S100z (S100 calcium binding protein Z) - Rat Genome Database

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Gene: S100z (S100 calcium binding protein Z) Rattus norvegicus
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Symbol: S100z
Name: S100 calcium binding protein Z
RGD ID: 1562902
Description: Predicted to enable calcium ion binding activity; calcium-dependent protein binding activity; and protein homodimerization activity. Orthologous to human S100Z (S100 calcium binding protein Z); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC294661; protein S100-Z; RGD1562902; S100 calcium binding protein, zeta; similar to S100 calcium binding protein, zeta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,472,527 - 28,476,750 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl228,472,527 - 28,476,750 (-)EnsemblGRCr8
mRatBN7.2226,737,796 - 26,753,611 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,738,776 - 26,752,390 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx233,776,927 - 33,778,551 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,877,145 - 31,878,769 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,692,975 - 26,694,599 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0225,188,381 - 25,203,627 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl225,188,782 - 25,190,495 (-)Ensemblrn6Rnor6.0
Rnor_5.0244,344,729 - 44,348,915 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4225,852,473 - 25,854,097 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera222,803,619 - 22,805,242 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11747429  


Genomics

Comparative Map Data
S100z
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,472,527 - 28,476,750 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl228,472,527 - 28,476,750 (-)EnsemblGRCr8
mRatBN7.2226,737,796 - 26,753,611 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,738,776 - 26,752,390 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx233,776,927 - 33,778,551 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0231,877,145 - 31,878,769 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0226,692,975 - 26,694,599 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0225,188,381 - 25,203,627 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl225,188,782 - 25,190,495 (-)Ensemblrn6Rnor6.0
Rnor_5.0244,344,729 - 44,348,915 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4225,852,473 - 25,854,097 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera222,803,619 - 22,805,242 (-)NCBICelera
Cytogenetic Map2q12NCBI
S100Z
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38576,850,014 - 76,952,953 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl576,850,001 - 76,921,650 (+)Ensemblhg38GRCh38
GRCh37576,145,839 - 76,217,475 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,181,582 - 76,252,812 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34576,181,581 - 76,209,800NCBI
Celera572,040,311 - 72,111,532 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,353,650 - 71,423,705 (+)NCBIHuRef
CHM1_1575,578,986 - 75,650,179 (+)NCBICHM1_1
T2T-CHM13v2.0577,331,819 - 77,434,785 (+)NCBIT2T-CHM13v2.0
S100z
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,613,809 - 95,615,163 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,613,776 - 95,615,229 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381395,477,301 - 95,478,655 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,477,268 - 95,478,721 (-)Ensemblmm10GRCm38
MGSCv371396,247,256 - 96,248,610 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361396,578,000 - 96,579,354 (-)NCBIMGSCv36mm8
Celera1399,097,071 - 99,098,425 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.53NCBI
S100z
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542524,014,039 - 24,022,870 (-)Ensembl
ChiLan1.0NW_00495542524,014,039 - 24,022,842 (-)NCBIChiLan1.0ChiLan1.0
S100Z
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2438,423,182 - 38,431,606 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1536,576,809 - 36,585,233 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0538,383,062 - 38,427,515 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1538,965,912 - 38,968,358 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl538,965,891 - 38,968,358 (-)EnsemblpanPan2panpan1.1
S100Z
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,773,107 - 29,784,376 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha331,012,343 - 31,023,607 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0329,692,313 - 29,703,569 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1329,629,032 - 29,640,293 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,609,848 - 29,621,178 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,979,092 - 29,990,346 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
S100z
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213190,745,073 - 190,747,842 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936549111,395 - 113,662 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936549111,395 - 113,662 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
S100Z
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,767,614 - 85,770,957 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1285,757,636 - 85,771,742 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,348,154 - 87,386,912 (+)NCBISscrofa10.2Sscrofa10.2susScr3
S100z
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248691,365,911 - 1,369,465 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248691,365,615 - 1,369,457 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
S100z
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13222,734,531 - 222,736,626 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in S100z
43 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:68
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000024202
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2142977529Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 4 24 73 49 52 30 35 30 6 194 83 11 52 64 80 22 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000024202   ⟹   ENSRNOP00000024202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,738,776 - 26,752,390 (-)Ensembl
Rnor_6.0 Ensembl225,188,782 - 25,190,495 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142490   ⟹   ENSRNOP00000101640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl228,472,527 - 28,476,750 (-)Ensembl
RefSeq Acc Id: NM_001191701   ⟹   NP_001178630
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,472,527 - 28,476,750 (-)NCBI
mRatBN7.2226,737,796 - 26,742,019 (-)NCBI
Rnor_6.0225,188,782 - 25,190,495 (-)NCBI
Rnor_5.0244,344,729 - 44,348,915 (-)NCBI
Celera222,803,619 - 22,805,242 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178630 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000101640
  ENSRNOP00000101640.1
RefSeq Acc Id: NP_001178630   ⟸   NM_001191701
- UniProtKB: D3ZEJ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024202   ⟸   ENSRNOT00000024202
Ensembl Acc Id: ENSRNOP00000101640   ⟸   ENSRNOT00000142490

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZEJ4-F1-model_v2 AlphaFold D3ZEJ4 1-99 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562902 AgrOrtholog
BioCyc Gene G2FUF-54806 BioCyc
Ensembl Genes ENSRNOG00000017998 Ensembl
  ENSRNOG00000078837 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000142490 ENTREZGENE
  ENSRNOT00000142490.1 UniProtKB/TrEMBL
NCBI Gene 294661 ENTREZGENE
PhenoGen S100z PhenoGen
RatGTEx ENSRNOG00000017998 RatGTEx
  ENSRNOG00000078837 RatGTEx
UniProt A0ABK0LJT5_RAT UniProtKB/TrEMBL
  D3ZEJ4 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 S100z  S100 calcium binding protein Z  S100z  S100 calcium binding protein, zeta   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 S100z  S100 calcium binding protein, zeta   S100z_predicted  S100 calcium binding protein, zeta (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 S100z_predicted  S100 calcium binding protein, zeta (predicted)  RGD1562902_predicted  similar to S100 calcium binding protein, zeta (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1562902_predicted  similar to S100 calcium binding protein, zeta (predicted)  LOC294661  similar to S100 calcium binding protein, zeta  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC294661  similar to S100 calcium binding protein, zeta      Symbol and Name status set to provisional 70820 PROVISIONAL