Morc4 (MORC family CW-type zinc finger 4) - Rat Genome Database

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Pathways
Gene: Morc4 (MORC family CW-type zinc finger 4) Rattus norvegicus
Analyze
Symbol: Morc4
Name: MORC family CW-type zinc finger 4
RGD ID: 1559905
Description: Predicted to enable histone H3K4me3 reader activity. Predicted to be involved in chromatin organization. Predicted to be active in nucleoplasm. Orthologous to human MORC4 (MORC family CW-type zinc finger 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC315914; microrchidia 4; MORC family CW-type zinc finger protein 4; RGD1559905; similar to zinc finger, CW-type with coiled-coil domain 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X108,269,197 - 108,317,611 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX108,269,383 - 108,317,553 (-)EnsemblGRCr8
mRatBN7.2X103,477,366 - 103,529,026 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX103,480,603 - 103,528,956 (-)EnsemblmRatBN7.2
Rnor_6.0X111,143,537 - 111,191,993 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX111,142,602 - 111,191,936 (-)Ensemblrn6Rnor6.0
Rnor_5.0353,403,152 - 53,454,821 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X127,559,355 - 127,607,731 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera344,398,586 - 44,447,138 (+)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Macrocephaly  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (IBA,IEA,ISO)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Morc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X108,269,197 - 108,317,611 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX108,269,383 - 108,317,553 (-)EnsemblGRCr8
mRatBN7.2X103,477,366 - 103,529,026 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX103,480,603 - 103,528,956 (-)EnsemblmRatBN7.2
Rnor_6.0X111,143,537 - 111,191,993 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX111,142,602 - 111,191,936 (-)Ensemblrn6Rnor6.0
Rnor_5.0353,403,152 - 53,454,821 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X127,559,355 - 127,607,731 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera344,398,586 - 44,447,138 (+)NCBICelera
Cytogenetic MapXq32NCBI
MORC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X106,940,738 - 107,000,212 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX106,813,871 - 107,000,254 (-)Ensemblhg38GRCh38
GRCh37X106,183,968 - 106,243,442 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X106,070,620 - 106,130,098 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X105,990,113 - 106,034,618NCBI
CeleraX106,655,351 - 106,714,844 (-)NCBICelera
Cytogenetic MapXq22.3NCBI
HuRefX95,811,934 - 95,871,281 (-)NCBIHuRef
CHM1_1X106,094,770 - 106,154,304 (-)NCBICHM1_1
T2T-CHM13v2.0X105,377,254 - 105,436,736 (-)NCBIT2T-CHM13v2.0
Morc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X138,722,384 - 138,772,440 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX138,722,381 - 138,772,426 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X139,821,635 - 139,871,692 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX139,821,632 - 139,871,677 (-)Ensemblmm10GRCm38
MGSCv37X136,357,385 - 136,406,047 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X135,167,999 - 135,218,018 (-)NCBIMGSCv36mm8
CeleraX123,085,534 - 123,135,372 (-)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX61.35NCBI
Morc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554909,045,590 - 9,111,716 (+)Ensembl
ChiLan1.0NW_0049554909,045,306 - 9,112,446 (+)NCBIChiLan1.0ChiLan1.0
MORC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X106,424,227 - 106,483,817 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X106,427,828 - 106,487,448 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X96,040,992 - 96,100,570 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X106,418,348 - 106,470,758 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX106,418,348 - 106,472,561 (-)EnsemblpanPan2panpan1.1
MORC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X80,497,473 - 80,550,625 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX80,497,504 - 80,551,569 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX66,616,564 - 66,669,726 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X82,140,864 - 82,194,102 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX82,140,895 - 82,194,095 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X79,605,771 - 79,658,931 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X81,315,640 - 81,368,605 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X81,094,634 - 81,147,807 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Morc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X79,846,743 - 79,902,577 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364997,755,368 - 7,811,282 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364997,755,405 - 7,811,718 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MORC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX87,369,319 - 87,427,253 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X87,369,311 - 87,427,296 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X101,815,542 - 101,816,412 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MORC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X94,773,194 - 94,833,949 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX94,774,205 - 94,833,647 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606519,857,817 - 19,918,580 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Morc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248039,760,407 - 9,818,738 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248039,760,440 - 9,867,349 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Morc4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X92,205,069 - 92,253,785 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Morc4
236 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:59
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000034925
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX92979612117740458Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X105468858125434318Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
RH130812  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X103,480,711 - 103,480,907 (+)MAPPERmRatBN7.2
Rnor_6.0X111,143,649 - 111,143,844NCBIRnor6.0
Rnor_5.0353,451,280 - 53,451,475UniSTSRnor5.0
RGSC_v3.4X127,559,481 - 127,559,676UniSTSRGSC3.4
Celera344,446,831 - 44,447,026UniSTS
RH 3.4 Map71120.81UniSTS
Cytogenetic MapXq35UniSTS
UniSTS:238089  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X103,481,126 - 103,481,405 (+)MAPPERmRatBN7.2
Rnor_6.0X111,144,064 - 111,144,342NCBIRnor6.0
Rnor_5.0353,450,782 - 53,451,060UniSTSRnor5.0
RGSC_v3.4X127,559,896 - 127,560,174UniSTSRGSC3.4
Celera344,446,333 - 44,446,611UniSTS
Cytogenetic MapXq35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 157 91 90 59 88 59 6 352 188 11 136 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000083613   ⟹   ENSRNOP00000075042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX111,177,731 - 111,191,936 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088050   ⟹   ENSRNOP00000073672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX108,269,383 - 108,317,553 (-)Ensembl
mRatBN7.2 EnsemblX103,480,603 - 103,528,956 (-)Ensembl
Rnor_6.0 EnsemblX111,143,523 - 111,191,932 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089115   ⟹   ENSRNOP00000073417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX111,142,602 - 111,179,152 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144074   ⟹   ENSRNOP00000098705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX108,269,935 - 108,317,553 (-)Ensembl
RefSeq Acc Id: XM_063280366   ⟹   XP_063136436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X108,269,962 - 108,305,189 (-)NCBI
RefSeq Acc Id: XM_236536   ⟹   XP_236536
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X108,269,197 - 108,317,611 (-)NCBI
mRatBN7.2X103,477,366 - 103,529,026 (-)NCBI
Rnor_6.0X111,143,537 - 111,191,992 (-)NCBI
Rnor_5.0353,403,152 - 53,454,821 (+)NCBI
RGSC_v3.4X127,559,355 - 127,607,731 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_063136436 (Get FASTA)   NCBI Sequence Viewer  
  XP_236536 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58848 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073672.2
  ENSRNOP00000098705
  ENSRNOP00000098705.1
RefSeq Acc Id: XP_236536   ⟸   XM_236536
- Peptide Label: isoform X2
- UniProtKB: A0A096MK24 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073417   ⟸   ENSRNOT00000089115
Ensembl Acc Id: ENSRNOP00000075042   ⟸   ENSRNOT00000083613
Ensembl Acc Id: ENSRNOP00000073672   ⟸   ENSRNOT00000088050
RefSeq Acc Id: XP_063136436   ⟸   XM_063280366
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000098705   ⟸   ENSRNOT00000144074
Protein Domains
CW-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MK24-F1-model_v2 AlphaFold A0A096MK24 1-928 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701960
Promoter ID:EPDNEW_R12478
Type:multiple initiation site
Name:Morc4_1
Description:MORC family CW-type zinc finger 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X111,191,945 - 111,192,005EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559905 AgrOrtholog
BioCyc Gene G2FUF-1552 BioCyc
Ensembl Genes ENSRNOG00000060846 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088050.3 UniProtKB/TrEMBL
  ENSRNOT00000144074 ENTREZGENE
  ENSRNOT00000144074.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.100 UniProtKB/TrEMBL
  3.30.565.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7443919 IMAGE-MGC_LOAD
InterPro HATPase_C_sf UniProtKB/TrEMBL
  MORC_ATPase UniProtKB/TrEMBL
  Morc_S5 UniProtKB/TrEMBL
  Znf_CW UniProtKB/TrEMBL
MGC_CLONE MGC:188323 IMAGE-MGC_LOAD
NCBI Gene 315914 ENTREZGENE
PANTHER MORC FAMILY CW-TYPE ZINC FINGER PROTEIN 4 UniProtKB/TrEMBL
  PTHR23336 UniProtKB/TrEMBL
Pfam HATPase_c_3 UniProtKB/TrEMBL
  Morc6_S5 UniProtKB/TrEMBL
  zf-CW UniProtKB/TrEMBL
PhenoGen Morc4 PhenoGen
PROSITE ZF_CW UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060846 RatGTEx
Superfamily-SCOP SSF55874 UniProtKB/TrEMBL
UniProt A0A096MK24 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LBQ1_RAT UniProtKB/TrEMBL
  B0BNJ3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Morc4  MORC family CW-type zinc finger 4  Morc4  microrchidia 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Morc4  microrchidia 4  Morc4_predicted  MORC family CW-type zinc finger 4 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Morc4_predicted  MORC family CW-type zinc finger 4 (predicted)  RGD1559905_predicted  similar to zinc finger, CW-type with coiled-coil domain 2 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1559905_predicted  similar to zinc finger, CW-type with coiled-coil domain 2 (predicted)  LOC315914  similar to zinc finger, CW-type with coiled-coil domain 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC315914  similar to zinc finger, CW-type with coiled-coil domain 2      Symbol and Name status set to provisional 70820 PROVISIONAL