Or6b2 (olfactory receptor family 6 subfamily B member 2) - Rat Genome Database

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Gene: Or6b2 (olfactory receptor family 6 subfamily B member 2) Rattus norvegicus
Analyze
Symbol: Or6b2 (Ensembl: Or6b2b)
Name: olfactory receptor family 6 subfamily B member 2 (Ensembl:olfactory receptor family 6 subfamily B member 2B)
RGD ID: 1332746
Description: Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to human OR6B2 (olfactory receptor family 6 subfamily B member 2) and OR6B3 (olfactory receptor family 6 subfamily B member 3); INTERACTS WITH acrylamide; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1343; olfactory receptor gene Olr1343; olfactory receptor Olr1343; Olr1343
RGD Orthologs
Human
Mouse
Bonobo
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89100,495,938 - 100,496,876 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9100,495,938 - 100,496,876 (-)EnsemblGRCr8
mRatBN7.2993,048,475 - 93,049,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,045,014 - 93,053,641 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9101,484,533 - 101,485,471 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09106,620,297 - 106,621,235 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09104,976,153 - 104,977,091 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0999,656,296 - 99,659,425 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl999,658,487 - 99,659,425 (-)Ensemblrn6Rnor6.0
Rnor_5.0999,323,601 - 99,324,539 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4991,696,327 - 91,697,265 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera990,587,098 - 90,588,036 (-)NCBICelera
RGSC_v3.1991,901,095 - 91,902,034 (-)NCBI
Cytogenetic Map9q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or6b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89100,495,938 - 100,496,876 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9100,495,938 - 100,496,876 (-)EnsemblGRCr8
mRatBN7.2993,048,475 - 93,049,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,045,014 - 93,053,641 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9101,484,533 - 101,485,471 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09106,620,297 - 106,621,235 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09104,976,153 - 104,977,091 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0999,656,296 - 99,659,425 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl999,658,487 - 99,659,425 (-)Ensemblrn6Rnor6.0
Rnor_5.0999,323,601 - 99,324,539 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4991,696,327 - 91,697,265 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera990,587,098 - 90,588,036 (-)NCBICelera
RGSC_v3.1991,901,095 - 91,902,034 (-)NCBI
Cytogenetic Map9q36NCBI
OR6B3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,044,571 - 240,053,521 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,044,571 - 240,053,807 (-)Ensemblhg38GRCh38
GRCh372240,983,988 - 240,992,938 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,633,167 - 240,634,162 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342240,704,483 - 240,705,479NCBI
Celera2234,657,516 - 234,658,511 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2232,742,367 - 232,743,362 (-)NCBIHuRef
CHM1_12240,990,010 - 240,991,005 (-)NCBICHM1_1
T2T-CHM13v2.02240,537,284 - 240,546,234 (-)NCBIT2T-CHM13v2.0
Or6b3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39192,438,770 - 92,446,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl192,434,088 - 92,446,383 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38192,511,048 - 92,518,515 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl192,506,366 - 92,518,661 (-)Ensemblmm10GRCm38
MGSCv37194,407,625 - 94,415,092 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36194,341,494 - 94,342,432 (-)NCBIMGSCv36mm8
Celera195,451,733 - 95,459,206 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.45NCBI
LOC100968789
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213142,694,264 - 142,703,270 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B142,709,230 - 142,718,236 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B127,289,492 - 127,290,483 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B246,105,172 - 246,106,170 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B246,105,172 - 246,106,170 (-)EnsemblpanPan2panpan1.1
LOC100625810
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.115139,049,403 - 139,050,341 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215154,082,948 - 154,083,886 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Or6b2
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:17
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000051686
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat


Expression

RNA-SEQ Expression

circulatory system
ectoderm
mesenchyme
mesoderm
nervous system
renal system
reproductive system
sensory system
visual system
1 5 2 1 5 1 9 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000051686   ⟹   ENSRNOP00000043588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl999,658,487 - 99,659,425 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119238   ⟹   ENSRNOP00000088878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl993,045,014 - 93,053,641 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144824   ⟹   ENSRNOP00000098979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9100,495,938 - 100,496,876 (-)Ensembl
RefSeq Acc Id: NM_001001088   ⟹   NP_001001088
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89100,495,938 - 100,496,876 (-)NCBI
mRatBN7.2993,048,475 - 93,049,413 (-)NCBI
Rnor_6.0999,658,487 - 99,659,425 (-)NCBI
Rnor_5.0999,323,601 - 99,324,539 (-)NCBI
RGSC_v3.4991,696,327 - 91,697,265 (-)RGD
Celera990,587,098 - 90,588,036 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001001088 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL91993 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000098979
  ENSRNOP00000098979.1
RefSeq Acc Id: NP_001001088   ⟸   NM_001001088
- UniProtKB: D3ZG63 (UniProtKB/TrEMBL),   A6JQU4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043588   ⟸   ENSRNOT00000051686
Ensembl Acc Id: ENSRNOP00000088878   ⟸   ENSRNOT00000119238
Ensembl Acc Id: ENSRNOP00000098979   ⟸   ENSRNOT00000144824
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZG63-F1-model_v2 AlphaFold D3ZG63 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1332746 AgrOrtholog
BioCyc Gene G2FUF-26689 BioCyc
Ensembl Genes ENSRNOG00000047906 Ensembl
  ENSRNOG00000063133 Ensembl
  ENSRNOG00000090099 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000144824 ENTREZGENE
  ENSRNOT00000144824.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_GPCR UniProtKB/TrEMBL
KEGG Report rno:405982 UniProtKB/TrEMBL
NCBI Gene 405982 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or6b2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047906 RatGTEx
  ENSRNOG00000063133 RatGTEx
  ENSRNOG00000090099 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0ABK0KWR4_RAT UniProtKB/TrEMBL
  A6JQU4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZG63 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or6b2  olfactory receptor family 6 subfamily B member 2  Olr1343  olfactory receptor 1343  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1343  olfactory receptor 1343   Olr1343_predicted  olfactory receptor 1343 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1343_predicted  olfactory receptor 1343 (predicted)      Symbol and Name status set to approved 70820 APPROVED