Rit1 (Ras-like without CAAX 1) - Rat Genome Database

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Gene: Rit1 (Ras-like without CAAX 1) Rattus norvegicus
Analyze
Symbol: Rit1
Name: Ras-like without CAAX 1
RGD ID: 1559874
Description: Predicted to enable GTPase activity; calmodulin binding activity; and guanyl ribonucleotide binding activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 8; RASopathy; and hepatocellular carcinoma. Orthologous to human RIT1 (Ras like without CAAX 1); INTERACTS WITH bisphenol A; cadmium dichloride; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GTP-binding protein Rit1; LOC499652; RGD1559874; similar to rit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,478,616 - 176,493,269 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2176,478,596 - 176,494,684 (+)EnsemblGRCr8
mRatBN7.22174,180,742 - 174,195,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,180,848 - 174,195,455 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2181,327,175 - 181,341,949 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,349,534 - 179,364,308 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,949,437 - 173,964,131 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,087,486 - 188,099,444 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,087,486 - 188,099,444 (+)Ensemblrn6Rnor6.0
Rnor_5.02207,487,476 - 207,498,920 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42180,846,683 - 180,859,135 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2168,125,309 - 168,137,930 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
cadmium dichloride  (EXP,ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
formaldehyde  (ISO)
gadodiamide hydrate  (ISO)
ifosfamide  (ISO)
inulin  (ISO)
lead diacetate  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
N(6)-dimethylallyladenine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chloride  (ISO)
quercetin  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. RIT1 oncoproteins escape LZTR1-mediated proteolysis. Castel P, etal., Science. 2019 Mar 15;363(6432):1226-1230. doi: 10.1126/science.aav1444.
2. Mutations in RIT1 cause Noonan syndrome with possible juvenile myelomonocytic leukemia but are not involved in acute lymphoblastic leukemia. Cave H, etal., Eur J Hum Genet. 2016 Jan 13. doi: 10.1038/ejhg.2015.273.
3. Next-generation sequencing identifies rare variants associated with Noonan syndrome. Chen PC, etal., Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11473-8. doi: 10.1073/pnas.1324128111. Epub 2014 Jul 21.
4. RIT1 suppresses esophageal squamous cell carcinoma growth and metastasis and predicts good prognosis. Feng YF, etal., Cell Death Dis. 2018 Oct 22;9(11):1085. doi: 10.1038/s41419-018-0979-x.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. HIF-1α-induced RIT1 promotes liver cancer growth and metastasis and its deficiency increases sensitivity to sorafenib. Song Z, etal., Cancer Lett. 2019 Sep 28;460:96-107. doi: 10.1016/j.canlet.2019.06.016. Epub 2019 Jun 24.
10. New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis. Takahara S, etal., EBioMedicine. 2019 Apr;42:43-53. doi: 10.1016/j.ebiom.2019.03.014. Epub 2019 Mar 18.
11. Spectrum of mutations and genotype-phenotype analysis in Noonan syndrome patients with RIT1 mutations. Yaoita M, etal., Hum Genet. 2016 Feb;135(2):209-22. doi: 10.1007/s00439-015-1627-5. Epub 2015 Dec 29.
Additional References at PubMed
PMID:8824319   PMID:10545207   PMID:23791108  


Genomics

Comparative Map Data
Rit1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,478,616 - 176,493,269 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2176,478,596 - 176,494,684 (+)EnsemblGRCr8
mRatBN7.22174,180,742 - 174,195,455 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,180,848 - 174,195,455 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2181,327,175 - 181,341,949 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,349,534 - 179,364,308 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,949,437 - 173,964,131 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,087,486 - 188,099,444 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,087,486 - 188,099,444 (+)Ensemblrn6Rnor6.0
Rnor_5.02207,487,476 - 207,498,920 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42180,846,683 - 180,859,135 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2168,125,309 - 168,137,930 (+)NCBICelera
Cytogenetic Map2q34NCBI
RIT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,897,808 - 155,911,349 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,897,808 - 155,911,408 (-)Ensemblhg38GRCh38
GRCh371155,867,599 - 155,881,140 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,134,225 - 154,147,801 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341152,682,962 - 152,694,199NCBI
Celera1128,940,503 - 128,954,081 (-)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,228,453 - 127,242,067 (-)NCBIHuRef
CHM1_11157,263,378 - 157,276,968 (-)NCBICHM1_1
T2T-CHM13v2.01155,035,925 - 155,049,482 (-)NCBIT2T-CHM13v2.0
Rit1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,624,154 - 88,638,354 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,624,145 - 88,638,356 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38388,716,842 - 88,731,048 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,716,838 - 88,731,049 (+)Ensemblmm10GRCm38
MGSCv37388,520,776 - 88,534,970 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36388,802,791 - 88,815,654 (+)NCBIMGSCv36mm8
Celera388,758,569 - 88,772,478 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.95NCBI
Rit1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,089,536 - 2,099,404 (-)Ensembl
ChiLan1.0NW_0049555452,089,530 - 2,099,404 (-)NCBIChiLan1.0ChiLan1.0
RIT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,943,872 - 93,973,237 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,674,831 - 93,704,667 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,232,277 - 131,245,437 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,062,994 - 135,075,183 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,063,000 - 135,074,942 (-)EnsemblpanPan2panpan1.1
RIT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,894,726 - 41,903,450 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,895,330 - 41,901,173 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha741,384,004 - 41,392,704 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0741,761,662 - 41,770,357 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,762,237 - 41,770,224 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,542,190 - 41,550,885 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,595,838 - 41,604,533 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,880,003 - 41,888,698 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rit1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,126,969 - 26,136,903 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,156,565 - 5,167,040 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,157,351 - 5,166,790 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,117,882 - 94,127,384 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1494,117,721 - 94,127,882 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,860,735 - 102,869,029 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RIT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,965,944 - 7,979,396 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,966,057 - 7,976,819 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660387,270,415 - 7,284,182 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rit1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248851,275,765 - 1,284,613 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rit1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1364,827,655 - 64,841,924 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rit1
406 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:302
Count of miRNA genes:187
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000027455
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837178247591Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2175279960178247591Rat

Markers in Region
RH131731  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,193,523 - 174,193,707 (+)MAPPERmRatBN7.2
Rnor_6.02188,099,724 - 188,099,907NCBIRnor6.0
Rnor_5.02207,499,200 - 207,499,383UniSTSRnor5.0
RGSC_v3.42180,859,415 - 180,859,598UniSTSRGSC3.4
Celera2168,138,210 - 168,138,393UniSTS
RH 3.4 Map21152.51UniSTS
Cytogenetic Map2q34UniSTS
BE102808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,192,957 - 174,193,131 (+)MAPPERmRatBN7.2
Rnor_6.02188,099,158 - 188,099,331NCBIRnor6.0
Rnor_5.02207,498,634 - 207,498,807UniSTSRnor5.0
RGSC_v3.42180,858,849 - 180,859,022UniSTSRGSC3.4
Celera2168,137,644 - 168,137,817UniSTS
RH 3.4 Map21156.0UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027455   ⟹   ENSRNOP00000027455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2188,087,486 - 188,099,444 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099308   ⟹   ENSRNOP00000090769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2176,478,596 - 176,494,684 (+)Ensembl
mRatBN7.2 Ensembl2174,180,848 - 174,195,455 (+)Ensembl
RefSeq Acc Id: NM_001396541   ⟹   NP_001383470
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,478,616 - 176,493,269 (+)NCBI
mRatBN7.22174,180,800 - 174,195,455 (+)NCBI
RefSeq Acc Id: NM_001396542   ⟹   NP_001383471
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,478,616 - 176,493,269 (+)NCBI
mRatBN7.22174,180,800 - 174,195,455 (+)NCBI
RefSeq Acc Id: NM_001396548   ⟹   NP_001383477
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,478,616 - 176,493,269 (+)NCBI
mRatBN7.22174,180,800 - 174,195,455 (+)NCBI
Ensembl Acc Id: ENSRNOP00000027455   ⟸   ENSRNOT00000027455
Ensembl Acc Id: ENSRNOP00000090769   ⟸   ENSRNOT00000099308
RefSeq Acc Id: NP_001383470   ⟸   NM_001396541
- Peptide Label: isoform 1
- UniProtKB: A0A8I6ABM0 (UniProtKB/TrEMBL),   A6J699 (UniProtKB/TrEMBL),   A6J6A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001383471   ⟸   NM_001396542
- Peptide Label: isoform 1
- UniProtKB: A0A8I6ABM0 (UniProtKB/TrEMBL),   A6J699 (UniProtKB/TrEMBL),   A6J6A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001383477   ⟸   NM_001396548
- Peptide Label: isoform 1
- UniProtKB: A0A8I6ABM0 (UniProtKB/TrEMBL),   A6J699 (UniProtKB/TrEMBL),   A6J6A2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJH4-F1-model_v2 AlphaFold D3ZJH4 1-192 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559874 AgrOrtholog
BioCyc Gene G2FUF-52465 BioCyc
Ensembl Genes ENSRNOG00000020232 Ensembl
  ENSRNOG00000064584 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000099308 ENTREZGENE
  ENSRNOT00000099308.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/TrEMBL
NCBI Gene 499652 ENTREZGENE
PANTHER PTHR24070 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PhenoGen Rit1 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020232 RatGTEx
  ENSRNOG00000064584 RatGTEx
SMART RAB UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6ABM0 ENTREZGENE, UniProtKB/TrEMBL
  A6J699 ENTREZGENE, UniProtKB/TrEMBL
  A6J6A2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Rit1  Ras-like without CAAX 1   Rit1_predicted  Ras-like without CAAX 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-04-05 Rit1_predicted    Rit1  Ras-like without CAAX 1 (predicted)  Symbol updated 1299863 APPROVED
2006-04-05 Rit1  Ras-like without CAAX 1 (predicted)  RGD1559874_predicted  similar to rit (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559874_predicted  similar to rit (predicted)  LOC499652  similar to rit  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499652  similar to rit      Symbol and Name status set to provisional 70820 PROVISIONAL