Shld2 (shieldin complex subunit 2) - Rat Genome Database

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Pathways
Gene: Shld2 (shieldin complex subunit 2) Rattus norvegicus
Analyze
Symbol: Shld2
Name: shieldin complex subunit 2
RGD ID: 1565067
Description: Predicted to be involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Predicted to be located in chromosome. Predicted to be active in nucleus and site of double-strand break. Orthologous to human SHLD2 (shieldin complex subunit 2); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam35a; family with sequence similarity 35, member A; hypothetical protein LOC364514; LOC364514; RGD1310009; uncharacterized protein LOC364514
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,554,921 - 9,646,186 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl169,553,854 - 9,588,510 (-)EnsemblGRCr8
mRatBN7.2169,544,940 - 9,640,323 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,548,660 - 9,639,965 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx169,562,132 - 9,660,662 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,706,838 - 10,805,376 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,557,197 - 9,655,744 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,570,307 - 10,661,528 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,570,314 - 10,661,528 (-)Ensemblrn6Rnor6.0
Rnor_5.0168,888,929 - 8,979,969 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4169,868,212 - 9,965,225 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera165,576,833 - 5,667,636 (+)NCBICelera
Cytogenetic Map16p15NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8889548   PMID:29656893   PMID:29789392  


Genomics

Comparative Map Data
Shld2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,554,921 - 9,646,186 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl169,553,854 - 9,588,510 (-)EnsemblGRCr8
mRatBN7.2169,544,940 - 9,640,323 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,548,660 - 9,639,965 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx169,562,132 - 9,660,662 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,706,838 - 10,805,376 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,557,197 - 9,655,744 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,570,307 - 10,661,528 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,570,314 - 10,661,528 (-)Ensemblrn6Rnor6.0
Rnor_5.0168,888,929 - 8,979,969 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4169,868,212 - 9,965,225 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera165,576,833 - 5,667,636 (+)NCBICelera
Cytogenetic Map16p15NCBI
SHLD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381087,094,473 - 87,191,465 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1087,094,006 - 87,191,478 (+)Ensemblhg38GRCh38
GRCh371088,854,963 - 88,951,222 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361088,844,933 - 88,941,202 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341088,844,932 - 88,941,200NCBI
Cytogenetic Map10q23.2NCBI
HuRef1082,778,394 - 82,789,042 (+)NCBIHuRef
CHM1_11089,136,724 - 89,232,977 (+)NCBICHM1_1
T2T-CHM13v2.01087,978,839 - 88,075,088 (+)NCBIT2T-CHM13v2.0
Shld2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391433,958,905 - 34,032,528 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1433,958,990 - 34,032,450 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381434,236,948 - 34,310,651 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,237,033 - 34,310,493 (-)Ensemblmm10GRCm38
MGSCv371435,050,219 - 35,123,689 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361433,066,133 - 33,139,458 (-)NCBIMGSCv36mm8
Celera1430,499,098 - 30,576,001 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.8NCBI
Shld2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555106,075,510 - 6,114,898 (+)Ensembl
ChiLan1.0NW_0049555106,021,477 - 6,114,745 (+)NCBIChiLan1.0ChiLan1.0
LOC103784056
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2859,311,152 - 59,353,528 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11059,316,469 - 59,359,047 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01043,572,547 - 43,624,201 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11487,923,049 - 87,928,101 (+)NCBIPanPan1.1PanPan1.1panPan2
SHLD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1434,665,111 - 34,740,645 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl434,688,245 - 34,763,705 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha434,654,858 - 34,732,283 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0435,023,800 - 35,101,252 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl435,039,120 - 35,101,249 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1434,869,031 - 34,946,347 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0435,038,013 - 35,115,455 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0435,544,430 - 35,621,946 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Shld2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721343,682,657 - 43,768,173 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366015,315,261 - 5,396,301 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366015,315,297 - 5,400,752 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHLD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1488,005,611 - 88,121,352 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11488,005,599 - 88,121,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21495,538,054 - 95,600,923 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SHLD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1944,565,105 - 44,652,926 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl944,564,792 - 44,605,562 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660484,377,310 - 4,464,557 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shld2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462484120,431 - 133,163 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462484121,077 - 133,155 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Shld2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1139,995,518 - 10,028,381 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Shld2
696 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16423421216278352Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16423421216278352Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421216061395Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16423433317730812Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
D16Mgh3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,638,913 - 9,639,137 (+)MAPPERmRatBN7.2
Rnor_6.01610,660,513 - 10,660,736NCBIRnor6.0
Rnor_5.0168,978,954 - 8,979,177UniSTSRnor5.0
RGSC_v3.4169,964,209 - 9,964,433RGDRGSC3.4
RGSC_v3.4169,964,210 - 9,964,433UniSTSRGSC3.4
Celera165,577,625 - 5,577,848UniSTS
RGSC_v3.1169,964,207 - 9,964,431RGD
Cytogenetic Map16p16UniSTS
D16Rat111  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8169,616,980 - 9,617,133 (+)Marker Load Pipeline
mRatBN7.2169,610,723 - 9,610,876 (+)MAPPERmRatBN7.2
Rnor_6.01610,632,323 - 10,632,475NCBIRnor6.0
Rnor_5.0168,950,916 - 8,951,068UniSTSRnor5.0
RGSC_v3.4169,936,041 - 9,936,194RGDRGSC3.4
RGSC_v3.4169,936,042 - 9,936,194UniSTSRGSC3.4
Celera165,605,767 - 5,605,907UniSTS
RGSC_v3.1169,935,977 - 9,936,344RGD
FHH x ACI Map165.4199UniSTS
FHH x ACI Map165.4199RGD
Cytogenetic Map16p16UniSTS
D16Mco9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,638,921 - 9,639,125 (+)MAPPERmRatBN7.2
Rnor_6.01610,660,521 - 10,660,724NCBIRnor6.0
Rnor_5.0168,978,962 - 8,979,165UniSTSRnor5.0
RGSC_v3.4169,964,217 - 9,964,421RGDRGSC3.4
RGSC_v3.4169,964,218 - 9,964,421UniSTSRGSC3.4
Celera165,577,637 - 5,577,840UniSTS
RGSC_v3.1169,964,215 - 9,964,419RGD
Cytogenetic Map16p16UniSTS
D16Arb11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,639,189 - 9,639,391 (+)MAPPERmRatBN7.2
Rnor_6.01610,660,789 - 10,660,990NCBIRnor6.0
Rnor_5.0168,979,230 - 8,979,431UniSTSRnor5.0
RGSC_v3.4169,964,485 - 9,964,687RGDRGSC3.4
RGSC_v3.4169,964,486 - 9,964,687UniSTSRGSC3.4
Celera165,577,371 - 5,577,572UniSTS
RGSC_v3.1169,964,483 - 9,964,685RGD
Cytogenetic Map16p16UniSTS
RH127633  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,587,907 - 9,588,085 (+)MAPPERmRatBN7.2
mRatBN7.22015,938,432 - 15,938,632 (+)MAPPERmRatBN7.2
Rnor_6.02017,076,057 - 17,076,256NCBIRnor6.0
Rnor_6.01610,609,508 - 10,609,685NCBIRnor6.0
Rnor_5.0168,928,049 - 8,928,226UniSTSRnor5.0
Rnor_5.02019,258,548 - 19,258,747UniSTSRnor5.0
RGSC_v3.4169,911,823 - 9,912,000UniSTSRGSC3.4
Celera2017,366,620 - 17,366,819UniSTS
RH 3.4 Map20204.1UniSTS
Cytogenetic Map16p16UniSTS
RH134298  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,550,551 - 9,550,736 (+)MAPPERmRatBN7.2
Rnor_6.01610,572,199 - 10,572,383NCBIRnor6.0
Rnor_5.0168,890,821 - 8,891,005UniSTSRnor5.0
RGSC_v3.4169,870,104 - 9,870,288UniSTSRGSC3.4
Celera165,665,560 - 5,665,744UniSTS
RH 3.4 Map1692.3UniSTS
Cytogenetic Map16p16UniSTS
AU047839  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2169,587,311 - 9,587,444 (+)MAPPERmRatBN7.2
Rnor_6.01610,608,913 - 10,609,045NCBIRnor6.0
Rnor_5.0168,927,455 - 8,927,587UniSTSRnor5.0
RGSC_v3.4169,911,228 - 9,911,360UniSTSRGSC3.4
Celera165,628,880 - 5,629,006UniSTS
Cytogenetic Map16p16UniSTS
GDB:277890  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8169,646,883 - 9,647,143 (+)Marker Load Pipeline
Celera165,575,880 - 5,576,138UniSTS
Cytogenetic Map16p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001025028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008771137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF420607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB613349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR474249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM098539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000085012   ⟹   ENSRNOP00000073233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl169,554,928 - 9,588,510 (-)Ensembl
mRatBN7.2 Ensembl169,548,660 - 9,639,965 (-)Ensembl
Rnor_6.0 Ensembl1610,570,314 - 10,661,528 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087737   ⟹   ENSRNOP00000069549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl169,554,928 - 9,588,510 (-)Ensembl
mRatBN7.2 Ensembl169,575,320 - 9,639,963 (-)Ensembl
Rnor_6.0 Ensembl1610,596,833 - 10,603,850 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100122   ⟹   ENSRNOP00000080208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl169,553,854 - 9,588,510 (-)Ensembl
mRatBN7.2 Ensembl169,576,904 - 9,639,963 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000148523   ⟹   ENSRNOP00000106916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl169,556,108 - 9,588,510 (-)Ensembl
RefSeq Acc Id: NM_001025028   ⟹   NP_001020199
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,554,921 - 9,646,186 (-)NCBI
mRatBN7.2169,548,660 - 9,639,929 (-)NCBI
Rnor_6.01610,570,307 - 10,661,528 (-)NCBI
Rnor_5.0168,888,929 - 8,979,969 (-)NCBI
RGSC_v3.4169,868,212 - 9,965,225 (-)RGD
Celera165,576,833 - 5,667,636 (+)RGD
Sequence:
RefSeq Acc Id: XM_008771135   ⟹   XP_008769357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,554,921 - 9,646,156 (-)NCBI
mRatBN7.2169,548,958 - 9,640,177 (-)NCBI
Rnor_6.01610,570,307 - 10,661,432 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771136   ⟹   XP_008769358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,554,921 - 9,646,156 (-)NCBI
mRatBN7.2169,548,958 - 9,640,177 (-)NCBI
Rnor_6.01610,570,307 - 10,661,432 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771137   ⟹   XP_008769359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,554,921 - 9,596,925 (-)NCBI
mRatBN7.2169,548,958 - 9,590,667 (-)NCBI
Rnor_6.01610,570,307 - 10,604,829 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600194   ⟹   XP_017455683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,554,921 - 9,646,156 (-)NCBI
mRatBN7.2169,548,660 - 9,640,177 (-)NCBI
Rnor_6.01610,570,307 - 10,661,432 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600195   ⟹   XP_017455684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,554,921 - 9,646,156 (-)NCBI
mRatBN7.2169,548,660 - 9,640,177 (-)NCBI
Rnor_6.01610,570,307 - 10,661,432 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094703   ⟹   XP_038950631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,554,921 - 9,646,156 (-)NCBI
mRatBN7.2169,548,958 - 9,640,177 (-)NCBI
RefSeq Acc Id: XM_063275584   ⟹   XP_063131654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,554,921 - 9,646,156 (-)NCBI
RefSeq Acc Id: XM_063275586   ⟹   XP_063131656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,554,921 - 9,646,156 (-)NCBI
RefSeq Acc Id: XM_063275587   ⟹   XP_063131657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,554,921 - 9,646,156 (-)NCBI
RefSeq Acc Id: XM_063275588   ⟹   XP_063131658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,566,459 - 9,646,156 (-)NCBI
RefSeq Acc Id: NP_001020199   ⟸   NM_001025028
- UniProtKB: A6KFS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769358   ⟸   XM_008771136
- Peptide Label: isoform X1
- UniProtKB: D3ZH67 (UniProtKB/TrEMBL),   A6KFS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769357   ⟸   XM_008771135
- Peptide Label: isoform X1
- UniProtKB: D3ZH67 (UniProtKB/TrEMBL),   A6KFS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769359   ⟸   XM_008771137
- Peptide Label: isoform X1
- UniProtKB: D3ZH67 (UniProtKB/TrEMBL),   A6KFS6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455683   ⟸   XM_017600194
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017455684   ⟸   XM_017600195
- Peptide Label: isoform X5
- Sequence:
Ensembl Acc Id: ENSRNOP00000069549   ⟸   ENSRNOT00000087737
Ensembl Acc Id: ENSRNOP00000073233   ⟸   ENSRNOT00000085012
RefSeq Acc Id: XP_038950631   ⟸   XM_039094703
- Peptide Label: isoform X1
- UniProtKB: D3ZH67 (UniProtKB/TrEMBL),   A6KFS6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000080208   ⟸   ENSRNOT00000100122
RefSeq Acc Id: XP_063131654   ⟸   XM_063275584
- Peptide Label: isoform X1
- UniProtKB: D3ZH67 (UniProtKB/TrEMBL),   A6KFS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131656   ⟸   XM_063275586
- Peptide Label: isoform X2
- UniProtKB: A6KFS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131657   ⟸   XM_063275587
- Peptide Label: isoform X3
- UniProtKB: A6KFS6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131658   ⟸   XM_063275588
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000106916   ⟸   ENSRNOT00000148523
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZH67-F1-model_v2 AlphaFold D3ZH67 1-911 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699955
Promoter ID:EPDNEW_R10479
Type:initiation region
Name:Fam35a_1
Description:family with sequence similarity 35, member A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01610,661,539 - 10,661,599EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565067 AgrOrtholog
BioCyc Gene G2FUF-12068 BioCyc
Ensembl Genes ENSRNOG00000059057 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085012 ENTREZGENE
  ENSRNOT00000085012.3 UniProtKB/TrEMBL
  ENSRNOT00000087737 ENTREZGENE
  ENSRNOT00000087737.3 UniProtKB/TrEMBL
  ENSRNOT00000100122.2 UniProtKB/TrEMBL
  ENSRNOT00000148523.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325236 IMAGE-MGC_LOAD
InterPro FAM35A UniProtKB/TrEMBL
  FAM35A_C UniProtKB/TrEMBL
  SHLD2_OB1 UniProtKB/TrEMBL
  SHLD2_OB2 UniProtKB/TrEMBL
KEGG Report rno:364514 UniProtKB/TrEMBL
MGC_CLONE MGC:109007 IMAGE-MGC_LOAD
NCBI Gene 364514 ENTREZGENE
PANTHER PTHR14495 UniProtKB/TrEMBL
  SHIELDIN COMPLEX SUBUNIT 2 UniProtKB/TrEMBL
Pfam FAM35_C UniProtKB/TrEMBL
  SHLD2_OB1 UniProtKB/TrEMBL
  SHLD2_OB2 UniProtKB/TrEMBL
PhenoGen Shld2 PhenoGen
RatGTEx ENSRNOG00000059057 RatGTEx
UniProt A0A8I5ZP43_RAT UniProtKB/TrEMBL
  A0ABK0L9B1_RAT UniProtKB/TrEMBL
  A0ABZ3NNB3_RAT UniProtKB/TrEMBL
  A6KFS6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZH67 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVM8_RAT UniProtKB/TrEMBL
UniProt Secondary A0A0G2JVN0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-07 Shld2  shieldin complex subunit 2  Fam35a  family with sequence similarity 35, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Fam35a  family with sequence similarity 35, member A  LOC364514  hypothetical protein LOC364514  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC364514  hypothetical protein LOC364514      Symbol and Name status set to provisional 70820 PROVISIONAL