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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359266 Species: Rattus norvegicus RGD Object: Gene Symbol: Pmaip1 Name: phorbol-12-myristate-13-acetate-induced protein 1

Acc ID: CHEBI:17356 Term: 2-acetamidofluorene Definition: An ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. CasRN: 53-96-3 Chemical ID: MESH:D015073

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA	PMID:19167416
increases expression	ISO	RGD:1621551	6480464	CTD	2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA	PMID:17317680
multiple interactions	ISO	RGD:1621551	6480464	CTD	TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of PMAIP1 mRNA] TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of PMAIP1 mRNA]	PMID:17317680