Gmnc (geminin coiled-coil domain containing) - Rat Genome Database

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Gene: Gmnc (geminin coiled-coil domain containing) Rattus norvegicus
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Symbol: Gmnc
Name: geminin coiled-coil domain containing
RGD ID: 1563170
Description: Predicted to enable transcription coactivator activity. Predicted to be involved in DNA replication; negative regulation of cell cycle; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within several processes, including cerebrospinal fluid circulation; multi-ciliated epithelial cell differentiation; and seminiferous tubule development. Predicted to be located in extracellular region. Predicted to be active in nucleus. Orthologous to human GMNC (geminin coiled-coil domain containing); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrolein; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: geminin coiled-coil domain-containing protein 1; LOC498102; RGD1563170
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81187,339,617 - 87,352,149 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1187,341,446 - 87,352,151 (+)EnsemblGRCr8
mRatBN7.21173,836,255 - 73,847,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,814,533 - 73,847,328 (+)EnsemblmRatBN7.2
Rnor_6.01177,237,033 - 77,247,723 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1177,239,098 - 77,246,315 (+)Ensemblrn6Rnor6.0
Rnor_5.01183,470,179 - 83,480,811 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41175,823,385 - 75,835,294 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1172,764,269 - 72,774,991 (+)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20383140   PMID:26882546  


Genomics

Comparative Map Data
Gmnc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81187,339,617 - 87,352,149 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1187,341,446 - 87,352,151 (+)EnsemblGRCr8
mRatBN7.21173,836,255 - 73,847,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1173,814,533 - 73,847,328 (+)EnsemblmRatBN7.2
Rnor_6.01177,237,033 - 77,247,723 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1177,239,098 - 77,246,315 (+)Ensemblrn6Rnor6.0
Rnor_5.01183,470,179 - 83,480,811 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41175,823,385 - 75,835,294 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1172,764,269 - 72,774,991 (+)NCBICelera
Cytogenetic Map11q22NCBI
GMNC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383190,843,271 - 190,862,694 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3190,852,737 - 190,892,429 (-)Ensemblhg38GRCh38
GRCh373190,570,526 - 190,580,483 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363192,055,778 - 192,063,645 (-)NCBIBuild 36Build 36hg18NCBI36
Celera3189,000,690 - 189,010,629 (-)NCBICelera
Cytogenetic Map3q28NCBI
HuRef3187,970,135 - 187,980,075 (-)NCBIHuRef
CHM1_13190,534,027 - 190,544,004 (-)NCBICHM1_1
T2T-CHM13v2.03193,659,602 - 193,679,021 (-)NCBIT2T-CHM13v2.0
Gmnc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391626,775,985 - 26,810,424 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1626,732,303 - 26,810,402 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381626,957,235 - 26,991,675 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1626,913,553 - 26,991,652 (-)Ensemblmm10GRCm38
MGSCv371626,957,321 - 26,990,060 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361626,872,468 - 26,905,207 (-)NCBIMGSCv36mm8
Celera1627,499,106 - 27,531,851 (-)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1618.56NCBI
Gmnc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542017,281,684 - 17,298,001 (+)Ensembl
ChiLan1.0NW_00495542017,286,789 - 17,297,574 (+)NCBIChiLan1.0ChiLan1.0
GMNC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22188,719,559 - 188,728,331 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13188,724,276 - 188,733,048 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03187,876,545 - 187,931,929 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13196,427,562 - 196,437,385 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3196,426,618 - 196,540,248 (-)EnsemblpanPan2panpan1.1
GMNC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13422,790,364 - 22,800,569 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3422,790,972 - 22,800,852 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3426,884,181 - 26,894,407 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03422,723,660 - 22,733,090 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3422,725,664 - 22,734,744 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13422,746,583 - 22,756,935 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03422,732,689 - 22,743,044 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03422,975,152 - 22,983,061 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gmnc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602120,613,222 - 120,650,593 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493690076,581 - 81,758 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493690076,581 - 83,550 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GMNC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13128,239,514 - 128,250,707 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113128,239,507 - 128,251,579 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213137,622,779 - 137,631,350 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GMNC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11585,060,719 - 85,070,285 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1585,061,562 - 85,067,339 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604158,682,333 - 58,700,120 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gmnc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473066,288,351 - 66,319,136 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473066,312,153 - 66,322,508 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gmnc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1413,281,996 - 13,290,237 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:90
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000058701
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 18 119 30 38 13 4 13 6 80 31 2 106 30 74 25 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000058701   ⟹   ENSRNOP00000055495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1187,341,490 - 87,352,151 (+)Ensembl
mRatBN7.2 Ensembl1173,814,533 - 73,847,328 (+)Ensembl
Rnor_6.0 Ensembl1177,239,098 - 77,246,315 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107893   ⟹   ENSRNOP00000083414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1187,342,947 - 87,352,151 (+)Ensembl
mRatBN7.2 Ensembl1173,814,564 - 73,847,328 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120173   ⟹   ENSRNOP00000080915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1187,341,446 - 87,352,151 (+)Ensembl
mRatBN7.2 Ensembl1173,836,451 - 73,847,328 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000173088   ⟹   ENSRNOP00000104465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1187,342,374 - 87,352,151 (+)Ensembl
RefSeq Acc Id: XM_006248531   ⟹   XP_006248593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,339,617 - 87,352,149 (+)NCBI
mRatBN7.21173,836,255 - 73,847,698 (+)NCBI
Rnor_6.01177,237,033 - 77,247,723 (+)NCBI
Rnor_5.01183,470,179 - 83,480,811 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088948   ⟹   XP_038944876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,339,617 - 87,352,149 (+)NCBI
mRatBN7.21173,836,255 - 73,847,698 (+)NCBI
RefSeq Acc Id: XP_006248593   ⟸   XM_006248531
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000055495   ⟸   ENSRNOT00000058701
RefSeq Acc Id: XP_038944876   ⟸   XM_039088948
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000083414   ⟸   ENSRNOT00000107893
Ensembl Acc Id: ENSRNOP00000080915   ⟸   ENSRNOT00000120173
Ensembl Acc Id: ENSRNOP00000104465   ⟸   ENSRNOT00000173088

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LTU7-F1-model_v2 AlphaFold F1LTU7 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563170 AgrOrtholog
BioCyc Gene G2FUF-20944 BioCyc
Ensembl Genes ENSRNOG00000038505 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058701.4 UniProtKB/TrEMBL
  ENSRNOT00000107893.2 UniProtKB/TrEMBL
  ENSRNOT00000120173 ENTREZGENE
  ENSRNOT00000120173.2 UniProtKB/TrEMBL
  ENSRNOT00000173088.1 UniProtKB/TrEMBL
KEGG Report rno:498102 UniProtKB/TrEMBL
NCBI Gene 498102 ENTREZGENE
PANTHER GEMININ UniProtKB/TrEMBL
  PTHR13372:SF2 UniProtKB/TrEMBL
PhenoGen Gmnc PhenoGen
RatGTEx ENSRNOG00000038505 RatGTEx
UniProt A0A8I5ZWJ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G7A5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LSC0_RAT UniProtKB/TrEMBL
  F1LTU7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-09-02 Gmnc  geminin coiled-coil domain containing  RGD1563170  RGD1563170  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563170  RGD1563170   RGD1563170_predicted  RGD1563170 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563170_predicted  RGD1563170 (predicted)  LOC498102  LOC498102  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498102  LOC498102      Symbol and Name status set to provisional 70820 PROVISIONAL