Gene: TRPM2 (transient receptor potential cation channel subfamily M member 2) Homo sapiens
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Symbol: TRPM2
Name: transient receptor potential cation channel subfamily M member 2
Description: The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EREG1; estrogen-responsive element-associated gene 1 protein; KNP3; long transient receptor potential channel 2; LTrpC-2; LTRPC2; MGC133383; NUDT9H; NUDT9L1; OTTHUMP00000038504; OTTHUMP00000038505; OTTHUMP00000109530; OTTHUMP00000207883; transient receptor potential cation channel, subfamily M, member 2; transient receptor potential channel 7; transient receptor potential melastatin 2; TRPC7
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,350,112 - 44,443,081 (+)NCBIGRCh38hg38GRCh38
GRCh372145,770,046 - 45,862,964 (+)NCBIGRCh37hg19GRCh37
Build 362144,597,912 - 44,687,392 (+)NCBINCBI36hg18NCBI36
Build 342144,597,998 - 44,687,118NCBI
Celera2130,878,659 - 30,971,052 (+)NCBI
Cytogenetic Map21q22.3NCBImapview
HuRef2131,143,769 - 31,237,293 (+)NCBI
CHM1_12145,334,322 - 45,423,804 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated
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Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TRPM2
NCBI Gene
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RGD Object Information
RGD ID: 1323582
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2017-09-12
Status: ACTIVE