Trpm2 (transient receptor potential cation channel, subfamily M, member 2) - Rat Genome Database

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Gene: Trpm2 (transient receptor potential cation channel, subfamily M, member 2) Rattus norvegicus
Analyze
Symbol: Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
RGD ID: 1311889
Description: Predicted to enable calcium ion binding activity; metal ion transmembrane transporter activity; and mono-ADP-D-ribose binding activity. Involved in several processes, including calcium ion import across plasma membrane; estrous cycle; and positive regulation of cellular response to oxidative stress. Located in neuronal cell body. Biomarker of transient cerebral ischemia. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC294329; transient receptor potential cation channel subfamily M member 2; transient receptor potential melastatin family 2; Trpm2-predicted
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,703,190 - 10,752,795 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2010,704,482 - 10,752,802 (+)EnsemblGRCr8
mRatBN7.22010,703,568 - 10,753,189 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,707,014 - 10,753,181 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2011,406,577 - 11,451,886 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,767,533 - 10,812,846 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,239,281 - 11,284,590 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,434,062 - 11,482,880 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,436,267 - 11,482,051 (+)Ensemblrn6Rnor6.0
Rnor_5.02013,604,119 - 13,652,782 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42011,053,301 - 11,099,740 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2012,212,844 - 12,258,113 (+)NCBICelera
RGSC_v3.12011,053,527 - 11,099,966 (+)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
ADP-D-ribose  (EXP,ISO)
aldehydo-D-glucose  (ISO)
allethrin  (EXP)
alpha-Zearalanol  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clotrimazole  (EXP,ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (ISO)
econazole  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
fenvalerate  (EXP)
flufenamic acid  (EXP)
fructose  (ISO)
genistein  (ISO)
glucose  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (EXP,ISO)
iron dichloride  (ISO)
lead nitrate  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
mercury dichloride  (ISO)
miconazole  (ISO)
monensin A  (ISO)
Moniliformin  (ISO)
N-(p-amylcinnamoyl)anthranilic acid  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
pinostrobin  (ISO)
pirinixic acid  (ISO)
pyrethrins  (EXP)
rotenone  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
sodium arsenite  (EXP)
tartrazine  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Regulation and localization of transient receptor potential melastatin 2 in rat uterus. Ahn C, etal., Reprod Sci. 2014 Oct;21(10):1288-95. doi: 10.1177/1933719114525276. Epub 2014 Feb 27.
2. Transient receptor potential melastatin 2 expression is increased following experimental traumatic brain injury in rats. Cook NL, etal., J Mol Neurosci. 2010 Oct;42(2):192-9. doi: 10.1007/s12031-010-9347-8. Epub 2010 Mar 23.
3. TRPM2 is elevated in the tMCAO stroke model, transcriptionally regulated, and functionally expressed in C13 microglia. Fonfria E, etal., J Recept Signal Transduct Res. 2006;26(3):179-98.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. A critical role of TRPM2 in neuronal cell death by hydrogen peroxide. Kaneko S, etal., J Pharmacol Sci. 2006 May;101(1):66-76. Epub 2006 Apr 29.
7. TRPM2 channels mediate acetaminophen-induced liver damage. Kheradpezhouh E, etal., Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3176-81. doi: 10.1073/pnas.1322657111. Epub 2014 Feb 3.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. Togashi K, etal., EMBO J. 2006 May 3;25(9):1804-15. Epub 2006 Apr 6.
Additional References at PubMed
PMID:11804595   PMID:16104849   PMID:16260005   PMID:17712480   PMID:19171771   PMID:19382906   PMID:21748272   PMID:21753080   PMID:21900507   PMID:22293297   PMID:23602965   PMID:24646700  
PMID:25059284   PMID:25339252   PMID:25620041   PMID:25849615   PMID:27068538   PMID:27333281   PMID:27383051   PMID:27562954   PMID:27872485   PMID:28363841   PMID:28775320   PMID:29107864  
PMID:29235496   PMID:29745897   PMID:29842890   PMID:30467180   PMID:31002158   PMID:31120580   PMID:32294037   PMID:37215981   PMID:37300693   PMID:37454827  


Genomics

Comparative Map Data
Trpm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,703,190 - 10,752,795 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2010,704,482 - 10,752,802 (+)EnsemblGRCr8
mRatBN7.22010,703,568 - 10,753,189 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,707,014 - 10,753,181 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2011,406,577 - 11,451,886 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,767,533 - 10,812,846 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,239,281 - 11,284,590 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,434,062 - 11,482,880 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,436,267 - 11,482,051 (+)Ensemblrn6Rnor6.0
Rnor_5.02013,604,119 - 13,652,782 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42011,053,301 - 11,099,740 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2012,212,844 - 12,258,113 (+)NCBICelera
RGSC_v3.12011,053,527 - 11,099,966 (+)NCBI
Cytogenetic Map20p12NCBI
TRPM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,350,141 - 44,442,644 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,350,072 - 44,445,246 (+)Ensemblhg38GRCh38
GRCh372145,773,504 - 45,862,527 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,597,912 - 44,687,392 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342144,597,998 - 44,687,118NCBI
Celera2130,878,659 - 30,971,052 (+)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,143,769 - 31,237,293 (+)NCBIHuRef
CHM1_12145,334,322 - 45,423,804 (+)NCBICHM1_1
T2T-CHM13v2.02142,704,228 - 42,803,115 (+)NCBIT2T-CHM13v2.0
Trpm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,743,556 - 77,805,746 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,743,556 - 77,806,397 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381077,907,722 - 77,969,909 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1077,907,722 - 77,970,563 (-)Ensemblmm10GRCm38
MGSCv371077,370,467 - 77,432,617 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361077,312,294 - 77,370,586 (-)NCBIMGSCv36mm8
Celera1078,953,541 - 79,008,872 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Trpm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,057,941 - 41,110,668 (-)Ensembl
ChiLan1.0NW_00495540741,062,217 - 41,110,500 (-)NCBIChiLan1.0ChiLan1.0
TRPM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22240,357,169 - 40,490,267 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12135,207,140 - 35,361,705 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,606,825 - 30,737,313 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12143,903,811 - 44,034,712 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2143,903,811 - 44,035,298 (+)EnsemblpanPan2panpan1.1
TRPM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13138,201,075 - 38,224,076 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3137,360,169 - 37,408,622 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03137,748,649 - 37,796,450 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3137,748,507 - 37,796,506 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13137,619,618 - 37,667,467 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03137,598,140 - 37,645,957 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03138,095,431 - 38,143,324 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Trpm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497137,390,730 - 37,445,869 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650021,942 - 77,260 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650021,960 - 76,895 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13207,212,457 - 207,262,064 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113207,212,339 - 207,263,313 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213217,096,227 - 217,138,676 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRPM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,082,391 - 88,170,340 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,087,448 - 88,170,344 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605416,206,670 - 16,292,923 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474529,757,106 - 29,806,795 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474529,757,267 - 29,809,607 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Trpm2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1181,210,664 - 1,259,458 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Trpm2
526 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:33
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000001631
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20904109911115921Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
Trpm2-predicted  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82010,729,149 - 10,730,112 (+)Marker Load Pipeline
mRatBN7.22010,729,530 - 10,730,493 (+)MAPPERmRatBN7.2
Rnor_6.02011,458,794 - 11,459,756NCBIRnor6.0
Rnor_5.02013,628,688 - 13,629,650UniSTSRnor5.0
RGSC_v3.42011,076,919 - 11,077,881UniSTSRGSC3.4
Celera2012,235,215 - 12,236,177UniSTS
RH 3.4 Map20151.8UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 164 91 90 59 92 59 6 354 190 11 138 81 90 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001011559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB193179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC109383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY749166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001631   ⟹   ENSRNOP00000001631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2010,704,482 - 10,752,802 (+)Ensembl
mRatBN7.2 Ensembl2010,707,014 - 10,753,181 (+)Ensembl
Rnor_6.0 Ensembl2011,436,267 - 11,482,051 (+)Ensembl
RefSeq Acc Id: NM_001011559   ⟹   NP_001011559
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,472 - 10,752,795 (+)NCBI
mRatBN7.22010,704,851 - 10,753,177 (+)NCBI
Rnor_6.02011,436,298 - 11,482,051 (+)NCBI
Rnor_5.02013,604,119 - 13,652,782 (+)NCBI
RGSC_v3.42011,053,301 - 11,099,740 (+)RGD
Celera2012,212,844 - 12,258,113 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256249   ⟹   XP_006256311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,365 - 10,752,795 (+)NCBI
mRatBN7.22010,704,744 - 10,753,189 (+)NCBI
Rnor_6.02011,434,062 - 11,482,880 (+)NCBI
Rnor_5.02013,604,119 - 13,652,782 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098554   ⟹   XP_038954482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,365 - 10,752,795 (+)NCBI
mRatBN7.22010,704,744 - 10,753,189 (+)NCBI
RefSeq Acc Id: XM_039098555   ⟹   XP_038954483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,703,190 - 10,752,795 (+)NCBI
mRatBN7.22010,703,568 - 10,753,189 (+)NCBI
RefSeq Acc Id: XM_039098556   ⟹   XP_038954484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,450 - 10,752,795 (+)NCBI
mRatBN7.22010,704,826 - 10,753,189 (+)NCBI
RefSeq Acc Id: XM_039098557   ⟹   XP_038954485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,706,094 - 10,752,795 (+)NCBI
mRatBN7.22010,706,477 - 10,753,189 (+)NCBI
RefSeq Acc Id: XM_039098559   ⟹   XP_038954487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,365 - 10,744,033 (+)NCBI
mRatBN7.22010,704,744 - 10,744,415 (+)NCBI
RefSeq Acc Id: XM_039098560   ⟹   XP_038954488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,723,088 - 10,752,795 (+)NCBI
mRatBN7.22010,723,469 - 10,753,189 (+)NCBI
RefSeq Acc Id: XM_039098562   ⟹   XP_038954490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,365 - 10,733,150 (+)NCBI
mRatBN7.22010,704,744 - 10,733,531 (+)NCBI
RefSeq Acc Id: XM_039098563   ⟹   XP_038954491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,365 - 10,731,295 (+)NCBI
mRatBN7.22010,704,744 - 10,731,684 (+)NCBI
RefSeq Acc Id: XM_039098564   ⟹   XP_038954492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,365 - 10,731,295 (+)NCBI
mRatBN7.22010,704,744 - 10,731,684 (+)NCBI
RefSeq Acc Id: XM_039098565   ⟹   XP_038954493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,729,179 - 10,752,795 (+)NCBI
mRatBN7.22010,729,561 - 10,753,189 (+)NCBI
RefSeq Acc Id: XM_063279050   ⟹   XP_063135120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,450 - 10,752,795 (+)NCBI
RefSeq Acc Id: XM_063279051   ⟹   XP_063135121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,450 - 10,752,795 (+)NCBI
RefSeq Acc Id: XM_063279052   ⟹   XP_063135122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,365 - 10,734,183 (+)NCBI
RefSeq Acc Id: XM_063279053   ⟹   XP_063135123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,730,818 - 10,752,795 (+)NCBI
RefSeq Acc Id: XM_063279054   ⟹   XP_063135124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,743,608 - 10,752,795 (+)NCBI
RefSeq Acc Id: XR_005497198
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,365 - 10,750,795 (+)NCBI
mRatBN7.22010,704,743 - 10,751,177 (+)NCBI
RefSeq Acc Id: XR_005497200
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,365 - 10,733,722 (+)NCBI
mRatBN7.22010,704,744 - 10,734,103 (+)NCBI
RefSeq Acc Id: XR_005497201
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,704,365 - 10,733,722 (+)NCBI
mRatBN7.22010,704,744 - 10,734,103 (+)NCBI
RefSeq Acc Id: NP_001011559   ⟸   NM_001011559
- UniProtKB: A0A8L2UH90 (UniProtKB/TrEMBL),   A6JK56 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256311   ⟸   XM_006256249
- Peptide Label: isoform X3
- UniProtKB: Q2PH54 (UniProtKB/Swiss-Prot),   Q5G856 (UniProtKB/Swiss-Prot),   E9PTA2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001631   ⟸   ENSRNOT00000001631
RefSeq Acc Id: XP_038954483   ⟸   XM_039098555
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954482   ⟸   XM_039098554
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954487   ⟸   XM_039098559
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038954490   ⟸   XM_039098562
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038954492   ⟸   XM_039098564
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038954491   ⟸   XM_039098563
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038954484   ⟸   XM_039098556
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954485   ⟸   XM_039098557
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954488   ⟸   XM_039098560
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038954493   ⟸   XM_039098565
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063135122   ⟸   XM_063279052
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063135120   ⟸   XM_063279050
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UH90 (UniProtKB/TrEMBL),   A6JK56 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135121   ⟸   XM_063279051
- Peptide Label: isoform X3
- UniProtKB: Q5G856 (UniProtKB/Swiss-Prot),   Q2PH54 (UniProtKB/Swiss-Prot),   E9PTA2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063135123   ⟸   XM_063279053
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063135124   ⟸   XM_063279054
- Peptide Label: isoform X12
Protein Domains
Nudix hydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTA2-F1-model_v2 AlphaFold E9PTA2 1-1507 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311889 AgrOrtholog
BioCyc Gene G2FUF-4271 BioCyc
Ensembl Genes ENSRNOG00000001216 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001631 ENTREZGENE
Gene3D-CATH 3.40.50.450 UniProtKB/Swiss-Prot
  Nucleoside Triphosphate Pyrophosphohydrolase UniProtKB/Swiss-Prot
InterPro Ion_trans_dom UniProtKB/Swiss-Prot
  NUDIX_hydrolase_dom UniProtKB/Swiss-Prot
  NUDIX_hydrolase_dom-like UniProtKB/Swiss-Prot
  TRPM UniProtKB/Swiss-Prot
  TRPM_SLOG UniProtKB/Swiss-Prot
KEGG Report rno:294329 UniProtKB/Swiss-Prot
NCBI Gene 294329 ENTREZGENE
PANTHER PTHR13800:SF2 UniProtKB/Swiss-Prot
  TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6 UniProtKB/Swiss-Prot
Pfam Ion_trans UniProtKB/Swiss-Prot
  LSDAT_euk UniProtKB/Swiss-Prot
  TRPM2 UniProtKB/Swiss-Prot
PhenoGen Trpm2 PhenoGen
PROSITE NUDIX UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001216 RatGTEx
Superfamily-SCOP SSF55811 UniProtKB/Swiss-Prot
UniProt A0A8L2UH90 ENTREZGENE, UniProtKB/TrEMBL
  A6JK56 ENTREZGENE, UniProtKB/TrEMBL
  E9PTA2 ENTREZGENE
  Q2PH54 ENTREZGENE
  Q5G856 ENTREZGENE
  TRPM2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q2PH54 UniProtKB/Swiss-Prot
  Q5G856 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-07 Trpm2  transient receptor potential cation channel, subfamily M, member 2  Trpm2_predicted  transient receptor potential cation channel, subfamily M, member 2 (predicted)  Symbol and Name status set to approved 1299863 APPROVED
2005-10-14 Trpm2_predicted  transient receptor potential cation channel, subfamily M, member 2 (predicted)  Trpm2-predicted    Data merged from RGD:634628 737654 APPROVED
2005-01-12 Trpm2_predicted  transient receptor potential cation channel, subfamily M, member 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED