Etv6 (ETS variant transcription factor 6) - Rat Genome Database

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Gene: Etv6 (ETS variant transcription factor 6) Rattus norvegicus
Analyze
Symbol: Etv6
Name: ETS variant transcription factor 6
RGD ID: 1559537
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Predicted to be involved in hematopoietic stem cell proliferation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including mesenchymal cell apoptotic process; regulation of DNA-templated transcription; and vitellogenesis. Predicted to be located in cytosol and nucleolus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and thrombocytopenia. Orthologous to human ETV6 (ETS variant transcription factor 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ets variant 6; ets variant gene 6 (TEL oncogene); LOC312777; MGC124677; similar to TEL protein; transcription factor ETV6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84168,580,405 - 168,819,817 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4168,580,138 - 168,819,802 (+)EnsemblGRCr8
mRatBN7.24166,849,031 - 167,085,211 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4166,847,686 - 167,084,992 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4173,142,448 - 173,378,418 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04168,925,517 - 169,161,489 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04167,551,450 - 167,787,271 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04167,754,684 - 167,992,370 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4167,754,525 - 167,992,168 (+)Ensemblrn6Rnor6.0
Rnor_5.04230,278,004 - 230,512,009 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44170,909,412 - 171,150,381 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4155,553,221 - 155,688,674 (+)NCBICelera
Cytogenetic Map4q43NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyltryptophan  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glycidyl methacrylate  (ISO)
GSK-J4  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indinavir  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
lead(0)  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylseleninic acid  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP,ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
saquinavir  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Deletions of CDKN1B and ETV6 in acute myeloid leukemia and myelodysplastic syndromes without cytogenetic evidence of 12p abnormalities. Andreasson P, etal., Genes Chromosomes Cancer. 1997 Jun;19(2):77-83.
2. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. Apperley JF, etal., N Engl J Med. 2002 Aug 15;347(7):481-7.
3. [Analysis and clinical significance of ETV6 rearrangement in myelodysplastic syndromes patients]. Ding BT, etal., Zhonghua Xue Ye Xue Za Zhi. 2007 Dec;28(12):804-7.
4. Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia. Ford AM, etal., Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4584-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Clonal eosinophils are a morphologic hallmark of ETV6/ABL1 positive acute myeloid leukemia. La Starza R, etal., Haematologica. 2002 Aug;87(8):789-94.
7. Identification of new translocations involving ETV6 in hematologic malignancies by fluorescence in situ hybridization and spectral karyotyping. Odero MD, etal., Genes Chromosomes Cancer. 2001 Jun;31(2):134-42.
8. A novel gene, MDS2, is fused to ETV6/TEL in a t(1;12)(p36.1;p13) in a patient with myelodysplastic syndrome. Odero MD, etal., Genes Chromosomes Cancer. 2002 Sep;35(1):11-9.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Peeters P, etal., Blood. 1997 Oct 1;90(7):2535-40.
11. Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders. Peeters P, etal., Cancer Res. 1997 Feb 15;57(4):564-9.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13). Yagasaki F, etal., Genes Chromosomes Cancer. 1999 Nov;26(3):192-202.
Additional References at PubMed
PMID:9018121   PMID:9250681   PMID:10514502   PMID:12527908   PMID:12588862   PMID:17606295   PMID:25581430  


Genomics

Comparative Map Data
Etv6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84168,580,405 - 168,819,817 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4168,580,138 - 168,819,802 (+)EnsemblGRCr8
mRatBN7.24166,849,031 - 167,085,211 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4166,847,686 - 167,084,992 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4173,142,448 - 173,378,418 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04168,925,517 - 169,161,489 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04167,551,450 - 167,787,271 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04167,754,684 - 167,992,370 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4167,754,525 - 167,992,168 (+)Ensemblrn6Rnor6.0
Rnor_5.04230,278,004 - 230,512,009 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44170,909,412 - 171,150,381 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4155,553,221 - 155,688,674 (+)NCBICelera
Cytogenetic Map4q43NCBI
ETV6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381211,649,674 - 11,895,377 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1211,649,623 - 11,895,386 (+)Ensemblhg38GRCh38
GRCh371211,802,608 - 12,048,311 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361211,694,055 - 11,939,603 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341211,694,054 - 11,939,590NCBI
Celera1216,945,067 - 17,191,403 (+)NCBICelera
Cytogenetic Map12p13.2NCBI
HuRef1211,670,991 - 11,813,778 (+)NCBIHuRef
CHM1_11211,768,106 - 12,013,345 (+)NCBICHM1_1
T2T-CHM13v2.01211,518,944 - 11,764,496 (+)NCBIT2T-CHM13v2.0
Etv6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396134,012,663 - 134,247,121 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6134,012,663 - 134,247,121 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386134,035,700 - 134,270,158 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6134,035,700 - 134,270,158 (+)Ensemblmm10GRCm38
MGSCv376133,985,725 - 134,220,176 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366134,001,400 - 134,235,851 (+)NCBIMGSCv36mm8
Celera6136,977,650 - 137,213,190 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map664.58NCBI
Etv6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554138,698,415 - 8,909,299 (+)Ensembl
ChiLan1.0NW_0049554138,698,412 - 8,912,011 (+)NCBIChiLan1.0ChiLan1.0
ETV6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21016,964,080 - 17,360,417 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11217,116,005 - 17,357,174 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01211,675,955 - 11,920,913 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11212,035,107 - 12,179,537 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,844,939 - 12,179,537 (+)EnsemblpanPan2panpan1.1
ETV6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12734,351,206 - 34,587,060 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2734,343,390 - 34,587,060 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2711,860,742 - 12,096,549 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02734,658,546 - 34,894,957 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2734,658,567 - 34,894,784 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12734,549,124 - 34,785,188 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02734,499,384 - 34,735,770 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02711,589,902 - 11,826,246 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Etv6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494595,600,416 - 95,729,629 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365875,330,665 - 5,457,264 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365875,328,467 - 5,457,260 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ETV6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl560,523,433 - 60,776,750 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1560,523,530 - 60,776,792 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2563,079,493 - 63,323,664 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ETV6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11111,567,522 - 11,812,292 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1111,567,632 - 11,811,716 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606923,507,501 - 23,755,706 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Etv6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475225,913,456 - 26,131,164 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475225,916,942 - 26,131,380 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Etv6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1615,177,337 - 15,411,906 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Etv6
887 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:47
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000007889
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
D4Mgh35  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24166,876,463 - 166,876,598 (+)MAPPERmRatBN7.2
Rnor_6.04167,783,922 - 167,784,056NCBIRnor6.0
Rnor_5.04230,305,621 - 230,305,755UniSTSRnor5.0
RGSC_v3.44170,937,387 - 170,937,522RGDRGSC3.4
RGSC_v3.44170,937,388 - 170,937,522UniSTSRGSC3.4
Celera4155,481,522 - 155,481,656UniSTS
RGSC_v3.14171,182,323 - 171,182,458RGD
Cytogenetic Map4q43UniSTS
RH136657  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24166,899,262 - 166,899,465 (+)MAPPERmRatBN7.2
Rnor_6.04167,807,984 - 167,808,186NCBIRnor6.0
Rnor_5.04230,327,963 - 230,328,165UniSTSRnor5.0
RGSC_v3.44170,960,345 - 170,960,547UniSTSRGSC3.4
Celera4155,504,319 - 155,504,521UniSTS
RH 3.4 Map41015.9UniSTS
Cytogenetic Map4q43UniSTS
BM387000  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24167,084,658 - 167,084,816 (+)MAPPERmRatBN7.2
Rnor_6.04167,991,884 - 167,992,041NCBIRnor6.0
Rnor_5.04230,511,674 - 230,511,831UniSTSRnor5.0
RGSC_v3.44171,150,046 - 171,150,203UniSTSRGSC3.4
Celera4155,688,339 - 155,688,496UniSTS
RH 3.4 Map41014.1UniSTS
Cytogenetic Map4q43UniSTS
AU049044  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24166,878,412 - 166,878,562 (+)MAPPERmRatBN7.2
Rnor_6.04167,785,871 - 167,786,020NCBIRnor6.0
Rnor_5.04230,307,570 - 230,307,719UniSTSRnor5.0
RGSC_v3.44170,939,337 - 170,939,486UniSTSRGSC3.4
Celera4155,483,471 - 155,483,620UniSTS
Cytogenetic Map4q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 173 91 90 59 93 59 6 360 193 11 159 84 92 31 23 23

Sequence


Ensembl Acc Id: ENSRNOT00000007889   ⟹   ENSRNOP00000007889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4166,847,686 - 167,084,992 (+)Ensembl
Rnor_6.0 Ensembl4167,754,525 - 167,992,168 (+)Ensembl
RefSeq Acc Id: NM_001037353   ⟹   NP_001032430
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84168,580,405 - 168,816,374 (+)NCBI
mRatBN7.24166,849,031 - 167,084,994 (+)NCBI
Rnor_6.04167,754,684 - 167,992,219 (+)NCBI
Rnor_5.04230,278,004 - 230,512,009 (+)NCBI
RGSC_v3.44170,909,412 - 171,150,381 (+)RGD
Celera4155,553,221 - 155,688,674 (+)RGD
Sequence:
RefSeq Acc Id: XM_039107692   ⟹   XP_038963620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84168,580,470 - 168,819,817 (+)NCBI
mRatBN7.24166,849,091 - 167,085,211 (+)NCBI
RefSeq Acc Id: XM_039107693   ⟹   XP_038963621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84168,780,362 - 168,819,817 (+)NCBI
mRatBN7.24167,056,593 - 167,085,211 (+)NCBI
RefSeq Acc Id: NP_001032430   ⟸   NM_001037353
- UniProtKB: Q3KRD1 (UniProtKB/TrEMBL),   F7FKU1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007889   ⟸   ENSRNOT00000007889
RefSeq Acc Id: XP_038963620   ⟸   XM_039107692
- Peptide Label: isoform X1
- UniProtKB: F7FKU1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963621   ⟸   XM_039107693
- Peptide Label: isoform X2
Protein Domains
ETS   PNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3KRD1-F1-model_v2 AlphaFold Q3KRD1 1-453 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693448
Promoter ID:EPDNEW_R3972
Type:initiation region
Name:Etv6_1
Description:ets variant 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04167,754,477 - 167,754,537EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559537 AgrOrtholog
BioCyc Gene G2FUF-42666 BioCyc
Ensembl Genes ENSRNOG00000005984 Ensembl
  ENSRNOG00000064991 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007889 ENTREZGENE
  ENSRNOT00000007889.7 UniProtKB/TrEMBL
  ENSRNOT00000114632.2 UniProtKB/TrEMBL
  ENSRNOT00000148801 ENTREZGENE
  ENSRNOT00000148801.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.150.50 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7930490 IMAGE-MGC_LOAD
InterPro Ets UniProtKB/TrEMBL
  ETS_fam UniProtKB/TrEMBL
  SAM_PNT UniProtKB/TrEMBL
  SAM_type UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:312777 UniProtKB/TrEMBL
MGC_CLONE MGC:124677 IMAGE-MGC_LOAD
NCBI Gene 312777 ENTREZGENE
PANTHER PTHR11849 UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR ETV6 UniProtKB/TrEMBL
Pfam Ets UniProtKB/TrEMBL
  SAM_PNT UniProtKB/TrEMBL
PharmGKB ETV6 RGD
PhenoGen Etv6 PhenoGen
PRINTS ETSDOMAIN UniProtKB/TrEMBL
PROSITE ETS_DOMAIN_2 UniProtKB/TrEMBL
  ETS_DOMAIN_3 UniProtKB/TrEMBL
  PNT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005984 RatGTEx
  ENSRNOG00000064991 RatGTEx
SMART ETS UniProtKB/TrEMBL
  SAM_PNT UniProtKB/TrEMBL
Superfamily-SCOP SAM_homology UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A0ABK0L1S7_RAT UniProtKB/TrEMBL
  F7FKU1 ENTREZGENE, UniProtKB/TrEMBL
  Q3KRD1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Etv6  ETS variant transcription factor 6  Etv6  ets variant 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Etv6  ets variant 6  Etv6  ets variant gene 6 (TEL oncogene)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-09-08 Etv6  ets variant gene 6 (TEL oncogene)  LOC312777  similar to TEL protein  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-02-09 LOC312777  similar to TEL protein      Symbol and Name status set to provisional 70820 PROVISIONAL