Serpinb9b (serine (or cysteine) peptidase inhibitor, clade B, member 9b) - Rat Genome Database

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Gene: Serpinb9b (serine (or cysteine) peptidase inhibitor, clade B, member 9b) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Serpinb9b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9b
RGD ID: 1562844
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Orthologous to human SERPINB9 (serpin family B member 9); INTERACTS WITH 17beta-estradiol; bisphenol A; cisplatin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leukocyte elastase inhibitor A-like; LOC100911107; LOC306892; RGD1562844; serpin B9-like; similar to serine (or cysteine) proteinase inhibitor, clade B, member 9
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,586,957 - 31,594,983 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1731,586,957 - 31,597,450 (-)EnsemblGRCr8
mRatBN7.21731,378,190 - 31,386,218 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1731,378,190 - 31,388,687 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1731,213,155 - 31,221,181 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01732,816,917 - 32,824,943 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01731,208,902 - 31,216,928 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,607,893 - 32,619,160 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,066,213 - 32,076,181 (-)NCBIrn6Rnor6.0
Rnor_5.01734,500,586 - 34,511,339 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41737,738,390 - 37,748,259 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1730,940,094 - 30,951,107 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Serpinb9b
34 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:28
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000074842
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat

Markers in Region
BI274644  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21731,378,444 - 31,378,637 (+)MAPPERmRatBN7.2
Rnor_6.01732,608,635 - 32,608,827NCBIRnor6.0
Rnor_6.01732,065,933 - 32,066,125NCBIRnor6.0
Rnor_5.01734,500,841 - 34,501,033UniSTSRnor5.0
Rnor_5.01733,959,752 - 33,959,944UniSTSRnor5.0
RGSC_v3.41737,738,023 - 37,738,215UniSTSRGSC3.4
Celera1730,940,836 - 30,941,028UniSTS
RH 3.4 Map17369.2UniSTS
Cytogenetic Map17p12UniSTS
RH142864  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21731,378,284 - 31,378,528 (+)MAPPERmRatBN7.2
Rnor_6.01732,608,475 - 32,608,718NCBIRnor6.0
Rnor_6.01732,065,773 - 32,066,016NCBIRnor6.0
Rnor_5.01734,500,681 - 34,500,924UniSTSRnor5.0
Rnor_5.01733,959,592 - 33,959,835UniSTSRnor5.0
RGSC_v3.41737,737,863 - 37,738,106UniSTSRGSC3.4
Celera1730,940,676 - 30,940,919UniSTS
RH 3.4 Map17356.8UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
6 1 24 41 30 1 11 3

Sequence


Ensembl Acc Id: ENSRNOT00000074842   ⟹   ENSRNOP00000064132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1731,587,492 - 31,597,450 (-)Ensembl
mRatBN7.2 Ensembl1731,378,725 - 31,388,687 (-)Ensembl
Rnor_6.0 Ensembl1732,066,213 - 32,076,181 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118780   ⟹   ENSRNOP00000079679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1731,586,957 - 31,594,983 (-)Ensembl
mRatBN7.2 Ensembl1731,378,190 - 31,386,218 (-)Ensembl
RefSeq Acc Id: NM_001346368   ⟹   NP_001333297
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,586,957 - 31,594,983 (-)NCBI
mRatBN7.21731,378,190 - 31,386,218 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001333297 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98337 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064132.3
  ENSRNOP00000079679
  ENSRNOP00000079679.1
RefSeq Acc Id: NP_001333297   ⟸   NM_001346368
- UniProtKB: A0A8I5ZNV4 (UniProtKB/TrEMBL),   A6J7I7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000064132   ⟸   ENSRNOT00000074842
Ensembl Acc Id: ENSRNOP00000079679   ⟸   ENSRNOT00000118780
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R455-F1-model_v2 AlphaFold M0R455 1-373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562844 AgrOrtholog
BioCyc Gene G2FUF-9583 BioCyc
Ensembl Genes ENSRNOG00000048576 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074842.4 UniProtKB/TrEMBL
  ENSRNOT00000118780 ENTREZGENE
  ENSRNOT00000118780.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Serpin_B9/Maspin UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:306892 UniProtKB/TrEMBL
NCBI Gene 306892 ENTREZGENE
PANTHER PTHR11461 UniProtKB/TrEMBL
  SERPIN B9 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpinb9b PhenoGen
PRINTS MASPIN UniProtKB/TrEMBL
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048576 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A0A8I5ZNV4 ENTREZGENE, UniProtKB/TrEMBL
  A6J7I7 ENTREZGENE, UniProtKB/TrEMBL
  M0R455_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Serpinb9b  serine (or cysteine) peptidase inhibitor, clade B, member 9b  RGD1562844  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9  Symbol and Name Changed 1299863 APPROVED
2021-03-09 RGD1562844  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9  LOC100911107  leukocyte elastase inhibitor A-like  Data merged from RGD:6495052 737654 PROVISIONAL
2012-07-05 LOC100911107  leukocyte elastase inhibitor A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1562844  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9   RGD1562844_predicted  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562844_predicted  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9 (predicted)  LOC306892  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC306892  similar to serine (or cysteine) proteinase inhibitor, clade B, member 9      Symbol and Name status set to provisional 70820 PROVISIONAL