ XM_063275977 |
- Peptide Label: | isoform X1 |
RefSeq Acc Id: | XP_063132048 ⟸ XM_063275978 |
- Peptide Label: | isoform X2 |
- UniProtKB: | D4A6Z8 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | XP_063132050 ⟸ XM_063275980 |
- Peptide Label: | isoform X4 |
RefSeq Acc Id: | XP_063132051 ⟸ XM_063275981 |
- Peptide Label: | isoform X5 |
RefSeq Acc Id: | XP_063132052 ⟸ XM_063275982 |
- Peptide Label: | isoform X7 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-D4A6Z8-F1-model_v2 | AlphaFold | D4A6Z8 | 1-1113 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13700167 | ||||||||
Promoter ID: | EPDNEW_R10687 | ||||||||
Type: | single initiation site | ||||||||
Name: | Kcnu1_1 | ||||||||
Description: | potassium calcium-activated channel subfamily U member 1 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:1585877 | AgrOrtholog |
BioCyc Gene | G2FUF-10981 | BioCyc |
Ensembl Genes | ENSRNOG00000014741 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000019935.8 | UniProtKB/TrEMBL |
ENSRNOT00000105941.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 1.10.287.70 | UniProtKB/TrEMBL |
NAD(P)-binding Rossmann-like Domain | UniProtKB/TrEMBL | |
InterPro | Ion_trans_dom | UniProtKB/TrEMBL |
K_chnl_Ca-activ_BK_asu | UniProtKB/TrEMBL | |
K_chnl_Slo-like | UniProtKB/TrEMBL | |
NAD(P)-bd_dom_sf | UniProtKB/TrEMBL | |
Slowpoke-like_C | UniProtKB/TrEMBL | |
KEGG Report | rno:680912 | UniProtKB/TrEMBL |
NCBI Gene | 680912 | ENTREZGENE |
PANTHER | CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN | UniProtKB/TrEMBL |
POTASSIUM CHANNEL SUBFAMILY U MEMBER 1 | UniProtKB/TrEMBL | |
Pfam | BK_channel_a | UniProtKB/TrEMBL |
Ion_trans | UniProtKB/TrEMBL | |
Slowpoke_C | UniProtKB/TrEMBL | |
PhenoGen | Kcnu1 | PhenoGen |
PRINTS | BKCHANNELA | UniProtKB/TrEMBL |
KCHANNEL | UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000014741 | RatGTEx |
Superfamily-SCOP | SSF51735 | UniProtKB/TrEMBL |
Voltage-gated potassium channels | UniProtKB/TrEMBL | |
UniProt | A0A8I6AEU3 | ENTREZGENE, UniProtKB/TrEMBL |
A6IW00 | ENTREZGENE, UniProtKB/TrEMBL | |
D4A6Z8 | ENTREZGENE, UniProtKB/TrEMBL |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2016-02-11 | Kcnu1 | potassium calcium-activated channel subfamily U member 1 | Kcnu1 | potassium channel, subfamily U, member 1 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2013-05-24 | Kcnu1 | potassium channel, subfamily U, member 1 | LOC684632 | similar to large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b | Data merged from RGD:1587940 | 1643240 | APPROVED |
2010-12-07 | Kcnu1 | potassium channel, subfamily U, member 1 | LOC680912 | similar to Calcium-activated potassium channel alpha subunit 1 (Calcium-activated potassium channel, subfamily M, alpha subunit 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha... | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2006-11-19 | LOC680912 | similar to Calcium-activated potassium channel alpha subunit 1 (Calcium-activated potassium channel, subfamily M, alpha subunit 1) (Maxi K channel) (MaxiK) (BK channel) (K(VCA)alpha) (BKCA alpha) (KCa1.1) (Slowpoke homolog) (Slo homolog) (Slo-alpha... | Symbol and Name status set to provisional | 70820 | PROVISIONAL | ||
2006-11-19 | LOC684632 | similar to large conductance calcium-activated potassium channel subfamily M alpha member 1 isoform b | Symbol and Name status set to provisional | 70820 | PROVISIONAL |