Epcip (exosomal polycystin 1 interacting protein) - Rat Genome Database

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Pathways
Gene: Epcip (exosomal polycystin 1 interacting protein) Rattus norvegicus
Analyze
Symbol: Epcip
Name: exosomal polycystin 1 interacting protein
RGD ID: 1562726
Description: Predicted to enable identical protein binding activity. Predicted to be involved in mitocytosis. Predicted to be located in extracellular exosome. Predicted to be active in migrasome. Orthologous to human EPCIP (exosomal polycystin 1 interacting protein); INTERACTS WITH 1-naphthyl isothiocyanate; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C11h21orf62; hypothetical protein LOC498060; LOC498060; polycystin-1-interacting protein 1; RGD1562726; similar to human chromosome 21 open reading frame 62; similar to Putative protein C21orf62 homolog; uncharacterized protein C21orf62 homolog; uncharacterized protein LOC498060
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,793,924 - 43,811,388 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1143,793,578 - 43,811,682 (-)EnsemblGRCr8
mRatBN7.21130,307,842 - 30,325,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,310,350 - 30,325,439 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1138,994,695 - 39,012,149 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01131,666,118 - 31,683,572 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01130,840,545 - 30,857,999 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,220,566 - 31,238,495 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,223,074 - 31,238,026 (-)Ensemblrn6Rnor6.0
Rnor_5.01134,831,057 - 34,848,558 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41131,039,805 - 31,055,914 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1129,976,897 - 29,991,831 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
mitocytosis  (IBA,IEA,ISO)

Cellular Component
extracellular exosome  (IEA,ISO)
migrasome  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Epcip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,793,924 - 43,811,388 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1143,793,578 - 43,811,682 (-)EnsemblGRCr8
mRatBN7.21130,307,842 - 30,325,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1130,310,350 - 30,325,439 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1138,994,695 - 39,012,149 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01131,666,118 - 31,683,572 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01130,840,545 - 30,857,999 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,220,566 - 31,238,495 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,223,074 - 31,238,026 (-)Ensemblrn6Rnor6.0
Rnor_5.01134,831,057 - 34,848,558 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41131,039,805 - 31,055,914 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1129,976,897 - 29,991,831 (-)NCBICelera
Cytogenetic Map11q11NCBI
EPCIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382132,790,673 - 32,813,703 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2132,790,673 - 32,813,743 (-)Ensemblhg38GRCh38
GRCh372134,162,984 - 34,186,013 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362133,084,855 - 33,107,876 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342133,087,745 - 33,107,829NCBI
Celera2119,346,641 - 19,369,711 (-)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2119,572,320 - 19,595,326 (-)NCBIHuRef
CHM1_12133,725,128 - 33,748,245 (-)NCBICHM1_1
T2T-CHM13v2.02131,156,897 - 31,179,935 (-)NCBIT2T-CHM13v2.0
Epcip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391690,841,534 - 90,866,040 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1690,850,823 - 90,892,010 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381691,054,877 - 91,130,103 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1691,053,935 - 91,095,122 (-)Ensemblmm10GRCm38
MGSCv371691,054,180 - 91,069,390 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361690,942,794 - 90,958,004 (-)NCBIMGSCv36mm8
Celera1692,135,605 - 92,150,807 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1652.35NCBI
Epcip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540732,229,108 - 32,249,097 (-)NCBIChiLan1.0ChiLan1.0
EPCIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22228,903,874 - 28,924,829 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12123,763,834 - 23,784,820 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02119,153,434 - 19,174,752 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12132,529,572 - 32,552,595 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2132,532,656 - 32,552,541 (-)EnsemblpanPan2panpan1.1
EPCIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13127,457,591 - 27,496,423 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3127,460,093 - 27,460,752 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3127,453,873 - 27,454,532 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03127,656,918 - 27,695,885 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3127,659,383 - 27,660,042 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13127,525,390 - 27,526,049 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03127,537,370 - 27,538,029 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03128,044,739 - 28,045,398 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Epcip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497128,038,572 - 28,055,382 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365009,427,898 - 9,428,617 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365009,412,507 - 9,429,250 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPCIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13196,387,383 - 196,404,714 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113196,387,380 - 196,404,856 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213206,399,336 - 206,416,823 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPCIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1259,346,296 - 59,367,721 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl259,366,479 - 59,367,135 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660711,886,621 - 1,907,779 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epcip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474521,034,962 - 21,035,675 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474521,031,717 - 21,064,616 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Epcip
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1453,521,967 - 53,535,473 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Epcip
45 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:122
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000032366
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11381815448818154Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)111080612555806125Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)113532319955805892Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)112995899657754989Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)112631803155806125Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat

Markers in Region
RH137379  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21130,311,400 - 30,311,606 (+)MAPPERmRatBN7.2
Rnor_6.01131,224,125 - 31,224,330NCBIRnor6.0
Rnor_5.01134,834,616 - 34,834,821UniSTSRnor5.0
RGSC_v3.41131,040,856 - 31,041,061UniSTSRGSC3.4
Celera1129,977,948 - 29,978,153UniSTS
RH 3.4 Map11180.4UniSTS
Cytogenetic Map11q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 9 66 164 84 83 52 52 52 6 305 149 11 143 83 94 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032366   ⟹   ENSRNOP00000060658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,793,691 - 43,811,466 (-)Ensembl
mRatBN7.2 Ensembl1130,310,350 - 30,325,304 (-)Ensembl
Rnor_6.0 Ensembl1131,223,074 - 31,238,026 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106623   ⟹   ENSRNOP00000084873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,793,849 - 43,807,302 (-)Ensembl
mRatBN7.2 Ensembl1130,310,363 - 30,319,606 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115117   ⟹   ENSRNOP00000086960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,793,804 - 43,807,748 (-)Ensembl
mRatBN7.2 Ensembl1130,310,363 - 30,320,416 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116580   ⟹   ENSRNOP00000089993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,797,235 - 43,799,279 (-)Ensembl
mRatBN7.2 Ensembl1130,311,195 - 30,324,009 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116851   ⟹   ENSRNOP00000094399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,793,578 - 43,811,682 (-)Ensembl
mRatBN7.2 Ensembl1130,310,363 - 30,325,439 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138270   ⟹   ENSRNOP00000111012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,797,828 - 43,810,080 (-)Ensembl
RefSeq Acc Id: NM_001109052   ⟹   NP_001102522
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,793,924 - 43,811,388 (-)NCBI
mRatBN7.21130,307,842 - 30,325,309 (-)NCBI
Rnor_6.01131,223,074 - 31,238,026 (-)NCBI
Rnor_5.01134,831,057 - 34,848,558 (-)NCBI
RGSC_v3.41131,039,805 - 31,055,914 (-)RGD
Celera1129,976,897 - 29,991,831 (-)RGD
Sequence:
RefSeq Acc Id: NP_001102522   ⟸   NM_001109052
- Peptide Label: precursor
- UniProtKB: D3ZJP2 (UniProtKB/TrEMBL),   A6JLE4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060658   ⟸   ENSRNOT00000032366
Ensembl Acc Id: ENSRNOP00000086960   ⟸   ENSRNOT00000115117
Ensembl Acc Id: ENSRNOP00000089993   ⟸   ENSRNOT00000116580
Ensembl Acc Id: ENSRNOP00000084873   ⟸   ENSRNOT00000106623
Ensembl Acc Id: ENSRNOP00000094399   ⟸   ENSRNOT00000116851
Ensembl Acc Id: ENSRNOP00000111012   ⟸   ENSRNOT00000138270

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJP2-F1-model_v2 AlphaFold D3ZJP2 1-211 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562726 AgrOrtholog
BioCyc Gene G2FUF-21921 BioCyc
Ensembl Genes ENSRNOG00000028670 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032366.5 UniProtKB/TrEMBL
  ENSRNOT00000106623.2 UniProtKB/TrEMBL
  ENSRNOT00000115117.2 UniProtKB/TrEMBL
  ENSRNOT00000116580.2 UniProtKB/TrEMBL
  ENSRNOT00000116851 ENTREZGENE
  ENSRNOT00000116851.2 UniProtKB/TrEMBL
  ENSRNOT00000138270.1 UniProtKB/TrEMBL
InterPro DUF4571 UniProtKB/TrEMBL
KEGG Report rno:498060 UniProtKB/TrEMBL
NCBI Gene 498060 ENTREZGENE
PANTHER PTHR35658 UniProtKB/TrEMBL
  RCG58666, ISOFORM CRA_A UniProtKB/TrEMBL
Pfam DUF4571 UniProtKB/TrEMBL
PhenoGen Epcip PhenoGen
RatGTEx ENSRNOG00000028670 RatGTEx
UniProt A6JLE4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJP2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-12-29 Epcip  exosomal polycystin 1 interacting protein  C11h21orf62  similar to human chromosome 21 open reading frame 62  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-09-19 C11h21orf62  similar to human chromosome 21 open reading frame 62  RGD1562726  similar to Putative protein C21orf62 homolog  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1562726  similar to Putative protein C21orf62 homolog   RGD1562726_predicted  similar to Putative protein C21orf62 homolog (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562726_predicted  similar to Putative protein C21orf62 homolog (predicted)  LOC498060  similar to Putative protein C21orf62 homolog  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498060  similar to Putative protein C21orf62 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL