RGD1565323 (similar to OTTMUSP00000000621) - Rat Genome Database

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Advanced Search (OLGA)
Gene: RGD1565323 (similar to OTTMUSP00000000621) Rattus norvegicus
Analyze
No known orthologs.
Symbol: RGD1565323
Name: similar to OTTMUSP00000000621
RGD ID: 1565323
Description: Predicted to enable myosin light chain kinase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Orthologous to human MYLK4 (myosin light chain kinase family member 4); INTERACTS WITH acrylamide; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: PREDICTED
Previously known as: hypothetical protein LOC691300; LOC306896; LOC691300; uncharacterized protein LOC691300
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Allele / Splice: RGD1565323Tn(sb-T2/Bart3)2.312Mcwi
Genetic Models: F344-RGD1565323Tn(sb-T2/Bart3)2.312Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,870,462 - 31,887,579 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1731,870,462 - 31,887,579 (+)EnsemblGRCr8
GRCr8 Ensembl1731,896,304 - 31,947,174 (+)EnsemblGRCr8
mRatBN7.21731,661,713 - 31,678,816 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1731,661,513 - 31,744,544 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1731,496,821 - 31,513,897 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01733,100,597 - 33,117,672 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01731,492,586 - 31,509,665 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,973,695 - 32,990,440 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,973,695 - 32,990,440 (+)Ensemblrn6Rnor6.0
Rnor_5.01734,865,901 - 34,882,646 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41738,022,396 - 38,039,975 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1731,224,046 - 31,241,165 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Variants

.
Variants in RGD1565323
48 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:143
Count of miRNA genes:111
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000065674
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat

Markers in Region
D17Mit2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81732,199,534 - 32,199,663 (+)Marker Load Pipeline
mRatBN7.21731,990,784 - 31,990,913 (+)MAPPERmRatBN7.2
Rnor_6.01733,303,627 - 33,303,755NCBIRnor6.0
Rnor_5.01735,195,242 - 35,195,370UniSTSRnor5.0
RGSC_v3.41738,353,858 - 38,353,987RGDRGSC3.4
RGSC_v3.41738,353,859 - 38,353,987UniSTSRGSC3.4
Celera1731,553,047 - 31,553,175UniSTS
RGSC_v3.11738,356,700 - 38,356,828RGD
RH 3.4 Map17373.9UniSTS
RH 3.4 Map17373.9RGD
RH 2.0 Map17267.3RGD
SHRSP x BN Map1725.62RGD
FHH x ACI Map1730.0699RGD
Cytogenetic Map17p12UniSTS
D17Rat181  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81732,104,761 - 32,104,921 (+)Marker Load Pipeline
mRatBN7.21731,896,010 - 31,896,169 (+)MAPPERmRatBN7.2
Rnor_6.01733,208,959 - 33,209,117NCBIRnor6.0
Rnor_5.01735,100,574 - 35,100,732UniSTSRnor5.0
RGSC_v3.41738,257,211 - 38,257,371RGDRGSC3.4
RGSC_v3.41738,257,213 - 38,257,371UniSTSRGSC3.4
Celera1731,458,614 - 31,458,772UniSTS
RGSC_v3.11738,260,052 - 38,260,212RGD
SHRSP x BN Map1726.9699UniSTS
SHRSP x BN Map1726.9699RGD
Cytogenetic Map17p12UniSTS
D17Got44  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81731,997,662 - 31,997,893 (+)Marker Load Pipeline
mRatBN7.21731,788,906 - 31,789,137 (+)MAPPERmRatBN7.2
Rnor_6.01733,101,993 - 33,102,223NCBIRnor6.0
Rnor_5.01734,993,608 - 34,993,838UniSTSRnor5.0
RGSC_v3.41738,150,036 - 38,150,267RGDRGSC3.4
RGSC_v3.41738,150,037 - 38,150,267UniSTSRGSC3.4
Celera1731,351,545 - 31,351,775UniSTS
RGSC_v3.11738,152,878 - 38,153,108RGD
RH 3.4 Map17356.5RGD
RH 3.4 Map17356.5UniSTS
RH 2.0 Map17263.2RGD
Cytogenetic Map17p12UniSTS
RH129029  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21731,747,052 - 31,747,245 (+)MAPPERmRatBN7.2
Rnor_6.01733,058,950 - 33,059,142NCBIRnor6.0
Rnor_6.01732,113,359 - 32,113,551NCBIRnor6.0
Rnor_5.01734,951,156 - 34,951,348UniSTSRnor5.0
Rnor_5.01734,007,178 - 34,007,370UniSTSRnor5.0
RGSC_v3.41738,108,192 - 38,108,384UniSTSRGSC3.4
Celera1731,309,811 - 31,310,003UniSTS
RH 3.4 Map17356.7UniSTS
Cytogenetic Map17p12UniSTS


Genetic Models
This gene RGD1565323 is modified in the following models/strains:
F344-RGD1565323Tn(sb-T2/Bart3)2.312Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
5 11 26 58 39 38 15 18 15 6 120 71 8 36 21 43 23

Sequence


Ensembl Acc Id: ENSRNOT00000065674   ⟹   ENSRNOP00000060563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1731,870,462 - 31,887,579 (+)Ensembl
mRatBN7.2 Ensembl1731,661,713 - 31,678,816 (+)Ensembl
Rnor_6.0 Ensembl1732,973,695 - 32,990,440 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072764   ⟹   ENSRNOP00000066587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1731,896,304 - 31,947,174 (+)Ensembl
mRatBN7.2 Ensembl1731,661,713 - 31,744,544 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000074775   ⟹   ENSRNOP00000064869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1731,919,643 - 31,947,174 (+)Ensembl
mRatBN7.2 Ensembl1731,661,513 - 31,744,544 (+)Ensembl
RefSeq Acc Id: NM_001109635   ⟹   NP_001103105
RefSeq Status: PREDICTED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,870,462 - 31,887,579 (+)NCBI
mRatBN7.21731,661,713 - 31,678,816 (+)NCBI
Rnor_6.01732,973,695 - 32,990,440 (+)NCBI
Rnor_5.01734,865,901 - 34,882,646 (+)NCBI
RGSC_v3.41738,022,396 - 38,039,975 (+)ENTREZGENE
Celera1731,224,046 - 31,241,165 (+)ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001103105 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98346 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060563
  ENSRNOP00000060563.1
  ENSRNOP00000064869.4
RefSeq Acc Id: NP_001103105   ⟸   NM_001109635
- UniProtKB: A6J7J6 (UniProtKB/TrEMBL),   D3ZN86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060563   ⟸   ENSRNOT00000065674
Ensembl Acc Id: ENSRNOP00000066587   ⟸   ENSRNOT00000072764
Ensembl Acc Id: ENSRNOP00000064869   ⟸   ENSRNOT00000074775

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZN86-F1-model_v2 AlphaFold D3ZN86 1-121 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700422
Promoter ID:EPDNEW_R10944
Type:initiation region
Name:RGD1565323_1
Description:similar to OTTMUSP00000000621
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01732,973,732 - 32,973,792EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565323 AgrOrtholog
BioCyc Gene G2FUF-9568 BioCyc
Ensembl Genes ENSRNOG00000021789 Ensembl
  ENSRNOG00000070083 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000074220 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065674 ENTREZGENE
  ENSRNOT00000065674.3 UniProtKB/TrEMBL
  ENSRNOT00000074775.4 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:691300 UniProtKB/TrEMBL
NCBI Gene RGD1565323 ENTREZGENE
PANTHER MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE 17 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen RGD1565323 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021789 RatGTEx
  ENSRNOG00000070083 RatGTEx
  ENSRNOG00000074220 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A6J7J6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZN86 ENTREZGENE, UniProtKB/TrEMBL
  M0R632_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-27 RGD1565323  similar to OTTMUSP00000000621  LOC691300  hypothetical protein LOC691300  Data merged from RGD:1585113 737654 APPROVED
2008-04-30 RGD1565323  similar to OTTMUSP00000000621   RGD1565323_predicted  similar to OTTMUSP00000000621 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC691300  hypothetical protein LOC691300      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1565323_predicted  similar to OTTMUSP00000000621 (predicted)  LOC306896  similar to OTTMUSP00000000621  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC306896  similar to OTTMUSP00000000621      Symbol and Name status set to provisional 70820 PROVISIONAL