Advanced Search (OLGA)

Gene: Ilrun (inflammation and lipid regulator with UBA-like and NBR1-like domains) Rattus norvegicus

Analyze

Symbol:

Ilrun

Name:

inflammation and lipid regulator with UBA-like and NBR1-like domains

RGD ID:

1559829

Description:

Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of defense response to virus; and negative regulation of protein localization to nucleus. Predicted to be located in cytoplasm and nucleus. Predicted to be active in phagophore assembly site. Orthologous to human ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains); INTERACTS WITH gentamycin; thioacetamide; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

chromosome 6 open reading frame 106-like; hypothetical protein LOC294154; LOC294154; LOC294294; MGC124820; RGD1310148; similar to chromosome 6 open reading frame 106 isoform a; similar to hypothetical protein MGC4614; uncharacterized protein C6orf106 homolog; uncharacterized protein LOC294154

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	5,811,721 - 5,878,082 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	5,811,734 - 5,877,978 (-)	Ensembl				GRCr8
mRatBN7.2	20	5,809,931 - 5,876,197 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	5,809,936 - 5,876,012 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	6,522,583 - 6,588,605 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	5,884,372 - 5,950,402 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	6,364,082 - 6,430,193 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	7,331,321 - 7,397,588 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	7,331,326 - 7,397,448 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	9,533,329 - 9,599,034 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	5,965,992 - 6,033,724 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	7,371,306 - 7,437,251 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,4,4'-trichlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

chrysene (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

dimethylarsinous acid (ISO)

elemental selenium (ISO)

ethanol (ISO)

fenthion (ISO)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gentamycin (EXP)

lithium chloride (ISO)

methidathion (ISO)

nickel sulfate (ISO)

paracetamol (ISO)

PCB138 (ISO)

raloxifene (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

tetraphene (ISO)

thimerosal (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

immune system process (IEA)

innate immune response (IEA)

macroautophagy (IBA)

negative regulation of defense response to virus (IEA,ISO)

negative regulation of protein localization to nucleus (IEA,ISO)

negative regulation of tumor necrosis factor production (IEA,ISO)

negative regulation of type I interferon production (IEA,ISO)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (IEA,ISO)

nuclear speck (IEA,ISO)

nucleus (IEA,ISO)

phagophore assembly site (IBA)

Molecular Function

protein binding (ISO)

ubiquitin binding (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:29802199

Genomics

Comparative Map Data

Ilrun
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	5,811,721 - 5,878,082 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	5,811,734 - 5,877,978 (-)	Ensembl				GRCr8
mRatBN7.2	20	5,809,931 - 5,876,197 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	5,809,936 - 5,876,012 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	6,522,583 - 6,588,605 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	5,884,372 - 5,950,402 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	6,364,082 - 6,430,193 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	7,331,321 - 7,397,588 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	7,331,326 - 7,397,448 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	9,533,329 - 9,599,034 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	5,965,992 - 6,033,724 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	7,371,306 - 7,437,251 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

ILRUN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	34,587,288 - 34,696,767 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	34,587,288 - 34,696,881 (-)	Ensembl			hg38	GRCh38
GRCh37	6	34,555,065 - 34,664,544 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	34,663,043 - 34,772,603 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	6	36,109,394 - 36,219,085 (-)	NCBI		Celera
Cytogenetic Map	6	p21.31	NCBI
HuRef	6	34,277,695 - 34,387,079 (-)	NCBI		HuRef
CHM1_1	6	34,558,029 - 34,667,828 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	34,411,143 - 34,520,743 (-)	NCBI		T2T-CHM13v2.0

Ilrun
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	27,970,206 - 28,039,516 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	27,970,209 - 28,039,622 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	27,751,232 - 27,820,542 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	27,751,235 - 27,820,648 (-)	Ensembl			mm10	GRCm38
MGSCv37	17	27,888,180 - 27,957,487 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	27,481,414 - 27,548,131 (-)	NCBI		MGSCv36	mm8
Celera	17	28,303,533 - 28,372,972 (-)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	14.59	NCBI

Ilrun
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	2,694,945 - 2,769,998 (-)	Ensembl
ChiLan1.0	NW_004955437	2,697,998 - 2,769,998 (-)	NCBI	ChiLan1.0	ChiLan1.0

ILRUN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	3,861,063 - 3,955,356 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	3,862,477 - 3,955,348 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	3,876,763 - 3,970,773 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	4,196,212 - 4,290,402 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	4,197,909 - 4,290,436 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	3,857,654 - 3,951,847 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	3,939,003 - 4,033,002 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	4,037,998 - 4,132,485 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ilrun
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	39,424,067 - 39,511,774 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	24,448,350 - 24,536,196 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	24,448,402 - 24,536,163 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ILRUN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	30,562,987 - 30,667,146 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	30,561,744 - 30,667,115 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	35,318,373 - 35,410,399 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Sscrofa10.2	7	35,167,561 - 35,188,220 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ILRUN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	37,402,940 - 37,555,871 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	37,402,966 - 37,516,822 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666044	34,506,953 - 34,624,366 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ilrun
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624754	22,613,396 - 22,694,022 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ilrun
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	18	6,035,137 - 6,102,632 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ilrun
600 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	357
Count of miRNA genes:	207
Interacting mature miRNAs:	265
Transcripts:	ENSRNOT00000059426
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
61474	Eae1	Experimental allergic encephalomyelitis QTL 1	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	20	1	6693431	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	1	26925056	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26128279	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24164241	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3626323	10078622	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29193376	Rat
70154	Insul2	Insulin level QTL 2	3.75		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	6693431	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	1	27341128	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	3626323	9244918	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29193376	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29193376	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29193376	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29193376	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1	14100378	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
17	13	78	199	91	90	59	144	59	6	457	260	17	182	113	114	31	34	34

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001039607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001410292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063278990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC118954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC112320	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000059426 ⟹ ENSRNOP00000056183

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	5,811,734 - 5,877,978 (-)	Ensembl
mRatBN7.2 Ensembl	20	5,809,936 - 5,876,012 (-)	Ensembl
Rnor_6.0 Ensembl	20	7,331,326 - 7,397,448 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095695 ⟹ ENSRNOP00000091752

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	5,811,734 - 5,877,978 (-)	Ensembl
mRatBN7.2 Ensembl	20	5,809,936 - 5,876,012 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099815 ⟹ ENSRNOP00000090973

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	5,811,326 - 5,876,012 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111162 ⟹ ENSRNOP00000093528

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	5,820,429 - 5,877,978 (-)	Ensembl
mRatBN7.2 Ensembl	20	5,818,644 - 5,876,012 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114745 ⟹ ENSRNOP00000080612

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	5,824,472 - 5,876,012 (-)	Ensembl

RefSeq Acc Id:

NM_001039607 ⟹ NP_001034696

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	5,811,721 - 5,877,978 (-)	NCBI
mRatBN7.2	20	5,809,931 - 5,876,197 (-)	NCBI
Rnor_6.0	20	7,331,321 - 7,397,393 (-)	NCBI
Rnor_5.0	20	9,533,329 - 9,599,034 (-)	NCBI
RGSC_v3.4	20	5,965,992 - 6,033,724 (-)	RGD
Celera	20	7,371,306 - 7,437,251 (-)	RGD

Sequence:

show sequence

GTGCGTCCGGGCCCCCCGCCATGGAGGGCATGGACGTGGACCTAGACCCCGAGCTCATGCAGAA
GTTCAGCTGCCTGGGCACCACAGACAAGGACGTGCTCATCTCCGAGTTCCAGCGGCTACTCGGC
TTTCAGCTCAACCCGGCCGGCTGCGCCTTCTTCCTGGACATGACCAACTGGAACTTACAAGCGG
CAATTGGCGCCTATTATGACTTTGAGAGCCCGAATGTCAGTGTGCCCTCCATGTCCTTTGTTGA
AGATGTCACCATAGGAGAAGGGGAGTCAATACCCCCTGATACCCAGTTCATAAAAACATGGCGG
ATTCAGAATTCTGGGGCAGAAGCCTGGCCTCCGGGGGTTTGTCTTAAATATGTCGGGGGAGACC
AGTTTGGACATGTGAACATGGTGATGGTGAGATCACTAGAGCCCCAAGAGATCGCAGATGTCAG
CGTCCAGATGTGCAGCCCCAGCAGAGCAGGAATGTACCAGGGACAGTGGCGGATGTGCACTGCT
ACTGGACTCTACTATGGAGATGTCATCTGGGTGATTCTCAGTGTGGAGGTGGGTGGACTTTTAG
GAGTAACGCAGCAGCTGTCATCCTTTGAAACGGAATTCAACACACAGCCACATCGCAAGGGGCT
CCACGGGCCTTACCCCTTCGGCCAGTCTTAAACGGGTGTCAGCAAGAAGAAAAACTAACAAAGA
CAGAAGGCCTGACTTTGGGGGGAGAGGGCAAGGGGTTCCTCTGGATTGCAGAACACATCGCATG
GACCCCTGGCTCAGACCCCCACCTACCCCCCAATCACGGAAGAAGAGGAAGAAAGAGACTAGTT
TTGAGTGAACTCAGTATGCGTGTGTGAATGCTGAACTGCGGAGTGGTTTGAGGCGACCGAGAAG
AGATCCACGCAGCCACCTTGGGTTTGGTGATGACGTCAGTCTAATGAGTTGTTAGGTCACTGGG
GAAGGGGAAGAAATTTAAATGGGGGAAAATAAGCCATCTTTTTAAACAAAAATTATTTTACCTA
CAGAGAGGTTGTAGTTTTGAGCACACGTTAGTTTCTCCCTCCCTCTTCCTGATGTTTATCTTCT
ACATAAAGGACAGCATGCTACAGGACAGCGCCTGCTCTGTGCCTGTCACAGTAAGGCTGGCGTG
GCATGCCTGGGACTCTGCTAGTCAGGGCTGCTGGGCACGCGCTGTGTGCCACCGACTGCAGAGT
CTGACCCCGTTTGTTCTTAGGGCATCTGCCAGTGAGAAGATGTCACCTTCCTCCTCTCTTCTCC
TTAACCTCTTGTTAATTCACCCCTTAGAACTGGTGTCTGTCAGCCTTGGGGCTTCTTAGCATCA
GAATCTCTCTGAGGCAAGGATTTCCTGTGTGGCCACAGAAGCTCCGGGCATTCCATCCCAGAGG
GTCCTTTCCATACACTTGTGACAGCTGGAGTGCAGTGGCTCCCGCTGCGTGTGCGCACGTGTGC
GCCATGCACACGGGGTTGTAGGGCGTCTGCAAGTGTGAAGTGTTCCCTGCTTCTCTTGTCACAC
AGCTCCCCTCCCTGGGTCTCCCCCACATGTCCTGTGGCTCCAGCCATTACAGAGTGATGGTGCA
GCCCCGGCAGGAGCCCCACCACTGACCACTACCCGAGAGGCCACAGTCAGGTGGAAATGAAAAG
ACCTGCAGTGGGGCGGGGCTGCTTAGTGTGGGCAGCAGGTGCCCACTGGTGTCCCGTGGACTCC
ACTTGGGTTGAAGTGTGGATGTCTCCATGGGACACTCAAACCAGGCTAGAACAGCTGTCTGCCA
AAGATACAAGAATATGCAAAGTCCTCCTCTAACCCCTCCTTCCCTAAGTCGGTGGCTTGAGAGC
CGGGGATTTGGATTTGGTGTGGTTGCTGGGTCCCCTGCCTGCCTCCAGCCCCCATGTGCTCCAG
GGTTGTGAGCAGAGCAGGGAGATCAAGGTGTGAGTGGCTGTAGGTGGTCTTCTAGCGCGGGTGC
GGGTCTGGTCTGCCTGCCTGTCTGTCTCTGTCTCTGGATGTTTGAGTTCCAAAAAGTGTGTGGT
GTGTGTGTTCCTCATCTTCTGAGACTGTTGATTTTAAACACTTGATTGTGAACGAAAAGCTTCT
ATGAAAACCCCTCACCTTTCCATATCCCCAAAAACAAACCAACAAAAGTCCCTGGGGCAGGTGG
AGAAGTCTGTGGCTGGGTCTCCAGTGAGGTGGGTGGACTTCTGTGTGACCCTTACTTCCTCTGC
ACACGTAGACCCTTGAGCCAAGAGCAGTTCCTACCAGGTGCCCAAGCCACAAGTCTCAGGGGGC
TTTGTCTGAGGACCTTCTTGGGGCCAGACAACTGATGCCAGTCTCTGAGGACACTGCCACCCTC
GAGCACATGCATGCCCAGCCATTCTCCTGCTCTGGCCTTGGAGCAGGGGCTCCAGACGCTCTCC
TGGAACCGAGAGGCTTCAGCCTGGCCTCACTGGCTTCCCCGTCTGACCCCCCTAGGACCACACT
TGCTCAGTTTCCAGCTGTCGCCAAGTGTCCTCCCTCTCCTCCTGTGCCCCTTCCTGCTTGTAGC
AGCCCCACTTGGCAAATGTAACGGCTCAGGTACCCTGGCTTCCTTCCCAGAAACAAGCCTTGTC
TGTGCATCCTGGAGAGGTAGCTCCTTCAGAAGGCCAGAGCTGGTGCAAGCCTTGACCATTCTGC
AGCCCTTAGAGCTGTCACACATGAGCACTTGGCCATCTTTTGGCAGGACCCCCATCTGACAGCA
CATGCCAAGTTTCAGGAGGATTGGGGGGCCATCAGTGGGTGCAGTCTTGGGAAGAATCTGTGTG
TGTACGTGTGTGTCTGTGCACGCACGTGTGCATGCCTATGTCTTTTTGACATGGAGACAACTGA
ATTTGGAATATTTGTCTACAAAGCAGCCTCCTATCCCCCCGTGTGGACTGGCTGTAGCCATAAG
CCAGGCGCTTACACCGAGATAGCTGGTGGCCAAGGTGGGAAGTGAGCATGAGTGTAAAGACCCG
GATTTAGCCCAGCTCCCAGCAGGAAAGGACAGAATCATCAGGCTCACAGGTGCAGACCAGTGTG
CTCTCTCCACCTGCCCTCTTACCCCTTGTTTCCTTGGGTGAATGTGGGGCAGCCTGCTGTCCCT
CCCTCCTGGACACTGATGGCTGTCTGGTGGGGGCTTGTGGTGCCTAGGAGATGAAGATGAGGTT
TTCCTTACCATGTAAATGAATATTTGTATGATTAAATTAACACAAAAAAACAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001410292 ⟹ NP_001397221

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	5,811,721 - 5,877,978 (-)	NCBI
mRatBN7.2	20	5,809,931 - 5,876,197 (-)	NCBI

RefSeq Acc Id:

XM_063278990 ⟹ XP_063135060

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	5,814,290 - 5,878,082 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001034696	(Get FASTA)	NCBI Sequence Viewer
	NP_001397221	(Get FASTA)	NCBI Sequence Viewer
	XP_063135060	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI12321	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000056183
	ENSRNOP00000056183.4
	ENSRNOP00000091752.1
	ENSRNOP00000093528
	ENSRNOP00000093528.1

RefSeq Acc Id:	NP_001034696 ⟸ NM_001039607
- Peptide Label:	isoform 2
- UniProtKB:	Q2M1K7 (UniProtKB/TrEMBL), F1MAI9 (UniProtKB/TrEMBL), A0A8I5ZQ01 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEGMDVDLDPELMQKFSCLGTTDKDVLISEFQRLLGFQLNPAGCAFFLDMTNWNLQAAIGAYYD FESPNVSVPSMSFVEDVTIGEGESIPPDTQFIKTWRIQNSGAEAWPPGVCLKYVGGDQFGHVNM VMVRSLEPQEIADVSVQMCSPSRAGMYQGQWRMCTATGLYYGDVIWVILSVEVGGLLGVTQQLS SFETEFNTQPHRKGLHGPYPFGQS hide sequence

Ensembl Acc Id:

ENSRNOP00000056183 ⟸ ENSRNOT00000059426

Ensembl Acc Id:

ENSRNOP00000080612 ⟸ ENSRNOT00000114745

Ensembl Acc Id:

ENSRNOP00000091752 ⟸ ENSRNOT00000095695

Ensembl Acc Id:

ENSRNOP00000093528 ⟸ ENSRNOT00000111162

Ensembl Acc Id:

ENSRNOP00000090973 ⟸ ENSRNOT00000099815

RefSeq Acc Id:	NP_001397221 ⟸ NM_001410292
- Peptide Label:	isoform 1
- UniProtKB:	A0A8J8XEJ8 (UniProtKB/TrEMBL), A6JJN5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063135060 ⟸ XM_063278990
- Peptide Label:	isoform X1
- UniProtKB:	A6JJN5 (UniProtKB/TrEMBL)

Protein Domains

Nbr1 FW

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q2M1K7-F1-model_v2	AlphaFold	Q2M1K7	1-216	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701450

Promoter ID:

EPDNEW_R11974

Type:

initiation region

Name:

LOC294154_1

Description:

similar to chromosome 6 open reading frame 106 isoform a

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	7,397,547 - 7,397,607	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1559829	AgrOrtholog
BioCyc Gene	G2FUF-4459	BioCyc
Ensembl Genes	ENSRNOG00000038883	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000059426	ENTREZGENE
	ENSRNOT00000059426.6	UniProtKB/TrEMBL
	ENSRNOT00000095695.2	UniProtKB/TrEMBL
	ENSRNOT00000111162	ENTREZGENE
	ENSRNOT00000111162.2	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
	DNA helicase RuvA subunit, C-terminal domain	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7933524	IMAGE-MGC_LOAD
InterPro	C6orf106_UBA-like	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	N_BRCA1_central	UniProtKB/TrEMBL
	UBA-like	UniProtKB/TrEMBL
KEGG Report	rno:294154	UniProtKB/TrEMBL
MGC_CLONE	MGC:124820	IMAGE-MGC_LOAD
NCBI Gene	294154	ENTREZGENE
PANTHER	OVARIAN CARCINOMA ANTIGEN CA125-RELATED	UniProtKB/TrEMBL
	PROTEIN ILRUN	UniProtKB/TrEMBL
Pfam	N_BRCA1_IG	UniProtKB/TrEMBL
	UBA_4	UniProtKB/TrEMBL
PhenoGen	Ilrun	PhenoGen
RatGTEx	ENSRNOG00000038883	RatGTEx
Superfamily-SCOP	UBA_like	UniProtKB/TrEMBL
UniProt	A0A8I5ZQ01	ENTREZGENE
	A0A8I6AFT0_RAT	UniProtKB/TrEMBL
	A0A8I6AK92_RAT	UniProtKB/TrEMBL
	A0A8J8XEJ8	ENTREZGENE, UniProtKB/TrEMBL
	A6JJN5	ENTREZGENE, UniProtKB/TrEMBL
	F1MAI9	ENTREZGENE
	Q2M1K7	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1MAI9	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-08-13	Ilrun	inflammation and lipid regulator with UBA-like and NBR1-like domains	LOC294154	similar to chromosome 6 open reading frame 106 isoform a	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-06-15	LOC294154	similar to chromosome 6 open reading frame 106 isoform a	RGD1310148	similar to hypothetical protein MGC4614	Data merged from RGD:1310148	1643240	APPROVED
2008-04-30	RGD1310148	similar to hypothetical protein MGC4614	RGD1310148_predicted	similar to hypothetical protein MGC4614 (predicted)	'predicted' is removed	2292626	APPROVED
2006-02-09	LOC294154	similar to chromosome 6 open reading frame 106 isoform a			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-20	RGD1310148_predicted	similar to hypothetical protein MGC4614 (predicted)	LOC294294_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC294294_predicted	similar to hypothetical protein MGC4614 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message