Cul4a (cullin 4A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Cul4a (cullin 4A) Rattus norvegicus
Analyze
Symbol: Cul4a
Name: cullin 4A
RGD ID: 1563853
Description: Predicted to enable ubiquitin ligase complex scaffold activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including cellular response to UV; positive regulation of protein catabolic process; and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Predicted to act upstream of or within several processes, including negative regulation of granulocyte differentiation; regulation of cell cycle phase transition; and regulation of nucleotide-excision repair. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CUL4A (cullin 4A); PARTICIPATES IN nucleotide excision repair pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cullin-4A; hypothetical protein LOC361181; LOC361181; RGD1563853; similar to cullin 4A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81683,086,688 - 83,124,503 (-)NCBIGRCr8
mRatBN7.21676,385,298 - 76,422,316 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,384,546 - 76,422,330 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,665,849 - 81,702,866 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01685,118,426 - 85,155,443 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,367,049 - 80,404,115 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,718,784 - 81,756,653 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,719,028 - 81,756,654 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01681,204,989 - 81,242,020 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,242,293 - 81,279,498 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1674,191,398 - 74,228,350 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A5  (ISO)
Brodifacoum  (EXP)
caffeine  (ISO)
choline  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
glyphosate  (ISO)
hexane  (EXP)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
menadione  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylhydrazine  (ISO)
phenytoin  (EXP)
resveratrol  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
topotecan  (EXP,ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vitamin E  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12077329   PMID:12393421   PMID:12477932   PMID:12732143   PMID:14739464   PMID:16467204   PMID:16949367   PMID:17085480   PMID:17616641   PMID:18339895   PMID:18381890   PMID:18794347  
PMID:19056892   PMID:19481525   PMID:20129063   PMID:20223979   PMID:22871113   PMID:26431207   PMID:26711351   PMID:28437394   PMID:31178959  


Genomics

Comparative Map Data
Cul4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81683,086,688 - 83,124,503 (-)NCBIGRCr8
mRatBN7.21676,385,298 - 76,422,316 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1676,384,546 - 76,422,330 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1681,665,849 - 81,702,866 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01685,118,426 - 85,155,443 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01680,367,049 - 80,404,115 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01681,718,784 - 81,756,653 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,719,028 - 81,756,654 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01681,204,989 - 81,242,020 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41681,242,293 - 81,279,498 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1674,191,398 - 74,228,350 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
CUL4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813113,208,193 - 113,267,108 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13113,208,193 - 113,267,108 (+)EnsemblGRCh38hg38GRCh38
GRCh3713113,862,507 - 113,921,422 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613112,911,087 - 112,967,393 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413112,911,086 - 112,967,392NCBI
Celera1394,689,332 - 94,746,025 (+)NCBICelera
Cytogenetic Map13q34NCBI
HuRef1394,301,391 - 94,358,301 (+)NCBIHuRef
CHM1_113113,831,366 - 113,888,434 (+)NCBICHM1_1
T2T-CHM13v2.013112,460,539 - 112,520,767 (+)NCBIT2T-CHM13v2.0
Cul4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39813,155,623 - 13,197,940 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl813,155,621 - 13,197,940 (+)EnsemblGRCm39 Ensembl
GRCm38813,105,623 - 13,147,940 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl813,105,621 - 13,147,940 (+)EnsemblGRCm38mm10GRCm38
MGSCv37813,105,721 - 13,147,940 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36813,105,720 - 13,147,753 (+)NCBIMGSCv36mm8
Celera813,272,636 - 13,315,964 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map85.73NCBI
Cul4a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955404583,261 - 617,914 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955404583,261 - 617,914 (-)NCBIChiLan1.0ChiLan1.0
CUL4A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214114,713,032 - 114,771,466 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113113,400,061 - 113,457,191 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01394,350,484 - 94,409,183 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113113,428,215 - 113,474,194 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13113,428,271 - 113,472,701 (+)Ensemblpanpan1.1panPan2
CUL4A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12260,624,215 - 60,667,844 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2260,624,241 - 60,666,616 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2260,336,591 - 60,379,892 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02261,249,926 - 61,292,535 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2261,249,885 - 61,293,566 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12260,748,228 - 60,791,990 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02260,750,419 - 60,794,121 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02260,781,867 - 60,825,233 (+)NCBIUU_Cfam_GSD_1.0
Cul4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945195,519,630 - 195,543,032 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936472408,659 - 432,379 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936472409,083 - 432,442 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUL4A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1178,557,013 - 78,589,193 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11178,557,030 - 78,588,964 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21186,146,594 - 86,178,480 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CUL4A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1391,211,238 - 91,267,236 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl391,212,193 - 91,268,838 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604648,249,225 - 48,306,414 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cul4a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624793688,135 - 722,490 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624793686,720 - 722,516 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cul4a
109 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:515
Count of miRNA genes:252
Interacting mature miRNAs:305
Transcripts:ENSRNOT00000026653
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

Markers in Region
AA866392  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21676,384,783 - 76,384,999 (+)MAPPERmRatBN7.2
Rnor_6.01681,719,038 - 81,719,253NCBIRnor6.0
Rnor_5.01681,204,475 - 81,204,690UniSTSRnor5.0
RGSC_v3.41681,241,779 - 81,241,994UniSTSRGSC3.4
Celera1674,190,884 - 74,191,099UniSTS
RH 3.4 Map16743.9UniSTS
Cytogenetic Map16q12.5UniSTS
AI228118  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21676,385,108 - 76,385,302 (+)MAPPERmRatBN7.2
Rnor_6.01681,719,363 - 81,719,556NCBIRnor6.0
Rnor_5.01681,204,800 - 81,204,993UniSTSRnor5.0
RGSC_v3.41681,242,104 - 81,242,297UniSTSRGSC3.4
Celera1674,191,209 - 74,191,402UniSTS
RH 3.4 Map16762.2UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026653   ⟹   ENSRNOP00000026653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,384,546 - 76,422,330 (-)Ensembl
Rnor_6.0 Ensembl1681,719,028 - 81,756,654 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092421   ⟹   ENSRNOP00000075917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1681,733,602 - 81,740,562 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092551   ⟹   ENSRNOP00000075804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,405,092 - 76,422,330 (-)Ensembl
Rnor_6.0 Ensembl1681,740,889 - 81,756,631 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096802   ⟹   ENSRNOP00000080416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1676,384,546 - 76,422,299 (-)Ensembl
RefSeq Acc Id: NM_001127301   ⟹   NP_001120773
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,087,440 - 83,124,457 (-)NCBI
mRatBN7.21676,385,298 - 76,422,316 (-)NCBI
Rnor_6.01681,719,552 - 81,756,653 (-)NCBI
Rnor_5.01681,204,989 - 81,242,020 (-)NCBI
RGSC_v3.41681,242,293 - 81,279,498 (-)RGD
Celera1674,191,398 - 74,228,350 (-)RGD
Sequence:
RefSeq Acc Id: XM_063275575   ⟹   XP_063131645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,086,688 - 83,124,503 (-)NCBI
RefSeq Acc Id: XM_063275576   ⟹   XP_063131646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,086,688 - 83,124,429 (-)NCBI
RefSeq Acc Id: XM_063275577   ⟹   XP_063131647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81683,086,688 - 83,107,397 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001120773   ⟸   NM_001127301
- UniProtKB: B2RYJ3 (UniProtKB/TrEMBL),   A6IWJ5 (UniProtKB/TrEMBL),   F7FNG5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075917   ⟸   ENSRNOT00000092421
RefSeq Acc Id: ENSRNOP00000075804   ⟸   ENSRNOT00000092551
RefSeq Acc Id: ENSRNOP00000026653   ⟸   ENSRNOT00000026653
RefSeq Acc Id: ENSRNOP00000080416   ⟸   ENSRNOT00000096802
RefSeq Acc Id: XP_063131645   ⟸   XM_063275575
- Peptide Label: isoform X1
- UniProtKB: B2RYJ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131646   ⟸   XM_063275576
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063131647   ⟸   XM_063275577
- Peptide Label: isoform X3
- UniProtKB: A6IWJ6 (UniProtKB/TrEMBL)
Protein Domains
Cullin family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYJ3-F1-model_v2 AlphaFold B2RYJ3 1-759 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700239
Promoter ID:EPDNEW_R10757
Type:multiple initiation site
Name:Cul4a_1
Description:cullin 4A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01681,756,652 - 81,756,712EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563853 AgrOrtholog
BioCyc Gene G2FUF-10701 BioCyc
Ensembl Genes ENSRNOG00000019649 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026653 ENTREZGENE
  ENSRNOT00000026653.8 UniProtKB/TrEMBL
  ENSRNOT00000092551.2 UniProtKB/TrEMBL
  ENSRNOT00000096802.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  Cullin Repeats UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7938235 IMAGE-MGC_LOAD
InterPro Cullin UniProtKB/TrEMBL
  Cullin_CS UniProtKB/TrEMBL
  Cullin_homology UniProtKB/TrEMBL
  Cullin_homology_sf UniProtKB/TrEMBL
  Cullin_N UniProtKB/TrEMBL
  Cullin_neddylation_domain UniProtKB/TrEMBL
  Cullin_repeat-like_dom UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:361181 UniProtKB/TrEMBL
MGC_CLONE MGC:188598 IMAGE-MGC_LOAD
NCBI Gene 361181 ENTREZGENE
PANTHER CULLIN-4A UniProtKB/TrEMBL
  PTHR11932 UniProtKB/TrEMBL
Pfam Cullin UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/TrEMBL
PhenoGen Cul4a PhenoGen
PROSITE CULLIN_1 UniProtKB/TrEMBL
  CULLIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019649 RatGTEx
SMART CULLIN UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/TrEMBL
Superfamily-SCOP Cullin_homology UniProtKB/TrEMBL
  Cullin_repeat-like UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A0A0U1RRT3_RAT UniProtKB/TrEMBL
  A0A8I5ZQ39_RAT UniProtKB/TrEMBL
  A6IWJ5 ENTREZGENE, UniProtKB/TrEMBL
  A6IWJ6 ENTREZGENE, UniProtKB/TrEMBL
  B2RYJ3 ENTREZGENE, UniProtKB/TrEMBL
  F7FNG5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-05 Cul4a  cullin 4A  RGD1563853  similar to cullin 4A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563853  similar to cullin 4A   RGD1563853_predicted  similar to cullin 4A (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563853_predicted  similar to cullin 4A (predicted)  LOC361181  similar to cullin 4A  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC361181  similar to cullin 4A      Symbol and Name status set to provisional 70820 PROVISIONAL