Gpr62 (G protein-coupled receptor 62) - Rat Genome Database

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Gene: Gpr62 (G protein-coupled receptor 62) Rattus norvegicus
Analyze
Symbol: Gpr62
Name: G protein-coupled receptor 62
RGD ID: 1560166
Description: Predicted to enable G protein-coupled receptor activity; arrestin family protein binding activity; and identical protein binding activity. Predicted to be involved in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway and positive regulation of calcium-mediated signaling. Predicted to be located in endosome membrane. Predicted to be part of receptor complex. Predicted to be active in endosome and plasma membrane. Orthologous to human GPR62 (G protein-coupled receptor 62); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: G-protein coupled receptor 62; LOC501049; probable G-protein coupled receptor 62; RGD1560166; similar to Probable G-protein coupled receptor 62 (hGPCR8)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88115,981,936 - 115,984,022 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8115,966,924 - 115,984,888 (-)EnsemblGRCr8
mRatBN7.28107,103,225 - 107,105,311 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,103,980 - 107,105,056 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8112,726,192 - 112,728,276 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,925,368 - 110,927,452 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,768,150 - 108,770,234 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd8116,868,610 - 116,870,695 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive8118,973,572 - 118,975,657 (-)NCBILyon_Normotensive
Lyon_Hypertensive8117,463,361 - 117,465,446 (-)NCBILyon_Hypertensive
F344_StmMcwi8108,867,520 - 108,869,604 (-)NCBIF344_StmMcwi
Rnor_6.08115,165,655 - 115,170,396 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,166,410 - 115,167,486 (-)Ensemblrn6Rnor6.0
Rnor_5.08114,530,370 - 114,532,328 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48111,608,094 - 111,609,768 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8106,415,136 - 106,419,877 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
endosome  (IBA,ISO)
endosome membrane  (IEA)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)
receptor complex  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23382219   PMID:28827538   PMID:28912303  


Genomics

Comparative Map Data
Gpr62
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88115,981,936 - 115,984,022 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8115,966,924 - 115,984,888 (-)EnsemblGRCr8
mRatBN7.28107,103,225 - 107,105,311 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,103,980 - 107,105,056 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8112,726,192 - 112,728,276 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,925,368 - 110,927,452 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,768,150 - 108,770,234 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd8116,868,610 - 116,870,695 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive8118,973,572 - 118,975,657 (-)NCBILyon_Normotensive
Lyon_Hypertensive8117,463,361 - 117,465,446 (-)NCBILyon_Hypertensive
F344_StmMcwi8108,867,520 - 108,869,604 (-)NCBIF344_StmMcwi
Rnor_6.08115,165,655 - 115,170,396 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,166,410 - 115,167,486 (-)Ensemblrn6Rnor6.0
Rnor_5.08114,530,370 - 114,532,328 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48111,608,094 - 111,609,768 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8106,415,136 - 106,419,877 (-)NCBICelera
Cytogenetic Map8q32NCBI
GPR62
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38351,955,381 - 51,957,499 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl351,955,381 - 51,957,499 (+)Ensemblhg38GRCh38
GRCh37351,989,397 - 51,991,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36351,964,370 - 51,966,560 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34351,964,436 - 51,966,559NCBI
Celera351,968,157 - 51,970,347 (+)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef352,052,668 - 52,054,858 (+)NCBIHuRef
CHM1_1351,942,017 - 51,944,207 (+)NCBICHM1_1
T2T-CHM13v2.0351,988,300 - 51,990,418 (+)NCBIT2T-CHM13v2.0
Gpr62
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,341,161 - 106,343,184 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9106,341,161 - 106,343,137 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389106,463,962 - 106,465,985 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,463,962 - 106,465,938 (-)Ensemblmm10GRCm38
MGSCv379106,366,291 - 106,368,271 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera9106,090,861 - 106,092,863 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.56NCBI
Gpr62
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555323,602,642 - 3,603,230 (+)NCBIChiLan1.0ChiLan1.0
GPR62
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2251,943,356 - 51,951,724 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1351,949,762 - 51,956,476 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0351,894,429 - 51,898,907 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,124,767 - 53,127,498 (+)NCBIPanPan1.1PanPan1.1panPan2
GPR62
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,759,025 - 37,761,826 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,759,803 - 37,760,897 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2037,740,478 - 37,742,688 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02038,109,593 - 38,111,803 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2038,110,362 - 38,111,456 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,473,198 - 37,475,408 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,881,956 - 37,884,163 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02038,166,823 - 38,169,034 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gpr62
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560266,541,527 - 66,543,722 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365293,302,380 - 3,303,471 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365293,301,400 - 3,304,413 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR62
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,088,198 - 34,089,289 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11334,083,913 - 34,090,065 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,282,337 - 37,289,579 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR62
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,323,936 - 13,326,119 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041153,609,057 - 153,611,207 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr62
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247305,775,020 - 5,776,102 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247305,774,461 - 5,776,591 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gpr62
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1897,763,774 - 97,765,483 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gpr62
10 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:50
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000033018
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 4 28 110 21 25 4 33 4 3 117 73 3 105 32 45 21 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000033018   ⟹   ENSRNOP00000038558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8115,982,007 - 115,984,500 (-)Ensembl
mRatBN7.2 Ensembl8107,103,980 - 107,105,056 (-)Ensembl
Rnor_6.0 Ensembl8115,166,410 - 115,167,486 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000133409   ⟹   ENSRNOP00000107302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8115,978,405 - 115,984,500 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138957   ⟹   ENSRNOP00000102728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8115,966,924 - 115,984,888 (-)Ensembl
RefSeq Acc Id: NM_001398913   ⟹   NP_001385842
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88115,981,936 - 115,984,022 (-)NCBI
mRatBN7.28107,103,225 - 107,105,311 (-)NCBI
Dahl_SR_JrHsd8116,868,610 - 116,870,695 (-)NCBI
Lyon_Normotensive8118,973,572 - 118,975,657 (-)NCBI
Lyon_Hypertensive8117,463,361 - 117,465,446 (-)NCBI
F344_StmMcwi8108,867,520 - 108,869,604 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001385842 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038558.2
  ENSRNOP00000102728
  ENSRNOP00000102728.1
  ENSRNOP00000107302.1
Ensembl Acc Id: ENSRNOP00000038558   ⟸   ENSRNOT00000033018
RefSeq Acc Id: NP_001385842   ⟸   NM_001398913
- UniProtKB: D4A2B1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102728   ⟸   ENSRNOT00000138957
Ensembl Acc Id: ENSRNOP00000107302   ⟸   ENSRNOT00000133409
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2B1-F1-model_v2 AlphaFold D4A2B1 1-358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560166 AgrOrtholog
BioCyc Gene G2FUF-29235 BioCyc
Ensembl Genes ENSRNOG00000022567 Ensembl
  ENSRNOG00000083309 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033018.4 UniProtKB/TrEMBL
  ENSRNOT00000133409.1 UniProtKB/TrEMBL
  ENSRNOT00000138957 ENTREZGENE
  ENSRNOT00000138957.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
NCBI Gene 501049 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR UniProtKB/TrEMBL
  G-PROTEIN COUPLED RECEPTOR 62 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Gpr62 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022567 RatGTEx
  ENSRNOG00000083309 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt D4A2B1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-11 Gpr62  G protein-coupled receptor 62  RGD1560166  similar to Probable G-protein coupled receptor 62 (hGPCR8)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560166  similar to Probable G-protein coupled receptor 62 (hGPCR8)   RGD1560166_predicted  similar to Probable G-protein coupled receptor 62 (hGPCR8) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560166_predicted  similar to Probable G-protein coupled receptor 62 (hGPCR8) (predicted)  LOC501049  similar to Probable G-protein coupled receptor 62 (hGPCR8)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501049  similar to Probable G-protein coupled receptor 62 (hGPCR8)      Symbol and Name status set to provisional 70820 PROVISIONAL