Myo6 (myosin VI) - Rat Genome Database

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Gene: Myo6 (myosin VI) Rattus norvegicus
Analyze
Symbol: Myo6
Name: myosin VI
RGD ID: 1560646
Description: Predicted to enable several functions, including ADP binding activity; actin filament binding activity; and calmodulin binding activity. Involved in response to xenobiotic stimulus. Located in several cellular components, including endocytic vesicle; microvillus; and ruffle membrane. Part of protein-containing complex. Used to study hypertension. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI); PARTICIPATES IN auditory mechanotransduction pathway; E-cadherin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC315840; RGD1560646; similar to Myosin VI; unconventional myosin-VI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8889,967,351 - 90,122,219 (+)NCBIGRCr8
mRatBN7.2881,087,157 - 81,242,022 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0887,583,649 - 87,731,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl887,630,916 - 87,731,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0887,121,910 - 87,268,900 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4885,203,987 - 85,368,026 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera880,810,746 - 80,962,891 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Myo6RatCOVID-19  ISOMYO6 (Homo sapiens)9068941mRNA:decreased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Myo6Rathypertension  IDA 2314963protein:altered localization:renal proximal tubule and microvillusRGD 
Myo6Ratovarian cancer disease_progressionISOMYO6 (Homo sapiens)2314958 RGD 
Myo6Ratprostate cancer  ISOMYO6 (Homo sapiens)2314956protein:increased expression:prostate gland epithelium and perinuclear region of cytoplasm RGD 
Myo6Ratsensorineural hearing loss  ISOMYO6 (Homo sapiens)1600556DFNA22 more ...RGD 
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Myo6Ratautosomal dominant nonsyndromic deafness  ISOMYO6 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal dominant nonsyndromic hearing lossClinVarPMID:25741868
Myo6Ratautosomal dominant nonsyndromic deafness 22  ISOMYO6 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11167014 more ...
Myo6Ratautosomal recessive nonsyndromic deafness  ISOMYO6 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive nonsyndromic deafnessClinVarPMID:25741868 and PMID:28492532
Myo6Ratautosomal recessive nonsyndromic deafness 37  ISOMYO6 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11167014 more ...
Myo6Ratessential tremor  ISOMYO6 (Homo sapiens)8554872ClinVar Annotator: match by term: Essential tremorClinVarPMID:12687499 more ...
Myo6Ratgenetic disease  ISOMYO6 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:11167014 more ...
Myo6RatHearing Loss  ISOMYO6 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
Myo6RatHearing Loss  ISOMYO6 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12687499 more ...
Myo6Ratjunctional epidermolysis bullosa with pyloric atresia  ISOMYO6 (Homo sapiens)8554872ClinVar Annotator: match by term: EPIDERMOLYSIS BULLOSA more ...ClinVarPMID:12687499 more ...
Myo6Ratmale infertility  ISOMYO6 (Homo sapiens)8554872ClinVar Annotator: match by term: Male infertilityClinVarPMID:17576681 more ...
Myo6RatMeniere's disease  ISOMYO6 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:24033266 and PMID:28492532
Myo6Ratnonsyndromic deafness  ISOMYO6 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12687499 more ...
Myo6RatNonsyndromic Sensorineural Hearing Loss  ISOMYO6 (Homo sapiens)8554872ClinVar Annotator: match by term: Nonsyndromic Hearing Loss and DominantClinVarPMID:25741868 and PMID:28492532
Myo6RatSensorineural Deafness with Hypertrophic Cardiomyopathy  ISOMYO6 (Homo sapiens)8554872ClinVar Annotator: match by term: Progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndromeClinVarPMID:15060111 more ...
Myo6RatUllrich congenital muscular dystrophy 2  ISOMYO6 (Homo sapiens)8554872ClinVar Annotator: match by term: Ullrich congenital muscular dystrophy 2ClinVarPMID:28492532
Myo6RatWaardenburg syndrome  ISOMYO6 (Homo sapiens)8554872ClinVar Annotator: match by term: Waardenburg syndromeClinVarPMID:25741868
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Original Reference(s)
Myo6Ratautosomal recessive nonsyndromic deafness 37  ISOMYO6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Myo6Ratsubstance-related disorder  ISOMYO6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20098672
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Original Reference(s)
Myo6Ratautosomal dominant nonsyndromic deafness 22  ISSMyo6 (Mus musculus)13592920OMIM:606346MouseDO 
Myo6Ratautosomal recessive nonsyndromic deafness 37  ISSMyo6 (Mus musculus)13592920OMIM:607821MouseDO 
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Myo6Ratautosomal dominant nonsyndromic deafness 22  ISOMYO6 (Homo sapiens)7240710 OMIM 
Myo6Ratautosomal recessive nonsyndromic deafness 37  ISOMYO6 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Myo6Rat(-)-epigallocatechin 3-gallate multiple interactionsISOMYO6 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MYO6 mRNACTDPMID:22079256
Myo6Rat(1->4)-beta-D-glucan multiple interactionsISOMyo6 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of MYO6 mRNACTDPMID:36331819
Myo6Rat1,2-dimethylhydrazine decreases expressionISOMyo6 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of MYO6 mRNACTDPMID:22206623
Myo6Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in increased expression of MYO6 mRNACTDPMID:26496021
Myo6Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMyo6 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of MYO6 mRNACTDPMID:19770486
Myo6Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMYO6 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of MYO6 mRNACTDPMID:27913140
Myo6Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMyo6 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of MYO6 mRNACTDPMID:27913140
Myo6Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of MYO6 mRNACTDPMID:27913140 and PMID:34747641
Myo6Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMyo6 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of MYO6 mRNACTDPMID:26377647
Myo6Rat2-hydroxypropanoic acid decreases expressionISOMYO6 (Homo sapiens)6480464Lactic Acid results in decreased expression of MYO6 mRNACTDPMID:30851411
Myo6Rat4-hydroxyphenyl retinamide increases expressionISOMyo6 (Mus musculus)6480464Fenretinide results in increased expression of MYO6 mRNACTDPMID:28973697
Myo6Rat5-fluorouracil affects response to substanceISOMYO6 (Homo sapiens)6480464MYO6 protein affects the susceptibility to FluorouracilCTDPMID:16217747
Myo6Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of MYO6 mRNACTDPMID:24780913
Myo6Ratacetaldehyde affects expressionISOMyo6 (Mus musculus)6480464Acetaldehyde affects the expression of MYO6 mRNACTDPMID:22634333
Myo6Rataflatoxin B1 increases expressionISOMYO6 (Homo sapiens)6480464Aflatoxin B1 results in increased expression of MYO6 mRNACTDPMID:21641981
Myo6Ratall-trans-retinoic acid increases expressionISOMYO6 (Homo sapiens)6480464Tretinoin results in increased expression of MYO6 mRNACTDPMID:21934132
Myo6Ratarsenous acid increases expressionISOMYO6 (Homo sapiens)6480464Arsenic Trioxide results in increased expression of MYO6 mRNACTDPMID:17258074
Myo6Ratbenzo[a]pyrene increases expressionISOMYO6 (Homo sapiens)6480464Benzo(a)pyrene results in increased expression of MYO6 mRNACTDPMID:21632981 and PMID:26238291
Myo6Ratbenzo[a]pyrene increases methylationISOMYO6 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of MYO6 promoterCTDPMID:27901495
Myo6Ratbicalutamide increases expressionISOMYO6 (Homo sapiens)6480464bicalutamide results in increased expression of MYO6 mRNACTDPMID:15790403 and PMID:16631469

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Biological Process
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Original Reference(s)
Myo6Ratactin filament organization involved_inIBAFB:FBgn0000317 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo6Ratactin filament-based movement involved_inISOMYO6 (Sus scrofa)1624291 PMID:10519557RGDPMID:10519557
Myo6Ratactin filament-based movement involved_inIBAFB:FBgn0011225 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo6Ratcellular response to electrical stimulus acts_upstream_of_or_withinISOMyo6 (Mus musculus)1624291 PMID:21052544RGDPMID:21052544
Myo6Ratchemical synaptic transmission acts_upstream_of_or_withinISOMyo6 (Mus musculus)1624291MGI:1856555 PMID:16819522RGDPMID:16819522
Myo6Ratdendrite development acts_upstream_of_or_withinISOMyo6 (Mus musculus)1624291MGI:1856555 PMID:15657400RGDPMID:15657400
Myo6RatDNA damage response, signal transduction by p53 class mediator involved_inISOMYO6 (Homo sapiens)1624291 PMID:16507995RGDPMID:16507995
Myo6RatDNA damage response, signal transduction by p53 class mediator involved_inIEAUniProtKB:Q9UM54 and ensembl:ENSP000003589941600115GO_REF:0000107EnsemblGO_REF:0000107
Myo6Ratendocytosis involved_inISOMYO6 (Homo sapiens)1624291 PMID:15247260RGDPMID:15247260
Myo6Ratendocytosis involved_inIEAUniProtKB:Q9UM54 and ensembl:ENSP000003589941600115GO_REF:0000107EnsemblGO_REF:0000107
Myo6Ratendocytosis acts_upstream_of_or_withinISOMyo6 (Mus musculus)1624291MGI:1856555 PMID:15657400RGDPMID:15657400
Myo6Ratendocytosis involved_inISOMYO6 (Sus scrofa)1624291 PMID:12857860RGDPMID:12857860
Myo6Ratestablishment of protein localization involved_inIEAARBA:ARBA000271101600115GO_REF:0000117UniProtGO_REF:0000117
Myo6Ratglutamate secretion acts_upstream_of_or_withinISOMyo6 (Mus musculus)1624291MGI:1856555 PMID:16819522RGDPMID:16819522
Myo6Ratinner ear auditory receptor cell differentiation involved_inIBAMGI:104785 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo6Ratinner ear auditory receptor cell differentiation acts_upstream_of_or_withinISOMyo6 (Mus musculus)1624291MGI:1856555 PMID:10525338 more ...RGDPMID:10525338 more ...
Myo6Ratinner ear development acts_upstream_of_or_withinISOMyo6 (Mus musculus)1624291MGI:1856555 PMID:10525338 more ...RGDPMID:10525338 more ...
Myo6Ratinner ear morphogenesis involved_inIBAMGI:104785 and PANTHER:PTN0026626041600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo6Ratinner ear morphogenesis acts_upstream_of_or_withinISOMyo6 (Mus musculus)1624291MGI:1856555 PMID:7493015RGDPMID:7493015
Myo6Ratintracellular protein transport involved_inISOMYO6 (Sus scrofa)1624291 PMID:12857860RGDPMID:12857860
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Cellular Component
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Myo6Ratactin cytoskeleton located_inIEAARBA:ARBA000292301600115GO_REF:0000117UniProtGO_REF:0000117
Myo6Ratactin cytoskeleton is_active_inIBACGD:CAL0000199209 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo6Ratactin filament located_inISOMYO6 (Sus scrofa)1624291 PMID:12857860RGDPMID:12857860
Myo6Ratapical part of cell  IDA 2314967 RGD 
Myo6Rataxon located_inISOMyo6 (Mus musculus)1624291 PMID:16819522RGDPMID:16819522
Myo6Ratbrush border located_inISOMyo6 (Mus musculus)1624291 PMID:22114352RGDPMID:22114352
Myo6Ratcell cortex located_inISOMYO6 (Sus scrofa)1624291 PMID:12857860RGDPMID:12857860
Myo6Ratclathrin-coated endocytic vesicle located_inISOMYO6 (Homo sapiens)1624291 PMID:11447109RGDPMID:11447109
Myo6Ratclathrin-coated endocytic vesicle located_inIEAUniProtKB:Q9UM54 and ensembl:ENSP000003589941600115GO_REF:0000107EnsemblGO_REF:0000107
Myo6Ratclathrin-coated pit NOT|located_inISOMYO6 (Sus scrofa)1624291 PMID:12857860RGDPMID:12857860
Myo6Ratcochlear hair cell ribbon synapse is_active_inISOMyo6 (Mus musculus)1624291 PMID:19744958RGDPMID:19744958
Myo6Ratcytoplasm located_inISOMYO6 (Homo sapiens)1624291 PMID:16507995 more ...RGDPMID:16507995 more ...
Myo6Ratcytoplasm located_inIEAUniProtKB:Q9UM54 and ensembl:ENSP000003589941600115GO_REF:0000107EnsemblGO_REF:0000107
Myo6Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Myo6Ratcytoplasm located_inISOMyo6 (Mus musculus)1624291 PMID:20016102 and PMID:21300049RGDPMID:20016102 and PMID:21300049
Myo6Ratcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
Myo6Ratcytoplasm is_active_inIBACGD:CAL0000199209 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo6Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Myo6Ratcytoplasm located_inISOMYO6 (Sus scrofa)1624291 PMID:12857860RGDPMID:12857860
Myo6Ratcytoplasmic vesicle located_inIEAUniProtKB:Q9UM54 and ensembl:ENSP000003589941600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Myo6Ratactin binding enablesIEAUniProtKB-KW:KW-00091600115GO_REF:0000043UniProtGO_REF:0000043
Myo6Ratactin filament binding enablesISOMYO6 (Homo sapiens)1624291 PMID:9852149RGDPMID:9852149
Myo6Ratactin filament binding enablesIEAUniProtKB:Q9UM54 and ensembl:ENSP000003589941600115GO_REF:0000107EnsemblGO_REF:0000107
Myo6Ratactin filament binding enablesIEAInterPro:IPR0089891600115GO_REF:0000002InterProGO_REF:0000002
Myo6Ratactin filament binding enablesIBAFB:FBgn0011225 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo6Ratactin filament binding enablesISOMYO6 (Sus scrofa)1624291 PMID:10519557RGDPMID:10519557
Myo6RatADP binding enablesISOMYO6 (Sus scrofa)1624291 PMID:10519557RGDPMID:10519557
Myo6RatATP binding enablesIEAUniRule:UR0006864691600115GO_REF:0000104UniProtGO_REF:0000104
Myo6RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Myo6RatATP binding enablesIEAInterPro:IPR001609 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Myo6Ratcalmodulin binding enablesISOMYO6 (Sus scrofa)1624291UniProtKB:P62149 and PMID:15037754RGDPMID:15037754
Myo6Ratcalmodulin binding enablesIEAUniProtKB-KW:KW-01121600115GO_REF:0000043UniProtGO_REF:0000043
Myo6Ratcytoskeletal motor activity enablesISOMYO6 (Sus scrofa)1624291 PMID:10519557RGDPMID:10519557
Myo6Ratcytoskeletal motor activity enablesIEAInterPro:IPR001609 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Myo6Ratcytoskeletal motor activity enablesIEAUniRule:UR0006864691600115GO_REF:0000104UniProtGO_REF:0000104
Myo6Ratidentical protein binding enablesISOMYO6 (Homo sapiens) and UniProtKB:Q9UM54-11624291UniProtKB:Q9UM54-1 and PMID:18511944RGDPMID:18511944
Myo6Ratmicrofilament motor activity enablesIBAFB:FBgn0000317 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo6Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Myo6Ratprotein binding  IPIPdlim2 (Rattus norvegicus)1359754 RGD 
Myo6Ratprotein binding enablesISOMYO6 (Homo sapiens) and UniProtKB:Q9UM54-11624291UniProtKB:Q96II8 and PMID:29467281RGDPMID:29467281
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RGD Manual Annotations


  
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Myo6Ratauditory mechanotransduction pathway   ISOMYO6 (Homo sapiens)8547672 RGD 
Myo6Ratauditory mechanotransduction pathway   ISOMYO6 (Homo sapiens)8547669 RGD 

Imported Annotations - PID (archival)

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Myo6RatE-cadherin signaling pathway  ISOMYO6 (Homo sapiens)6484113 PIDPID:200182

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#
Reference Title
Reference Citation
1. Expression of myosin VI within the early endocytic pathway in adult and developing proximal tubules. Biemesderfer D, etal., Am J Physiol Renal Physiol. 2002 May;282(5):F785-94.
2. The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation. Buss F, etal., J Cell Biol. 1998 Dec 14;143(6):1535-45.
3. Regulation of myosin-VI targeting to endocytic compartments. Dance AL, etal., Traffic. 2004 Oct;5(10):798-813.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins. Majewski L, etal., Nucleus. 2018 Jan 1;9(1):125-141. doi: 10.1080/19491034.2017.1421881.
6. MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss. Melchionda S, etal., Am J Hum Genet. 2001 Sep;69(3):635-40. Epub 2001 Jul 20.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. The auditory hair cell ribbon synapse: from assembly to function. Safieddine S, etal., Annu Rev Neurosci. 2012;35:509-28. doi: 10.1146/annurev-neuro-061010-113705.
14. Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. Sahlender DA, etal., J Cell Biol. 2005 Apr 25;169(2):285-95. Epub 2005 Apr 18.
15. Review series: The cell biology of hearing. Schwander M, etal., J Cell Biol. 2010 Jul 12;190(1):9-20. doi: 10.1083/jcb.201001138.
16. Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A. Torrado M, etal., Invest Ophthalmol Vis Sci 2004 Nov;45(11):3955-63.
17. GOLPH2 and MYO6: putative prostate cancer markers localized to the Golgi apparatus. Wei S, etal., Prostate. 2008 Sep 15;68(13):1387-95.
18. Interaction of SAP97 with Minus-end-directed Actin Motor Myosin VI. IMPLICATIONS FOR AMPA RECEPTOR TRAFFICKING. Wu H, etal., J Biol Chem 2002 Aug 23;277(34):30928-34.
19. Reducing blood pressure in SHR with enalapril provokes redistribution of NHE3, NaPi2, and NCC and decreases NaPi2 and ACE abundance. Yang LE, etal., Am J Physiol Renal Physiol. 2007 Oct;293(4):F1197-208. Epub 2007 Jul 25.
20. Effects of dietary salt on renal Na+ transporter subcellular distribution, abundance, and phosphorylation status. Yang LE, etal., Am J Physiol Renal Physiol. 2008 Oct;295(4):F1003-16. Epub 2008 Jul 23.
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PMID:5980120   PMID:7493015   PMID:10519557   PMID:10525338   PMID:11447109   PMID:12857860   PMID:15037754   PMID:15247260   PMID:15657400   PMID:15975910   PMID:16025302   PMID:16507995  
PMID:16819522   PMID:16949370   PMID:16962269   PMID:17329413   PMID:18511944   PMID:19056867   PMID:19744958   PMID:19946888   PMID:20016102   PMID:20198214   PMID:20351096   PMID:21052544  
PMID:21300049   PMID:22105175   PMID:22105702   PMID:22114352   PMID:22475431   PMID:23275125   PMID:23376485   PMID:24625528   PMID:25468996   PMID:25896210   PMID:28096472   PMID:35352799  



Myo6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8889,967,351 - 90,122,219 (+)NCBIGRCr8
mRatBN7.2881,087,157 - 81,242,022 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0887,583,649 - 87,731,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl887,630,916 - 87,731,269 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0887,121,910 - 87,268,900 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4885,203,987 - 85,368,026 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera880,810,746 - 80,962,891 (+)NCBICelera
Cytogenetic Map8q31NCBI
MYO6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38675,749,239 - 75,919,537 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl675,749,201 - 75,919,537 (+)EnsemblGRCh38hg38GRCh38
GRCh37676,458,956 - 76,629,254 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36676,515,629 - 76,685,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 34676,515,702 - 76,682,665NCBI
Celera676,852,216 - 77,022,585 (+)NCBICelera
Cytogenetic Map6q14.1NCBI
HuRef673,657,457 - 73,828,024 (+)NCBIHuRef
CHM1_1676,625,146 - 76,795,504 (+)NCBICHM1_1
T2T-CHM13v2.0676,926,117 - 77,096,418 (+)NCBIT2T-CHM13v2.0
Myo6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39980,072,262 - 80,219,011 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl980,072,313 - 80,219,011 (+)EnsemblGRCm39 Ensembl
GRCm38980,164,976 - 80,311,729 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl980,165,031 - 80,311,729 (+)EnsemblGRCm38mm10GRCm38
MGSCv37980,012,841 - 80,159,536 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36979,950,724 - 80,097,413 (+)NCBIMGSCv36mm8
Celera977,304,677 - 77,455,393 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.98NCBI
Myo6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555024,218,885 - 4,356,988 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555024,219,067 - 4,356,988 (+)NCBIChiLan1.0ChiLan1.0
MYO6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2595,797,543 - 95,965,239 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1693,675,327 - 93,845,906 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0673,593,794 - 73,764,352 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1676,882,994 - 77,050,015 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl676,951,634 - 77,048,796 (+)Ensemblpanpan1.1panPan2
MYO6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11237,359,200 - 37,502,342 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1237,413,570 - 37,500,724 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1237,238,751 - 37,384,310 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01238,063,158 - 38,289,614 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1238,063,189 - 38,287,255 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11237,466,515 - 37,612,373 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01237,455,898 - 37,602,259 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01237,586,007 - 37,731,589 (+)NCBIUU_Cfam_GSD_1.0
Myo6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494672,743,121 - 72,882,178 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367881,174,544 - 1,262,746 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367881,125,332 - 1,264,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl189,992,866 - 90,137,734 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1189,992,860 - 90,137,767 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21100,972,527 - 101,143,888 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYO6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.113527,361 - 620,418 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl13457,495 - 618,858 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040176,761,726 - 176,924,982 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248192,896,374 - 2,999,819 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248192,835,783 - 2,999,819 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Myo6
1068 total Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
8 87631018 87631019 G A snv CDR, LEW/Crl (2019), LEW/NCrlBR (RGD), LEW/Crl (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:250
Count of miRNA genes:109
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000016428, ENSRNOT00000064856
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 56 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat

1 to 10 of 56 rows
RH133282  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2881,239,463 - 81,239,648 (+)MAPPERmRatBN7.2
Rnor_6.0887,728,711 - 87,728,895NCBIRnor6.0
Rnor_5.0887,266,340 - 87,266,524UniSTSRnor5.0
RGSC_v3.4885,367,836 - 85,368,020UniSTSRGSC3.4
Celera880,960,331 - 80,960,515UniSTS
RH 3.4 Map8930.3UniSTS
Cytogenetic Map8q31UniSTS
U49739  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2881,238,156 - 81,238,344 (+)MAPPERmRatBN7.2
Rnor_6.0887,727,404 - 87,727,591NCBIRnor6.0
Rnor_5.0887,265,033 - 87,265,220UniSTSRnor5.0
RGSC_v3.4885,366,529 - 85,366,716UniSTSRGSC3.4
Celera880,959,024 - 80,959,211UniSTS
Cytogenetic Map8q31UniSTS
BF399451  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2881,093,922 - 81,094,110 (+)MAPPERmRatBN7.2
Rnor_6.0887,590,409 - 87,590,596NCBIRnor6.0
Rnor_5.0887,128,666 - 87,128,853UniSTSRnor5.0
RGSC_v3.4885,210,706 - 85,210,893UniSTSRGSC3.4
Celera880,817,378 - 80,817,565UniSTS
RH 3.4 Map8933.5UniSTS
Cytogenetic Map8q31UniSTS
AU048109  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera880,871,294 - 80,871,470UniSTS
Cytogenetic Map8q31UniSTS
PMC124268P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2881,237,301 - 81,238,188 (+)MAPPERmRatBN7.2
Rnor_6.0887,726,549 - 87,727,435NCBIRnor6.0
Rnor_5.0887,264,178 - 87,265,064UniSTSRnor5.0
RGSC_v3.4885,365,674 - 85,366,560UniSTSRGSC3.4
Celera880,958,169 - 80,959,055UniSTS
Cytogenetic Map8q31UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 19 of 19 rows
RefSeq Transcripts NM_001427259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001061392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006226502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008766425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017603689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005488327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENSRNOT00000016428   ⟹   ENSRNOP00000016428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)Ensembl
Rnor_6.0 Ensembl887,630,916 - 87,731,269 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103299   ⟹   ENSRNOP00000091730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108142   ⟹   ENSRNOP00000091239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112254   ⟹   ENSRNOP00000077341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119730   ⟹   ENSRNOP00000083145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120263   ⟹   ENSRNOP00000083134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl881,087,139 - 81,239,292 (+)Ensembl
RefSeq Acc Id: NM_001427259   ⟹   NP_001414188
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8889,967,397 - 90,122,219 (+)NCBI
RefSeq Acc Id: XM_008766423   ⟹   XP_008764645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8889,967,351 - 90,122,219 (+)NCBI
mRatBN7.2881,087,158 - 81,242,022 (+)NCBI
Rnor_6.0887,583,649 - 87,731,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008766425   ⟹   XP_008764647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8889,967,351 - 90,122,219 (+)NCBI
mRatBN7.2881,087,160 - 81,242,022 (+)NCBI
Rnor_6.0887,583,650 - 87,731,271 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082536   ⟹   XP_038938464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8889,967,351 - 90,122,219 (+)NCBI
mRatBN7.2881,087,158 - 81,242,022 (+)NCBI
RefSeq Acc Id: XM_063265552   ⟹   XP_063121622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8890,053,437 - 90,122,219 (+)NCBI
RefSeq Acc Id: XM_063265553   ⟹   XP_063121623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8890,053,437 - 90,122,219 (+)NCBI
RefSeq Acc Id: XR_005488326
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8889,967,351 - 90,084,056 (+)NCBI
mRatBN7.2881,087,157 - 81,203,859 (+)NCBI
RefSeq Acc Id: XR_005488327
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8889,967,351 - 90,084,056 (+)NCBI
mRatBN7.2881,087,158 - 81,203,859 (+)NCBI
1 to 5 of 12 rows
1 to 5 of 12 rows
RefSeq Acc Id: XP_008764645   ⟸   XM_008766423
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ACM8 (UniProtKB/TrEMBL),   A0A8I5ZYN7 (UniProtKB/TrEMBL),   A0A8I6AEW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764647   ⟸   XM_008766425
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AEW8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016428   ⟸   ENSRNOT00000016428
RefSeq Acc Id: XP_038938464   ⟸   XM_039082536
- Peptide Label: isoform X2
- UniProtKB: D4A5I9 (UniProtKB/TrEMBL),   A0A8I5ZYN7 (UniProtKB/TrEMBL),   A0A8I6AEW8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091239   ⟸   ENSRNOT00000108142
Myosin motor   Myosin N-terminal SH3-like

Name Modeler Protein Id AA Range Protein Structure
AF-D4A5I9-F1-model_v2 AlphaFold D4A5I9 1-1285 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 47 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-29733 BioCyc
Ensembl Genes ENSRNOG00000011852 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016428 ENTREZGENE
  ENSRNOT00000016428.9 UniProtKB/TrEMBL
  ENSRNOT00000103299 ENTREZGENE
  ENSRNOT00000103299.1 UniProtKB/TrEMBL
  ENSRNOT00000108142.1 UniProtKB/TrEMBL
  ENSRNOT00000112254 ENTREZGENE
  ENSRNOT00000112254.1 UniProtKB/TrEMBL
  ENSRNOT00000119730.1 UniProtKB/TrEMBL
  ENSRNOT00000120263 ENTREZGENE
  ENSRNOT00000120263.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/TrEMBL
  2.30.30.360 UniProtKB/TrEMBL
  3.30.70.1590 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  6.10.220.10 UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/TrEMBL
InterPro Kinesin_motor_dom_sf UniProtKB/TrEMBL
  MYO6_lever UniProtKB/TrEMBL
  Myosin-VI_CBD UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  Myosin_N UniProtKB/TrEMBL
  Myosin_S1_N UniProtKB/TrEMBL
  MYSc_Myo6 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 315840 ENTREZGENE
PANTHER MYOSIN UniProtKB/TrEMBL
  UNCONVENTIONAL MYOSIN-VI UniProtKB/TrEMBL
Pfam MYO6_lever UniProtKB/TrEMBL
  Myosin-VI_CBD UniProtKB/TrEMBL
  Myosin_head UniProtKB/TrEMBL
PhenoGen Myo6 PhenoGen
PRINTS MYOSINHEAVY UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/TrEMBL
  SH3_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011852 RatGTEx
SMART MYSc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
1 to 40 of 47 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Myo6  myosin VI  RGD1560646  similar to Myosin VI  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-03-14 RGD1560646  similar to Myosin VI  RGD1560646_predicted  similar to Myosin VI (predicted)  Symbol and Name updated 1299863 PROVISIONAL
2006-03-07 RGD1560646_predicted  similar to Myosin VI (predicted)  LOC315840  similar to Myosin VI  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC315840  similar to Myosin VI      Symbol and Name status set to provisional 70820 PROVISIONAL