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Gene: Dnah5 (dynein, axonemal, heavy chain 5) Rattus norvegicus

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Symbol:

Dnah5

Name:

dynein, axonemal, heavy chain 5

RGD ID:

1560828

Description:

Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility and outer dynein arm assembly. Predicted to act upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and lateral ventricle development. Predicted to be located in 9+0 motile cilium; axoneme; and glial cell projection. Predicted to be part of outer dynein arm. Predicted to be active in 9+2 motile cilium. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 3. Orthologous to human DNAH5 (dynein axonemal heavy chain 5); INTERACTS WITH ammonium chloride; arsane; arsenic atom.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

axonemal beta dynein heavy chain 5; ciliary dynein heavy chain 5; DLP5; Dnahc5; Dnahc8; dynein axonemal heavy chain 5; dynein heavy chain; dynein heavy chain 5, axonemal; dynein-like prot ein 5; dynein-like protein 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DNAH5 (dynein axonemal heavy chain 5)	HGNC	Ensembl, Inparanoid, OrthoDB, Panther
Mus musculus (house mouse):	Dnah5 (dynein, axonemal, heavy chain 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dnah5 (dynein axonemal heavy chain 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DNAH5 (dynein axonemal heavy chain 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DNAH5 (dynein axonemal heavy chain 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dnah5 (dynein axonemal heavy chain 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DNAH5 (dynein axonemal heavy chain 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DNAH5 (dynein axonemal heavy chain 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dnah5 (dynein axonemal heavy chain 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Dnah5 (dynein axonemal heavy chain 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DNAH5 (dynein axonemal heavy chain 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Homo sapiens (human):	DNAH5 (dynein axonemal heavy chain 5)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dnah5 (dynein, axonemal, heavy chain 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Dnah5 (dynein, axonemal, heavy chain 5)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dnah5 (dynein, axonemal, heavy chain 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	dnah5 (dynein, axonemal, heavy chain 5)	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	kl-3	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	dnah5	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	dnah5	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	80,668,182 - 80,985,918 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	80,668,208 - 80,985,914 (+)	Ensembl				GRCr8
mRatBN7.2	2	78,937,788 - 79,255,551 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	78,937,800 - 79,254,890 (+)	Ensembl				mRatBN7.2
Rnor_6.0	2	80,947,730 - 81,143,997 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0	2	81,159,060 - 81,337,560 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	80,948,658 - 81,143,447 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	100,825,558 - 101,002,352 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	2	100,627,199 - 100,809,390 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	80,126,196 - 80,390,674 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	74,613,354 - 74,877,574 (+)	NCBI		Celera
Cytogenetic Map	2	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asthma (ISO)

autism spectrum disorder (ISO)

Ciliary Motility Disorders (ISO)

genetic disease (ISO)

glycine encephalopathy 1 (ISO)

infertility (ISO)

Kartagener syndrome (ISO,ISS)

male infertility (ISO)

otitis media (ISS)

primary ciliary dyskinesia (ISO,ISS)

primary ciliary dyskinesia 3 (ISO,ISS)

primary ciliary dyskinesia 9 (ISO)

tetralogy of Fallot (ISS)

visceral heterotaxy (ISO,ISS)

visceral heterotaxy 5 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (EXP)

arsenic atom (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (EXP)

bisphenol F (ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

DDE (ISO)

dioxygen (ISO)

epoxiconazole (ISO)

folic acid (ISO)

gentamycin (EXP)

methoxychlor (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N,N-diethyl-m-toluamide (ISO)

N-ethyl-N-nitrosourea (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

pentanal (ISO)

phenethyl caffeate (EXP)

pirinixic acid (EXP)

silicon dioxide (ISO)

sodium arsenite (EXP)

streptozocin (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

Triptolide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cilium assembly (ISO)

cilium movement (ISO)

cilium movement involved in cell motility (IBA)

determination of left/right symmetry (ISO)

epithelial cilium movement involved in extracellular fluid movement (ISO)

flagellated sperm motility (ISO)

heart development (ISO)

lateral ventricle development (ISO)

microtubule-based movement (IEA)

outer dynein arm assembly (IBA,ISO)

Cellular Component

9+0 motile cilium (IEA,ISO)

9+2 motile cilium (IBA,IEA,ISO)

axonemal dynein complex (IEA,ISO)

axoneme (IEA,ISO,ISS)

cytoplasm (IEA,ISO)

dynein complex (IEA)

extracellular region (IEA)

microtubule (IEA)

motile cilium (IEA,ISO,ISS)

outer dynein arm (IBA,IEA,ISO)

Molecular Function

ATP binding (IEA)

dynein intermediate chain binding (IBA,IEA)

dynein light intermediate chain binding (IBA,IEA)

microtubule motor activity (IEA,ISO)

minus-end-directed microtubule motor activity (IBA,IEA)

nucleotide binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left-right asymmetry.	Olbrich H, etal., Nat Genet. 2002 Feb;30(2):143-4. Epub 2002 Jan 14.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation
8.	Identification and molecular evolution of new dynein-like protein sequences in rat brain.	Tanaka Y, etal., J Cell Sci 1995 May;108 ( Pt 5):1883-93.
9.	Multiple mouse chromosomal loci for dynein-based motility.	Vaughan KT, etal., Genomics 1996 Aug 15;36(1):29-38.

Additional References at PubMed

PMID:11062149	PMID:11912187	PMID:15750039	PMID:16492982	PMID:16627867	PMID:17515466	PMID:18492703	PMID:18950741	PMID:19222235	PMID:22499950	PMID:23261302	PMID:23849778
PMID:24203976	PMID:25192045	PMID:25807483	PMID:26387594	PMID:26909801	PMID:27353389	PMID:28289722	PMID:29916806	PMID:31178125	PMID:32357304

Genomics

Comparative Map Data

Dnah5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	80,668,182 - 80,985,918 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	80,668,208 - 80,985,914 (+)	Ensembl				GRCr8
mRatBN7.2	2	78,937,788 - 79,255,551 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	78,937,800 - 79,254,890 (+)	Ensembl				mRatBN7.2
Rnor_6.0	2	80,947,730 - 81,143,997 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0	2	81,159,060 - 81,337,560 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	80,948,658 - 81,143,447 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	100,825,558 - 101,002,352 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	2	100,627,199 - 100,809,390 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	80,126,196 - 80,390,674 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	74,613,354 - 74,877,574 (+)	NCBI		Celera
Cytogenetic Map	2	q22	NCBI

DNAH5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	13,690,328 - 14,011,818 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	13,690,328 - 14,011,818 (-)	Ensembl			hg38	GRCh38
GRCh37	5	13,690,437 - 13,944,797 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	13,745,039 - 13,997,589 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	13,745,038 - 13,997,589	NCBI
Celera	5	13,715,619 - 13,969,162 (-)	NCBI		Celera
Cytogenetic Map	5	p15.2	NCBI
HuRef	5	13,661,841 - 13,916,517 (-)	NCBI		HuRef
CHM1_1	5	13,690,308 - 13,944,156 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	13,627,358 - 13,948,914 (-)	NCBI		T2T-CHM13v2.0

Dnah5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	28,155,000 - 28,472,191 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	28,203,898 - 28,472,198 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	28,154,854 - 28,472,045 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	28,203,752 - 28,472,052 (+)	Ensembl			mm10	GRCm38
MGSCv37	15	28,133,521 - 28,401,800 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	28,148,355 - 28,415,259 (+)	NCBI		MGSCv36	mm8
Celera	15	28,952,222 - 29,215,703 (+)	NCBI		Celera
Cytogenetic Map	15	B1	NCBI
cM Map	15	10.9	NCBI

Dnah5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955426	3,106,410 - 3,353,502 (-)	Ensembl
ChiLan1.0	NW_004955426	3,105,631 - 3,406,587 (-)	NCBI	ChiLan1.0	ChiLan1.0

DNAH5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	13,914,183 - 14,246,527 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	12,067,789 - 12,400,137 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	13,989,114 - 14,316,855 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	13,833,309 - 14,159,871 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	13,851,391 - 14,093,358 (-)	Ensembl			panPan2	panpan1.1

DNAH5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	816,088 - 1,040,052 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	805,455 - 1,038,273 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	5,235,833 - 5,530,906 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	649,213 - 944,561 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	649,200 - 944,407 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	663,314 - 958,206 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	661,426 - 955,971 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	904,270 - 1,199,480 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dnah5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	233,673,500 - 233,953,547 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936665	2,314,175 - 2,545,579 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936665	2,267,272 - 2,545,765 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DNAH5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	3,114,273 - 3,430,341 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	16	3,114,267 - 3,366,189 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	3,466,224 - 3,706,296 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DNAH5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	13,401,980 - 13,718,900 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	13,401,092 - 13,652,755 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666064	14,822,926 - 15,141,477 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dnah5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624751	10,799,892 - 11,050,403 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624751	10,799,102 - 11,110,180 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dnah5
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	152,289,658 - 152,591,007 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dnah5
2139 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	263
Count of miRNA genes:	177
Interacting mature miRNAs:	200
Transcripts:	ENSRNOT00000017372, ENSRNOT00000074252, ENSRNOT00000074689
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578777	Stresp15	Stress response QTL 15	2	0.05	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	2	61556902	106556902	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	61051883	104684275	Rat
10755436	Coatc8	Coat color QTL 8		0.02431	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	36750344	81750344	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	61051541	105724065	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
152025242	Bw191	Body weight QTL 191	3.62		body mass (VT:0001259)		2	40306867	124537199	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
61465	Bp13	Blood pressure QTL 13	3.3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	78269809	104744824	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	41801363	104744824	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
631208	Bw1	Body weight QTL1	5.09		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	2	44904355	85286097	Rat
2317058	Aia13	Adjuvant induced arthritis QTL 13	2.9		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	2	78269809	123269809	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1300155	Bp174	Blood pressure QTL 174	4.09		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	44537979	112567334	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	61051541	105724065	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	83465677	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	51266859	96266859	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	60861391	105861391	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	38426449	111295694	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	36868643	81868643	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	44904355	89904355	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	61051541	143746880	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat

Markers in Region

D2Uwm31

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	80,728,051 - 80,728,244 (+)	Marker Load Pipeline
mRatBN7.2	2	78,997,662 - 78,997,855 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	80,964,992 - 80,965,184	NCBI	Rnor6.0
Rnor_5.0	2	100,630,972 - 100,631,164	UniSTS	Rnor5.0
RGSC_v3.4	2	80,130,990 - 80,131,182	UniSTS	RGSC3.4
Celera	2	74,630,894 - 74,631,086	UniSTS
RGSC_v3.1	2	80,075,951 - 80,076,144	RGD
Cytogenetic Map	2	q22	UniSTS

AU048434

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	80,776,807 - 80,777,110 (+)	Marker Load Pipeline
mRatBN7.2	2	79,046,420 - 79,046,719 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	81,013,978 - 81,014,276	NCBI	Rnor6.0
Rnor_5.0	2	100,679,921 - 100,680,219	UniSTS	Rnor5.0
RGSC_v3.4	2	80,180,056 - 80,180,354	UniSTS	RGSC3.4
Celera	2	74,679,580 - 74,679,878	UniSTS
Cytogenetic Map	2	q22	UniSTS

AU049271

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	80,765,982 - 80,766,199 (+)	Marker Load Pipeline
mRatBN7.2	2	79,035,595 - 79,035,812 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	81,003,174 - 81,003,390	NCBI	Rnor6.0
Rnor_5.0	2	100,669,154 - 100,669,370	UniSTS	Rnor5.0
RGSC_v3.4	2	80,168,927 - 80,169,143	UniSTS	RGSC3.4
Celera	2	74,668,824 - 74,669,040	UniSTS
Cytogenetic Map	2	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
6	9	60	151	57	56	27	14	27	6	194	104	10	123	49	81	29	8	8

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001419569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103563	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_226891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473992	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D26496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U61747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000074689 ⟹ ENSRNOP00000065896

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	78,980,771 - 79,237,702 (+)	Ensembl
Rnor_6.0 Ensembl	2	80,948,658 - 81,143,447 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098157 ⟹ ENSRNOP00000085962

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	80,711,186 - 80,985,914 (+)	Ensembl
mRatBN7.2 Ensembl	2	78,980,771 - 79,254,890 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101312 ⟹ ENSRNOP00000078949

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	80,668,208 - 80,985,914 (+)	Ensembl
mRatBN7.2 Ensembl	2	78,937,800 - 79,254,890 (+)	Ensembl

RefSeq Acc Id:

NM_001419569 ⟹ NP_001406498

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	80,711,186 - 80,985,914 (+)	NCBI
mRatBN7.2	2	78,980,794 - 79,255,551 (+)	NCBI

RefSeq Acc Id:

XM_039103563 ⟹ XP_038959491

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	80,668,182 - 80,985,918 (+)	NCBI
mRatBN7.2	2	78,937,788 - 79,254,088 (+)	NCBI

RefSeq Acc Id:

XM_063281529 ⟹ XP_063137599

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	80,711,002 - 80,985,918 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001406498	(Get FASTA)	NCBI Sequence Viewer
	XP_038959491	(Get FASTA)	NCBI Sequence Viewer
	XP_063137599	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC52801	(Get FASTA)	NCBI Sequence Viewer
	BAA05504	(Get FASTA)	NCBI Sequence Viewer
	EDL82632	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000078949
	ENSRNOP00000085962
GenBank Protein	M0R8U1	(Get FASTA)	NCBI Sequence Viewer

Ensembl Acc Id:

ENSRNOP00000065896 ⟸ ENSRNOT00000074689

RefSeq Acc Id:	XP_038959491 ⟸ XM_039103563
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6G2L4 (UniProtKB/TrEMBL), A0A8L2QZ25 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000078949 ⟸ ENSRNOT00000101312

Ensembl Acc Id:

ENSRNOP00000085962 ⟸ ENSRNOT00000098157

RefSeq Acc Id:	NP_001406498 ⟸ NM_001419569
- UniProtKB:	A0A8L2QZ25 (UniProtKB/TrEMBL), A0A8I6A195 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063137599 ⟸ XM_063281529
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2QZ25 (UniProtKB/TrEMBL)

Protein Domains

AAA+ ATPase

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560828	AgrOrtholog
BioCyc Gene	G2FUF-53908	BioCyc
Ensembl Genes	ENSRNOG00000048363	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000098157	ENTREZGENE
	ENSRNOT00000101312	ENTREZGENE
Gene3D-CATH	1.10.287.2620	UniProtKB/Swiss-Prot
	1.10.472.130	UniProtKB/Swiss-Prot
	1.10.8.710	UniProtKB/Swiss-Prot
	1.20.140.100	UniProtKB/Swiss-Prot
	1.20.58.1120	UniProtKB/Swiss-Prot
	1.20.920.20	UniProtKB/Swiss-Prot
	1.20.920.30	UniProtKB/Swiss-Prot
	3.20.180.20	UniProtKB/Swiss-Prot
	3.40.50.300	UniProtKB/Swiss-Prot
InterPro	AAA+_ATPase	UniProtKB/Swiss-Prot
	AAA_6	UniProtKB/Swiss-Prot
	DHC_fam	UniProtKB/Swiss-Prot
	DNAH3_AAA_lid_1	UniProtKB/Swiss-Prot
	DYH2-5-8_CC	UniProtKB/Swiss-Prot
	Dynein_2_C	UniProtKB/Swiss-Prot
	Dynein_2_N	UniProtKB/Swiss-Prot
	Dynein_AAA1S	UniProtKB/Swiss-Prot
	Dynein_AAA5_ext	UniProtKB/Swiss-Prot
	Dynein_HC_stalk	UniProtKB/Swiss-Prot
	Dynein_heavy_chain_D4_dom	UniProtKB/Swiss-Prot
	Dynein_heavy_dom-1	UniProtKB/Swiss-Prot
	Dynein_heavy_dom-2	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
NCBI Gene	294854	ENTREZGENE
PANTHER	DYNEIN AXONEMAL HEAVY CHAIN 5	UniProtKB/Swiss-Prot
	MALE FERTILITY FACTOR KL5	UniProtKB/Swiss-Prot
Pfam	AAA_6	UniProtKB/Swiss-Prot
	AAA_7	UniProtKB/Swiss-Prot
	AAA_8	UniProtKB/Swiss-Prot
	AAA_lid_1	UniProtKB/Swiss-Prot
	DHC_N1	UniProtKB/Swiss-Prot
	DHC_N2	UniProtKB/Swiss-Prot
	DYH2-5-8_CC	UniProtKB/Swiss-Prot
	Dynein_AAA_lid	UniProtKB/Swiss-Prot
	PF12777	UniProtKB/Swiss-Prot
PhenoGen	Dnah5	PhenoGen
RatGTEx	ENSRNOG00000048363	RatGTEx
SMART	AAA	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A8I6A195	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G2L4	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QZ25	ENTREZGENE
	DYH5_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-17	Dnah5	dynein, axonemal, heavy chain 5	Dnahc5	dynein, axonemal, heavy chain 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Dnahc5	dynein, axonemal, heavy chain 5	DLP5	dynein-like prot ein 5	Symbol and Name updated	1299863	APPROVED
2006-02-09	DLP5	dynein-like prot ein 5			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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