Tomm6 (translocase of outer mitochondrial membrane 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tomm6 (translocase of outer mitochondrial membrane 6) Rattus norvegicus
Analyze
Symbol: Tomm6
Name: translocase of outer mitochondrial membrane 6
RGD ID: 1583567
Description: Orthologous to human TOMM6 (translocase of outer mitochondrial membrane 6); PARTICIPATES IN beta-barrel pathway of mitochondrial protein import; carrier pathway of mitochondrial protein import; presequence pathway of mitochondrial protein import; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC681123; LOC681123; mitochondrial import receptor subunit TOM6 homolog; prickle homolog 4; Prickle4; translocase of outer mitochondrial membrane 6 homolog; translocase of outer mitochondrial membrane 6 homolog (yeast)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,801,806 - 20,803,174 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2913,304,269 - 13,305,637 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx921,884,264 - 21,885,659 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,948,349 - 26,949,740 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0925,247,670 - 25,249,065 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0915,313,346 - 15,314,872 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,313,523 - 15,314,435 (+)Ensemblrn6Rnor6.0
Rnor_5.0914,237,422 - 14,239,082 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.498,770,266 - 8,771,794 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera911,056,548 - 11,058,097 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Biogenesis of mitochondrial outer membrane proteins, problems and diseases. Ellenrieder L, etal., Biol Chem. 2015 Oct 1;396(11):1199-213. doi: 10.1515/hsz-2015-0170.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Assembly of beta-barrel proteins in the mitochondrial outer membrane. Hohr AI, etal., Biochim Biophys Acta. 2015 Jan;1853(1):74-88. doi: 10.1016/j.bbamcr.2014.10.006. Epub 2014 Oct 8.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. Unlocking the presequence import pathway. Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
7. Cooperation of protein machineries in mitochondrial protein sorting. Wenz LS, etal., Biochim Biophys Acta. 2015 May;1853(5):1119-29. doi: 10.1016/j.bbamcr.2015.01.012. Epub 2015 Jan 26.
Additional References at PubMed
PMID:18614015  


Genomics

Comparative Map Data
Tomm6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,801,806 - 20,803,174 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.2913,304,269 - 13,305,637 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx921,884,264 - 21,885,659 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,948,349 - 26,949,740 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0925,247,670 - 25,249,065 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0915,313,346 - 15,314,872 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl915,313,523 - 15,314,435 (+)Ensemblrn6Rnor6.0
Rnor_5.0914,237,422 - 14,239,082 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.498,770,266 - 8,771,794 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera911,056,548 - 11,058,097 (+)NCBICelera
Cytogenetic Map9q12NCBI
TOMM6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,787,694 - 41,789,895 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,787,652 - 41,790,064 (+)Ensemblhg38GRCh38
GRCh37641,755,432 - 41,757,633 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,755,181 - 41,757,634 (+)NCBIBuild 36Build 36hg18NCBI36
Celera643,308,511 - 43,310,964 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef641,473,902 - 41,476,358 (+)NCBIHuRef
CHM1_1641,758,556 - 41,760,993 (+)NCBICHM1_1
T2T-CHM13v2.0641,616,256 - 41,618,460 (+)NCBIT2T-CHM13v2.0
Tomm6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,997,570 - 47,999,311 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1747,997,571 - 47,999,311 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381747,686,645 - 47,688,386 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1747,686,646 - 47,688,386 (-)Ensemblmm10GRCm38
MGSCv371747,823,594 - 47,825,335 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361747,149,931 - 47,151,577 (-)NCBIMGSCv36mm8
MGSCv361746,713,792 - 46,715,438 (-)NCBIMGSCv36mm8
Celera1751,123,550 - 51,125,054 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.87NCBI
Tomm6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,183,219 - 8,184,602 (+)Ensembl
ChiLan1.0NW_0049554378,183,219 - 8,184,602 (+)NCBIChiLan1.0ChiLan1.0
TOMM6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2556,279,899 - 56,364,018 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1652,149,662 - 52,234,010 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0641,372,723 - 41,456,258 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,676,825 - 42,678,679 (+)NCBIPanPan1.1PanPan1.1panPan2
TOMM6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11210,473,592 - 10,484,374 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1210,473,592 - 10,474,864 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1210,503,030 - 10,513,859 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01210,953,801 - 10,964,628 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1210,952,850 - 10,955,126 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11210,484,373 - 10,495,202 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01210,568,053 - 10,578,880 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01210,661,769 - 10,672,596 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tomm6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,952,077 - 45,953,661 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647618,006,543 - 18,008,871 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647618,006,541 - 18,008,872 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOMM6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,969,909 - 36,978,283 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1736,976,478 - 36,976,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2742,385,968 - 42,386,368 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOMM6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11730,373,701 - 30,376,124 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1730,373,701 - 30,375,892 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604441,781,665 - 41,783,917 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tomm6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,276,494 - 17,282,676 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475417,276,487 - 17,282,770 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tomm6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1482,188,128 - 82,189,692 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tomm6
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:20
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000070805
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9360535521031556Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
RH127416  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8920,802,686 - 20,803,069 (+)Marker Load Pipeline
mRatBN7.2913,305,149 - 13,305,532 (+)MAPPERmRatBN7.2
Rnor_6.0915,314,385 - 15,314,767NCBIRnor6.0
Rnor_5.0914,238,595 - 14,238,977UniSTSRnor5.0
RGSC_v3.498,771,305 - 8,771,687UniSTSRGSC3.4
Celera911,057,610 - 11,057,992UniSTS
RH 3.4 Map960.2UniSTS
Cytogenetic Map9q12UniSTS
RH133301  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2913,305,767 - 13,305,962 (+)MAPPERmRatBN7.2
Rnor_6.0915,315,003 - 15,315,197NCBIRnor6.0
Rnor_5.0914,239,213 - 14,239,407UniSTSRnor5.0
RGSC_v3.498,771,923 - 8,772,117UniSTSRGSC3.4
Celera911,058,228 - 11,058,422UniSTS
RH 3.4 Map944.2UniSTS
Cytogenetic Map9q12UniSTS
RH129299  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2913,305,385 - 13,305,595 (+)MAPPERmRatBN7.2
Rnor_6.0915,314,621 - 15,314,830NCBIRnor6.0
Rnor_5.0914,238,831 - 14,239,040UniSTSRnor5.0
RGSC_v3.498,771,541 - 8,771,750UniSTSRGSC3.4
Celera911,057,846 - 11,058,055UniSTS
Cytogenetic Map9q12UniSTS
AA891796  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2913,305,381 - 13,305,590 (+)MAPPERmRatBN7.2
Rnor_6.0915,314,617 - 15,314,825NCBIRnor6.0
Rnor_5.0914,238,827 - 14,239,035UniSTSRnor5.0
RGSC_v3.498,771,537 - 8,771,745UniSTSRGSC3.4
Celera911,057,842 - 11,058,050UniSTS
RH 3.4 Map958.8UniSTS
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000070805   ⟹   ENSRNOP00000065096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl915,313,523 - 15,314,435 (+)Ensembl
RefSeq Acc Id: NM_001399365   ⟹   NP_001386294
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,801,806 - 20,803,174 (+)NCBI
mRatBN7.2913,304,269 - 13,305,637 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386294 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18894 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000065096   ⟸   ENSRNOT00000070805
RefSeq Acc Id: NP_001386294   ⟸   NM_001399365
- UniProtKB: A6JII8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJS3-F1-model_v2 AlphaFold D3ZJS3 1-74 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696502
Promoter ID:EPDNEW_R7019
Type:initiation region
Name:Tomm6_1
Description:translocase of outer mitochondrial membrane 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0915,313,478 - 15,313,538EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583567 AgrOrtholog
BioCyc Gene G2FUF-28277 BioCyc
Ensembl Genes ENSRNOG00000046316 Ensembl
InterPro TOMM6 UniProtKB/TrEMBL
NCBI Gene 681123 ENTREZGENE
PANTHER MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM6 HOMOLOG UniProtKB/TrEMBL
  MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM6 HOMOLOG UniProtKB/TrEMBL
Pfam TOM6p UniProtKB/TrEMBL
PhenoGen Tomm6 PhenoGen
RatGTEx ENSRNOG00000046316 RatGTEx
UniProt A6JII8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Tomm6  translocase of outer mitochondrial membrane 6  Tomm6  translocase of outer mitochondrial membrane 6 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-04 Tomm6  translocase of outer mitochondrial membrane 6 homolog (yeast)  Prickle4  prickle homolog 4 (Drosophila)  Symbol and Name updated 1299863 APPROVED
2008-03-05 Prickle4  prickle homolog 4 (Drosophila)  LOC681123  hypothetical protein LOC681123  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC681123  hypothetical protein LOC681123      Symbol and Name status set to provisional 70820 PROVISIONAL