Kcnu1 (potassium channel, subfamily U, member 1) - Rat Genome Database

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Gene: Kcnu1 (potassium channel, subfamily U, member 1) Mus musculus
Analyze
Symbol: Kcnu1
Name: potassium channel, subfamily U, member 1
RGD ID: 1616853
MGI Page MGI
Description: Enables potassium channel activity. Acts upstream of or within several processes, including establishment of localization in cell; potassium ion transmembrane transport; and protein stabilization. Predicted to be located in plasma membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in membrane. Is expressed in germ cell of testis. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human KCNU1 (potassium calcium-activated channel subfamily U member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium-activated potassium channel subunit alpha-3; calcium-activated potassium channel, subfamily M subunit alpha-3; Kcnm; Kcnma3; KSper; mSlo3; pH-sensitive maxi potassium channel; pore-forming subunit of the sperm-specific alkalization activated K(+) current; potassium channel subfamily U member 1; potassium large conductance pH-sensitive channel, subfamily M, alpha member 3; S; Slo3; slowpoke homolog 3
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,338,656 - 26,427,971 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,339,651 - 26,427,967 (+)EnsemblGRCm39 Ensembl
GRCm38825,848,627 - 25,937,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,849,623 - 25,937,939 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,960,095 - 27,048,406 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,315,201 - 27,403,347 (+)NCBIMGSCv36mm8
Celera827,317,965 - 27,405,769 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.17NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9452476   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12192410   PMID:12466851   PMID:14610273   PMID:16141072   PMID:16141073   PMID:16940554  
PMID:16940555   PMID:19338774   PMID:19473978   PMID:19516020   PMID:19578543   PMID:19934650   PMID:20138882   PMID:20392696   PMID:21427226   PMID:21677750   PMID:21873635   PMID:22084117  
PMID:23129643   PMID:23577126   PMID:23980198   PMID:24813608   PMID:25271166   PMID:25675513   PMID:25855261   PMID:26060254   PMID:27627854   PMID:31270758   PMID:32984353  


Genomics

Comparative Map Data
Kcnu1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,338,656 - 26,427,971 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,339,651 - 26,427,967 (+)EnsemblGRCm39 Ensembl
GRCm38825,848,627 - 25,937,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,849,623 - 25,937,939 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,960,095 - 27,048,406 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,315,201 - 27,403,347 (+)NCBIMGSCv36mm8
Celera827,317,965 - 27,405,769 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.17NCBI
KCNU1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38836,784,374 - 36,936,125 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl836,784,324 - 36,936,125 (+)EnsemblGRCh38hg38GRCh38
GRCh37836,641,892 - 36,793,643 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36836,761,000 - 36,912,801 (+)NCBINCBI36Build 36hg18NCBI36
Build 34836,761,058 - 36,912,799NCBI
Celera835,592,114 - 35,743,914 (+)NCBICelera
Cytogenetic Map8p11.23NCBI
HuRef835,176,234 - 35,328,030 (+)NCBIHuRef
CHM1_1836,844,078 - 36,995,868 (+)NCBICHM1_1
T2T-CHM13v2.0837,060,432 - 37,212,188 (+)NCBIT2T-CHM13v2.0
Kcnu1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81672,844,692 - 72,932,216 (-)NCBIGRCr8
mRatBN7.21666,141,696 - 66,229,493 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,141,976 - 66,229,465 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01670,913,825 - 70,998,593 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1670,913,817 - 70,998,575 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01670,577,547 - 70,663,252 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,517,667 - 70,604,946 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1664,052,606 - 64,139,348 (-)NCBICelera
Cytogenetic Map16q12.4NCBI
KCNU1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2755,334,556 - 55,490,675 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1831,058,504 - 31,209,437 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0836,081,180 - 36,231,982 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1833,261,491 - 33,412,532 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl833,261,041 - 33,412,972 (+)Ensemblpanpan1.1panPan2
KCNU1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11628,333,783 - 28,478,433 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1628,334,505 - 28,478,385 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1628,849,104 - 28,996,123 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01630,237,142 - 30,381,628 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1630,237,799 - 30,381,574 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11628,453,068 - 28,597,470 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01629,030,890 - 29,175,529 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01629,069,713 - 29,214,130 (-)NCBIUU_Cfam_GSD_1.0
Kcnu1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494350,995,030 - 51,159,837 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936710331,610 - 465,981 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936710301,387 - 465,935 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNU1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1549,316,673 - 49,444,385 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11549,317,110 - 49,444,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21556,423,626 - 56,550,938 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103215616
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1834,798,614 - 34,960,466 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl834,826,303 - 34,960,259 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666335277 - 87,857 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnu1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247806,748,764 - 6,904,697 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247806,751,411 - 6,929,900 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnu1
3231 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:379
Count of miRNA genes:243
Interacting mature miRNAs:257
Transcripts:ENSMUST00000098858, ENSMUST00000120653, ENSMUST00000126226
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000098858   ⟹   ENSMUSP00000096457
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl826,339,651 - 26,427,967 (+)Ensembl
GRCm38.p6 Ensembl825,849,623 - 25,937,939 (+)Ensembl
RefSeq Acc Id: ENSMUST00000120653   ⟹   ENSMUSP00000113442
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl826,401,708 - 26,427,961 (+)Ensembl
GRCm38.p6 Ensembl825,911,680 - 25,937,933 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126226   ⟹   ENSMUSP00000123273
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl826,401,720 - 26,411,537 (+)Ensembl
GRCm38.p6 Ensembl825,911,692 - 25,921,509 (+)Ensembl
RefSeq Acc Id: ENSMUST00000210273
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl826,352,464 - 26,375,465 (+)Ensembl
GRCm38.p6 Ensembl825,862,436 - 25,885,437 (+)Ensembl
RefSeq Acc Id: NM_008432   ⟹   NP_032458
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39826,339,651 - 26,427,962 (+)NCBI
GRCm38825,849,623 - 25,937,934 (+)NCBI
MGSCv37826,960,095 - 27,048,406 (+)RGD
Celera827,317,965 - 27,405,769 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006509024   ⟹   XP_006509087
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39826,339,652 - 26,427,971 (+)NCBI
GRCm38825,849,624 - 25,937,943 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017312581   ⟹   XP_017168070
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39826,339,652 - 26,427,971 (+)NCBI
GRCm38825,849,624 - 25,937,943 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017312582   ⟹   XP_017168071
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39826,339,652 - 26,427,971 (+)NCBI
GRCm38825,849,624 - 25,937,943 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017312583   ⟹   XP_017168072
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39826,338,656 - 26,427,971 (+)NCBI
GRCm38825,848,627 - 25,937,943 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003947236
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39826,339,652 - 26,427,962 (+)NCBI
GRCm38825,849,624 - 25,937,934 (+)NCBI
Sequence:
RefSeq Acc Id: XR_003947237
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39826,339,652 - 26,427,962 (+)NCBI
GRCm38825,849,624 - 25,937,934 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032458   ⟸   NM_008432
- UniProtKB: O54982 (UniProtKB/Swiss-Prot),   G3X9P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006509087   ⟸   XM_006509024
- Peptide Label: isoform X1
- UniProtKB: O54982 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017168072   ⟸   XM_017312583
- Peptide Label: isoform X4
- UniProtKB: O54982 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017168071   ⟸   XM_017312582
- Peptide Label: isoform X3
- UniProtKB: O54982 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017168070   ⟸   XM_017312581
- Peptide Label: isoform X2
- UniProtKB: O54982 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000096457   ⟸   ENSMUST00000098858
RefSeq Acc Id: ENSMUSP00000123273   ⟸   ENSMUST00000126226
RefSeq Acc Id: ENSMUSP00000113442   ⟸   ENSMUST00000120653
Protein Domains
Ca2+-activated K+ channel Slowpoke-like C-terminal   Calcium-activated potassium channel BK alpha   Ion transport   RCK N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54982-F1-model_v2 AlphaFold O54982 1-1121 view protein structure

Promoters
RGD ID:8666781
Promoter ID:EPDNEW_M11422
Type:initiation region
Name:Kcnu1_2
Description:Mus musculus potassium channel, subfamily U, member 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11423  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38825,849,626 - 25,849,686EPDNEW
RGD ID:8666783
Promoter ID:EPDNEW_M11423
Type:single initiation site
Name:Kcnu1_1
Description:Mus musculus potassium channel, subfamily U, member 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M11422  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38825,911,680 - 25,911,740EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1202300 AgrOrtholog
Ensembl Genes ENSMUSG00000031576 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000098858 ENTREZGENE
  ENSMUST00000098858.11 UniProtKB/TrEMBL
  ENSMUST00000120653.8 UniProtKB/TrEMBL
  ENSMUST00000126226.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_BK_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_Slo-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Slowpoke-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16532 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1202300 ENTREZGENE
NCBI Gene 16532 ENTREZGENE
PANTHER CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POTASSIUM CHANNEL SUBFAMILY U MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BK_channel_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Slowpoke_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnu1 PhenoGen
PRINTS BKCHANNELA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z073_MOUSE UniProtKB/TrEMBL
  D3Z5P2_MOUSE UniProtKB/TrEMBL
  G3X9P7 ENTREZGENE, UniProtKB/TrEMBL
  KCNU1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE