Sapcd1 (suppressor APC domain containing 1) - Rat Genome Database

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Gene: Sapcd1 (suppressor APC domain containing 1) Rattus norvegicus
Analyze
Symbol: Sapcd1
Name: suppressor APC domain containing 1
RGD ID: 1359359
Description: Orthologous to human SAPCD1 (suppressor APC domain containing 1); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ng23; suppressor APC domain-containing protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,798,124 - 3,800,422 (+)NCBIGRCr8
mRatBN7.2203,793,980 - 3,795,767 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,793,967 - 3,795,790 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,493,527 - 4,495,296 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,855,582 - 3,857,351 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,393,487 - 4,395,256 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,018,264 - 5,020,375 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,018,264 - 5,020,150 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,091,280 - 7,093,208 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,862,654 - 3,864,441 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,862,880 - 3,864,623 (+)NCBI
Celera204,230,730 - 4,232,517 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, etal., Genome Res 2004 Apr;14(4):631-9.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Sapcd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,798,124 - 3,800,422 (+)NCBIGRCr8
mRatBN7.2203,793,980 - 3,795,767 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,793,967 - 3,795,790 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,493,527 - 4,495,296 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,855,582 - 3,857,351 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,393,487 - 4,395,256 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,018,264 - 5,020,375 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,018,264 - 5,020,150 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,091,280 - 7,093,208 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,862,654 - 3,864,441 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,862,880 - 3,864,623 (+)NCBI
Celera204,230,730 - 4,232,517 (-)NCBICelera
Cytogenetic Map20p12NCBI
SAPCD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,762,656 - 31,764,850 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,762,656 - 31,764,850 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,730,433 - 31,732,627 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,838,752 - 31,840,606 (+)NCBINCBI36Build 36hg18NCBI36
Celera633,329,018 - 33,330,872 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,517,201 - 31,519,056 (+)NCBIHuRef
CHM1_1631,732,896 - 31,734,750 (+)NCBICHM1_1
T2T-CHM13v2.0631,615,703 - 31,617,897 (+)NCBIT2T-CHM13v2.0
Sapcd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,244,935 - 35,247,600 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,244,935 - 35,246,992 (-)EnsemblGRCm39 Ensembl
GRCm381735,025,959 - 35,028,557 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,025,959 - 35,028,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,162,904 - 35,164,961 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,633,553 - 34,635,972 (-)NCBIMGSCv36mm8
Celera1738,122,185 - 38,124,257 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.56NCBI
Sapcd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437297,644 - 299,220 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955437297,605 - 299,242 (+)NCBIChiLan1.0ChiLan1.0
SAPCD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,239,423 - 46,241,581 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,201,545 - 42,203,085 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,423,704 - 31,425,719 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,311,318 - 32,313,411 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,311,318 - 32,313,406 (+)Ensemblpanpan1.1panPan2
SAPCD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,243,489 - 1,245,476 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,243,974 - 1,245,429 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,380,013 - 1,382,521 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,386,741 - 1,389,249 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,387,226 - 1,388,682 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,245,965 - 1,248,472 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,313,127 - 1,315,635 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,381,060 - 1,383,565 (+)NCBIUU_Cfam_GSD_1.0
Sapcd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,784,149 - 35,789,598 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,775,618 - 1,777,048 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,772,656 - 1,777,202 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAPCD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,258,684 - 40,261,092 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,259,121 - 40,260,597 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,675,242 - 31,677,350 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sapcd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,452,429 - 24,453,725 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sapcd1
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:201
Count of miRNA genes:142
Interacting mature miRNAs:159
Transcripts:ENSRNOT00000001146
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat

Markers in Region
BG372572  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,792,642 - 3,793,155 (-)MAPPERmRatBN7.2
Rnor_6.0205,020,876 - 5,021,388NCBIRnor6.0
Rnor_5.0207,093,892 - 7,094,404UniSTSRnor5.0
RGSC_v3.4203,861,317 - 3,861,829UniSTSRGSC3.4
Celera204,233,342 - 4,233,854UniSTS
RH 3.4 Map213.3UniSTS
Cytogenetic Map20p12UniSTS
RH129081  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,795,579 - 3,795,742 (-)MAPPERmRatBN7.2
Rnor_6.0205,018,289 - 5,018,451NCBIRnor6.0
Rnor_5.0207,091,305 - 7,091,467UniSTSRnor5.0
RGSC_v3.4203,864,254 - 3,864,416UniSTSRGSC3.4
Celera204,230,755 - 4,230,917UniSTS
RH 3.4 Map2052.22UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 82 81 50 25 50 6 209 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000001146   ⟹   ENSRNOP00000001146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,793,967 - 3,795,790 (+)Ensembl
Rnor_6.0 Ensembl205,018,264 - 5,020,150 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080415   ⟹   ENSRNOP00000073502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,018,562 - 5,020,026 (-)Ensembl
RefSeq Acc Id: NM_001004069   ⟹   NP_001004069
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,798,635 - 3,800,422 (+)NCBI
mRatBN7.2203,793,980 - 3,795,767 (+)NCBI
Rnor_6.0205,018,264 - 5,020,051 (-)NCBI
Rnor_5.0207,091,280 - 7,093,208 (-)NCBI
RGSC_v3.4203,862,654 - 3,864,441 (+)RGD
Celera204,230,730 - 4,232,517 (-)RGD
Sequence:
RefSeq Acc Id: XM_063279360   ⟹   XP_063135430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,798,124 - 3,800,141 (+)NCBI
RefSeq Acc Id: XM_063279361   ⟹   XP_063135431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,798,601 - 3,800,106 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001004069 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135430 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135431 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE83983 (Get FASTA)   NCBI Sequence Viewer  
  EDL83488 (Get FASTA)   NCBI Sequence Viewer  
  EDL83489 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001146.3
RefSeq Acc Id: NP_001004069   ⟸   NM_001004069
- UniProtKB: Q6MG63 (UniProtKB/TrEMBL),   A6KTQ9 (UniProtKB/TrEMBL),   A6KTQ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073502   ⟸   ENSRNOT00000080415
Ensembl Acc Id: ENSRNOP00000001146   ⟸   ENSRNOT00000001146
RefSeq Acc Id: XP_063135430   ⟸   XM_063279360
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063135431   ⟸   XM_063279361
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MG63-F1-model_v2 AlphaFold Q6MG63 1-147 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701389
Promoter ID:EPDNEW_R11906
Type:multiple initiation site
Name:Sapcd1_1
Description:suppressor APC domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,020,062 - 5,020,122EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359359 AgrOrtholog
BioCyc Gene G2FUF-4631 BioCyc
Ensembl Genes ENSRNOG00000000858 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001146.7 UniProtKB/TrEMBL
InterPro Suppressor_APCD_1/2 UniProtKB/TrEMBL
KEGG Report rno:406170 UniProtKB/TrEMBL
NCBI Gene 406170 ENTREZGENE
PANTHER PTHR14907 UniProtKB/TrEMBL
  SUPPRESSOR APC DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
Pfam Suppressor_APC UniProtKB/TrEMBL
PhenoGen Sapcd1 PhenoGen
RatGTEx ENSRNOG00000000858 RatGTEx
UniProt A6KTQ8 ENTREZGENE, UniProtKB/TrEMBL
  A6KTQ9 ENTREZGENE, UniProtKB/TrEMBL
  Q6MG63 ENTREZGENE
UniProt Secondary Q6MG63 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-05 Sapcd1  suppressor APC domain containing 1  Ng23  Ng23 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ng23  Ng23 protein      Symbol and Name updated 1559027 APPROVED
2005-07-29 Ng23  Ng23 protein      Symbol and Name status set to provisional 70820 PROVISIONAL