Tusc2 (tumor suppressor 2, mitochondrial calcium regulator) - Rat Genome Database

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Gene: Tusc2 (tumor suppressor 2, mitochondrial calcium regulator) Rattus norvegicus
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Symbol: Tusc2
Name: tumor suppressor 2, mitochondrial calcium regulator
RGD ID: 1561664
Description: Predicted to be involved in inflammatory response and regulation of mitochondrial membrane potential. Predicted to act upstream of or within several processes, including natural killer cell differentiation; neutrophil-mediated killing of gram-negative bacterium; and regulation of cytokine production. Predicted to be active in mitochondrion. Orthologous to human TUSC2 (tumor suppressor 2, mitochondrial calcium regulator); INTERACTS WITH bisphenol A; Cuprizon; finasteride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC501052; similar to Fus1 protein; tumor suppressor candidate 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,115,479 - 117,118,697 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8117,115,479 - 117,118,697 (+)EnsemblGRCr8
mRatBN7.28108,236,838 - 108,240,056 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,236,838 - 108,240,056 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,863,865 - 113,867,083 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,063,021 - 112,066,239 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,905,802 - 109,909,020 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,318,963 - 116,322,181 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,318,963 - 116,322,181 (+)Ensemblrn6Rnor6.0
Rnor_5.08115,675,223 - 115,678,441 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48112,810,678 - 112,813,896 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8107,543,405 - 107,546,623 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrion  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:17318811   PMID:22513871   PMID:22871113   PMID:24042119  


Genomics

Comparative Map Data
Tusc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,115,479 - 117,118,697 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8117,115,479 - 117,118,697 (+)EnsemblGRCr8
mRatBN7.28108,236,838 - 108,240,056 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,236,838 - 108,240,056 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8113,863,865 - 113,867,083 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,063,021 - 112,066,239 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,905,802 - 109,909,020 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,318,963 - 116,322,181 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,318,963 - 116,322,181 (+)Ensemblrn6Rnor6.0
Rnor_5.08115,675,223 - 115,678,441 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48112,810,678 - 112,813,896 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8107,543,405 - 107,546,623 (+)NCBICelera
Cytogenetic Map8q32NCBI
TUSC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,324,909 - 50,328,223 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,320,027 - 50,328,251 (-)Ensemblhg38GRCh38
GRCh37350,362,340 - 50,365,654 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,337,345 - 50,340,672 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34350,337,344 - 50,340,672NCBI
Celera350,335,176 - 50,338,503 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef350,418,054 - 50,421,381 (-)NCBIHuRef
CHM1_1350,314,607 - 50,317,934 (-)NCBICHM1_1
T2T-CHM13v2.0350,354,633 - 50,357,947 (-)NCBIT2T-CHM13v2.0
Tusc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,440,454 - 107,443,307 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,440,454 - 107,443,311 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389107,563,255 - 107,566,108 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,563,255 - 107,566,112 (+)Ensemblmm10GRCm38
MGSCv379107,465,586 - 107,468,439 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369107,421,356 - 107,424,209 (+)NCBIMGSCv36mm8
Celera9107,172,004 - 107,174,857 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.12NCBI
Tusc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,128,430 - 2,131,235 (-)Ensembl
ChiLan1.0NW_0049555322,128,430 - 2,131,235 (-)NCBIChiLan1.0ChiLan1.0
TUSC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,305,496 - 50,308,825 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,310,271 - 50,313,590 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,251,034 - 50,254,351 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,486,641 - 51,489,962 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,486,641 - 51,489,962 (-)EnsemblpanPan2panpan1.1
TUSC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,024,814 - 39,026,209 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,945,496 - 38,948,454 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02039,380,487 - 39,383,449 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,380,448 - 39,383,448 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,748,320 - 38,751,276 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,151,878 - 39,154,836 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,431,895 - 39,434,853 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
TUSC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,711,487 - 11,715,095 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2211,711,386 - 11,715,057 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041155,271,415 - 155,275,018 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tusc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247304,177,351 - 4,181,036 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tusc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1898,879,718 - 98,882,900 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tusc2
37 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:197
Count of miRNA genes:142
Interacting mature miRNAs:178
Transcripts:ENSRNOT00000036556
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
RH127876  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,239,617 - 108,239,823 (+)MAPPERmRatBN7.2
Rnor_6.08116,321,743 - 116,321,948NCBIRnor6.0
Rnor_5.08115,678,003 - 115,678,208UniSTSRnor5.0
RGSC_v3.48112,813,458 - 112,813,663UniSTSRGSC3.4
Celera8107,546,185 - 107,546,390UniSTS
RH 3.4 Map81117.7UniSTS
Cytogenetic Map8q32UniSTS
RH125715  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,239,798 - 108,240,039 (+)MAPPERmRatBN7.2
Rnor_6.08116,321,924 - 116,322,164NCBIRnor6.0
Rnor_5.08115,678,184 - 115,678,424UniSTSRnor5.0
RGSC_v3.48112,813,639 - 112,813,879UniSTSRGSC3.4
Celera8107,546,366 - 107,546,606UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 85 212 91 90 59 158 59 6 490 286 22 190 114 124 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000036556   ⟹   ENSRNOP00000031045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8117,115,479 - 117,118,697 (+)Ensembl
mRatBN7.2 Ensembl8108,236,838 - 108,240,056 (+)Ensembl
Rnor_6.0 Ensembl8116,318,963 - 116,322,181 (+)Ensembl
RefSeq Acc Id: NM_001109297   ⟹   NP_001102767
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,115,479 - 117,118,697 (+)NCBI
mRatBN7.28108,236,838 - 108,240,056 (+)NCBI
Rnor_6.08116,318,963 - 116,322,181 (+)NCBI
Rnor_5.08115,675,223 - 115,678,441 (+)NCBI
RGSC_v3.48112,810,678 - 112,813,896 (+)RGD
Celera8107,543,405 - 107,546,623 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102767 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77247 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031045
  ENSRNOP00000031045.3
RefSeq Acc Id: NP_001102767   ⟸   NM_001109297
- UniProtKB: D3Z8Q5 (UniProtKB/TrEMBL),   A6I2Y1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031045   ⟸   ENSRNOT00000036556

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z8Q5-F1-model_v2 AlphaFold D3Z8Q5 1-110 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696271
Promoter ID:EPDNEW_R6796
Type:initiation region
Name:Tusc2_1
Description:tumor suppressor candidate 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,319,382 - 116,319,442EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561664 AgrOrtholog
BioCyc Gene G2FUF-29192 BioCyc
Ensembl Genes ENSRNOG00000021528 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036556 ENTREZGENE
  ENSRNOT00000036556.5 UniProtKB/TrEMBL
InterPro FUS1 UniProtKB/TrEMBL
KEGG Report rno:501052 UniProtKB/TrEMBL
NCBI Gene 501052 ENTREZGENE
PANTHER PTHR15453 UniProtKB/TrEMBL
  TUMOR SUPPRESSOR CANDIDATE 2 UniProtKB/TrEMBL
Pfam TUSC2 UniProtKB/TrEMBL
PhenoGen Tusc2 PhenoGen
RatGTEx ENSRNOG00000021528 RatGTEx
UniProt A6I2Y1 ENTREZGENE, UniProtKB/TrEMBL
  D3Z8Q5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-01 Tusc2  tumor suppressor 2, mitochondrial calcium regulator  Tusc2  tumor suppressor candidate 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Tusc2  tumor suppressor candidate 2  LOC501052  similar to Fus1 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC501052  similar to Fus1 protein      Symbol and Name status set to provisional 70820 PROVISIONAL