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Gene: Sufu (SUFU negative regulator of hedgehog signaling) Rattus norvegicus

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Symbol:

Sufu

Name:

SUFU negative regulator of hedgehog signaling

RGD ID:

1559462

Description:

Predicted to enable beta-catenin binding activity; protein kinase binding activity; and protein sequestering activity. Involved in positive regulation of cellular response to drug and spermatid development. Predicted to be located in cilium. Predicted to be part of GLI-SUFU complex. Predicted to be active in cytoplasm and nucleus. Used to study medulloblastoma. Biomarker of brain glioblastoma multiforme and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome 2. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling); PARTICIPATES IN Hedgehog signaling pathway; basal cell carcinoma pathway; INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

suppressor of fused; suppressor of fused homolog; suppressor of fused homolog (Drosophila)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	255,199,108 - 255,296,983 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	255,199,164 - 255,296,981 (+)	Ensembl				GRCr8
mRatBN7.2	1	245,257,725 - 245,355,576 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	245,257,768 - 245,355,577 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	253,379,193 - 253,479,376 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	260,073,830 - 260,172,100 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	252,725,633 - 252,823,412 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	266,143,766 - 266,241,742 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	266,143,818 - 266,239,016 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	273,574,697 - 273,672,663 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	251,612,377 - 251,708,109 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	241,040,495 - 241,135,358 (+)	NCBI		Celera
Cytogenetic Map	1	q54	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

B-lymphoblastic leukemia/lymphoma (ISO)

basal cell carcinoma (ISO)

brain glioblastoma multiforme (IEP)

congenital fibrosarcoma (ISO)

craniopharyngioma (ISO)

familial meningioma (ISO)

gastrointestinal stromal tumor (ISO)

Hereditary Neoplastic Syndromes (ISO)

holoprosencephaly (ISO)

Joubert syndrome 32 (ISO)

medulloblastoma (IGI,ISO)

meningioma (ISO)

Neurodevelopmental Disorders (ISO)

nevoid basal cell carcinoma syndrome (ISO,ISS)

nevoid basal cell carcinoma syndrome 1 (ISO)

nevoid basal cell carcinoma syndrome 2 (ISO)

ocular motor apraxia, Cogan type (ISO)

pre-malignant neoplasm (IEP)

prostate cancer (ISO)

Somatic Meningioma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile (EXP)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

3-phenylprop-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

amphetamine (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

citalopram (EXP)

copper(II) sulfate (ISO)

coumarin (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

escitalopram (EXP)

ethanol (ISO)

hydralazine (ISO)

iron dichloride (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (EXP)

nitrates (ISO)

oroxylin A (EXP)

ozone (ISO)

paracetamol (EXP)

pirinixic acid (ISO)

potassium dichromate (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

sodium arsenite (ISO)

sonidegib (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

vismodegib (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aorta development (ISO)

coronary vasculature development (ISO)

determination of left/right symmetry (ISO)

heart looping (ISO)

maintenance of protein localization in organelle (ISO)

negative regulation of smoothened signaling pathway (IBA,IEA,ISO)

negative regulation of transcription by RNA polymerase II (ISO)

negative regulation of ubiquitin-dependent protein catabolic process (ISO)

neural tube closure (ISO)

positive regulation of cellular response to drug (IEP)

regulation of DNA-templated transcription (IEA,ISO)

skin development (ISO)

smoothened signaling pathway (ISO)

spermatid development (IEP)

spinal cord dorsal/ventral patterning (ISO)

ventricular septum development (ISO)

Cellular Component

cilium (IEA,ISO)

cytoplasm (IBA,IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

beta-catenin binding (IEA,ISO)

protein binding (ISO)

protein kinase binding (IEA,ISO)

protein sequestering activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

basal cell carcinoma pathway (IEA)

Hedgehog signaling pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Dynamic changes of Sonic Hedgehog signaling pathway in gastric mucosa of rats with MNNG-induced gastric precancerous lesions.	Cai D, etal., J Cell Physiol. 2019 Jul;234(7):10827-10834. doi: 10.1002/jcp.27908. Epub 2018 Dec 7.
2.	SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation.	Ding X, etal., J Exp Clin Cancer Res. 2019 Sep 13;38(1):404. doi: 10.1186/s13046-019-1411-9.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Impact of surgeon laparoscopic training and case volume of laparoscopic surgery on conversion during elective laparoscopic colorectal surgery.	Massarotti H, etal., Colorectal Dis. 2017 Jan;19(1):76-85. doi: 10.1111/codi.13402.
5.	Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.	Mimeault M and Batra SK, Pharmacol Rev. 2010 Sep;62(3):497-524.
6.	Hedgehog signalling promotes germ cell survival in the rat testis.	Mäkelä JA, etal., Reproduction. 2011 Nov;142(5):711-21. doi: 10.1530/REP-11-0110. Epub 2011 Sep 5.
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Comprehensive gene review and curation	RGD comprehensive gene curation
13.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14.	Mutations in SUFU predispose to medulloblastoma.	Taylor MD, etal., Nat Genet. 2002 Jul;31(3):306-10. Epub 2002 Jun 17.
15.	Oroxylin A increases the sensitivity of temozolomide on glioma cells by hypoxia-inducible factor 1α/hedgehog pathway under hypoxia.	Wei M, etal., J Cell Physiol. 2019 Aug;234(10):17392-17404. doi: 10.1002/jcp.28361. Epub 2019 Feb 20.

Additional References at PubMed

PMID:10531011	PMID:10564661	PMID:10806483	PMID:11477086	PMID:16155214	PMID:16254602	PMID:16316410	PMID:16459298	PMID:18488998	PMID:19684112	PMID:20360384	PMID:20643644
PMID:21209331	PMID:21543335	PMID:25807483	PMID:27234298	PMID:28965847	PMID:29487109	PMID:30342851

Genomics

Comparative Map Data

Sufu
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	255,199,108 - 255,296,983 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	255,199,164 - 255,296,981 (+)	Ensembl				GRCr8
mRatBN7.2	1	245,257,725 - 245,355,576 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	245,257,768 - 245,355,577 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	253,379,193 - 253,479,376 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	260,073,830 - 260,172,100 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	252,725,633 - 252,823,412 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	266,143,766 - 266,241,742 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	266,143,818 - 266,239,016 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	273,574,697 - 273,672,663 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	251,612,377 - 251,708,109 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	241,040,495 - 241,135,358 (+)	NCBI		Celera
Cytogenetic Map	1	q54	NCBI

SUFU
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	102,502,819 - 102,633,535 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	102,503,952 - 102,633,535 (+)	Ensembl			hg38	GRCh38
GRCh37	10	104,263,729 - 104,393,292 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	104,253,754 - 104,383,199 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	104,253,753 - 104,383,199	NCBI
Celera	10	98,004,628 - 98,134,149 (+)	NCBI		Celera
Cytogenetic Map	10	q24.32	NCBI
HuRef	10	97,897,496 - 98,026,978 (+)	NCBI		HuRef
CHM1_1	10	104,547,179 - 104,677,032 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	103,387,806 - 103,518,575 (+)	NCBI		T2T-CHM13v2.0

Sufu
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	46,385,335 - 46,477,243 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	46,385,335 - 46,477,243 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	46,396,896 - 46,488,804 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	46,396,896 - 46,488,804 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	46,471,408 - 46,561,150 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	46,450,229 - 46,539,971 (+)	NCBI		MGSCv36	mm8
Celera	19	47,160,488 - 47,250,442 (+)	NCBI		Celera
Cytogenetic Map	19	C3	NCBI
cM Map	19	38.85	NCBI

Sufu
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955485	7,808,131 - 7,925,677 (-)	Ensembl
ChiLan1.0	NW_004955485	7,805,244 - 7,925,414 (-)	NCBI	ChiLan1.0	ChiLan1.0

SUFU
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	114,389,841 - 114,515,759 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	114,395,163 - 114,521,085 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	99,107,516 - 99,231,761 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	102,571,886 - 102,696,472 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	102,571,886 - 102,696,472 (+)	Ensembl			panPan2	panpan1.1

SUFU
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	14,992,989 - 15,115,499 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	14,992,618 - 15,112,389 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	15,165,295 - 15,287,811 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	15,467,025 - 15,589,735 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	15,466,996 - 15,589,728 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	15,011,961 - 15,134,129 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	15,051,335 - 15,173,877 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	15,183,706 - 15,305,945 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sufu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	31,665,075 - 31,778,513 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936600	3,268,260 - 3,381,781 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936600	3,270,662 - 3,381,722 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SUFU
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	113,500,842 - 113,626,003 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	113,500,001 - 113,628,064 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	123,356,101 - 123,481,988 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SUFU
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	95,532,228 - 95,660,594 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	95,532,242 - 95,657,290 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	56,639,722 - 56,772,532 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sufu
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624831	1,882,077 - 2,012,341 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624831	1,882,114 - 2,012,341 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sufu
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	45,856,918 - 45,952,094 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sufu
563 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	108
Count of miRNA genes:	92
Interacting mature miRNAs:	100
Transcripts:	ENSRNOT00000026987
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	160111531	262090437	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	266453731	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	186658830	266453731	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	210980612	255980612	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	226175591	270518180	Rat
1578775	Iddm21	Insulin dependent diabetes mellitus QTL 21	4.13		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	245782829	270518180	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	205233991	267096252	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	218829748	263829748	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	186658830	266453731	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
631837	Niddm35	Non-insulin dependent diabetes mellitus QTL 35		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	248619887	269633915	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
631836	Stl31	Serum triglyceride level QTL 31	4.64	5e-06	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	247133834	270518180	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	210980612	255980612	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	160111531	262090437	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	237995023	269633915	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	233480549	270108840	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	200449456	256003563	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	234540191	270518180	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	233480549	270108840	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	210980612	255980612	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	223134011	262090599	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	210980612	255980612	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	160111426	262090599	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	225108840	270108840	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	228180370	266453608	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	154961463	266453731	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	224633915	269633915	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	232312773	270518180	Rat
2316896	Gluco57	Glucose level QTL 57	7.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	238398865	255849249	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	212738576	257738576	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	194786607	262083703	Rat
61400	Niddm1	Non-insulin dependent diabetes mellitus QTL 1	11		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	228180243	255849249	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	210980612	255980612	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	210980612	255980612	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	233204160	270518180	Rat
1581544	Rf52	Renal function QTL 52		0.05	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	1	241569529	269633915	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	210980612	255980612	Rat
631536	Lnnr2	Liver neoplastic nodule remodeling QTL 2	2.9	0.0005	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	1	243953669	270518180	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	226175591	270518180	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	233349180	270518180	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	210980612	255980612	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	228174566	270518180	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001024899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001439944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006231546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC097694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026987 ⟹ ENSRNOP00000026987

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	255,199,164 - 255,283,813 (+)	Ensembl
mRatBN7.2 Ensembl	1	245,257,768 - 245,342,406 (+)	Ensembl
Rnor_6.0 Ensembl	1	266,143,818 - 266,239,016 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095114 ⟹ ENSRNOP00000087532

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	255,199,164 - 255,296,981 (+)	Ensembl
mRatBN7.2 Ensembl	1	245,257,824 - 245,355,577 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106973 ⟹ ENSRNOP00000079470

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	255,199,359 - 255,262,263 (+)	Ensembl
mRatBN7.2 Ensembl	1	245,257,943 - 245,321,073 (+)	Ensembl

RefSeq Acc Id:

NM_001024899 ⟹ NP_001020070

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	255,199,189 - 255,294,258 (+)	NCBI
mRatBN7.2	1	245,257,773 - 245,352,851 (+)	NCBI
Rnor_6.0	1	266,143,818 - 266,239,017 (+)	NCBI
Rnor_5.0	1	273,574,697 - 273,672,663 (+)	NCBI
RGSC_v3.4	1	251,612,377 - 251,708,109 (+)	RGD
Celera	1	241,040,495 - 241,135,358 (+)	RGD

Sequence:

show sequence

CTTGAAGGCTCCGACTTGGGCGGACGGAGCCTCGTGCGCAGGCGCGGAGTTAGACCTCGCCGTA
GCCCCCATCGCCTCGGGGACTCTTCATCCACAGTGGGTCCGCTGGCCCATAGGGGCGCTTTCCC
TCCTCTACCCTCCCGGGTTCCCCGCGCGCCCTACGCGCCCCAATGGCGGAGCTGAGGCCTAGCG
TCGCCCCCGGCCCCGCCGCGCCCCCGGCCTCTGGCCCTAGTGCCCCCCCGGCCTTTGCTTCACT
CTTTCCCCCGGGACTCCACGCCATCTACGGAGAGTGCCGCCGCCTCTACCCTGACCAGCCGAAC
CCGCTCCAGGTTACCGCTATCGTCAAGTACTGGTTGGGTGGTCCAGACCCCTTGGATTATGTAA
GCATGTACAGGAATATGGGGAGTCCTTCTGCCAACATCCCTGAGCACTGGCACTACATCAGCTT
TGGCCTGAGTGATCTCTACGGTGACAACAGAGTCCACGAGTTTACAGGAACAGACGGACCAAGT
GGATTTGGCTTTGAATTGACATTTCGTCTGAAGAGAGAAACTGGGGAGTCTGCCCCACCAACAT
GGCCAGCAGAGCTGATGCAGGGCCTAGCCCGATATGTCTTCCAGTCAGAGAATACCTTCTGTAG
TGGGGACCACGTGTCTTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTG
CTGACGGAGGACCCACAGATGCAGCCTGTGCAGACACCCTTTGGGGTAGTTACTTTCCTCCAGA
TTGTTGGTGTCTGCACTGAGGAGTTACACTCAGCCCAGCAGTGGAATGGGCAGGGCATCCTGGA
GCTGCTGCGGACAGTGCCCATTGCTGGCGGTCCCTGGCTGATAACTGACATGCGGAGGGGAGAA
ACCATATTCGAGATCGATCCACACCTGCAACAGGAGAGAGTTGACAAAGGCATCGAGACAGACG
GTTCTAACCTGAGCGGTGTCAGTGCCAAGTGTGCCTGGGATGACCTCAGCCGGCCTCCGGAGGA
CGATGAGGATAGCCGGAGCATCTGCCTCGGCACGCAGCCTCGAAGGCTGTCTGGCAAAGACACA
GAGCAGATCCGGGAGACCCTGAGGCGAGGACTGGAGATTAACAGCAAACCTGTCCTTCCACCAA
TCAATTCTCAAAGGCAGAATGGCCTCACCTACGACCGAGCCCCGAGCCGTAAGGACAGCTTGGG
CAGTGACATCTCCACGGCTGTTATCCCCCACGAGCTGATCCGCACACGGCAGCTCGAAAGCGTG
CATCTGAAATTTAACCAGGAGTCGGGAGCCCTCATCCCCCTCTGCCTAAGGGGCAGACTCCTGC
ATGGCCGGCACTTCACCTACAAGAGTATCACAGGTGACATGGCCATCACGTTTGTGTCCACCGG
AGTGGAAGGCGCCTTTGCCACTGAGGAACATCCTTACGCAGCTCACGGACCCTGGTTACAAATT
CTGTTGACAGAAGAGTTTGTAGAGAAAATGTTGGAGGACTTAGAAGATCTAACTTCTCCAGAGG
AATTTAAACTTCCCAAAGAGTACAGCTGGCCTGAAAAGAAGCTCAAAGTGTCCATCCTCCCCGA
CGTGGTGTTCGACAGTCCGCTGCACTAGCCTGAGCTAGGCCCTGCAGGGGCCAAGAGGAGCCCA
GCTGCTCCTAGTGACTTCCAGTGTGGCAGCTTGTAAAGGAGACACCCATGAATAAAAGGGCAAA
TGTGAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006231546 ⟹ XP_006231608

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	255,199,108 - 255,296,983 (+)	NCBI
mRatBN7.2	1	245,257,725 - 245,355,576 (+)	NCBI
Rnor_6.0	1	266,143,766 - 266,241,742 (+)	NCBI
Rnor_5.0	1	273,574,697 - 273,672,663 (+)	NCBI

Sequence:

show sequence

CGCCCCACCCTCTGGAGCTCCCCGCGGTCCCACAGCATCCTCTGGCCGACGTCTTGAAGGCTCC
GACTTGGGCGGACGGAGCCTCGTGCGCAGGCGCGGAGTTAGACCTCGCCGTAGCCCCCATCGCC
TCGGGGACTCTTCATCCACAGTGGGTCCGCTGGCCCATAGGGGCGCTTTCCCTCCTCTACCCTC
CCGGGTTCCCCGCGCGCCCTACGCGCCCCAATGGCGGAGCTGAGGCCTAGCGTCGCCCCCGGCC
CCGCCGCGCCCCCGGCCTCTGGCCCTAGTGCCCCCCCGGCCTTTGCTTCACTCTTTCCCCCGGG
ACTCCACGCCATCTACGGAGAGTGCCGCCGCCTCTACCCTGACCAGCCGAACCCGCTCCAGGTT
ACCGCTATCGTCAAGTACTGGTTGGGTGGTCCAGACCCCTTGGATTATGTAAGCATGTACAGGA
ATATGGGGAGTCCTTCTGCCAACATCCCTGAGCACTGGCACTACATCAGCTTTGGCCTGAGTGA
TCTCTACGGTGACAACAGAGTCCACGAGTTTACAGGAACAGACGGACCAAGTGGATTTGGCTTT
GAATTGACATTTCGTCTGAAGAGAGAAACTGGGGAGTCTGCCCCACCAACATGGCCAGCAGAGC
TGATGCAGGGCCTAGCCCGATATGTCTTCCAGTCAGAGAATACCTTCTGTAGTGGGGACCACGT
GTCTTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACGGAGGAC
CCACAGATGCAGCCTGTGCAGACACCCTTTGGGGTAGTTACTTTCCTCCAGATTGTTGGTGTCT
GCACTGAGGAGTTACACTCAGCCCAGCAGTGGAATGGGCAGGGCATCCTGGAGCTGCTGCGGAC
AGTGCCCATTGCTGGCGGTCCCTGGCTGATAACTGACATGCGGAGGGGAGAAACCATATTCGAG
ATCGATCCACACCTGCAAGAGAGAGTTGACAAAGGCATCGAGACAGACGGTTCTAACCTGAGCG
GTGTCAGTGCCAAGTGTGCCTGGGATGACCTCAGCCGGCCTCCGGAGGACGATGAGGATAGCCG
GAGCATCTGCCTCGGCACGCAGCCTCGAAGGCTGTCTGGCAAAGACACAGAGCAGATCCGGGAG
ACCCTGAGGCGAGGACTGGAGATTAACAGCAAACCTGTCCTTCCACCAATCAATTCTCAAAGGC
AGAATGGCCTCACCTACGACCGAGCCCCGAGCCGTAAGGACAGCTTGGGCAGTGACATCTCCAC
GGCTGTTATCCCCCACGAGCTGATCCGCACACGGCAGCTCGAAAGCGTGCATCTGAAATTTAAC
CAGGAGTCGGGAGCCCTCATCCCCCTCTGCCTAAGGGGCAGACTCCTGCATGGCCGGCACTTCA
CCTACAAGAGTATCACAGGTGACATGGCCATCACGTTTGTGTCCACCGGAGTGGAAGGCGCCTT
TGCCACTGAGGAACATCCTTACGCAGCTCACGGACCCTGGTTACAAATTCTGTTGACAGAAGAG
TTTGTAGAGAAAATGTTGGAGGACTTAGAAGATCTAACTTCTCCAGAGGAATTTAAACTTCCCA
AAGAGTACAGCTGGCCTGAAAAGAAGCTCAAAGTGTCCATCCTCCCCGACGTGGTGTTCGACAG
TCCGCTGCACTAGCCTGAGCTAGGCCCTGCAGGGGCCAAGAGGAGCCCAGCTGCTCCTAGTGAC
TTCCAGTGTGGCAGCTTGTAAAGGAGACACCCATGAATAAAAGGGCAAATGTGAGGGATGACTG
CAAAGTACCACACCCATCACAGGCCCCGCCCACCTCGGGCTCAGCGGGGCCTCACTCCTAGCAA
CCAAGCCCATGTGACCAGGCCCCTGTCCTACGTGTCAGTGAGTGAGTAAGGGTGCACCTGCAGA
CCCTCCCCACACACCCGCTGATGCCCCAGGTTTCACTGATGCGCTCCTGGGATAAGACATCATA
CAGCCTGGTGTGCAGAATGCACATGAGGACACTGCCTGATCAGCCCCAGTGAGCTTCTCAGGCT
GCTCCACCCTGCGGAACCGTTGCTTTTTCTTTCCTGAGAATGTTGTGGAAACCGGATGGTATTT
TTATTGCTCAGCAAAGATGGTTCAGAAGCCATGTATATAGTGATTTTTAAACAGGACTTATTTC
TAGATGAACTTTATTGTTCTCTTAGACAAGGGTTTGGGGGCTCTGCCCCCCCCATCCCACATAC
CCTCTTCCTAAAAAGATGCTTGGTGCTGCCTGTCTGCTCTGGACCCTGGAGAAGGCTGGGGACA
GCTGACATACTCCATGTAGACCTGGGTATAGATTTGCTGTGGCCTGGAAGGTGTGCCACTGCCT
TCCAAGTGAAGTAGGCTTCTACAAGACTCTGGGGACTTGAGGGACTCAAGGACATGGTGGCCCT
AGCTATGTCTTCCAGTCTTTCTTACCCAGCCAGGCCTCCCAAGAAGAGGGTAAAGCCCACTGCC
TCCCCATCCTGCTCAGGGCCCCCAGCGCTTTGATCCCCCCTTCCCTTGAGTCCCAGCGCCCACG
CTGTCTAGCTTATGTCCTTTCATTTTGCTGACACTGCTCCCTGTGGCCCTTCATCTTTCCCACA
TCCATTCTGTACCTGTCTTCTATCACTGTCTCTTCCTGCAGCCTGGCCCTCTTGTGGGTTCCCT
GCTCTCACTCCCAGGACTGCAGATCTGCTTGCCTTCCAGGGACATTTGGGAGCTGTGTAGGAGA
GATCTCCCTCTTCTGAACTGGAACTGGCAAGCCCCTTCCAGCATTCTTGCCTGCCTCTAGATCA
GGGTGGATGGGGATGGTCTTCGTTCATTCTTTAAATTCAAATGTCTCCAAGGAAAGATATGTTA
TCTGCCAGGGGCCCTGCAGGAGCTCCCCTGCTCTGGCTGCCTCTACCCACCACCTACAACGGGT
GCCTCTAGGGGCCTTGTGAATCCTGTCTGGGGTCTCAAAGAAGCAGAAATTGGCCTTTGAAGGA
ATGGCTCCATCTGGCCTCATCTGCATATCCTAGGTCTAAGCTTAACCAGCACTTAGAGGCAGAC
CCATCAGGAGCATCTGAGAGAGGCTGGCTGCAGACCCTAACCAGCCAATCAATATAGATGCCTG
TCTGGAACAGACACCATACCGCCCTGGGACTTTTCCACAAGGACATTTCAAACCCTACCTTTAA
AGCTCTTGTCTTCTGAAAGTTTATGGGCCAAGAAATGCTATCAGCACAGCCTATGTTCCTTGCC
ATCACCAGTGTGGTAATAGTACTCCCTCCCTAATTCTCTCCGGAGACCTGCCTCAGGGCCCCTT
CTGCATTCTCCCCTATCTCCATTTGTCTGGCTTTGGGGCAAGAATGCATGCTATGAGCATCACG
TAGTTTATGTTAGTACTGTGGTCAACAACTTGCCCTTATTCTGTGAGATCTTTGCAGACAGGTG
GTTGCCACCACCTGCTTGGGTGGCTCCATACTTGGGGAGCAGGGACTGGCAGGTAGGCTCCAGA
TGTCCATAGGTCCTGAGGTCTTTCCTCCCCCTGCCCTGTCAGGCACCTCAGGAATGTCTAAAAT
CCTGCTGGGTCCAGACCCCCATCACTCCTGTAGTGGCTGATCTCAGCCTGGTCTGACCAGGTCT
CCTTTCCCTCGGGCTCTGGTTTCTTCCAGAGGAATCTCAGGGAAAGAGGTTCACCATTAAACTG
CTGGCTGGGAAGAGACCCTAACATCGGATTAAGCAAGACTGGCCTTACCAAGACATGTGATGGG
TGCTCTGTAGAGGGACCCTTTCTTTCCCTCCCCGAACCAGCTCTTTGGGGTTGTTAATCCGTCA
TGGGGAGGGGTTCAGGAGTCTTCCTCCCTGACTCTACATTTCCCCACCCTTCAACCTTCCAAGT
CCACAGGACCAGAGATTCTGAAAGGAAGGGACTTCAACTTCCTGTAACTCAAGCTTCCGGGGCC
TGTGTGGACTGCAGAGGGTGGCTGTGCCAGCTGCCGTGCTAAGGAAGCACGGTACTCCTTTTCC
AAGTGAGACACTCCAACAGGGCTTGTAGAAGCTGTGGGAGTGAGTCTAAAGGGCGAGGGCATGT
ACACTGCAGACCCTGGGTCCTGGGACTGAGTCTTGAGATTGATAGCAGGGAGAGAACATGAAGC
TTGGTGCCCCTATGGGGCAGATCAGAAAACTCCCTGAACTGTATTTTTTTAACCTGGTCTTCCC
TCTCTGGCTTCCATGATGTTGGTGCCAGGTGAGGTGTCTGGGTCCCTGTTACAAGTCAGGAACC
CTGTTGGGAGACCCGCTTTTGTACAAAGATCTGAATGCTGCAATGAACAGACTTTTGTACATTT
TTATATCAGTTTTTAATGTCAGTGGCGACTCAGTTCCTGGGGCTACAGCTGGCTCAGGATTTTT
GTAAGAAATTTTGAGTGACTCACTTAGATTTTGTTCCCACTTGTCCCTCTTCCTCTGTGTAATC
TAAGTGCATTAAACATATCTGCAGGAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001020070	(Get FASTA)	NCBI Sequence Viewer
	NP_001426873	(Get FASTA)	NCBI Sequence Viewer
	XP_006231608	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97447	(Get FASTA)	NCBI Sequence Viewer
	EDL94350	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026987
	ENSRNOP00000026987.5
	ENSRNOP00000079470.1
	ENSRNOP00000087532
	ENSRNOP00000087532.2

RefSeq Acc Id:

NP_001020070 ⟸ NM_001024899

- UniProtKB:

Q4V8C6 (UniProtKB/TrEMBL), A0A8I6A606 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAELRPSVAPGPAAPPASGPSAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGG
PDPLDYVSMYRNMGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRET
GESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPF
GVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQQERV
DKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICLGTQPRRLSGKDTEQIRETLRRGLEIN
SKPVLPPINSQRQNGLTYDRAPSRKDSLGSDISTAVIPHELIRTRQLESVHLKFNQESGALIPL
CLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDL
EDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH

hide sequence

RefSeq Acc Id:

XP_006231608 ⟸ XM_006231546

- Peptide Label:

isoform X1

- Sequence:

show sequence

MAELRPSVAPGPAAPPASGPSAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGG
PDPLDYVSMYRNMGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRET
GESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPF
GVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVD
KGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICLGTQPRRLSGKDTEQIRETLRRGLEINS
KPVLPPINSQRQNGLTYDRAPSRKDSLGSDISTAVIPHELIRTRQLESVHLKFNQESGALIPLC
LRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLEDLE
DLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSPLH

hide sequence

Ensembl Acc Id:

ENSRNOP00000026987 ⟸ ENSRNOT00000026987

Ensembl Acc Id:

ENSRNOP00000087532 ⟸ ENSRNOT00000095114

Ensembl Acc Id:

ENSRNOP00000079470 ⟸ ENSRNOT00000106973

Protein Domains

Suppressor of fused C-terminal Suppressor of fused-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4V8C6-F1-model_v2	AlphaFold	Q4V8C6	1-485	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690965

Promoter ID:

EPDNEW_R1490

Type:

initiation region

Name:

Sufu_1

Description:

SUFU negative regulator of hedgehog signaling

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	266,143,810 - 266,143,870	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1559462	AgrOrtholog
BioCyc Gene	G2FUF-55508	BioCyc
Ensembl Genes	ENSRNOG00000019807	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026987	ENTREZGENE
	ENSRNOT00000026987.7	UniProtKB/TrEMBL
	ENSRNOT00000095114	ENTREZGENE
	ENSRNOT00000095114.2	UniProtKB/TrEMBL
	ENSRNOT00000106973.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1360.230	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7456556	IMAGE-MGC_LOAD
InterPro	SUFU-like	UniProtKB/TrEMBL
	SUFU_C	UniProtKB/TrEMBL
	SUFU_C_sf	UniProtKB/TrEMBL
	SUFU_domain	UniProtKB/TrEMBL
	SUFU_N	UniProtKB/TrEMBL
	Suppressor_of_fused_protein	UniProtKB/TrEMBL
KEGG Report	rno:361769	UniProtKB/TrEMBL
MGC_CLONE	MGC:114507	IMAGE-MGC_LOAD
NCBI Gene	361769	ENTREZGENE
PANTHER	PTHR10928	UniProtKB/TrEMBL
	SUPPRESSOR OF FUSED HOMOLOG	UniProtKB/TrEMBL
Pfam	SUFU	UniProtKB/TrEMBL
	SUFU_C	UniProtKB/TrEMBL
PhenoGen	Sufu	PhenoGen
PIRSF	Suppressor_of_fused_protein	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019807	RatGTEx
Superfamily-SCOP	SSF103359	UniProtKB/TrEMBL
UniProt	A0A8I5ZN76_RAT	UniProtKB/TrEMBL
	A0A8I6A606	ENTREZGENE, UniProtKB/TrEMBL
	F7FL48_RAT	UniProtKB/TrEMBL
	Q4V8C6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-21	Sufu	SUFU negative regulator of hedgehog signaling	Sufu	suppressor of fused homolog (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Sufu	suppressor of fused homolog (Drosophila)	Sufu	suppressor of fused	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	Sufu	suppressor of fused			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)