ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains) - Rat Genome Database

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Gene: ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains) Sus scrofa
Analyze
Symbol: ILRUN
Name: inflammation and lipid regulator with UBA-like and NBR1-like domains
RGD ID: 14253008
Description: ENCODES a protein that exhibits ubiquitin binding (inferred); INVOLVED IN macroautophagy (inferred); negative regulation of defense response to virus (inferred); negative regulation of protein localization to nucleus (inferred); ASSOCIATED WITH proteasome-associated autoinflammatory syndrome 1 (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C6orf106; C7H6orf106; chromosome 7 C6orf106 homolog; N/A; uncharacterized protein C6orf106 homolog; uncharacterized protein C6orf106-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl730,562,987 - 30,667,146 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1730,561,744 - 30,667,115 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2735,318,373 - 35,410,399 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2735,167,561 - 35,188,220 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:30032202  


Genomics

Comparative Map Data
ILRUN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl730,562,987 - 30,667,146 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1730,561,744 - 30,667,115 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2735,318,373 - 35,410,399 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2735,167,561 - 35,188,220 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ILRUN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38634,587,288 - 34,696,767 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl634,587,288 - 34,696,859 (-)EnsemblGRCh38hg38GRCh38
GRCh37634,555,065 - 34,664,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36634,663,043 - 34,772,603 (-)NCBINCBI36Build 36hg18NCBI36
Celera636,109,394 - 36,219,085 (-)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef634,277,695 - 34,387,079 (-)NCBIHuRef
CHM1_1634,558,029 - 34,667,828 (-)NCBICHM1_1
T2T-CHM13v2.0634,411,143 - 34,520,743 (-)NCBIT2T-CHM13v2.0
Ilrun
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,970,206 - 28,039,516 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,970,209 - 28,039,622 (-)EnsemblGRCm39 Ensembl
GRCm381727,751,232 - 27,820,542 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,751,235 - 27,820,648 (-)EnsemblGRCm38mm10GRCm38
MGSCv371727,888,180 - 27,957,487 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361727,481,414 - 27,548,131 (-)NCBIMGSCv36mm8
Celera1728,303,533 - 28,372,972 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.59NCBI
Ilrun
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,811,721 - 5,878,082 (-)NCBIGRCr8
mRatBN7.2205,809,931 - 5,876,197 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,809,936 - 5,876,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx206,522,583 - 6,588,605 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,884,372 - 5,950,402 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,364,082 - 6,430,193 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,331,321 - 7,397,588 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,331,326 - 7,397,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0209,533,329 - 9,599,034 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,965,992 - 6,033,724 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera207,371,306 - 7,437,251 (-)NCBICelera
Cytogenetic Map20p12NCBI
Ilrun
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,694,945 - 2,769,998 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,697,998 - 2,769,998 (-)NCBIChiLan1.0ChiLan1.0
ILRUN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,861,063 - 3,955,356 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,862,477 - 3,955,348 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha123,876,763 - 3,970,773 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0124,196,212 - 4,290,402 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl124,197,909 - 4,290,436 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,857,654 - 3,951,847 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,939,003 - 4,033,002 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,037,998 - 4,132,485 (-)NCBIUU_Cfam_GSD_1.0
Ilrun
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494639,424,067 - 39,511,774 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647624,448,350 - 24,536,196 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647624,448,402 - 24,536,163 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ILRUN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11737,402,940 - 37,555,871 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1737,402,966 - 37,516,822 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604434,506,953 - 34,624,366 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ilrun
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475422,613,396 - 22,694,022 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ILRUN
1944 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000049038   ⟹   ENSSSCP00000041462
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl730,562,987 - 30,667,146 (-)Ensembl
RefSeq Acc Id: NM_001243026   ⟹   NP_001229955
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1730,561,744 - 30,667,115 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001229955   ⟸   NM_001243026
- Sequence:
RefSeq Acc Id: ENSSSCP00000041462   ⟸   ENSSSCT00000049038
Protein Domains
Next to BRCA1 central


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001527 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00015047722 UniProtKB/TrEMBL
  ENSSSCG00025052091 UniProtKB/TrEMBL
  ENSSSCG00030074635 UniProtKB/TrEMBL
  ENSSSCG00035027288 UniProtKB/TrEMBL
  ENSSSCG00045038342 UniProtKB/TrEMBL
  ENSSSCG00050058154 UniProtKB/TrEMBL
  ENSSSCG00055016776 UniProtKB/TrEMBL
  ENSSSCG00060076471 UniProtKB/TrEMBL
  ENSSSCG00065057525 UniProtKB/TrEMBL
  ENSSSCG00070006641 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000049038.3 UniProtKB/TrEMBL
  ENSSSCT00015063641.1 UniProtKB/TrEMBL
  ENSSSCT00015063728.1 UniProtKB/TrEMBL
  ENSSSCT00025071293.1 UniProtKB/TrEMBL
  ENSSSCT00025071449.1 UniProtKB/TrEMBL
  ENSSSCT00030104784.1 UniProtKB/TrEMBL
  ENSSSCT00030104788.1 UniProtKB/TrEMBL
  ENSSSCT00035036070.1 UniProtKB/TrEMBL
  ENSSSCT00035036073.1 UniProtKB/TrEMBL
  ENSSSCT00045066498.1 UniProtKB/TrEMBL
  ENSSSCT00045066517.1 UniProtKB/TrEMBL
  ENSSSCT00050079293.1 UniProtKB/TrEMBL
  ENSSSCT00050079301.1 UniProtKB/TrEMBL
  ENSSSCT00055033142.1 UniProtKB/TrEMBL
  ENSSSCT00055033203.1 UniProtKB/TrEMBL
  ENSSSCT00060104902.1 UniProtKB/TrEMBL
  ENSSSCT00060104996.1 UniProtKB/TrEMBL
  ENSSSCT00065078715.1 UniProtKB/TrEMBL
  ENSSSCT00065078734.1 UniProtKB/TrEMBL
  ENSSSCT00070012721.1 UniProtKB/TrEMBL
  ENSSSCT00070012734.1 UniProtKB/TrEMBL
  ENSSSCT00070012750.1 UniProtKB/TrEMBL
  ENSSSCT00070012754.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro C6orf106_UBA-like UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  N_BRCA1_central UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/TrEMBL
NCBI Gene C7H6orf106 ENTREZGENE
PANTHER OVARIAN CARCINOMA ANTIGEN CA125-RELATED UniProtKB/TrEMBL
  PROTEIN ILRUN UniProtKB/TrEMBL
Pfam N_BRCA1_IG UniProtKB/TrEMBL
  UBA_4 UniProtKB/TrEMBL
Superfamily-SCOP SSF46934 UniProtKB/TrEMBL
UniProt A0A287ACB5_PIG UniProtKB/TrEMBL
  A0A4X1T504_PIG UniProtKB/TrEMBL
  A0A4X1T524_PIG UniProtKB/TrEMBL
  A0A4X1T5U3_PIG UniProtKB/TrEMBL
  A0A4X1T6T7_PIG UniProtKB/TrEMBL
  A0A8D0NYU2_PIG UniProtKB/TrEMBL
  A0A8D0Y7W7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:89122 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-26 ILRUN  inflammation and lipid regulator with UBA-like and NBR1-like domains  C7H6orf106  chromosome 7 C6orf106 homolog  Symbol and/or name change 5135510 APPROVED