Spi1 (Spi-1 proto-oncogene) - Rat Genome Database

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Gene: Spi1 (Spi-1 proto-oncogene) Rattus norvegicus
Analyze
Symbol: Spi1
Name: Spi-1 proto-oncogene
RGD ID: 1359607
Description: Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in cellular response to ethanol; osteoclast differentiation; and regulation of DNA-templated transcription. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Used to study alcohol use disorder. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in agammaglobulinemia 10. Orthologous to human SPI1 (Spi-1 proto-oncogene); PARTICIPATES IN DNA modification pathway; interleukin-4 signaling pathway; acute myeloid leukemia pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hematopoietic transcription factor PU.1; LOC103691845; Pu.1; SFFV proviral integration 1; Sfpi1; spleen focus forming virus (SFFV) proviral integration oncogene; spleen focus forming virus (SFFV) proviral integration oncogene spi1; spleen focus forming virus proviral integration oncogene spi1; transcription factor PU.1; uncharacterized LOC103691845
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,529,509 - 97,548,204 (+)NCBIGRCr8
mRatBN7.2377,059,744 - 77,093,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,073,012 - 77,092,393 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,552,207 - 80,570,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,151,217 - 89,169,847 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,002,389 - 87,021,093 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,918,127 - 79,937,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,918,969 - 79,938,301 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,627,684 - 86,646,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,456,353 - 75,475,722 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,352,724 - 75,372,093 (+)NCBI
Celera376,282,068 - 76,300,680 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
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Original Reference(s)
Spi1Ratalcohol use disorder treatmentIDA 9586725 RGD 
Spi1Ratalcohol use disorder  IEP 9586723protein:decreased expression:alveolar macrophageRGD 
Spi1RatBrain Hypoxia-Ischemia  IEP 9586724protein:increased expression:CA1 field of hippocampusRGD 
Spi1RatTransplant Rejection treatmentIMP 9586451 RGD 
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Spi1Ratagammaglobulinemia 10  ISOSPI1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:33951726
Spi1Ratcongenital disorder of glycosylation type IIc  ISOSPI1 (Homo sapiens)8554872ClinVar Annotator: match by term: Rambam Hasharon syndromeClinVarPMID:16455955 more ...
Spi1Ratfetal akinesia deformation sequence syndrome 1  ISOSPI1 (Homo sapiens)8554872ClinVar Annotator: match by term: Fetal akinesia deformation sequence 1ClinVarPMID:17686188 and PMID:28492532
Spi1Rathypertrophic cardiomyopathy  ISOSPI1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertrophic cardiomyopathyClinVarPMID:19574547 more ...
Spi1Ratintellectual disability  ISOSPI1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
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Spi1Ratacute myeloid leukemia  ISOSPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26237430
Spi1Ratmyeloid leukemia  ISOSPI1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:17361223
Spi1RatT-cell acute lymphoblastic leukemia  ISOSPI1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28671687
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Spi1Ratacute myeloid leukemia  ISSSpi1 (Mus musculus)13592920OMIM:601626MouseDO 
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Original Reference(s)
Spi1Ratagammaglobulinemia 10  ISOSPI1 (Homo sapiens)7240710 OMIM 

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Spi1Rat(1->4)-beta-D-glucan multiple interactionsISOSpi1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SPI1 mRNACTDPMID:36331819
Spi1Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SPI1 mRNACTDPMID:32741896
Spi1Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SPI1 mRNACTDPMID:32741896
Spi1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOSpi1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of SPI1 mRNACTDPMID:24058054
Spi1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of SPI1 mRNACTDPMID:33387578
Spi1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of SPI1 mRNACTDPMID:34747641
Spi1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOSpi1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of SPI1 mRNACTDPMID:26290441 and PMID:37172768
Spi1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOSpi1 (Mus musculus)64804642 more ...CTDPMID:38648751
Spi1Rat2-bromohexadecanoic acid multiple interactionsISOSPI1 (Homo sapiens)64804642-bromopalmitate promotes the reaction [Tretinoin results in increased expression of SPI1 mRNA]CTDPMID:30076181
Spi1Rat3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol decreases expressionISOSPI1 (Homo sapiens)6480464fluorotelomer alcohols results in decreased expression of SPI1 mRNACTDPMID:30794351
Spi1Rat3-phenoxybenzoic acid multiple interactionsISOSPI1 (Homo sapiens)64804643-phenoxybenzoic acid inhibits the reaction [Tretinoin results in increased expression of SPI1 mRNA] and Acetylcysteine inhibits the reaction [3-phenoxybenzoic acid inhibits the reaction [Tretinoin results in increased expression of SPI1 mRNA]]CTDPMID:29945211
Spi1Rat4,4'-diaminodiphenylmethane decreases expressionISOSpi1 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of SPI1 mRNACTDPMID:18648102
Spi1Rat4,4'-sulfonyldiphenol increases expressionISOSpi1 (Mus musculus)6480464bisphenol S results in increased expression of SPI1 mRNACTDPMID:30951980
Spi1Rat4,4'-sulfonyldiphenol decreases expressionISOSpi1 (Mus musculus)6480464bisphenol S results in decreased expression of SPI1 mRNACTDPMID:39298647
Spi1Rat4-hydroxybenzoic acid multiple interactionsISOSpi1 (Mus musculus)64804644-hydroxybenzoic acid inhibits the reaction [SPI1 protein binds to LY96 promoter] and 4-hydroxybenzoic acid inhibits the reaction [SPI1 protein binds to TLR4 promoter]CTDPMID:39389441
Spi1Rat5-aza-2'-deoxycytidine affects methylationISOSpi1 (Mus musculus)6480464Decitabine affects the methylation of SPI1 geneCTDPMID:17586044
Spi1Rat5-aza-2'-deoxycytidine affects methylationISOSPI1 (Homo sapiens)6480464Decitabine affects the methylation of SPI1 promoterCTDPMID:17545613
Spi1Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of SPI1 mRNACTDPMID:31881176
Spi1Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of SPI1 mRNACTDPMID:28959563
Spi1Rataflatoxin B1 affects methylationISOSPI1 (Homo sapiens)6480464Aflatoxin B1 affects the methylation of SPI1 intronCTDPMID:30157460

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Biological Process
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Spi1Ratanatomical structure regression acts_upstream_of_or_withinIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratanatomical structure regression acts_upstream_of_or_withinISOSpi1 (Mus musculus)1624291MGI:1927876 PMID:16163358RGDPMID:16163358
Spi1Ratapoptotic process involved in blood vessel morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratapoptotic process involved in blood vessel morphogenesis acts_upstream_of_or_withinISOSpi1 (Mus musculus)1624291MGI:1927876 PMID:16163358RGDPMID:16163358
Spi1Ratcell differentiation involved_inIBAFB:FBgn0000097 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Spi1Ratcellular response to ethanol  IEP 9586723 RGD 
Spi1Ratdefense response to tumor cell involved_inIEAUniProtKB:P17947 and ensembl:ENSP000003677991600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratdefense response to tumor cell involved_inISOSPI1 (Homo sapiens)1624291 PMID:28362429 more ...RGDPMID:28362429 more ...
Spi1Ratendothelial to hematopoietic transition involved_inISOSpi1 (Mus musculus)1624291 PMID:25252941RGDPMID:25252941
Spi1Ratendothelial to hematopoietic transition involved_inIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Raterythrocyte differentiation acts_upstream_of_or_withinISOSpi1 (Mus musculus)1624291MGI:1930970 PMID:9133423RGDPMID:9133423
Spi1Raterythrocyte differentiation acts_upstream_of_or_withinIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratfollicular B cell differentiation involved_inISOSpi1 (Mus musculus)1624291UniProtKB:P23611 and PMID:31000603RGDPMID:31000603
Spi1Ratfollicular B cell differentiation involved_inIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratgerminal center B cell differentiation involved_inIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratgerminal center B cell differentiation involved_inISOSpi1 (Mus musculus)1624291UniProtKB:P23611 and PMID:31000603RGDPMID:31000603
Spi1Ratgranulocyte differentiation acts_upstream_of_or_withinISOSpi1 (Mus musculus)1624291 PMID:11980719RGDPMID:11980719
Spi1Ratgranulocyte differentiation acts_upstream_of_or_withinIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratimmature B cell differentiation involved_inISOSpi1 (Mus musculus)1624291UniProtKB:O35906 and PMID:28062693RGDPMID:28062693
Spi1Ratimmature B cell differentiation involved_inIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Spi1Ratchromatin located_inIEAUniProtKB:P17947 and ensembl:ENSP000003677991600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratchromatin located_inISOSpi1 (Mus musculus)1624291 PMID:15187136RGDPMID:15187136
Spi1Ratchromatin located_inISOSPI1 (Homo sapiens)1624291 PMID:15304486RGDPMID:15304486
Spi1Ratchromatin located_inIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratnucleoplasm located_inIEAUniProtKB:P17947 and ensembl:ENSP000003677991600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratnucleoplasm located_inISOSPI1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Spi1Ratnucleus located_inIEAUniProtKB:P17947 and ensembl:ENSP000003677991600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratnucleus is_active_inIBAFB:FBgn0000097 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Spi1Ratnucleus located_inISOSPI1 (Homo sapiens)1624291 PMID:20972335 more ...RGDPMID:20972335 more ...
Spi1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Spi1Ratnucleus located_inISOSpi1 (Mus musculus)1624291 PMID:15304486 more ...RGDPMID:15304486 more ...
Spi1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Spi1Ratnucleus located_inIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Rattranscription regulator complex part_ofIEAUniProtKB:P17947 and ensembl:ENSP000003677991600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Rattranscription regulator complex part_ofISOSPI1 (Homo sapiens)1624291 PMID:24429361RGDPMID:24429361
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Molecular Function
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Spi1Ratchromatin binding enablesISOSpi1 (Mus musculus)1624291 PMID:30171019 and PMID:30911105RGDPMID:30171019 and PMID:30911105
Spi1Ratchromatin binding enablesIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratcis-regulatory region sequence-specific DNA binding enablesISOSPI1 (Homo sapiens)1624291 PMID:28481873 more ...RGDPMID:28481873 more ...
Spi1Ratcis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratcis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:P17947 and ensembl:ENSP000003677991600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1Ratcis-regulatory region sequence-specific DNA binding enablesISOSpi1 (Mus musculus)1624291 PMID:28338898 more ...RGDPMID:28338898 more ...
Spi1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Spi1RatDNA binding enablesISOSpi1 (Mus musculus)1624291 PMID:15361867 and PMID:7592651RGDPMID:15361867 and PMID:7592651
Spi1RatDNA binding enablesIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1RatDNA-binding transcription activator activity enablesIEAUniProtKB:P17947 and ensembl:ENSP000003677991600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1RatDNA-binding transcription activator activity enablesISOSPI1 (Homo sapiens)1624291 PMID:20139074RGDPMID:20139074
Spi1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOSpi1 (Mus musculus)1624291 PMID:15304486RGDPMID:15304486
Spi1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1RatDNA-binding transcription factor activity  IDA 633204 RGD 
Spi1RatDNA-binding transcription factor activity enablesIEAUniProtKB:P17947 and ensembl:ENSP000003677991600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1RatDNA-binding transcription factor activity enablesIEAUniProtKB:P17433 and ensembl:ENSMUSP000000021801600115GO_REF:0000107EnsemblGO_REF:0000107
Spi1RatDNA-binding transcription factor activity enablesISOSpi1 (Mus musculus)1624291 PMID:11980719 more ...RGDPMID:11980719 more ...
Spi1RatDNA-binding transcription factor activity enablesISOSPI1 (Homo sapiens)1624291 PMID:12833137 more ...RGDPMID:12833137 more ...
Spi1RatDNA-binding transcription factor activity enablesIEAInterPro:IPR000418 and InterPro:IPR0463281600115GO_REF:0000002InterProGO_REF:0000002
Spi1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOSpi1 (Mus musculus)1624291 PMID:15304486 and PMID:16735694RGDPMID:15304486 and PMID:16735694
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RGD Manual Annotations


  
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Spi1RatDNA modification pathway   ISOSPI1 (Homo sapiens)8695944 RGD 

Imported Annotations - KEGG (archival)

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Spi1Ratacute myeloid leukemia pathway  IEA 6907045 KEGGrno:05221

Imported Annotations - PID (archival)

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Spi1Ratinterleukin-4 signaling pathway  ISOSPI1 (Homo sapiens)6484113 PIDPID:200022

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Reference Title
Reference Citation
1. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. Dakic A, etal., J Exp Med 2005 May 2;201(9):1487-502.
2. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
3. PU.1 and USF are required for macrophage-specific mannose receptor promoter activity. Egan BS, etal., J Biol Chem. 1999 Mar 26;274(13):9098-107.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The hematopoietic transcription factor PU.1 represses gelatinase A transcription in glomerular mesangial cells. Harendza S, etal., J Biol Chem 2000 Jun 30;275(26):19552-9.
6. Ethanol increases osteoclastogenesis associated with the increased expression of RANK, PU.1 and MITF in vitro and in vivo. Iitsuka N, etal., Int J Mol Med. 2012 Jul;30(1):165-72. doi: 10.3892/ijmm.2012.974. Epub 2012 Apr 20.
7. Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage. Joshi PC, etal., J Immunol. 2005 Nov 15;175(10):6837-45.
8. Zinc supplementation restores PU.1 and Nrf2 nuclear binding in alveolar macrophages and improves redox balance and bacterial clearance in the lungs of alcohol-fed rats. Mehta AJ, etal., Alcohol Clin Exp Res. 2011 Aug;35(8):1519-28. doi: 10.1111/j.1530-0277.2011.01488.x. Epub 2011 Mar 29.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1 mutants: molecular cloning of rat Icsbp (Irf-8) cDNA. Nakano N, etal., Immunogenetics. 2005 Mar;56(12):871-7. Epub 2005 Feb 2.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. PU.1 expression in microglia. Walton MR, etal., J Neuroimmunol. 2000 May 1;104(2):109-15.
18. PU.1-silenced dendritic cells prolong allograft survival in rats receiving intestinal transplantation. Xu XW, etal., World J Gastroenterol. 2013 Nov 21;19(43):7766-71. doi: 10.3748/wjg.v19.i43.7766.
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PMID:1409581   PMID:7592651   PMID:9133423   PMID:10648399   PMID:11980719   PMID:12833137   PMID:14962908   PMID:15100295   PMID:15187136   PMID:15304324   PMID:15304486   PMID:15361867  
PMID:16002702   PMID:16163358   PMID:16735694   PMID:18063754   PMID:18384814   PMID:19379700   PMID:19796622   PMID:20139074   PMID:20972335   PMID:22206666   PMID:23775123   PMID:23980096  
PMID:24429361   PMID:25840997   PMID:29482641   PMID:33970748   PMID:36299239  



Spi1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,529,509 - 97,548,204 (+)NCBIGRCr8
mRatBN7.2377,059,744 - 77,093,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,073,012 - 77,092,393 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,552,207 - 80,570,836 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,151,217 - 89,169,847 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,002,389 - 87,021,093 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,918,127 - 79,937,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,918,969 - 79,938,301 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,627,684 - 86,646,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,456,353 - 75,475,722 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,352,724 - 75,372,093 (+)NCBI
Celera376,282,068 - 76,300,680 (+)NCBICelera
Cytogenetic Map3q24NCBI
SPI1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,354,860 - 47,378,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,354,860 - 47,409,369 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,376,411 - 47,400,098 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,332,985 - 47,356,703 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,332,987 - 47,356,674NCBI
Celera1147,515,686 - 47,541,505 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,075,532 - 47,099,721 (-)NCBIHuRef
CHM1_11147,375,652 - 47,399,367 (-)NCBICHM1_1
T2T-CHM13v2.01147,511,687 - 47,538,667 (-)NCBIT2T-CHM13v2.0
Spi1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,912,750 - 90,946,104 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,912,735 - 90,946,101 (+)EnsemblGRCm39 Ensembl
GRCm38291,082,374 - 91,115,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,082,390 - 91,115,756 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,936,954 - 90,955,913 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,897,636 - 90,916,595 (+)NCBIMGSCv36mm8
Celera292,481,297 - 92,500,928 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
Spi1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422873,735 - 886,560 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422873,735 - 886,560 (+)NCBIChiLan1.0ChiLan1.0
SPI1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,555,991 - 49,581,635 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,575,785 - 49,601,430 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,301,245 - 47,326,891 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,853,991 - 47,880,259 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,853,991 - 47,880,259 (-)Ensemblpanpan1.1panPan2
SPI1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,253,849 - 42,269,497 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,253,811 - 42,269,727 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,983,530 - 40,999,141 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,908,919 - 42,924,536 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,908,267 - 42,924,759 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,395,271 - 42,410,877 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,950,490 - 41,966,095 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,679,725 - 42,695,395 (+)NCBIUU_Cfam_GSD_1.0
Spi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,741,101 - 19,757,903 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,852,740 - 1,870,472 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,852,759 - 1,870,647 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPI1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,227,881 - 15,245,677 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,227,850 - 15,245,679 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,434,712 - 16,452,518 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPI1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,935,037 - 17,961,638 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,935,922 - 17,961,717 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038115,237,583 - 115,263,142 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spi1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,394,704 - 1,404,406 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247671,376,649 - 1,404,382 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Spi1
144 total Variants

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:54
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000016306
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 38 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat

1 to 10 of 38 rows
RH135185  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,081,666 - 77,081,876 (+)MAPPERmRatBN7.2
Rnor_6.0379,926,980 - 79,927,189NCBIRnor6.0
Rnor_5.0386,635,733 - 86,635,942UniSTSRnor5.0
RGSC_v3.4375,464,322 - 75,464,531UniSTSRGSC3.4
Celera376,290,041 - 76,290,250UniSTS
Cytogenetic Map3q24UniSTS
PMC186377P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,092,176 - 77,092,256 (+)MAPPERmRatBN7.2
Rnor_6.0379,937,489 - 79,937,568NCBIRnor6.0
Rnor_5.0386,646,242 - 86,646,321UniSTSRnor5.0
RGSC_v3.4375,475,505 - 75,475,584UniSTSRGSC3.4
Celera376,300,463 - 76,300,542UniSTS
Cytogenetic Map3q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000016306   ⟹   ENSRNOP00000016306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,075,595 - 77,092,393 (+)Ensembl
Rnor_6.0 Ensembl379,918,969 - 79,938,301 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114733   ⟹   ENSRNOP00000077751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,073,012 - 77,092,393 (+)Ensembl
RefSeq Acc Id: NM_001005892   ⟹   NP_001005892
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,529,509 - 97,548,204 (+)NCBI
mRatBN7.2377,073,696 - 77,092,394 (+)NCBI
Rnor_6.0379,919,011 - 79,937,706 (+)NCBI
Rnor_5.0386,627,684 - 86,646,468 (+)NCBI
RGSC_v3.4375,456,353 - 75,475,722 (+)RGD
Celera376,282,068 - 76,300,680 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234532   ⟹   XP_006234594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,529,567 - 97,548,204 (+)NCBI
mRatBN7.2377,072,615 - 77,093,730 (+)NCBI
Rnor_6.0379,918,127 - 79,937,708 (+)NCBI
Rnor_5.0386,627,684 - 86,646,468 (+)NCBI
Sequence:
Protein RefSeqs NP_001005892 (Get FASTA)   NCBI Sequence Viewer  
  XP_006234594 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91185 (Get FASTA)   NCBI Sequence Viewer  
  BAD35169 (Get FASTA)   NCBI Sequence Viewer  
  EDL79507 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016306
  ENSRNOP00000108151
GenBank Protein Q6BDS1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001005892   ⟸   NM_001005892
- UniProtKB: Q5BK69 (UniProtKB/Swiss-Prot),   Q6BDS1 (UniProtKB/Swiss-Prot),   A6HNA6 (UniProtKB/TrEMBL),   A0A8L2UIY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234594   ⟸   XM_006234532
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZJK5 (UniProtKB/TrEMBL),   A0A8L2UIY0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016306   ⟸   ENSRNOT00000016306
Ensembl Acc Id: ENSRNOP00000077751   ⟸   ENSRNOT00000114733
ETS

Name Modeler Protein Id AA Range Protein Structure
AF-Q6BDS1-F1-model_v2 AlphaFold Q6BDS1 1-271 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692206
Promoter ID:EPDNEW_R2731
Type:multiple initiation site
Name:Spi1_1
Description:Spi-1 proto-oncogene
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0379,918,976 - 79,919,036EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-48751 BioCyc
Ensembl Genes ENSRNOG00000012172 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016306 ENTREZGENE
  ENSRNOT00000142253 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7366435 IMAGE-MGC_LOAD
InterPro Ets_dom UniProtKB/Swiss-Prot
  ETS_fam UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:366126 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108838 IMAGE-MGC_LOAD
NCBI Gene 366126 ENTREZGENE
PANTHER PTHR11849 UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR PU.1 UniProtKB/Swiss-Prot
Pfam Ets UniProtKB/Swiss-Prot
PhenoGen Spi1 PhenoGen
PRINTS ETSDOMAIN UniProtKB/Swiss-Prot
PROSITE ETS_DOMAIN_1 UniProtKB/Swiss-Prot
  ETS_DOMAIN_2 UniProtKB/Swiss-Prot
  ETS_DOMAIN_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012172 RatGTEx
SMART ETS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt A0A8I5ZJK5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UIY0 ENTREZGENE, UniProtKB/TrEMBL
  A6HNA6 ENTREZGENE, UniProtKB/TrEMBL
  Q5BK69 ENTREZGENE
  Q6BDS1 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5BK69 UniProtKB/Swiss-Prot
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Spi1  Spi-1 proto-oncogene  LOC103691845  uncharacterized LOC103691845  Data merged from RGD:9236003 737654 PROVISIONAL
2014-08-25 LOC103691845  uncharacterized LOC103691845      Symbol and Name status set to provisional 70820 PROVISIONAL
2014-07-10 Spi1  Spi-1 proto-oncogene  Spi1  spleen focus forming virus (SFFV) proviral integration oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-23 Spi1  spleen focus forming virus (SFFV) proviral integration oncogene  Spi1  spleen focus forming virus (SFFV) proviral integration oncogene spi1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-02-24 Spi1  spleen focus forming virus (SFFV) proviral integration oncogene spi1  Spi1  spleen focus forming virus proviral integration oncogene spi1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-02-23 Spi1  spleen focus forming virus proviral integration oncogene spi1  Sfpi1  SFFV proviral integration 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Sfpi1  SFFV proviral integration 1      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Sfpi1  SFFV proviral integration 1      Symbol and Name status set to provisional 70820 PROVISIONAL