Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Epdr1 | Rat | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of EPDR1 mRNA | CTD | PMID:30723492 | Epdr1 | Rat | 17beta-estradiol | multiple interactions | ISO | EPDR1 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of EPDR1 mRNA | CTD | PMID:30165855 | Epdr1 | Rat | 17beta-estradiol | decreases expression | ISO | Epdr1 (Mus musculus) | 6480464 | Estradiol results in decreased expression of EPDR1 protein | CTD | PMID:26903627 | Epdr1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Epdr1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EPDR1 mRNA | CTD | PMID:21354282 | Epdr1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of EPDR1 mRNA | CTD | PMID:34747641 | Epdr1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of EPDR1 mRNA | CTD | PMID:32109520 | Epdr1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Epdr1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EPDR1 mRNA | CTD | PMID:23238561 | Epdr1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EPDR1 mRNA | CTD | PMID:23238561 | Epdr1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of EPDR1 mRNA | CTD | PMID:20106945|PMID:21632981 | Epdr1 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Epdr1 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of EPDR1 mRNA | CTD | PMID:32071231 | Epdr1 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of EPDR1 protein | CTD | PMID:34186270 | Epdr1 | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of EPDR1 mRNA | CTD | PMID:30047161 | Epdr1 | Rat | acetylsalicylic acid | decreases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Aspirin results in decreased expression of EPDR1 mRNA | CTD | PMID:20457246 | Epdr1 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of EPDR1 mRNA | CTD | PMID:28959563 | Epdr1 | Rat | acrylamide | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of EPDR1 mRNA | CTD | PMID:32763439 | Epdr1 | Rat | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of EPDR1 mRNA | CTD | PMID:23630614 | Epdr1 | Rat | aflatoxin B1 | decreases methylation | ISO | EPDR1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of EPDR1 gene | CTD | PMID:27153756 | Epdr1 | Rat | aflatoxin B1 | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of EPDR1 mRNA | CTD | PMID:27153756 | Epdr1 | Rat | aflatoxin M1 | decreases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Aflatoxin M1 results in decreased expression of EPDR1 mRNA | CTD | PMID:30928695 | Epdr1 | Rat | all-trans-retinoic acid | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of EPDR1 mRNA | CTD | PMID:23830798 | Epdr1 | Rat | all-trans-retinoic acid | decreases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of EPDR1 mRNA | CTD | PMID:33167477 | Epdr1 | Rat | antirheumatic drug | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of EPDR1 mRNA | CTD | PMID:24449571 | Epdr1 | Rat | belinostat | decreases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | belinostat results in decreased expression of EPDR1 mRNA | CTD | PMID:27188386 | Epdr1 | Rat | benzo[a]pyrene | increases expression | ISO | Epdr1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of EPDR1 mRNA | CTD | PMID:22228805 | Epdr1 | Rat | benzo[a]pyrene | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of EPDR1 mRNA; Benzo(a)pyrene results in increased expression of EPDR1 more ... | CTD | PMID:32234424|PMID:33278487 | Epdr1 | Rat | benzo[a]pyrene | increases methylation | ISO | EPDR1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of EPDR1 exon | CTD | PMID:27901495 | Epdr1 | Rat | beta-naphthoflavone | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EPDR1 mRNA | CTD | PMID:18164116 | Epdr1 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of EPDR1 mRNA | CTD | PMID:31163220 | Epdr1 | Rat | bis(2-ethylhexyl) phthalate | increases expression | ISO | Epdr1 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased expression of EPDR1 mRNA | CTD | PMID:33754040 | Epdr1 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated more ... | CTD | PMID:31199487 | Epdr1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of EPDR1 mRNA | CTD | PMID:25181051 | Epdr1 | Rat | bisphenol A | decreases expression | ISO | Epdr1 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of EPDR1 mRNA | CTD | PMID:32071231 | Epdr1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of EPDR1 mRNA | CTD | PMID:30816183|PMID:32528016|PMID:34947998 | Epdr1 | Rat | bisphenol A | decreases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of EPDR1 mRNA; bisphenol A results in decreased expression more ... | CTD | PMID:25912373|PMID:34186270 | Epdr1 | Rat | bisphenol AF | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | bisphenol AF results in increased expression of EPDR1 protein | CTD | PMID:34186270 | Epdr1 | Rat | bisphenol F | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | bisphenol F results in increased expression of EPDR1 protein | CTD | PMID:34186270 | Epdr1 | Rat | butanal | decreases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of EPDR1 mRNA | CTD | PMID:26079696 | Epdr1 | Rat | Butylbenzyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated more ... | CTD | PMID:31199487 | Epdr1 | Rat | cadmium atom | multiple interactions | ISO | Epdr1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EPDR1 more ... | CTD | PMID:37325564 | Epdr1 | Rat | cadmium dichloride | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of EPDR1 protein | CTD | PMID:24527689 | Epdr1 | Rat | cadmium dichloride | multiple interactions | ISO | Epdr1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of EPDR1 more ... | CTD | PMID:37325564 | Epdr1 | Rat | carbon nanotube | decreases expression | ISO | Epdr1 (Mus musculus) | 6480464 | Nanotubes, Carbon results in decreased expression of EPDR1 mRNA | CTD | PMID:25554681 | Epdr1 | Rat | choline | multiple interactions | ISO | Epdr1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Epdr1 | Rat | cisplatin | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of EPDR1 mRNA | CTD | PMID:27392435|PMID:27594783 | Epdr1 | Rat | clothianidin | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | clothianidin results in increased expression of EPDR1 mRNA | CTD | PMID:29044138 | Epdr1 | Rat | Dibutyl phosphate | affects expression | ISO | EPDR1 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of EPDR1 mRNA | CTD | PMID:37042841 | Epdr1 | Rat | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated more ... | CTD | PMID:31199487 | Epdr1 | Rat | diethyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated more ... | CTD | PMID:31199487 | Epdr1 | Rat | diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of EPDR1 mRNA | CTD | PMID:17005392 | Epdr1 | Rat | diisobutyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated more ... | CTD | PMID:31199487 | Epdr1 | Rat | diisononyl phthalate | multiple interactions | EXP | | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated more ... | CTD | PMID:31199487 | Epdr1 | Rat | dorsomorphin | multiple interactions | ISO | EPDR1 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Epdr1 | Rat | folic acid | multiple interactions | ISO | Epdr1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Epdr1 | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of EPDR1 mRNA | CTD | PMID:27387713 | Epdr1 | Rat | L-methionine | multiple interactions | ISO | Epdr1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... | CTD | PMID:20938992 | Epdr1 | Rat | manganese(II) chloride | increases expression | EXP | | 6480464 | manganese chloride results in increased expression of EPDR1 mRNA | CTD | PMID:28801915 | Epdr1 | Rat | mercury dibromide | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of EPDR1 mRNA | CTD | PMID:26272509 | Epdr1 | Rat | mercury dibromide | multiple interactions | ISO | EPDR1 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Epdr1 | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of EPDR1 mRNA | CTD | PMID:30047161 | Epdr1 | Rat | methylmercury chloride | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of EPDR1 mRNA | CTD | PMID:28001369 | Epdr1 | Rat | mono(2-ethylhexyl) phthalate | decreases expression | ISO | Epdr1 (Mus musculus) | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of EPDR1 mRNA | CTD | PMID:22401849 | Epdr1 | Rat | N-methyl-4-phenylpyridinium | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of EPDR1 mRNA | CTD | PMID:24810058 | Epdr1 | Rat | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EPDR1 mRNA | CTD | PMID:18164116 | Epdr1 | Rat | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of EPDR1 mRNA | CTD | PMID:19638242 | Epdr1 | Rat | nickel atom | decreases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Nickel results in decreased expression of EPDR1 mRNA | CTD | PMID:24768652|PMID:25583101 | Epdr1 | Rat | nickel sulfate | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of EPDR1 mRNA | CTD | PMID:22714537 | Epdr1 | Rat | p-chloromercuribenzoic acid | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in increased expression of EPDR1 mRNA | CTD | PMID:26272509 | Epdr1 | Rat | p-chloromercuribenzoic acid | multiple interactions | ISO | EPDR1 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Epdr1 | Rat | perfluorohexanesulfonic acid | increases expression | ISO | Epdr1 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of EPDR1 mRNA | CTD | PMID:37995155 | Epdr1 | Rat | perfluorooctanoic acid | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in increased expression of EPDR1 protein | CTD | PMID:26879310 | Epdr1 | Rat | phenylmercury acetate | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of EPDR1 mRNA | CTD | PMID:26272509 | Epdr1 | Rat | phenylmercury acetate | multiple interactions | ISO | EPDR1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Epdr1 | Rat | pirinixic acid | multiple interactions | ISO | EPDR1 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... | CTD | PMID:19710929 | Epdr1 | Rat | pirinixic acid | increases expression | ISO | Epdr1 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of EPDR1 mRNA | CTD | PMID:23811191 | Epdr1 | Rat | rotenone | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Rotenone results in increased expression of EPDR1 mRNA | CTD | PMID:29955902 | Epdr1 | Rat | SB 431542 | multiple interactions | ISO | EPDR1 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Epdr1 | Rat | silicon dioxide | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of EPDR1 mRNA | CTD | PMID:23806026 | Epdr1 | Rat | sodium arsenite | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of EPDR1 mRNA | CTD | PMID:22714537 | Epdr1 | Rat | sodium arsenite | decreases expression | ISO | Epdr1 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of EPDR1 mRNA | CTD | PMID:37682722 | Epdr1 | Rat | sulforaphane | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | sulforaphane results in increased expression of EPDR1 mRNA | CTD | PMID:31838189 | Epdr1 | Rat | sunitinib | decreases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of EPDR1 mRNA | CTD | PMID:31533062 | Epdr1 | Rat | tamoxifen | increases expression | ISO | Epdr1 (Mus musculus) | 6480464 | Tamoxifen results in increased expression of EPDR1 mRNA | CTD | PMID:25123088 | Epdr1 | Rat | tetrachloromethane | increases expression | ISO | Epdr1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of EPDR1 mRNA | CTD | PMID:17484886 | Epdr1 | Rat | titanium dioxide | decreases methylation | ISO | Epdr1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of EPDR1 gene | CTD | PMID:35295148 | Epdr1 | Rat | triclosan | decreases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of EPDR1 mRNA | CTD | PMID:30510588 | Epdr1 | Rat | trimellitic anhydride | increases expression | ISO | Epdr1 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of EPDR1 mRNA | CTD | PMID:19042947 | Epdr1 | Rat | triphenyl phosphate | affects expression | ISO | EPDR1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of EPDR1 mRNA | CTD | PMID:37042841 | Epdr1 | Rat | valproic acid | affects expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of EPDR1 mRNA | CTD | PMID:25979313 | Epdr1 | Rat | valproic acid | multiple interactions | ISO | EPDR1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Epdr1 | Rat | valproic acid | increases expression | ISO | EPDR1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of EPDR1 mRNA | CTD | PMID:23179753|PMID:26272509|PMID:27188386 | Epdr1 | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of EPDR1 mRNA | CTD | PMID:22570695 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||






















