Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Cul4a | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CUL4A mRNA] | CTD | PMID:31150632 | Cul4a | Rat | (-)-demecolcine | increases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Demecolcine results in increased expression of CUL4A mRNA | CTD | PMID:23649840 | Cul4a | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Cul4a (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CUL4A mRNA | CTD | PMID:36331819 | Cul4a | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Cul4a (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CUL4A mRNA] | CTD | PMID:22206623 | Cul4a | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Cul4a (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in increased expression of CUL4A mRNA | CTD | PMID:22206623 | Cul4a | Rat | 1-chloro-2,4-dinitrobenzene | affects binding | ISO | CUL4A (Homo sapiens) | 6480464 | Dinitrochlorobenzene binds to CUL4A protein | CTD | PMID:32991956 | Cul4a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CUL4A mRNA | CTD | PMID:21215274 | Cul4a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Cul4a (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of CUL4A mRNA | CTD | PMID:21570461 | Cul4a | Rat | 2,4,6-tribromophenol | increases expression | ISO | CUL4A (Homo sapiens) | 6480464 | 2,4,6-tribromophenol results in increased expression of CUL4A mRNA | CTD | PMID:31675489 | Cul4a | Rat | 2-butoxyethanol | increases expression | ISO | Cul4a (Mus musculus) | 6480464 | n-butoxyethanol results in increased expression of CUL4A mRNA | CTD | PMID:19812364 | Cul4a | Rat | 2-methylcholine | affects expression | ISO | CUL4A (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of CUL4A mRNA | CTD | PMID:21179406 | Cul4a | Rat | 3,3',5,5'-tetrabromobisphenol A | increases expression | ISO | CUL4A (Homo sapiens) | 6480464 | tetrabromobisphenol A results in increased expression of CUL4A protein | CTD | PMID:31675489 | Cul4a | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Cul4a (Mus musculus) | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CUL4A mRNA | CTD | PMID:26251327 | Cul4a | Rat | 3,4-methylenedioxymethamphetamine | increases methylation | ISO | Cul4a (Mus musculus) | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of CUL4A promoter | CTD | PMID:26251327 | Cul4a | Rat | 4,4'-diaminodiphenylmethane | affects expression | ISO | Cul4a (Mus musculus) | 6480464 | 4,4'-diaminodiphenylmethane affects the expression of CUL4A mRNA | CTD | PMID:18648102 | Cul4a | Rat | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... | CTD | PMID:36041667 | Cul4a | Rat | 5-fluorouracil | affects response to substance | ISO | Cul4a (Mus musculus) | 6480464 | CUL4A protein affects the susceptibility to Fluorouracil | CTD | PMID:16467204 | Cul4a | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of CUL4A mRNA | CTD | PMID:31881176 | Cul4a | Rat | acrolein | multiple interactions | ISO | CUL4A (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... | CTD | PMID:32699268|PMID:32845096 | Cul4a | Rat | all-trans-retinoic acid | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of CUL4A mRNA | CTD | PMID:17218384|PMID:33167477 | Cul4a | Rat | alpha-pinene | multiple interactions | ISO | CUL4A (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... | CTD | PMID:32699268 | Cul4a | Rat | aristolochic acid A | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of CUL4A mRNA | CTD | PMID:33212167 | Cul4a | Rat | arsane | multiple interactions | ISO | CUL4A (Homo sapiens) | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CUL4A more ... | CTD | PMID:39836092 | Cul4a | Rat | arsenic atom | multiple interactions | ISO | CUL4A (Homo sapiens) | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CUL4A more ... | CTD | PMID:39836092 | Cul4a | Rat | benzene | increases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Benzene results in increased expression of CUL4A mRNA | CTD | PMID:19162166 | Cul4a | Rat | benzo[a]pyrene | decreases expression | ISO | Cul4a (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of CUL4A mRNA | CTD | PMID:22228805 | Cul4a | Rat | benzo[a]pyrene | increases methylation | ISO | CUL4A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of CUL4A 5' UTR | CTD | PMID:27901495 | Cul4a | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CUL4A mRNA | CTD | PMID:19150397 | Cul4a | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Cul4a (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of CUL4A mRNA | CTD | PMID:33754040 | Cul4a | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of CUL4A mRNA | CTD | PMID:26982218|PMID:34947998 | Cul4a | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... | CTD | PMID:36041667 | Cul4a | Rat | bisphenol A | decreases expression | ISO | Cul4a (Mus musculus) | 6480464 | bisphenol A results in decreased expression of CUL4A mRNA | CTD | PMID:38074096 | Cul4a | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CUL4A mRNA | CTD | PMID:25181051 | Cul4a | Rat | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... | CTD | PMID:36041667 | Cul4a | Rat | bleomycin A5 | increases expression | ISO | CUL4A (Homo sapiens) | 6480464 | bleomycetin results in increased expression of CUL4A mRNA | CTD | PMID:21040473 | Cul4a | Rat | Brodifacoum | increases expression | EXP | | 6480464 | bromfenacoum results in increased expression of CUL4A protein | CTD | PMID:28903499 | Cul4a | Rat | Butylbenzyl phthalate | increases methylation | ISO | Cul4a (Mus musculus) | 6480464 | butylbenzyl phthalate results in increased methylation of CUL4A intron | CTD | PMID:28392331 | Cul4a | Rat | cadmium dichloride | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of CUL4A mRNA | CTD | PMID:38568856 | Cul4a | Rat | caffeine | decreases phosphorylation | ISO | CUL4A (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of CUL4A protein | CTD | PMID:35688186 | Cul4a | Rat | choline | multiple interactions | ISO | Cul4a (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ... | CTD | PMID:20938992 | Cul4a | Rat | crocidolite asbestos | decreases expression | ISO | Cul4a (Mus musculus) | 6480464 | Asbestos, Crocidolite results in decreased expression of CUL4A mRNA | CTD | PMID:29279043 | Cul4a | Rat | cyclosporin A | increases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of CUL4A mRNA | CTD | PMID:20106945 | Cul4a | Rat | cyclosporin A | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of CUL4A mRNA | CTD | PMID:25562108 | Cul4a | Rat | decabromodiphenyl ether | increases expression | ISO | CUL4A (Homo sapiens) | 6480464 | decabromobiphenyl ether results in increased expression of CUL4A protein | CTD | PMID:31675489 | Cul4a | Rat | elemental selenium | multiple interactions | ISO | CUL4A (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of CUL4A mRNA | CTD | PMID:19244175 | Cul4a | Rat | ethanol | affects splicing | ISO | Cul4a (Mus musculus) | 6480464 | Ethanol affects the splicing of CUL4A mRNA | CTD | PMID:30319688 | Cul4a | Rat | ethyl methanesulfonate | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of CUL4A mRNA | CTD | PMID:23649840 | Cul4a | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of CUL4A mRNA | CTD | PMID:24793618 | Cul4a | Rat | folic acid | multiple interactions | ISO | Cul4a (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ... | CTD | PMID:20938992|PMID:22206623 | Cul4a | Rat | folic acid | decreases expression | ISO | Cul4a (Mus musculus) | 6480464 | Folic Acid results in decreased expression of CUL4A mRNA | CTD | PMID:25629700 | Cul4a | Rat | glyphosate | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Glyphosate results in decreased expression of CUL4A mRNA | CTD | PMID:31295307 | Cul4a | Rat | GSK-J4 | increases expression | ISO | CUL4A (Homo sapiens) | 6480464 | GSK-J4 results in increased expression of CUL4A mRNA | CTD | PMID:29301935 | Cul4a | Rat | hexane | decreases methylation | EXP | | 6480464 | n-hexane results in decreased methylation of CUL4A promoter | CTD | PMID:23740543 | Cul4a | Rat | hydrogen peroxide | affects expression | ISO | CUL4A (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of CUL4A mRNA | CTD | PMID:21179406 | Cul4a | Rat | irinotecan | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Irinotecan analog results in decreased expression of CUL4A mRNA | CTD | PMID:18927307 | Cul4a | Rat | ivermectin | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of CUL4A protein | CTD | PMID:32959892 | Cul4a | Rat | L-methionine | multiple interactions | ISO | Cul4a (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ... | CTD | PMID:20938992 | Cul4a | Rat | menadione | affects expression | ISO | CUL4A (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of CUL4A mRNA | CTD | PMID:20044591 | Cul4a | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of CUL4A gene | CTD | PMID:35440735 | Cul4a | Rat | methyl methanesulfonate | increases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of CUL4A mRNA | CTD | PMID:23649840 | Cul4a | Rat | methylmercury chloride | increases expression | ISO | CUL4A (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of CUL4A mRNA | CTD | PMID:28001369 | Cul4a | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of CUL4A mRNA | CTD | PMID:25729387 | Cul4a | Rat | ozone | multiple interactions | ISO | CUL4A (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of more ... | CTD | PMID:32699268|PMID:32845096 | Cul4a | Rat | paracetamol | affects expression | ISO | Cul4a (Mus musculus) | 6480464 | Acetaminophen affects the expression of CUL4A mRNA | CTD | PMID:17562736 | Cul4a | Rat | paracetamol | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of CUL4A mRNA | CTD | PMID:21420995 | Cul4a | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Cul4a (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CUL4A mRNA | CTD | PMID:36331819 | Cul4a | Rat | perfluorooctanoic acid | decreases expression | ISO | Cul4a (Mus musculus) | 6480464 | perfluorooctanoic acid results in decreased expression of CUL4A protein | CTD | PMID:36214631 | Cul4a | Rat | phenobarbital | affects expression | ISO | Cul4a (Mus musculus) | 6480464 | Phenobarbital affects the expression of CUL4A mRNA | CTD | PMID:23091169 | Cul4a | Rat | phenylhydrazine | affects response to substance | ISO | Cul4a (Mus musculus) | 6480464 | CUL4A protein affects the susceptibility to phenylhydrazine | CTD | PMID:16467204 | Cul4a | Rat | phenytoin | increases expression | EXP | | 6480464 | Phenytoin results in increased expression of CUL4A mRNA | CTD | PMID:20345932 | Cul4a | Rat | resveratrol | multiple interactions | ISO | CUL4A (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of CUL4A mRNA | CTD | PMID:23557933 | Cul4a | Rat | selenium atom | multiple interactions | ISO | CUL4A (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of CUL4A mRNA | CTD | PMID:19244175 | Cul4a | Rat | sodium arsenite | affects methylation | ISO | CUL4A (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of CUL4A gene | CTD | PMID:28589171 | Cul4a | Rat | sodium arsenite | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of CUL4A protein | CTD | PMID:38228842 | Cul4a | Rat | sodium arsenite | multiple interactions | ISO | CUL4A (Homo sapiens) | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CUL4A more ... | CTD | PMID:39836092 | Cul4a | Rat | temozolomide | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of CUL4A mRNA | CTD | PMID:31758290 | Cul4a | Rat | tert-butyl hydroperoxide | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of CUL4A mRNA | CTD | PMID:15336504 | Cul4a | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of CUL4A mRNA | CTD | PMID:31150632 | Cul4a | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of CUL4A mRNA] | CTD | PMID:31150632 | Cul4a | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of CUL4A mRNA | CTD | PMID:34492290 | Cul4a | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of CUL4A mRNA | CTD | PMID:25729387 | Cul4a | Rat | topotecan | affects response to substance | ISO | CUL4A (Homo sapiens) | 6480464 | CUL4A protein affects the susceptibility to Topotecan | CTD | PMID:16217747 | Cul4a | Rat | triphenyl phosphate | affects expression | ISO | CUL4A (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of CUL4A mRNA | CTD | PMID:37042841 | Cul4a | Rat | triptonide | increases expression | ISO | Cul4a (Mus musculus) | 6480464 | triptonide results in increased expression of CUL4A mRNA | CTD | PMID:33045310 | Cul4a | Rat | tunicamycin | decreases expression | ISO | Cul4a (Mus musculus) | 6480464 | Tunicamycin results in decreased expression of CUL4A mRNA | CTD | PMID:17127020 | Cul4a | Rat | valproic acid | decreases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of CUL4A mRNA | CTD | PMID:23179753 | Cul4a | Rat | valproic acid | decreases methylation | ISO | CUL4A (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of CUL4A gene | CTD | PMID:29154799 | Cul4a | Rat | valproic acid | affects expression | ISO | CUL4A (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CUL4A mRNA | CTD | PMID:25979313 | Cul4a | Rat | vincristine | increases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Vincristine results in increased expression of CUL4A mRNA | CTD | PMID:23649840 | Cul4a | Rat | vitamin E | multiple interactions | ISO | CUL4A (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of CUL4A mRNA | CTD | PMID:19244175 | Cul4a | Rat | vitamin E | increases expression | ISO | CUL4A (Homo sapiens) | 6480464 | Vitamin E results in increased expression of CUL4A mRNA | CTD | PMID:19244175 | Cul4a | Rat | zoledronic acid | increases expression | ISO | CUL4A (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of CUL4A mRNA | CTD | PMID:24714768 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















