Usp18 (ubiquitin specific peptidase 18) - Rat Genome Database

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Gene: Usp18 (ubiquitin specific peptidase 18) Rattus norvegicus
Analyze
Symbol: Usp18
Name: ubiquitin specific peptidase 18
RGD ID: 1359153
Description: Predicted to enable ISG15-specific peptidase activity; cysteine-type deubiquitinase activity; and molecular adaptor activity. Predicted to be involved in regulation of defense response; regulation of protein stability; and response to stilbenoid. Predicted to act upstream of or within antiviral innate immune response and response to bacterium. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including USP18 (ubiquitin specific peptidase 18); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100359614; LOC312688; similar to ubiquitin specific protease UBP43; ubiquitin specific peptidase 18-like; ubl carboxyl-terminal hydrolase 18
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84156,143,770 - 156,171,292 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4156,143,815 - 156,171,292 (+)EnsemblGRCr8
mRatBN7.24154,471,634 - 154,499,154 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4154,471,592 - 154,499,144 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4160,737,808 - 160,765,283 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04156,521,289 - 156,548,767 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04155,144,802 - 155,172,259 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04153,812,312 - 153,834,374 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4153,805,993 - 153,834,430 (+)Ensemblrn6Rnor6.0
Rnor_5.04220,901,558 - 220,922,139 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44157,692,720 - 157,694,884 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4143,317,875 - 143,338,351 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
Actein  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethylbenzene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fumonisin B1  (ISO)
Genipin  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
indometacin  (ISO)
inulin  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
lead diacetate  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
o-xylene  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IBA,ISO)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. UBP43 (USP18) specifically removes ISG15 from conjugated proteins. Malakhov MP, etal., J Biol Chem 2002 Mar 22;277(12):9976-81. Epub 2002 Jan 11.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients. Murakawa M, etal., J Med Virol. 2017 Jul;89(7):1241-1247. doi: 10.1002/jmv.24763. Epub 2017 Feb 27.
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:16139798   PMID:16382139   PMID:17086191   PMID:23012479   PMID:27325888   PMID:37356565   PMID:38340205   PMID:38691302   PMID:39094924  


Genomics

Comparative Map Data
Usp18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84156,143,770 - 156,171,292 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4156,143,815 - 156,171,292 (+)EnsemblGRCr8
mRatBN7.24154,471,634 - 154,499,154 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4154,471,592 - 154,499,144 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4160,737,808 - 160,765,283 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04156,521,289 - 156,548,767 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04155,144,802 - 155,172,259 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04153,812,312 - 153,834,374 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4153,805,993 - 153,834,430 (+)Ensemblrn6Rnor6.0
Rnor_5.04220,901,558 - 220,922,139 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44157,692,720 - 157,694,884 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4143,317,875 - 143,338,351 (+)NCBICelera
Cytogenetic Map4q42NCBI
USP18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,150,170 - 18,177,397 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,148,399 - 18,177,397 (+)Ensemblhg38GRCh38
GRCh372218,632,937 - 18,660,164 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,012,758 - 17,040,164 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342217,007,311 - 17,034,714NCBI
Celera222,251,821 - 2,269,866 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef222,445,183 - 2,472,579 (+)NCBIHuRef
CHM1_12218,632,478 - 18,659,884 (+)NCBICHM1_1
T2T-CHM13v2.02218,822,080 - 18,849,307 (+)NCBIT2T-CHM13v2.0
Usp18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396121,222,865 - 121,247,876 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6121,222,865 - 121,247,876 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386121,245,906 - 121,270,917 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6121,245,906 - 121,270,917 (+)Ensemblmm10GRCm38
MGSCv376121,195,924 - 121,220,935 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366121,211,575 - 121,236,536 (+)NCBIMGSCv36mm8
Celera6123,079,923 - 123,105,170 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.17NCBI
Usp18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554546,171,569 - 6,203,091 (+)Ensembl
ChiLan1.0NW_0049554546,171,575 - 6,200,879 (+)NCBIChiLan1.0ChiLan1.0
USP18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22328,464,266 - 28,491,820 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12231,012,239 - 31,041,912 (+)NCBINHGRI_mPanPan1
USP18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12745,739,845 - 45,814,668 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha27868,159 - 943,927 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02746,107,395 - 46,183,398 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2746,106,886 - 46,183,378 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12746,041,070 - 46,116,807 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02746,008,145 - 46,083,815 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.027223,830 - 299,560 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Usp18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945109,829,924 - 109,854,928 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368071,090,882 - 1,114,770 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049368071,090,928 - 1,116,166 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl570,183,308 - 70,229,572 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1570,183,321 - 70,227,990 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2572,536,548 - 72,595,957 (+)NCBISscrofa10.2Sscrofa10.2susScr3
USP18
(Chlorocebus sabaeus - green monkey)		 No map positions available.
Usp18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247359,158,597 - 9,187,503 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Usp18
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1625,475,470 - 25,492,652 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Usp18
529 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:194
Count of miRNA genes:143
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000056174
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4150095743159267220Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
RH130260  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24154,498,940 - 154,499,122 (+)MAPPERmRatBN7.2
Rnor_6.04153,834,161 - 153,834,342NCBIRnor6.0
Rnor_5.04220,921,926 - 220,922,107UniSTSRnor5.0
RGSC_v3.44157,694,671 - 157,694,852UniSTSRGSC3.4
Celera4143,338,138 - 143,338,319UniSTS
RH 3.4 Map4993.9UniSTS
Cytogenetic Map4q42UniSTS
RH144655  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84156,151,896 - 156,152,050 (+)Marker Load Pipeline
mRatBN7.24154,479,755 - 154,479,909 (+)MAPPERmRatBN7.2
Rnor_6.04153,814,052 - 153,814,205NCBIRnor6.0
Rnor_5.04220,903,298 - 220,903,451UniSTSRnor5.0
Celera4143,319,615 - 143,319,768UniSTS
RH 3.4 Map4994.2UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000056174   ⟹   ENSRNOP00000053020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4156,143,815 - 156,171,292 (+)Ensembl
mRatBN7.2 Ensembl4154,471,592 - 154,499,144 (+)Ensembl
Rnor_6.0 Ensembl4153,805,993 - 153,834,430 (+)Ensembl
RefSeq Acc Id: NM_001014058   ⟹   NP_001014080
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84156,143,826 - 156,171,292 (+)NCBI
mRatBN7.24154,471,685 - 154,499,154 (+)NCBI
Rnor_6.04153,812,312 - 153,834,374 (+)NCBI
Rnor_5.04220,901,558 - 220,922,139 (+)NCBI
RGSC_v3.44157,692,720 - 157,694,884 (+)RGD
Celera4143,317,875 - 143,338,351 (+)RGD
Sequence:
RefSeq Acc Id: XM_039107665   ⟹   XP_038963593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84156,143,789 - 156,171,292 (+)NCBI
mRatBN7.24154,471,648 - 154,499,154 (+)NCBI
RefSeq Acc Id: XM_039107666   ⟹   XP_038963594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84156,143,770 - 156,166,202 (+)NCBI
mRatBN7.24154,471,634 - 154,493,887 (+)NCBI
RefSeq Acc Id: NP_001014080   ⟸   NM_001014058
- UniProtKB: Q6AYC7 (UniProtKB/TrEMBL),   F1LNS1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053020   ⟸   ENSRNOT00000056174
RefSeq Acc Id: XP_038963594   ⟸   XM_039107666
- Peptide Label: isoform X2
- UniProtKB: A6ILC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963593   ⟸   XM_039107665
- Peptide Label: isoform X1
- UniProtKB: A6ILC1 (UniProtKB/TrEMBL)
Protein Domains
USP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYC7-F1-model_v2 AlphaFold Q6AYC7 1-362 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693363
Promoter ID:EPDNEW_R3887
Type:multiple initiation site
Name:Usp18_1
Description:ubiquitin specific peptidase 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04153,805,985 - 153,806,045EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359153 AgrOrtholog
BioCyc Gene G2FUF-43181 BioCyc
Ensembl Genes ENSRNOG00000037198 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056174 ENTREZGENE
  ENSRNOT00000056174.6 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124857 IMAGE-MGC_LOAD
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_C19ubi-hydrolase_C_CS UniProtKB/TrEMBL
  Peptidase_C19 UniProtKB/TrEMBL
  Peptidase_C19 UniProtKB/TrEMBL
  UCH/PAN2 UniProtKB/TrEMBL
KEGG Report rno:312688 UniProtKB/TrEMBL
MGC_CLONE MGC:94088 IMAGE-MGC_LOAD
NCBI Gene 312688 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/TrEMBL
  UBL CARBOXYL-TERMINAL HYDROLASE 18-RELATED UniProtKB/TrEMBL
Pfam UCH UniProtKB/TrEMBL
PhenoGen Usp18 PhenoGen
PROSITE UCH_2_1 UniProtKB/TrEMBL
  UCH_2_2 UniProtKB/TrEMBL
  UCH_2_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037198 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A6ILC0 ENTREZGENE, UniProtKB/TrEMBL
  A6ILC1 ENTREZGENE, UniProtKB/TrEMBL
  A6ILC2_RAT UniProtKB/TrEMBL
  F1LNS1 ENTREZGENE
  Q6AYC7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LNS1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Usp18  ubiquitin specific peptidase 18  LOC100359614  ubiquitin specific peptidase 18-like  Data merged from RGD:2699571 737654 PROVISIONAL
2010-07-02 LOC100359614  ubiquitin specific peptidase 18-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Usp18  ubiquitin specific peptidase 18  LOC312688  similar to ubiquitin specific protease UBP43  Symbol and Name updated 1299863 APPROVED
2005-07-29 LOC312688  similar to ubiquitin specific protease UBP43      Symbol and Name status set to provisional 70820 PROVISIONAL