Mb21d2 (Mab-21 domain containing 2) - Rat Genome Database

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Pathways
Gene: Mb21d2 (Mab-21 domain containing 2) Rattus norvegicus
Analyze
Symbol: Mb21d2
Name: Mab-21 domain containing 2
RGD ID: 1559643
Description: Predicted to enable nucleotidyltransferase activity. Orthologous to human MB21D2 (Mab-21 domain containing 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cobalt dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC498100; LOC498100; nucleotidyltransferase MB21D2; RGD1559643; similar to hypothetical protein A430031N04; uncharacterized protein LOC498100
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81185,330,526 - 85,429,543 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1185,330,503 - 85,476,241 (+)EnsemblGRCr8
mRatBN7.21171,825,748 - 71,924,770 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1171,825,748 - 71,924,769 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1180,664,208 - 80,763,345 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01173,299,191 - 73,398,331 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01172,356,210 - 72,455,744 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01175,434,198 - 75,533,476 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,434,197 - 75,533,520 (+)Ensemblrn6Rnor6.0
Rnor_5.01178,476,278 - 78,575,234 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41173,733,241 - 73,831,764 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1170,785,779 - 70,884,785 (+)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse:




References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23209302   PMID:25468996  


Genomics

Comparative Map Data
Mb21d2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81185,330,526 - 85,429,543 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1185,330,503 - 85,476,241 (+)EnsemblGRCr8
mRatBN7.21171,825,748 - 71,924,770 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1171,825,748 - 71,924,769 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1180,664,208 - 80,763,345 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01173,299,191 - 73,398,331 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01172,356,210 - 72,455,744 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01175,434,198 - 75,533,476 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1175,434,197 - 75,533,520 (+)Ensemblrn6Rnor6.0
Rnor_5.01178,476,278 - 78,575,234 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41173,733,241 - 73,831,764 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1170,785,779 - 70,884,785 (+)NCBICelera
Cytogenetic Map11q22NCBI
MB21D2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383192,796,815 - 192,917,856 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3192,796,815 - 192,917,856 (-)Ensemblhg38GRCh38
GRCh373192,514,604 - 192,635,645 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363193,997,298 - 194,118,644 (-)NCBIBuild 36Build 36hg18NCBI36
Celera3190,940,598 - 191,061,951 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3189,912,504 - 190,033,550 (-)NCBIHuRef
CHM1_13192,477,484 - 192,598,833 (-)NCBICHM1_1
T2T-CHM13v2.03195,492,752 - 195,613,821 (-)NCBIT2T-CHM13v2.0
Mb21d2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391628,644,928 - 28,748,802 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1628,644,928 - 28,748,425 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381628,826,176 - 28,929,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1628,826,176 - 28,929,673 (-)Ensemblmm10GRCm38
MGSCv371628,826,262 - 28,929,784 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361628,745,923 - 28,849,445 (-)NCBIMGSCv36mm8
Celera1629,338,478 - 29,439,066 (-)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1619.71NCBI
Mb21d2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542015,609,097 - 15,725,757 (+)Ensembl
ChiLan1.0NW_00495542015,609,102 - 15,723,377 (+)NCBIChiLan1.0ChiLan1.0
MB21D2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22190,728,802 - 190,848,707 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13190,733,522 - 190,853,463 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03190,102,740 - 190,223,242 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13200,422,231 - 200,542,208 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3200,423,812 - 200,425,125 (-)EnsemblpanPan2panpan1.1
MB21D2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13424,412,254 - 24,519,829 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3424,413,832 - 24,415,384 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3428,503,429 - 28,610,998 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03424,358,075 - 24,469,214 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3424,358,082 - 24,469,149 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13424,393,327 - 24,501,221 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03424,363,295 - 24,471,262 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03424,604,192 - 24,712,241 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mb21d2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602122,430,645 - 122,544,764 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367111,704,977 - 1,817,529 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367111,705,050 - 1,819,160 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MB21D2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13129,875,636 - 129,997,215 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113129,875,632 - 129,997,340 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213139,373,173 - 139,522,651 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MB21D2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11586,891,375 - 87,009,318 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1586,891,383 - 87,009,025 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604160,555,745 - 60,673,822 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mb21d2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473064,579,729 - 64,693,287 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473064,579,777 - 64,693,183 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mb21d2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1413,758,808 - 13,858,068 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mb21d2
737 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:193
Count of miRNA genes:136
Interacting mature miRNAs:165
Transcripts:ENSRNOT00000032569
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 79 59 6 343 179 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032569   ⟹   ENSRNOP00000033286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1185,330,503 - 85,429,541 (+)Ensembl
mRatBN7.2 Ensembl1171,825,748 - 71,924,769 (+)Ensembl
Rnor_6.0 Ensembl1175,434,197 - 75,533,520 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122184   ⟹   ENSRNOP00000112066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1185,426,194 - 85,429,584 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000123556   ⟹   ENSRNOP00000106960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1185,403,644 - 85,428,983 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124031   ⟹   ENSRNOP00000100118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1185,389,994 - 85,428,983 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128452   ⟹   ENSRNOP00000108683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1185,343,331 - 85,429,655 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000137353   ⟹   ENSRNOP00000109201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1185,410,215 - 85,429,980 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000171722   ⟹   ENSRNOP00000099371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1185,331,094 - 85,476,241 (+)Ensembl
RefSeq Acc Id: NM_001109056   ⟹   NP_001102526
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81185,330,526 - 85,429,542 (+)NCBI
mRatBN7.21171,825,748 - 71,924,769 (+)NCBI
Rnor_6.01175,434,198 - 75,533,475 (+)NCBI
Rnor_5.01178,476,278 - 78,575,234 (+)NCBI
RGSC_v3.41173,733,241 - 73,831,764 (+)RGD
Celera1170,785,779 - 70,884,785 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248523   ⟹   XP_006248585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81185,402,128 - 85,429,543 (+)NCBI
mRatBN7.21171,899,074 - 71,924,770 (+)NCBI
Rnor_6.01175,506,037 - 75,533,476 (+)NCBI
Rnor_5.01178,476,278 - 78,575,234 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001102526   ⟸   NM_001109056
- UniProtKB: D4ACS3 (UniProtKB/TrEMBL),   A6JRX1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248585   ⟸   XM_006248523
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000033286   ⟸   ENSRNOT00000032569
Ensembl Acc Id: ENSRNOP00000108683   ⟸   ENSRNOT00000128452
Ensembl Acc Id: ENSRNOP00000109201   ⟸   ENSRNOT00000137353
Ensembl Acc Id: ENSRNOP00000100118   ⟸   ENSRNOT00000124031
Ensembl Acc Id: ENSRNOP00000106960   ⟸   ENSRNOT00000123556
Ensembl Acc Id: ENSRNOP00000099371   ⟸   ENSRNOT00000171722
Ensembl Acc Id: ENSRNOP00000112066   ⟸   ENSRNOT00000122184
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACS3-F1-model_v2 AlphaFold D4ACS3 1-491 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698233
Promoter ID:EPDNEW_R8758
Type:initiation region
Name:Mb21d2_1
Description:Mab-21 domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01175,434,226 - 75,434,286EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559643 AgrOrtholog
BioCyc Gene G2FUF-20961 BioCyc
Ensembl Genes ENSRNOG00000024040 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032569 ENTREZGENE
  ENSRNOT00000032569.7 UniProtKB/TrEMBL
  ENSRNOT00000122184.1 UniProtKB/TrEMBL
  ENSRNOT00000123556 ENTREZGENE
  ENSRNOT00000123556.1 UniProtKB/TrEMBL
  ENSRNOT00000124031.1 UniProtKB/TrEMBL
  ENSRNOT00000128452.1 UniProtKB/TrEMBL
  ENSRNOT00000137353.1 UniProtKB/TrEMBL
  ENSRNOT00000171722.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1410.40 UniProtKB/TrEMBL
  3.30.460.90 UniProtKB/TrEMBL
InterPro Mab-21-like_nuc_Trfase UniProtKB/TrEMBL
  Mab-21_dom UniProtKB/TrEMBL
  Mab-21_HhH/H2TH-like UniProtKB/TrEMBL
KEGG Report rno:498100 UniProtKB/TrEMBL
NCBI Gene 498100 ENTREZGENE
PANTHER CELL FATE DETERMINING PROTEIN MAB21-RELATED UniProtKB/TrEMBL
  PROTEIN MB21D2 UniProtKB/TrEMBL
Pfam Mab-21 UniProtKB/TrEMBL
  Mab-21_C UniProtKB/TrEMBL
PhenoGen Mb21d2 PhenoGen
RatGTEx ENSRNOG00000024040 RatGTEx
SMART Mab-21 UniProtKB/TrEMBL
UniProt A0ABK0L6R1_RAT UniProtKB/TrEMBL
  A0ABK0LM47_RAT UniProtKB/TrEMBL
  A0ABK0LPX6_RAT UniProtKB/TrEMBL
  A6JRX1 ENTREZGENE, UniProtKB/TrEMBL
  D4ACS3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-26 Mb21d2  Mab-21 domain containing 2  RGD1559643  similar to hypothetical protein A430031N04  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1559643  similar to hypothetical protein A430031N04   RGD1559643_predicted  similar to hypothetical protein A430031N04 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559643_predicted  similar to hypothetical protein A430031N04 (predicted)  LOC498100  similar to hypothetical protein A430031N04  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498100  similar to hypothetical protein A430031N04      Symbol and Name status set to provisional 70820 PROVISIONAL