Tdp2 (tyrosyl-DNA phosphodiesterase 2) - Rat Genome Database

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Gene: Tdp2 (tyrosyl-DNA phosphodiesterase 2) Rattus norvegicus
Analyze
Symbol: Tdp2
Name: tyrosyl-DNA phosphodiesterase 2
RGD ID: 1560342
Description: Predicted to enable metal ion binding activity; phosphoric diester hydrolase activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair and neuron development. Predicted to be located in nucleus. Predicted to be active in PML body and cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 23. Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2); INTERACTS WITH azoxystrobin; bisphenol A; chlorpyrifos.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; LOC498749; MGC124734; similar to putative TRAF and TNF receptor associated protein; Traf and Tnf receptor associated protein; TRAF and TNF receptor-associated protein; Ttrap; tyr-DNA phosphodiesterase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,656,969 - 40,668,362 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1740,656,971 - 40,668,288 (-)EnsemblGRCr8
mRatBN7.21740,228,943 - 40,240,337 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1740,228,947 - 40,240,313 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1740,297,128 - 40,308,451 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,901,173 - 41,912,496 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01740,184,268 - 40,195,590 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01742,229,667 - 42,241,025 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,229,642 - 42,241,066 (-)Ensemblrn6Rnor6.0
Rnor_5.01744,097,466 - 44,108,824 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41747,290,530 - 47,301,849 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1739,866,248 - 39,877,568 (-)NCBICelera
Cytogenetic Map17p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nuclear body  (IEA,ISO)
nucleolus  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
PML body  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:19794497   PMID:21030584   PMID:22405347   PMID:22822062   PMID:22908287   PMID:24658003  


Genomics

Comparative Map Data
Tdp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,656,969 - 40,668,362 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1740,656,971 - 40,668,288 (-)EnsemblGRCr8
mRatBN7.21740,228,943 - 40,240,337 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1740,228,947 - 40,240,313 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1740,297,128 - 40,308,451 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,901,173 - 41,912,496 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01740,184,268 - 40,195,590 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01742,229,667 - 42,241,025 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1742,229,642 - 42,241,066 (-)Ensemblrn6Rnor6.0
Rnor_5.01744,097,466 - 44,108,824 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41747,290,530 - 47,301,849 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1739,866,248 - 39,877,568 (-)NCBICelera
Cytogenetic Map17p11NCBI
TDP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38624,649,979 - 24,666,899 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl624,649,978 - 24,666,930 (-)Ensemblhg38GRCh38
GRCh37624,650,207 - 24,667,127 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36624,758,184 - 24,775,094 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34624,758,184 - 24,775,094NCBI
Celera625,883,542 - 25,900,457 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef624,599,621 - 24,616,537 (-)NCBIHuRef
CHM1_1624,654,343 - 24,671,259 (-)NCBICHM1_1
T2T-CHM13v2.0624,520,363 - 24,537,292 (-)NCBIT2T-CHM13v2.0
Tdp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391325,015,642 - 25,026,136 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1325,015,662 - 25,026,136 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381324,831,659 - 24,842,153 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1324,831,679 - 24,842,153 (+)Ensemblmm10GRCm38
MGSCv371324,923,528 - 24,934,022 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361324,839,150 - 24,849,611 (+)NCBIMGSCv36mm8
Celera1325,062,324 - 25,072,818 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1310.7NCBI
Tdp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554832,375,313 - 2,388,892 (+)Ensembl
ChiLan1.0NW_0049554832,375,213 - 2,385,354 (+)NCBIChiLan1.0ChiLan1.0
TDP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2539,300,990 - 39,318,562 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1635,300,448 - 35,318,023 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0624,487,551 - 24,505,268 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1624,819,494 - 24,837,189 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl624,819,494 - 24,837,189 (-)EnsemblpanPan2panpan1.1
TDP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13522,693,203 - 22,707,054 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3522,693,110 - 22,707,008 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3522,660,843 - 22,674,624 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03522,815,655 - 22,829,433 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3522,814,198 - 22,829,404 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13522,621,127 - 22,634,899 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03522,668,709 - 22,682,476 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03524,105,036 - 24,118,785 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tdp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024411772475 - 1,113 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004948563494 - 1,113 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TDP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl719,489,384 - 19,502,520 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1719,489,381 - 19,502,437 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2720,642,148 - 20,655,198 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TDP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11747,582,857 - 47,599,871 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1747,583,014 - 47,600,628 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604424,580,645 - 24,597,659 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tdp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247562,363,718 - 2,375,152 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247562,363,400 - 2,374,839 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tdp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11443,875,279 - 43,886,649 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tdp2
87 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:99
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000059570
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000059570   ⟹   ENSRNOP00000056326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1740,656,971 - 40,668,288 (-)Ensembl
mRatBN7.2 Ensembl1740,228,947 - 40,240,313 (-)Ensembl
Rnor_6.0 Ensembl1742,229,642 - 42,241,066 (-)Ensembl
RefSeq Acc Id: NM_001034947   ⟹   NP_001030119
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,656,969 - 40,668,288 (-)NCBI
mRatBN7.21740,228,943 - 40,240,262 (-)NCBI
Rnor_6.01742,229,667 - 42,241,025 (-)NCBI
Rnor_5.01744,097,466 - 44,108,824 (-)NCBI
RGSC_v3.41747,290,530 - 47,301,849 (-)RGD
Celera1739,866,248 - 39,877,568 (-)RGD
Sequence:
RefSeq Acc Id: XM_063276691   ⟹   XP_063132761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,659,085 - 40,668,362 (-)NCBI
RefSeq Acc Id: XM_063276692   ⟹   XP_063132762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,658,496 - 40,668,362 (-)NCBI
RefSeq Acc Id: XR_005495318
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,659,085 - 40,668,362 (-)NCBI
mRatBN7.21740,231,032 - 40,240,337 (-)NCBI
RefSeq Acc Id: XR_005495319
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,659,085 - 40,668,362 (-)NCBI
mRatBN7.21740,228,943 - 40,240,337 (-)NCBI
RefSeq Acc Id: XR_010058918
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,659,085 - 40,668,361 (-)NCBI
RefSeq Acc Id: XR_010058919
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,659,085 - 40,668,361 (-)NCBI
RefSeq Acc Id: XR_010058920
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,659,085 - 40,668,361 (-)NCBI
RefSeq Acc Id: NP_001030119   ⟸   NM_001034947
- UniProtKB: Q3T1H5 (UniProtKB/Swiss-Prot),   A6KLF1 (UniProtKB/TrEMBL),   G3V9Q6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056326   ⟸   ENSRNOT00000059570
RefSeq Acc Id: XP_063132762   ⟸   XM_063276692
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063132761   ⟸   XM_063276691
- Peptide Label: isoform X1
Protein Domains
Endonuclease/exonuclease/phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3T1H5-F1-model_v2 AlphaFold Q3T1H5 1-366 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700442
Promoter ID:EPDNEW_R10966
Type:initiation region
Name:Tdp2_1
Description:tyrosyl-DNA phosphodiesterase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01742,241,052 - 42,241,112EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560342 AgrOrtholog
BioCyc Gene G2FUF-9423 BioCyc
Ensembl Genes ENSRNOG00000018246 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000059570 ENTREZGENE
Gene3D-CATH 3.60.10.10 UniProtKB/Swiss-Prot
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7937874 IMAGE-MGC_LOAD
InterPro Endo/exonu/phosph_ase_sf UniProtKB/Swiss-Prot
  Endo/exonuclease/phosphatase UniProtKB/Swiss-Prot
  TDP2-like UniProtKB/Swiss-Prot
KEGG Report rno:498749 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124734 IMAGE-MGC_LOAD
NCBI Gene 498749 ENTREZGENE
PANTHER TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN UniProtKB/Swiss-Prot
  TYROSYL-DNA PHOSPHODIESTERASE 2 UniProtKB/Swiss-Prot
Pfam Exo_endo_phos UniProtKB/Swiss-Prot
  UBA_4 UniProtKB/Swiss-Prot
PhenoGen Tdp2 PhenoGen
RatGTEx ENSRNOG00000018246 RatGTEx
Superfamily-SCOP SSF56219 UniProtKB/Swiss-Prot
UniProt A6KLF1 ENTREZGENE, UniProtKB/TrEMBL
  G3V9Q6 ENTREZGENE, UniProtKB/TrEMBL
  Q3T1H5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Tdp2  tyrosyl-DNA phosphodiesterase 2  Ttrap  Traf and Tnf receptor associated protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Ttrap  Traf and Tnf receptor associated protein  LOC498749  similar to putative TRAF and TNF receptor associated protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC498749  similar to putative TRAF and TNF receptor associated protein      Symbol and Name status set to provisional 70820 PROVISIONAL