RGD Reference Report - Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections. - Rat Genome Database

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Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

Authors: Cheng, HJ  Bagri, A  Yaron, A  Stein, E  Pleasure, SJ  Tessier-Lavigne, M 
Citation: Cheng HJ, etal., Neuron 2001 Oct 25;32(2):249-63.
RGD ID: 1303936
Pubmed: PMID:11683995   (View Abstract at PubMed)

Plexins are receptors implicated in mediating signaling by semaphorins, a family of axonal chemorepellents. The role of specific plexins in mediating semaphorin function in vivo has not, however, yet been examined in vertebrates. Here, we show that plexin-A3 is the most ubiquitously expressed plexin family member within regions of the developing mammalian nervous system known to contain semaphorin-responsive neurons. Using a chimeric receptor construct, we provide evidence that plexin-A3 can transduce a repulsive signal in growth cones in vitro. Analysis of plexin-A3 knockout mice shows that plexin-A3 contributes to Sema3F and Sema3A signaling and that plexin-A3 regulates the development of hippocampal axonal projections in vivo.

Objects referenced in this article
Gene Neurod6 neurogenic differentiation 6 Mus musculus
Gene Plxna1 plexin A1 Mus musculus
Gene Plxna2 plexin A2 Mus musculus
Gene Plxna3 plexin A3 Mus musculus
Gene Plxna4 plexin A4 Mus musculus
Gene Plxnb1 plexin B1 Mus musculus
Gene Plxnb2 plexin B2 Mus musculus
Gene Plxnc1 plexin C1 Mus musculus
Gene Plxnd1 plexin D1 Mus musculus
Gene Prox1 prospero homeobox 1 Mus musculus
Gene Plxna3 plexin A3 Rattus norvegicus

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