Pole3 (DNA polymerase epsilon 3, accessory subunit) - Rat Genome Database

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Gene: Pole3 (DNA polymerase epsilon 3, accessory subunit) Rattus norvegicus
Analyze
Symbol: Pole3
Name: DNA polymerase epsilon 3, accessory subunit
RGD ID: 1359475
Description: Predicted to enable chromatin DNA binding activity. Predicted to be involved in several processes, including chromatin remodeling; leading strand elongation; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in pericentric heterochromatin. Predicted to be part of ATAC complex; CHRAC; and epsilon DNA polymerase complex. Orthologous to human POLE3 (DNA polymerase epsilon 3, accessory subunit); PARTICIPATES IN ISWI family mediated chromatin remodeling pathway; nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA polymerase epsilon subunit 3; DNA polymerase epsilon subunit p17; DNA polymerase II subunit 3; DNA-directed DNA polymerase epsilon 3; MGC94182; MGC94830; polymerase (DNA directed), epsilon 3 (p17 subunit); polymerase (DNA directed), epsilon 3, accessory subunit; polymerase (DNA) epsilon 3, accessory subunit; similar to DNA polymerase epsilon p17 subunit (DNA polymerase epsilon subunit 3) (Chromatin accessibility complex 17) (HuCHRAC17) (CHRAC-17)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Pole3-ps3  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8580,989,508 - 80,992,742 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl580,989,511 - 80,992,742 (-)EnsemblGRCr8
GRCr8 Ensembl7111,109,080 - 111,131,961 (-)EnsemblGRCr8
mRatBN7.2575,973,941 - 75,977,175 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,236,321 - 109,236,758 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl575,974,717 - 75,977,231 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx578,373,292 - 78,376,528 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,190,389 - 80,193,625 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,165,904 - 80,169,140 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0578,380,813 - 78,384,047 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,380,816 - 78,384,047 (-)Ensemblrn6Rnor6.0
Rnor_5.0582,500,184 - 82,503,419 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4579,517,590 - 79,520,825 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera574,915,292 - 74,918,526 (-)NCBICelera
RGSC_v3.1579,522,705 - 79,525,938 (-)NCBI
Cytogenetic Map5q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
clotrimazole  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deguelin  (ISO)
diclofenac  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
fenpyroximate  (ISO)
finasteride  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nimesulide  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
pyrimidifen  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
tebufenpyrad  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Hargreaves DC and Crabtree GR, Cell Res. 2011 Mar;21(3):396-420. doi: 10.1038/cr.2011.32. Epub 2011 Mar 1.
3. Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. Li Y, etal., J Biol Chem 2000 Jul 28;275(30):23247-52.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. DNA polymerase epsilon - more than a polymerase. Pospiech H and Syvaoja JE, ScientificWorldJournal. 2003 Mar 24;3:87-104.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. ATAC-king the complexity of SAGA during evolution. Spedale G, etal., Genes Dev. 2012 Mar 15;26(6):527-41. doi: 10.1101/gad.184705.111.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:18838386  


Genomics

Comparative Map Data
Pole3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8580,989,508 - 80,992,742 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl580,989,511 - 80,992,742 (-)EnsemblGRCr8
GRCr8 Ensembl7111,109,080 - 111,131,961 (-)EnsemblGRCr8
mRatBN7.2575,973,941 - 75,977,175 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,236,321 - 109,236,758 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl575,974,717 - 75,977,231 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx578,373,292 - 78,376,528 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,190,389 - 80,193,625 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,165,904 - 80,169,140 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0578,380,813 - 78,384,047 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl578,380,816 - 78,384,047 (-)Ensemblrn6Rnor6.0
Rnor_5.0582,500,184 - 82,503,419 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4579,517,590 - 79,520,825 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera574,915,292 - 74,918,526 (-)NCBICelera
RGSC_v3.1579,522,705 - 79,525,938 (-)NCBI
Cytogenetic Map5q24NCBI
POLE3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389113,407,235 - 113,410,749 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9113,407,232 - 113,410,723 (-)Ensemblhg38GRCh38
GRCh379116,169,515 - 116,173,029 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369115,209,342 - 115,212,773 (-)NCBIBuild 36Build 36hg18NCBI36
Build 349113,249,074 - 113,252,506NCBI
Celera986,817,115 - 86,820,629 (-)NCBICelera
Cytogenetic Map9q32NCBI
HuRef985,776,442 - 85,779,955 (-)NCBIHuRef
CHM1_19116,316,144 - 116,319,658 (-)NCBICHM1_1
T2T-CHM13v2.09125,606,053 - 125,609,566 (-)NCBIT2T-CHM13v2.0
Pole3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39462,440,889 - 62,443,305 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl462,440,886 - 62,443,305 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38462,523,798 - 62,525,014 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl462,522,649 - 62,525,068 (-)Ensemblmm10GRCm38
MGSCv37462,184,832 - 62,186,048 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36462,010,159 - 62,011,375 (-)NCBIMGSCv36mm8
Celera461,191,011 - 61,192,227 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map433.17NCBI
Pole3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541914,086,940 - 14,089,330 (+)Ensembl
ChiLan1.0NW_00495541914,086,940 - 14,089,906 (+)NCBIChiLan1.0ChiLan1.0
POLE3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21125,962,959 - 25,966,434 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1925,965,670 - 25,968,781 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0984,509,237 - 84,512,651 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19112,879,325 - 112,883,051 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9112,879,047 - 112,882,951 (-)EnsemblpanPan2panpan1.1
POLE3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11167,757,779 - 67,760,417 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1167,758,918 - 67,760,374 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1166,162,467 - 66,165,109 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01168,882,601 - 68,884,601 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1168,881,948 - 68,884,589 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11167,400,021 - 67,402,671 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01167,430,940 - 67,433,593 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01168,167,899 - 68,170,545 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pole3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947183,043,822 - 183,045,595 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936559220,935 - 223,128 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936559220,941 - 222,783 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLE3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1254,033,385 - 254,035,978 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11254,033,378 - 254,036,224 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21284,828,761 - 284,831,384 (-)NCBISscrofa10.2Sscrofa10.2susScr3
POLE3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11226,162,934 - 26,164,931 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1226,163,107 - 26,165,214 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603516,634,891 - 16,637,389 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pole3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476021,692,715 - 21,695,826 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476021,692,734 - 21,695,636 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pole3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1191,008,731 - 91,012,038 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pole3
8 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:316
Count of miRNA genes:195
Interacting mature miRNAs:242
Transcripts:ENSRNOT00000020722
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)573779642103472210Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56458901693503770Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)56458901691762830Rat

Markers in Region
RH134463  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8580,990,409 - 80,990,876 (+)Marker Load Pipeline
mRatBN7.2575,974,842 - 75,975,309 (+)MAPPERmRatBN7.2
Rnor_6.0578,381,715 - 78,382,181NCBIRnor6.0
Rnor_5.0582,501,087 - 82,501,553UniSTSRnor5.0
RGSC_v3.4579,518,493 - 79,518,959UniSTSRGSC3.4
Celera574,916,194 - 74,916,660UniSTS
RH 3.4 Map5559.0UniSTS
Cytogenetic Map5q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
22 12 73 196 125 120 77 98 77 12 414 216 11 163 91 111 43 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000112884   ⟹   ENSRNOP00000093308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl580,989,511 - 80,992,742 (-)Ensembl
mRatBN7.2 Ensembl575,974,717 - 75,977,231 (-)Ensembl
RefSeq Acc Id: NM_001007652   ⟹   NP_001007653
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8580,989,508 - 80,992,742 (-)NCBI
mRatBN7.2575,973,941 - 75,977,175 (-)NCBI
Rnor_6.0578,380,813 - 78,384,047 (-)NCBI
Rnor_5.0582,500,184 - 82,503,419 (-)NCBI
RGSC_v3.4579,517,590 - 79,520,825 (-)RGD
Celera574,915,292 - 74,918,526 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001007653 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81988 (Get FASTA)   NCBI Sequence Viewer  
  AAH83800 (Get FASTA)   NCBI Sequence Viewer  
  EDM10547 (Get FASTA)   NCBI Sequence Viewer  
  EDM10548 (Get FASTA)   NCBI Sequence Viewer  
  EDM10549 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006416.1
  ENSRNOP00000093308
GenBank Protein Q642A5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007653   ⟸   NM_001007652
- UniProtKB: Q642A5 (UniProtKB/Swiss-Prot),   A6J7V8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000093308   ⟸   ENSRNOT00000112884
Protein Domains
Transcription factor CBF/NF-Y/archaeal histone

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q642A5-F1-model_v2 AlphaFold Q642A5 1-145 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693795
Promoter ID:EPDNEW_R4318
Type:initiation region
Name:Pole3_1
Description:DNA polymerase epsilon 3, accessory subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0578,384,086 - 78,384,146EPDNEW
RGD ID:13693802
Promoter ID:EPDNEW_R4320
Type:multiple initiation site
Name:AC099453_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0578,393,110 - 78,393,170EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359475 AgrOrtholog
BioCyc Gene G2FUF-41087 BioCyc
Ensembl Genes ENSRNOG00000004843 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000055277 Ensembl
  ENSRNOG00000070688 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000006416.3 UniProtKB/Swiss-Prot
  ENSRNOT00000112884 ENTREZGENE
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108773 IMAGE-MGC_LOAD
  IMAGE:7129121 IMAGE-MGC_LOAD
InterPro CBFA_NFYB_domain UniProtKB/Swiss-Prot
  DNA_Pol-Epsilon_Subunit UniProtKB/Swiss-Prot
  Histone-fold UniProtKB/Swiss-Prot
KEGG Report rno:298098 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94182 IMAGE-MGC_LOAD
  MGC:94830 IMAGE-MGC_LOAD
NCBI Gene 298098 ENTREZGENE
PANTHER DNA POLYMERASE EPSILON SUBUNIT 3 UniProtKB/Swiss-Prot
  DNA POLYMERASE EPSILON SUBUNIT 3 UniProtKB/Swiss-Prot
Pfam CBFD_NFYB_HMF UniProtKB/Swiss-Prot
PhenoGen Pole3 PhenoGen
RatGTEx ENSRNOG00000004843 RatGTEx
  ENSRNOG00000055277 RatGTEx
  ENSRNOG00000070688 RatGTEx
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot
UniProt A0A8I6AK16_RAT UniProtKB/TrEMBL
  A6J7V8 ENTREZGENE, UniProtKB/TrEMBL
  A6J7W0_RAT UniProtKB/TrEMBL
  DPOE3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Pole3  DNA polymerase epsilon 3, accessory subunit  Pole3  polymerase (DNA) epsilon 3, accessory subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-09 Pole3  polymerase (DNA) epsilon 3, accessory subunit  Pole3  polymerase (DNA directed), epsilon 3, accessory subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Pole3  polymerase (DNA directed), epsilon 3, accessory subunit  Pole3  polymerase (DNA directed), epsilon 3 (p17 subunit)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Pole3  polymerase (DNA directed), epsilon 3 (p17 subunit)  MGC94182  similar to DNA polymerase epsilon p17 subunit (DNA polymerase epsilon subunit 3) (Chromatin accessibility complex 17) (HuCHRAC17) (CHRAC-17)  Symbol and Name updated 1299863 APPROVED
2005-07-29 MGC94182  similar to DNA polymerase epsilon p17 subunit (DNA polymerase epsilon subunit 3) (Chromatin accessibility complex 17) (HuCHRAC17) (CHRAC-17)      Symbol and Name status set to provisional 70820 PROVISIONAL