Pmaip1 (phorbol-12-myristate-13-acetate-induced protein 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Pmaip1 (phorbol-12-myristate-13-acetate-induced protein 1) Rattus norvegicus
Analyze
Symbol: Pmaip1
Name: phorbol-12-myristate-13-acetate-induced protein 1
RGD ID: 1359266
Description: Involved in positive regulation of apoptotic process. Predicted to be located in cytosol and nucleus. Predicted to be part of Bcl-2 family protein complex. Predicted to be active in mitochondrion. Orthologous to human PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1); PARTICIPATES IN intrinsic apoptotic pathway; p53 signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Noxa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81862,255,970 - 62,262,384 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1862,255,598 - 62,262,382 (+)EnsemblGRCr8
mRatBN7.21859,986,020 - 59,992,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1859,986,017 - 59,992,429 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1862,070,712 - 62,074,695 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01862,769,423 - 62,773,407 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01860,619,311 - 60,623,296 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,159,128 - 62,179,635 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,174,670 - 62,181,102 (+)Ensemblrn6Rnor6.0
Rnor_5.01861,365,056 - 61,369,043 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41862,914,845 - 62,918,832 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1858,105,912 - 58,109,899 (+)NCBICelera
RGSC_v3.11862,988,045 - 62,992,033 (+)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Nerolidylcatechol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-O-methylguanine  (ISO)
9,10-phenanthroquinone  (ISO)
ABT-737  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Aurin  (ISO)
baicalein  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzyl bromide  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carboplatin  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloromethylisothiazolinone  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dihydroartemisinin  (ISO)
dimethyl sulfate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
Dodecyl gallate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elesclomol  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenvalerate  (ISO)
flubendazole  (ISO)
flusilazole  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP,ISO)
glucose  (ISO)
glutaraldehyde  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexaconazole  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
indometacin  (ISO)
ionomycin  (ISO)
iopamidol  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
LY294002  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
melatonin  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metiram  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
N(6)-dimethylallyladenine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitric oxide  (ISO)
Nutlin-3  (ISO)
o-xylene  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
patulin  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
pevonedistat  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
promethazine  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
ruthenium atom  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S63845  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
selinexor  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
torcetrapib  (ISO)
triacsin C  (ISO)
triadimefon  (ISO)
Tributyltin oxide  (ISO)
tricetin  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
venetoclax  (ISO)
versicolorin A  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
cellular response to glucose starvation  (ISO)
cellular response to hypoxia  (ISO)
defense response to virus  (ISO)
DNA damage response  (IEA,ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of mitochondrial membrane potential  (ISO)
positive regulation of apoptotic process  (IEA,IMP,ISO)
positive regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
positive regulation of establishment of protein localization to mitochondrion  (ISO)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
proteasomal protein catabolic process  (ISO)
reactive oxygen species metabolic process  (ISO)
regulation of mitochondrial membrane permeability  (ISO)
release of cytochrome c from mitochondria  (IEA,ISO)
response to dsRNA  (ISO)
response to UV  (ISO)
response to X-ray  (ISO)
T cell homeostasis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Mild hypothermia diminishes oxidative DNA damage and pro-death signaling events after cerebral ischemia: a mechanism for neuroprotection. Ji X, etal., Front Biosci. 2007 Jan 1;12:1737-47.
4. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
5. Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression. Onoue S, etal., FEBS J. 2008 Nov;275(22):5542-51.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling. Zhang G, etal., J Biol Chem. 2008 Sep 5;283(36):24343-58. Epub 2008 Jul 9.
Additional References at PubMed
PMID:10807576   PMID:12879012   PMID:12952892   PMID:14500711   PMID:14500851   PMID:14651853   PMID:14699081   PMID:15102863   PMID:15703398   PMID:15705586   PMID:15901672   PMID:16407291  
PMID:17024184   PMID:17289999   PMID:17599062   PMID:18411339   PMID:19052818   PMID:20810912   PMID:21145489   PMID:21454712   PMID:21525171   PMID:21660051   PMID:22785021   PMID:28131915  
PMID:37580530   PMID:38691334  


Genomics

Comparative Map Data
Pmaip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81862,255,970 - 62,262,384 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1862,255,598 - 62,262,382 (+)EnsemblGRCr8
mRatBN7.21859,986,020 - 59,992,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1859,986,017 - 59,992,429 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1862,070,712 - 62,074,695 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01862,769,423 - 62,773,407 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01860,619,311 - 60,623,296 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,159,128 - 62,179,635 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,174,670 - 62,181,102 (+)Ensemblrn6Rnor6.0
Rnor_5.01861,365,056 - 61,369,043 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41862,914,845 - 62,918,832 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1858,105,912 - 58,109,899 (+)NCBICelera
RGSC_v3.11862,988,045 - 62,992,033 (+)NCBI
Cytogenetic Map18q12.1NCBI
PMAIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381859,899,996 - 59,904,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1859,899,644 - 59,904,305 (+)Ensemblhg38GRCh38
GRCh371857,567,228 - 57,571,537 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361855,718,172 - 55,722,518 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341855,718,216 - 55,722,517NCBI
Celera1854,285,254 - 54,289,600 (+)NCBICelera
Cytogenetic Map18q21.32NCBI
HuRef1854,276,682 - 54,281,028 (+)NCBIHuRef
CHM1_11857,562,830 - 57,567,176 (+)NCBICHM1_1
T2T-CHM13v2.01860,102,671 - 60,106,980 (+)NCBIT2T-CHM13v2.0
Pmaip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391866,591,675 - 66,598,629 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1866,591,604 - 66,598,636 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381866,458,604 - 66,465,558 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1866,458,533 - 66,465,565 (+)Ensemblmm10GRCm38
MGSCv371866,618,258 - 66,625,212 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361866,583,973 - 66,590,927 (+)NCBIMGSCv36mm8
Celera1867,745,077 - 67,752,031 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.52NCBI
Pmaip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540244,005,616 - 44,013,273 (+)Ensembl
ChiLan1.0NW_00495540244,005,517 - 44,010,722 (+)NCBIChiLan1.0ChiLan1.0
LOC100979315
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21777,437,419 - 77,441,738 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11863,130,031 - 63,134,350 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01853,286,590 - 53,290,913 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11856,611,098 - 56,615,449 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1856,611,098 - 56,615,449 (+)EnsemblpanPan2panpan1.1
PMAIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1116,469,793 - 16,472,910 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl116,469,793 - 16,472,910 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha117,446,017 - 17,449,325 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0116,340,520 - 16,344,361 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl116,340,520 - 16,344,361 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1116,376,897 - 16,380,246 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0116,303,869 - 16,307,124 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0116,558,934 - 16,562,268 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pmaip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494429,746,960 - 29,747,884 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364974,985,995 - 4,986,720 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMAIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1161,182,887 - 161,188,164 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11161,184,458 - 161,188,138 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,853,630 - 178,857,420 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PMAIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11819,861,182 - 19,865,628 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1819,862,743 - 19,865,250 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660605,737,434 - 5,741,800 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pmaip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247925,330,289 - 5,338,067 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pmaip1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11564,808,452 - 64,813,433 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pmaip1
81 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:103
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000025362
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186198220476619168Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186144685386134022Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186160038472538878Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000025362   ⟹   ENSRNOP00000025361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1862,255,598 - 62,262,382 (+)Ensembl
mRatBN7.2 Ensembl1859,986,017 - 59,992,429 (+)Ensembl
Rnor_6.0 Ensembl1862,174,670 - 62,181,102 (+)Ensembl
RefSeq Acc Id: NM_001008385   ⟹   NP_001008386
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81862,255,970 - 62,262,384 (+)NCBI
mRatBN7.21859,986,020 - 59,992,434 (+)NCBI
Rnor_6.01862,174,850 - 62,178,837 (+)NCBI
Rnor_5.01861,365,056 - 61,369,043 (+)NCBI
RGSC_v3.41862,914,845 - 62,918,832 (+)RGD
Celera1858,105,912 - 58,109,899 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008386 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV51955 (Get FASTA)   NCBI Sequence Viewer  
  EDM14710 (Get FASTA)   NCBI Sequence Viewer  
  Q5U777 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008386   ⟸   NM_001008385
- UniProtKB: Q5U777 (UniProtKB/Swiss-Prot),   A6IXS9 (UniProtKB/TrEMBL),   A0A8L2UK23 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025361   ⟸   ENSRNOT00000025362

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U777-F1-model_v2 AlphaFold Q5U777 1-105 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700839
Promoter ID:EPDNEW_R11361
Type:single initiation site
Name:Pmaip1_1
Description:phorbol-12-myristate-13-acetate-induced protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01862,174,683 - 62,174,743EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359266 AgrOrtholog
BioCyc Gene G2FUF-7188 BioCyc
Ensembl Genes ENSRNOG00000018770 Ensembl
InterPro Noxa UniProtKB/Swiss-Prot
KEGG Report rno:492821 UniProtKB/Swiss-Prot
NCBI Gene 492821 ENTREZGENE
PANTHER PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR14299 UniProtKB/Swiss-Prot
Pfam PMAIP1 UniProtKB/Swiss-Prot
PhenoGen Pmaip1 PhenoGen
RatGTEx ENSRNOG00000018770 RatGTEx
UniProt A0A8L2UK23 ENTREZGENE, UniProtKB/TrEMBL
  A6IXS9 ENTREZGENE, UniProtKB/TrEMBL
  APR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Pmaip1  phorbol-12-myristate-13-acetate-induced protein 1      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Pmaip1  phorbol-12-myristate-13-acetate-induced protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL