Akr1c3l1 (aldo-keto reductase family 1 member C3-like 1) - Rat Genome Database

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Gene: Akr1c3l1 (aldo-keto reductase family 1 member C3-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Akr1c3l1
Name: aldo-keto reductase family 1 member C3-like 1
RGD ID: 1564865
Description: Predicted to enable bile acid binding activity; ketosteroid monooxygenase activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in glycoside metabolic process; progesterone metabolic process; and prostaglandin metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; alcohol dependence; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 20-alpha-hydroxysteroid dehydrogenase-like; LOC498789; RGD1309566; RGD1564865; similar to 20-alpha-hydroxysteroid dehydrogenase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81770,745,496 - 70,791,411 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1770,745,496 - 70,791,322 (+)EnsemblGRCr8
mRatBN7.21765,847,580 - 65,881,488 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1765,835,634 - 65,881,488 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1769,335,420 - 69,368,125 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,164,268 - 73,196,973 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,207,249 - 67,239,954 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,468,427 - 69,497,132 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,468,427 - 69,497,132 (+)Ensemblrn6Rnor6.0
Rnor_5.01771,182,342 - 71,211,047 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41776,868,408 - 76,903,914 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1765,374,757 - 65,408,224 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21427058   PMID:33482148  


Genomics

Variants

.
Variants in Akr1c3l1
368 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:87
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000058413
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)177061350286062352Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175819406487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176369714782818564Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)176456982086954580Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 5 2 14 56 59 47 9 47 148 17 9 77 33 12

Sequence


Ensembl Acc Id: ENSRNOT00000058413   ⟹   ENSRNOP00000055214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1770,745,496 - 70,791,321 (+)Ensembl
mRatBN7.2 Ensembl1765,835,634 - 65,881,488 (+)Ensembl
Rnor_6.0 Ensembl1769,468,427 - 69,497,132 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096835   ⟹   ENSRNOP00000079498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1770,757,475 - 70,791,321 (+)Ensembl
mRatBN7.2 Ensembl1765,847,316 - 65,881,488 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106629   ⟹   ENSRNOP00000094993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1770,745,520 - 70,791,321 (+)Ensembl
mRatBN7.2 Ensembl1765,847,316 - 65,881,488 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107717   ⟹   ENSRNOP00000090438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1770,757,475 - 70,791,322 (+)Ensembl
mRatBN7.2 Ensembl1765,847,316 - 65,881,488 (+)Ensembl
RefSeq Acc Id: NM_001164396   ⟹   NP_001157868
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,757,501 - 70,791,409 (+)NCBI
mRatBN7.21765,847,580 - 65,881,488 (+)NCBI
Rnor_6.01769,468,427 - 69,497,132 (+)NCBI
Rnor_5.01771,182,342 - 71,211,047 (+)NCBI
RGSC_v3.41776,868,408 - 76,903,914 (+)RGD
Celera1765,374,757 - 65,408,224 (+)RGD
Sequence:
RefSeq Acc Id: XM_063276697   ⟹   XP_063132767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,745,496 - 70,791,411 (+)NCBI
RefSeq Acc Id: XM_063276698   ⟹   XP_063132768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,745,496 - 70,791,411 (+)NCBI
RefSeq Acc Id: XM_063276699   ⟹   XP_063132769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,756,592 - 70,791,411 (+)NCBI
RefSeq Acc Id: XM_063276700   ⟹   XP_063132770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81770,756,592 - 70,791,411 (+)NCBI
RefSeq Acc Id: NP_001157868   ⟸   NM_001164396
- UniProtKB: A0A8I5ZMV2 (UniProtKB/TrEMBL),   A0A8I6ADN4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055214   ⟸   ENSRNOT00000058413
Ensembl Acc Id: ENSRNOP00000079498   ⟸   ENSRNOT00000096835
Ensembl Acc Id: ENSRNOP00000094993   ⟸   ENSRNOT00000106629
Ensembl Acc Id: ENSRNOP00000090438   ⟸   ENSRNOT00000107717
RefSeq Acc Id: XP_063132767   ⟸   XM_063276697
- Peptide Label: isoform X1
- UniProtKB: F1LU12 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132768   ⟸   XM_063276698
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063132769   ⟸   XM_063276699
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AN46 (UniProtKB/TrEMBL),   A0A8I6ADN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132770   ⟸   XM_063276700
- Peptide Label: isoform X4
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LU12-F1-model_v2 AlphaFold F1LU12 1-295 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564865 AgrOrtholog
BioCyc Gene G2FUF-8839 BioCyc
Ensembl Genes ENSRNOG00000038361 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058413 ENTREZGENE
  ENSRNOT00000058413.5 UniProtKB/TrEMBL
  ENSRNOT00000096835 ENTREZGENE
  ENSRNOT00000096835.2 UniProtKB/TrEMBL
  ENSRNOT00000106629 ENTREZGENE
  ENSRNOT00000106629.2 UniProtKB/TrEMBL
  ENSRNOT00000107717.2 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.100 UniProtKB/TrEMBL
InterPro AKR1C UniProtKB/TrEMBL
  Aldo/ket_reductase_CS UniProtKB/TrEMBL
  Aldo/keto_reductase_subgr UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/TrEMBL
KEGG Report rno:498789 UniProtKB/TrEMBL
NCBI Gene 498789 ENTREZGENE
PANTHER ALDO/KETO REDUCTASE UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/TrEMBL
PhenoGen Akr1c3l1 PhenoGen
PIRSF AKR UniProtKB/TrEMBL
PRINTS ALDKETRDTASE UniProtKB/TrEMBL
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/TrEMBL
  ALDOKETO_REDUCTASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038361 RatGTEx
Superfamily-SCOP Aldo/ket_red UniProtKB/TrEMBL
UniProt A0A8I5ZMV2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADN4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AN46 ENTREZGENE, UniProtKB/TrEMBL
  F1LU12 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-02-04 Akr1c3l1  aldo-keto reductase family 1 member C3-like 1  AKR1C3l1  aldo-keto reductase family 1 member C3-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-11-15 AKR1C3l1  aldo-keto reductase family 1 member C3-like 1  RGD1564865  similar to 20-alpha-hydroxysteroid dehydrogenase  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1564865  similar to 20-alpha-hydroxysteroid dehydrogenase   RGD1564865_predicted  similar to 20-alpha-hydroxysteroid dehydrogenase (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1564865_predicted  similar to 20-alpha-hydroxysteroid dehydrogenase (predicted)  LOC498789  similar to 20-alpha-hydroxysteroid dehydrogenase  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498789  similar to 20-alpha-hydroxysteroid dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL