DNAH5 (dynein axonemal heavy chain 5) - Rat Genome Database

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Gene: DNAH5 (dynein axonemal heavy chain 5) Canis lupus familiaris
Analyze
Symbol: DNAH5
Name: dynein axonemal heavy chain 5
RGD ID: 12062902
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); dynein intermediate chain binding (inferred); INVOLVED IN cilium assembly (ortholog); cilium movement (ortholog); determination of left/right symmetry (ortholog); ASSOCIATED WITH asthma (ortholog); autism spectrum disorder (ortholog); Ciliary Motility Disorders (ortholog); FOUND IN 9+0 motile cilium (inferred); 9+2 motile cilium (inferred); axonemal dynein complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dynein heavy chain 5, axonemal
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.134816,088 - 1,040,052 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl34805,455 - 1,038,273 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha345,235,833 - 5,530,906 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.034649,213 - 944,561 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl34649,200 - 944,407 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.134663,314 - 958,206 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.034661,426 - 955,971 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.034904,270 - 1,199,480 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DNAH5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.134816,088 - 1,040,052 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl34805,455 - 1,038,273 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha345,235,833 - 5,530,906 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.034649,213 - 944,561 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl34649,200 - 944,407 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.134663,314 - 958,206 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.034661,426 - 955,971 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.034904,270 - 1,199,480 (+)NCBIUU_Cfam_GSD_1.0
DNAH5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38513,690,328 - 14,011,818 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl513,690,328 - 14,011,818 (-)EnsemblGRCh38hg38GRCh38
GRCh37513,690,437 - 13,944,797 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36513,745,039 - 13,997,589 (-)NCBINCBI36Build 36hg18NCBI36
Build 34513,745,038 - 13,997,589NCBI
Celera513,715,619 - 13,969,162 (-)NCBICelera
Cytogenetic Map5p15.2NCBI
HuRef513,661,841 - 13,916,517 (-)NCBIHuRef
CHM1_1513,690,308 - 13,944,156 (-)NCBICHM1_1
T2T-CHM13v2.0513,627,358 - 13,948,914 (-)NCBIT2T-CHM13v2.0
Dnah5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391528,155,000 - 28,472,191 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1528,203,898 - 28,472,198 (+)EnsemblGRCm39 Ensembl
GRCm381528,154,854 - 28,472,045 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1528,203,752 - 28,472,052 (+)EnsemblGRCm38mm10GRCm38
MGSCv371528,133,521 - 28,401,800 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361528,148,355 - 28,415,259 (+)NCBIMGSCv36mm8
Celera1528,952,222 - 29,215,703 (+)NCBICelera
Cytogenetic Map15B1NCBI
cM Map1510.9NCBI
Dnah5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8280,668,182 - 80,985,918 (+)NCBIGRCr8
mRatBN7.2278,937,788 - 79,255,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl278,937,800 - 79,254,890 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0280,947,730 - 81,143,997 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0281,159,060 - 81,337,560 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl280,948,658 - 81,143,447 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02100,825,558 - 101,002,352 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02100,627,199 - 100,809,390 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4280,126,196 - 80,390,674 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera274,613,354 - 74,877,574 (+)NCBICelera
Cytogenetic Map2q22NCBI
Dnah5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554263,106,410 - 3,353,502 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554263,105,631 - 3,406,587 (-)NCBIChiLan1.0ChiLan1.0
DNAH5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2413,914,183 - 14,246,527 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1512,067,789 - 12,400,137 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0513,989,114 - 14,316,855 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1513,833,309 - 14,159,871 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl513,851,391 - 14,093,358 (-)Ensemblpanpan1.1panPan2
Dnah5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213233,673,500 - 233,953,547 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366652,314,175 - 2,545,579 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366652,267,272 - 2,545,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAH5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl163,114,273 - 3,430,341 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1163,114,267 - 3,366,189 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2163,466,224 - 3,706,296 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNAH5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1413,401,980 - 13,718,900 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl413,401,092 - 13,652,755 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606414,822,926 - 15,141,477 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnah5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475110,799,892 - 11,050,403 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475110,799,102 - 11,110,180 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DNAH5
2925 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 3 4
Below cutoff 5 5 22 6 6 6 6 6 9 8 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000015711   ⟹   ENSCAFP00000014541
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl34805,455 - 1,038,273 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845030328   ⟹   ENSCAFP00845023783
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl34649,200 - 944,407 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845030971   ⟹   ENSCAFP00845024268
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl34649,200 - 944,407 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845031774   ⟹   ENSCAFP00845024865
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl34649,200 - 944,407 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845032485   ⟹   ENSCAFP00845025401
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl34649,200 - 944,407 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845033165   ⟹   ENSCAFP00845025963
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl34649,200 - 944,407 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845033729   ⟹   ENSCAFP00845026402
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl34711,264 - 944,407 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845034388   ⟹   ENSCAFP00845026925
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl34711,264 - 944,407 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845035041   ⟹   ENSCAFP00845027439
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl34711,264 - 942,256 (+)Ensembl
RefSeq Acc Id: XM_038445472   ⟹   XP_038301400
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.034649,213 - 944,561 (+)NCBI
RefSeq Acc Id: XM_038462821   ⟹   XP_038318749
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha345,235,833 - 5,530,906 (+)NCBI
RefSeq Acc Id: XM_038519657   ⟹   XP_038375585
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.134663,314 - 958,206 (+)NCBI
RefSeq Acc Id: XM_038583304   ⟹   XP_038439232
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.034904,270 - 1,199,480 (+)NCBI
RefSeq Acc Id: XM_038647708   ⟹   XP_038503636
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.034661,426 - 955,971 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000014541   ⟸   ENSCAFT00000015711
RefSeq Acc Id: XP_038375585   ⟸   XM_038519657
RefSeq Acc Id: XP_038503636   ⟸   XM_038647708
RefSeq Acc Id: XP_038301400   ⟸   XM_038445472
- UniProtKB: A0A8I3P3X0 (UniProtKB/TrEMBL),   A0A8I3P3X4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038318749   ⟸   XM_038462821
- UniProtKB: A0A8P0PQJ5 (UniProtKB/TrEMBL),   A0A8P0PRR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038439232   ⟸   XM_038583304
- UniProtKB: A0A8I3P3X4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845024865   ⟸   ENSCAFT00845031774
RefSeq Acc Id: ENSCAFP00845025963   ⟸   ENSCAFT00845033165
RefSeq Acc Id: ENSCAFP00845023783   ⟸   ENSCAFT00845030328
RefSeq Acc Id: ENSCAFP00845026925   ⟸   ENSCAFT00845034388
RefSeq Acc Id: ENSCAFP00845026402   ⟸   ENSCAFT00845033729
RefSeq Acc Id: ENSCAFP00845025401   ⟸   ENSCAFT00845032485
RefSeq Acc Id: ENSCAFP00845027439   ⟸   ENSCAFT00845035041
RefSeq Acc Id: ENSCAFP00845024268   ⟸   ENSCAFT00845030971
Protein Domains
AAA+ ATPase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009850 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845017070 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000015711.7 UniProtKB/TrEMBL
  ENSCAFT00000097980.1 UniProtKB/TrEMBL
  ENSCAFT00000099389.1 UniProtKB/TrEMBL
  ENSCAFT00000101365.1 UniProtKB/TrEMBL
  ENSCAFT00000101654.1 UniProtKB/TrEMBL
  ENSCAFT00000109502.1 UniProtKB/TrEMBL
  ENSCAFT00000109816.1 UniProtKB/TrEMBL
  ENSCAFT00000109822.1 UniProtKB/TrEMBL
  ENSCAFT00845030328 ENTREZGENE
  ENSCAFT00845030328.1 UniProtKB/TrEMBL
  ENSCAFT00845030971.1 UniProtKB/TrEMBL
  ENSCAFT00845031774.1 UniProtKB/TrEMBL
  ENSCAFT00845032485.1 UniProtKB/TrEMBL
  ENSCAFT00845033165.1 UniProtKB/TrEMBL
  ENSCAFT00845033729.1 UniProtKB/TrEMBL
  ENSCAFT00845034388.1 UniProtKB/TrEMBL
  ENSCAFT00845035041.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.2620 UniProtKB/TrEMBL
  1.10.472.130 UniProtKB/TrEMBL
  1.10.8.1220 UniProtKB/TrEMBL
  1.10.8.710 UniProtKB/TrEMBL
  1.10.8.720 UniProtKB/TrEMBL
  1.20.1270.280 UniProtKB/TrEMBL
  1.20.140.100 UniProtKB/TrEMBL
  1.20.58.1120 UniProtKB/TrEMBL
  1.20.920.20 UniProtKB/TrEMBL
  1.20.920.30 UniProtKB/TrEMBL
  3.10.490.20 UniProtKB/TrEMBL
  3.20.180.20 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  6.10.140.1060 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  AAA_6 UniProtKB/TrEMBL
  AAA_9 UniProtKB/TrEMBL
  AAA_lid_11 UniProtKB/TrEMBL
  AAA_lid_11_sf UniProtKB/TrEMBL
  ATPase_dyneun-rel_AAA UniProtKB/TrEMBL
  DHC_fam UniProtKB/TrEMBL
  DNAH3_AAA_lid_1 UniProtKB/TrEMBL
  Dynein_2_N UniProtKB/TrEMBL
  Dynein_AAA1S UniProtKB/TrEMBL
  Dynein_AAA5_ext UniProtKB/TrEMBL
  Dynein_C UniProtKB/TrEMBL
  Dynein_C_barrel UniProtKB/TrEMBL
  Dynein_HC_stalk UniProtKB/TrEMBL
  Dynein_heavy_chain_D4_dom UniProtKB/TrEMBL
  Dynein_heavy_D6_P-loop UniProtKB/TrEMBL
  Dynein_heavy_linker UniProtKB/TrEMBL
  Dynein_heavy_tail UniProtKB/TrEMBL
  Dynein_linker_3 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene DNAH5 ENTREZGENE
PANTHER DYNEIN AXONEMAL HEAVY CHAIN 5 UniProtKB/TrEMBL
  MALE FERTILITY FACTOR KL5 UniProtKB/TrEMBL
Pfam AAA_5 UniProtKB/TrEMBL
  AAA_6 UniProtKB/TrEMBL
  AAA_7 UniProtKB/TrEMBL
  AAA_8 UniProtKB/TrEMBL
  AAA_9 UniProtKB/TrEMBL
  AAA_lid_1 UniProtKB/TrEMBL
  AAA_lid_11 UniProtKB/TrEMBL
  DHC_N1 UniProtKB/TrEMBL
  DHC_N2 UniProtKB/TrEMBL
  Dynein_AAA_lid UniProtKB/TrEMBL
  Dynein_C UniProtKB/TrEMBL
  Dynein_heavy UniProtKB/TrEMBL
  PF12777 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I3P2U3_CANLF UniProtKB/TrEMBL
  A0A8I3P3X0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P3X4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P5W4_CANLF UniProtKB/TrEMBL
  A0A8I3P5W9_CANLF UniProtKB/TrEMBL
  A0A8I3P8A2_CANLF UniProtKB/TrEMBL
  A0A8I3P9C0_CANLF UniProtKB/TrEMBL
  A0A8I3P9V3_CANLF UniProtKB/TrEMBL
  A0A8P0PHV9_CANLF UniProtKB/TrEMBL
  A0A8P0PPD2_CANLF UniProtKB/TrEMBL
  A0A8P0PQJ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PRR0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SET2_CANLF UniProtKB/TrEMBL
  A0A8P0TK35_CANLF UniProtKB/TrEMBL
  A0A8P0TNT3_CANLF UniProtKB/TrEMBL
  A0A8P0TQF2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:40016 ENTREZGENE