Plxna3 (plexin A3) - Rat Genome Database

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Pathways
Gene: Plxna3 (plexin A3) Rattus norvegicus
Analyze
Symbol: Plxna3
Name: plexin A3
RGD ID: 1584973
Description: Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including nervous system development; positive regulation of cytoskeleton organization; and semaphorin-plexin signaling pathway. Predicted to act upstream of or within several processes, including hippocampus development; negative regulation of axon extension involved in axon guidance; and neuron development. Predicted to be located in membrane. Predicted to be part of semaphorin receptor complex. Predicted to be active in plasma membrane. Orthologous to human PLXNA3 (plexin A3); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Plexin 4; Plexin 4, SEX, homolog to the cMet/HGF receptors; plexin A3 (mapped); plexin-A3; Plxn4; Plxna3_mapped; SEX
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X157,266,986 - 157,282,896 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX157,267,107 - 157,282,891 (+)EnsemblGRCr8
mRatBN7.2X152,115,699 - 152,131,608 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX152,115,819 - 152,131,603 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX154,256,947 - 154,272,736 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,820,173 - 157,835,962 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,491,971 - 155,507,760 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,363,400 - 156,379,433 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,363,405 - 156,379,189 (-)Ensemblrn6Rnor6.0
Rnor_5.01152,103,535 - 152,119,342 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X160,261,781 - 160,277,570 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1135,765,043 - 135,780,832 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse:




References

References - curated
# Reference Title Reference Citation
1. Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections. Cheng HJ, etal., Neuron 2001 Oct 25;32(2):249-63.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Disposition of 14C-labelled FCE 22101 in animals. Strolin Benedetti M, etal., J Antimicrob Chemother 1989 Mar;23 Suppl C:165-71.
Additional References at PubMed
PMID:18804103   PMID:19717441   PMID:21835343   PMID:23063687  


Genomics

Comparative Map Data
Plxna3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X157,266,986 - 157,282,896 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX157,267,107 - 157,282,891 (+)EnsemblGRCr8
mRatBN7.2X152,115,699 - 152,131,608 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX152,115,819 - 152,131,603 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX154,256,947 - 154,272,736 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,820,173 - 157,835,962 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,491,971 - 155,507,760 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,363,400 - 156,379,433 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,363,405 - 156,379,189 (-)Ensemblrn6Rnor6.0
Rnor_5.01152,103,535 - 152,119,342 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X160,261,781 - 160,277,570 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1135,765,043 - 135,780,832 (-)NCBICelera
Cytogenetic MapXq37NCBI
PLXNA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,458,281 - 154,477,779 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX154,458,280 - 154,477,779 (+)Ensemblhg38GRCh38
GRCh37X153,686,621 - 153,706,118 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,339,817 - 153,355,179 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X153,250,326 - 153,265,688NCBI
CeleraX153,847,674 - 153,863,036 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,263,786 - 142,279,038 (+)NCBIHuRef
CHM1_1X153,598,267 - 153,613,626 (+)NCBICHM1_1
T2T-CHM13v2.0X152,694,791 - 152,714,288 (+)NCBIT2T-CHM13v2.0
Plxna3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,372,644 - 73,388,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX73,372,672 - 73,388,295 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X74,328,290 - 74,344,689 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,329,066 - 74,344,689 (+)Ensemblmm10GRCm38
MGSCv37X71,574,405 - 71,590,028 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X70,581,819 - 70,596,483 (+)NCBIMGSCv36mm8
CeleraX65,582,855 - 65,598,478 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.0NCBI
Plxna3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580957,860 - 972,772 (+)Ensembl
ChiLan1.0NW_004955580958,033 - 972,123 (+)NCBIChiLan1.0ChiLan1.0
PLXNA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X154,432,646 - 154,448,014 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X154,436,251 - 154,455,295 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,900,029 - 143,915,391 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,772,700 - 153,786,167 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,772,700 - 153,786,167 (+)EnsemblpanPan2panpan1.1
PLXNA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X122,165,460 - 122,180,727 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX122,167,144 - 122,180,951 (+)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0X125,307,120 - 125,321,660 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX125,306,775 - 125,321,599 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X121,076,136 - 121,090,670 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,591,257 - 123,605,728 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,352,967 - 123,367,509 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plxna3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,471,987 - 119,488,955 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368091,209,743 - 1,226,728 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049368091,209,787 - 1,226,726 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLXNA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,983,943 - 124,997,072 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X124,982,307 - 124,997,098 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,588,358 - 143,603,211 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLXNA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,706,354 - 128,721,971 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,708,424 - 128,721,971 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606566,695,159 - 66,710,804 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plxna3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946926,521 - 939,483 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624946924,956 - 939,483 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Plxna3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X128,335,484 - 128,350,770 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:825
Count of miRNA genes:296
Interacting mature miRNAs:375
Transcripts:ENSRNOT00000056307
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat

Markers in Region
RH131167  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,130,726 - 152,130,908 (-)MAPPERmRatBN7.2
Rnor_6.0X156,364,100 - 156,364,281NCBIRnor6.0
Rnor_5.01152,104,235 - 152,104,416UniSTSRnor5.0
RGSC_v3.4X160,262,481 - 160,262,662UniSTSRGSC3.4
Celera1135,765,743 - 135,765,924UniSTS
Cytogenetic MapXq37UniSTS
REN89674  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,120,474 - 152,120,806 (-)MAPPERmRatBN7.2
Rnor_6.0X156,374,202 - 156,374,533NCBIRnor6.0
Rnor_5.01152,114,336 - 152,114,667UniSTSRnor5.0
RGSC_v3.4X160,272,583 - 160,272,914UniSTSRGSC3.4
Celera1135,775,845 - 135,776,176UniSTS
Cytogenetic MapXq37UniSTS
REN89678  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X152,121,515 - 152,121,792 (-)MAPPERmRatBN7.2
Rnor_6.0X156,373,216 - 156,373,492NCBIRnor6.0
Rnor_5.01152,113,350 - 152,113,626UniSTSRnor5.0
RGSC_v3.4X160,271,597 - 160,271,873UniSTSRGSC3.4
Celera1135,774,859 - 135,775,135UniSTS
Cytogenetic MapXq37UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 84 59 6 347 184 11 141 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000083148   ⟹   ENSRNOP00000068735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX157,267,107 - 157,282,891 (+)Ensembl
mRatBN7.2 EnsemblX152,115,819 - 152,131,603 (+)Ensembl
Rnor_6.0 EnsemblX156,363,405 - 156,379,189 (-)Ensembl
RefSeq Acc Id: NM_001107581   ⟹   NP_001101051
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,267,107 - 157,282,896 (+)NCBI
mRatBN7.2X152,115,819 - 152,131,608 (+)NCBI
Rnor_6.0X156,363,400 - 156,379,189 (-)NCBI
Rnor_5.01152,103,535 - 152,119,342 (-)NCBI
RGSC_v3.4X160,261,781 - 160,277,570 (-)RGD
Celera1135,765,043 - 135,780,832 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229577   ⟹   XP_006229639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,266,986 - 157,282,452 (+)NCBI
mRatBN7.2X152,115,699 - 152,131,164 (+)NCBI
Rnor_6.0X156,363,400 - 156,379,334 (-)NCBI
Rnor_5.01152,103,535 - 152,119,342 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099684   ⟹   XP_038955612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X157,266,986 - 157,282,452 (+)NCBI
mRatBN7.2X152,115,699 - 152,131,164 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001101051 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229639 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955612 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZPX4 (Get FASTA)   NCBI Sequence Viewer  
  EDL84972 (Get FASTA)   NCBI Sequence Viewer  
  EDL84973 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068735
  ENSRNOP00000068735.1
RefSeq Acc Id: NP_001101051   ⟸   NM_001107581
- Peptide Label: precursor
- UniProtKB: D3ZPX4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006229639   ⟸   XM_006229577
- Peptide Label: isoform X1
- UniProtKB: D3ZPX4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068735   ⟸   ENSRNOT00000083148
RefSeq Acc Id: XP_038955612   ⟸   XM_039099684
- Peptide Label: isoform X2
Protein Domains
IPT/TIG   Plexin cytoplasmic RasGAP   Sema

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZPX4-F1-model_v2 AlphaFold D3ZPX4 1-1872 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702042
Promoter ID:EPDNEW_R12566
Type:single initiation site
Name:Plxna3_1
Description:plexin A3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X156,379,189 - 156,379,249EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584973 AgrOrtholog
BioCyc Gene G2FUF-624 BioCyc
Ensembl Genes ENSRNOG00000060464 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083148 ENTREZGENE
  ENSRNOT00000083148.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot
  GTPase Activation - p120gap, domain 1 UniProtKB/Swiss-Prot
InterPro Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
  IPT_dom UniProtKB/Swiss-Prot
  Plexin UniProtKB/Swiss-Prot
  Plexin_cytoplasmic_RasGAP_dom UniProtKB/Swiss-Prot
  Plexin_RBD UniProtKB/Swiss-Prot
  Plexin_repeat UniProtKB/Swiss-Prot
  PSI UniProtKB/Swiss-Prot
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot
  Semap_dom UniProtKB/Swiss-Prot
  Semap_dom_sf UniProtKB/Swiss-Prot
  TIG1_plexin UniProtKB/Swiss-Prot
  TIG2_plexin UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:309280 UniProtKB/Swiss-Prot
NCBI Gene 309280 ENTREZGENE
PANTHER PLEXIN-A3 UniProtKB/Swiss-Prot
  PTHR22625 UniProtKB/Swiss-Prot
Pfam Plexin_cytopl UniProtKB/Swiss-Prot
  Plexin_RBD UniProtKB/Swiss-Prot
  PSI UniProtKB/Swiss-Prot
  PSI_PlexinA-B UniProtKB/Swiss-Prot
  Sema UniProtKB/Swiss-Prot
  TIG UniProtKB/Swiss-Prot
  TIG_2 UniProtKB/Swiss-Prot
  TIG_plexin UniProtKB/Swiss-Prot
PhenoGen Plxna3 PhenoGen
PROSITE SEMA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060464 RatGTEx
SMART IPT UniProtKB/Swiss-Prot
  PSI UniProtKB/Swiss-Prot
  Sema UniProtKB/Swiss-Prot
Superfamily-SCOP Plexin repeat UniProtKB/Swiss-Prot
  SSF101912 UniProtKB/Swiss-Prot
  SSF48350 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot
UniProt A6KRQ7_RAT UniProtKB/TrEMBL
  D3ZPX4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-13   plexin A3  Plxna3  plexin A3 (mapped)  Name updated 737654 APPROVED
2007-04-11 Plxna3  plexin A3 (mapped)  Plxna3_mapped  plexin A3 (mapped)  Data merged from RGD:3357 737654 APPROVED
2006-11-19 Plxna3  plexin A3 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Plxna3_mapped  plexin A3 (mapped)  Plxna3  plexin A3  Symbol and Name updated 1556543 APPROVED
2003-04-09 Plxna3  plexin A3  Plxn4  Plexin 4  Symbol and Name updated 629477 APPROVED
2002-06-10 Plxn4  Plexin 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology mouse homolog Plexin-A3 receptor is activated by and mediates semaphorin signalling to trigger stereotyped pruning of specific hippocampal mossy fiber and pyramidal axon branches 1303935
gene_homology mouse homolog Plexin-A3 receptor is activated by and mediates semaphorin signalling to trigger stereotyped pruning of specific hippocampal mossy fiber and pyramidal axon branches 1303936