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Gene: Cnksr1 (connector enhancer of kinase suppressor of Ras 1) Rattus norvegicus

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Symbol:

Cnksr1

Name:

connector enhancer of kinase suppressor of Ras 1

RGD ID:

1311879

Description:

Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in synapse organization. Predicted to be located in cell cortex. Orthologous to human CNKSR1 (connector enhancer of kinase suppressor of Ras 1); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; interleukin-3 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC298545; MGC124829

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	151,731,222 - 151,742,049 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	151,731,224 - 151,742,203 (-)	Ensembl				GRCr8
mRatBN7.2	5	146,447,495 - 146,458,332 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	146,447,497 - 146,458,212 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	149,149,245 - 149,159,880 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	150,919,634 - 150,930,291 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	150,905,459 - 150,916,094 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	152,447,348 - 152,458,005 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	152,446,845 - 152,458,023 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	156,206,363 - 156,217,020 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	152,972,551 - 152,983,208 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	144,865,185 - 144,875,842 (-)	NCBI		Celera
RGSC_v3.1	5	152,982,589 - 152,993,370 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (ISO)

Neurodevelopmental Disorders (ISO)

Usher syndrome type 2C (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

calcitriol (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dexamethasone (EXP)

dicrotophos (ISO)

dioxygen (ISO)

doxorubicin (ISO)

endosulfan (EXP)

folic acid (ISO)

furan (EXP)

isoprenaline (ISO)

manganese(II) chloride (EXP)

methimazole (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-methyl-4-phenylpyridinium (EXP)

pirinixic acid (ISO)

rotenone (EXP)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

testosterone (EXP,ISO)

thioacetamide (EXP)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

synapse organization (IEA)

Cellular Component

cell cortex (IEA,ISO)

Molecular Function

protein binding (ISO)

protein-macromolecule adaptor activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

angiotensin II signaling pathway via AT2 receptor (ISO)

interleukin-3 signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
2.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	An ATIPical family of angiotensin II AT2 receptor-interacting proteins.	Rodrigues-Ferreira S and Nahmias C, Trends Endocrinol Metab. 2010 Nov;21(11):684-90.

Additional References at PubMed

PMID:12477932	PMID:14749388	PMID:15075335

Genomics

Comparative Map Data

Cnksr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	151,731,222 - 151,742,049 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	151,731,224 - 151,742,203 (-)	Ensembl				GRCr8
mRatBN7.2	5	146,447,495 - 146,458,332 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	146,447,497 - 146,458,212 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	149,149,245 - 149,159,880 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	150,919,634 - 150,930,291 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	150,905,459 - 150,916,094 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	152,447,348 - 152,458,005 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	152,446,845 - 152,458,023 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	156,206,363 - 156,217,020 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	152,972,551 - 152,983,208 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	144,865,185 - 144,875,842 (-)	NCBI		Celera
RGSC_v3.1	5	152,982,589 - 152,993,370 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

CNKSR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	26,177,491 - 26,189,884 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	26,177,476 - 26,189,884 (+)	Ensembl			hg38	GRCh38
GRCh37	1	26,503,982 - 26,516,375 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	26,376,590 - 26,388,962 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	26,188,144 - 26,200,515	NCBI
Celera	1	24,900,351 - 24,912,738 (+)	NCBI		Celera
Cytogenetic Map	1	p36.11	NCBI
HuRef	1	24,758,021 - 24,770,408 (+)	NCBI		HuRef
CHM1_1	1	26,617,199 - 26,629,585 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	26,014,921 - 26,027,308 (+)	NCBI		T2T-CHM13v2.0

Cnksr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	133,955,352 - 133,965,737 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	133,955,352 - 133,965,710 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	134,228,041 - 134,238,416 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	134,228,041 - 134,238,399 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	133,783,957 - 133,794,314 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	133,500,118 - 133,510,475 (-)	NCBI		MGSCv36	mm8
MGSCv36	4	131,800,745 - 131,810,306 (-)	NCBI		MGSCv36	mm8
Celera	4	132,407,888 - 132,418,211 (-)	NCBI		Celera
Cytogenetic Map	4	D2.3	NCBI
cM Map	4	66.5	NCBI

Cnksr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	5,624,306 - 5,634,923 (+)	Ensembl
ChiLan1.0	NW_004955452	5,624,334 - 5,634,861 (+)	NCBI	ChiLan1.0	ChiLan1.0

CNKSR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	200,681,749 - 200,700,402 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	199,779,866 - 199,798,352 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	25,438,092 - 25,450,953 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	26,505,376 - 26,517,561 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	26,505,513 - 26,517,225 (+)	Ensembl			panPan2	panpan1.1

CNKSR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	73,805,333 - 73,814,711 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	73,805,710 - 73,814,725 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	70,381,662 - 70,391,005 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	74,368,429 - 74,377,772 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	74,368,438 - 74,389,997 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	71,192,826 - 71,202,168 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	72,198,576 - 72,207,918 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	73,202,496 - 73,211,838 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cnksr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	44,872,995 - 44,882,216 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	10,699,819 - 10,706,591 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	10,697,777 - 10,706,988 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CNKSR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	83,598,372 - 83,608,607 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	83,598,363 - 83,608,617 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	77,200,943 - 77,208,114 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CNKSR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	106,577,470 - 106,596,544 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	106,577,809 - 106,589,788 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	9,828,678 - 9,841,637 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cnksr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	10,234,670 - 10,253,631 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624764	10,223,039 - 10,253,937 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cnksr1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	24,005,740 - 24,016,635 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cnksr1
24 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	285
Count of miRNA genes:	174
Interacting mature miRNAs:	192
Transcripts:	ENSRNOT00000031225
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	149642129	171146538	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134369218	156289444	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	149805999	162987697	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	148093485	172129029	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	149661912	166600247	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

BI294230

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	146,447,674 - 146,447,832 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	152,447,528 - 152,447,685	NCBI	Rnor6.0
Rnor_5.0	5	156,206,543 - 156,206,700	UniSTS	Rnor5.0
RGSC_v3.4	5	152,972,731 - 152,972,888	UniSTS	RGSC3.4
Celera	5	144,865,365 - 144,865,522	UniSTS
RH 3.4 Map	5	986.1	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

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alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	142	90	89	58	32	58	6	295	132	11	118	81	92	31	14	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001039011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287451	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287452	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287453	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC099788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000031225 ⟹ ENSRNOP00000029346

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	151,731,224 - 151,741,879 (-)	Ensembl
mRatBN7.2 Ensembl	5	146,447,497 - 146,458,153 (-)	Ensembl
Rnor_6.0 Ensembl	5	152,446,845 - 152,458,023 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097555 ⟹ ENSRNOP00000095433

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	151,731,224 - 151,742,203 (-)	Ensembl
mRatBN7.2 Ensembl	5	146,447,497 - 146,458,212 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105866 ⟹ ENSRNOP00000088159

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	146,447,497 - 146,458,153 (-)	Ensembl

RefSeq Acc Id:

NM_001039011 ⟹ NP_001034100

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	151,731,222 - 151,741,879 (-)	NCBI
mRatBN7.2	5	146,447,495 - 146,458,153 (-)	NCBI
Rnor_6.0	5	152,447,348 - 152,458,005 (-)	NCBI
Rnor_5.0	5	156,206,363 - 156,217,020 (-)	NCBI
RGSC_v3.4	5	152,972,551 - 152,983,208 (-)	RGD
Celera	5	144,865,185 - 144,875,842 (-)	RGD

Sequence:

show sequence

GTCTGGACGCTGCGGGCGGAGCTCAGTATGGAGCCCGTGGAGACCTGGACCCCCGGGAAGGTGG
CAGCTTGGCTGAGAGGCCTTGATGACGTCCTACAGGACTATCCCTTCGAGGACTGGGAGCTGCC
TGGAAAGTACCTGCTGCAGCTCTGTCCCCAAAACCTCGAGGCTCTGACCGTGTGGCCTCTGGGC
CACCAGGAGCTCATTCTACATGGAGTGGAACAGCTCCGGGCCCTGGGCTCTAAGTTACAGACCG
AGAACCTCAAGAGCCTAGCCCAGGGGCTGCTGGACAGGACCCAGGCCTTCCAAAGCTTGGTCCA
AGGCCGTCTGAGAGACTGTGCTGAGACACCCGCCGATGTCCTCAATGCTGCTGTAGAGCTGGTA
CGGGAGGCTCATGCCCTGCTCTCTTGGCTCAACAGGTACCTCTTCACTCACTTAAATGACTTCT
CCGCCTGCCAAGAGATTGGTGTGCTGTGCGGAGAGCTGGGCCAAGTCTTGCAGGAGGATTGCCT
AGAGGCTGAGAAAGAAAGCAACACCCTGAGGATTTGCGGCCGTGTGGCTGGGATCTGTCACAAC
ATCCTGGGCTGCAGCCCGGAGGAGCTGCTGGAACAGAGGGCCGTGTTGGAGCTGGTGCAGCTGG
ACGACCCTTCCGGCCTAGAAATTCACACCACCAGCAACTGCCTACACTTTGTGTCTCGAGTAGG
CGTCCAGGCTGCCACCGGCTCCCAGATCCTGCCCGGAGATGAGATCATCCAAATCAATGAGCAG
GTGGTGGTCGGCTGGCCCCATAAAAACATGCTGAGGGAGCTGCTGAGGGAGCCAGCAAGGGTCA
GCCTTGTACTAAAGAAGATTCCCGTGCCAGAGACCCCCTCAAAGACGCCCCCGGACTCCCCTCA
GCGGCTAAGCCAATCGCTGCCCCTGAACCCACCGTCTCCCAGGGTTCCACGCGAAGGTCTTTTT
GACTTCAAGCTGTTTACAGATGGAAACCCCAGCCCCAGCCCTGCGTGGACAGACTCTACCTCCC
TTGACGCTCAGCCCACGCCCACTCCCCCTGGGCCACCAGGCACTCTTCCAGAAGAAACAGCAGA
ACCTCTGGAGGCTTCGGGACACCTTGACAAGAGTCCCACCGTTGGTCGGAAGAATTCAAAAGGT
ATAGCTACAAGGCTGAGCCGCCGGCGGGTGTCCTGCCGAGAGCTGGGTCTGCCGGACTGTGATG
GATGGCTTCTACTGCGGAAGGTACCCGGTGGTTTTATGGGCGCTCGCTGGCGTCGCTGCTGGTT
CGTGCTCAAGGGACACACCCTATACTGGTACCGCCAACCGCAGGATGAAAAGGCGGAAGGACTT
ATCAACATCTCCAATTACAGCCTGGAGTGCGGGCATGACCAGAAGAAAAAATATGTGTTCCAGC
TGACCCACGATGTGTACAAGCCCTTCATCTTTGCCTCGGAGACCCTGTCTGATCTGAGCATGTG
GGTGCGGCATCTTGTCACCTGCATTTCCAAGTATCAGACTCTAGGTCGGGCCCCCTCCGCCAGA
GAGGAAGACTGCTACAGTGAGACCGAAGCAGAAGACCCTGATGAAGAGGCAGGGTCCCGCTCAG
CTTCTCCTGGTCCAGCTCAAGCTTGGAATGACACATCGCCCTCGGCTTCACCCCTGCAGAGTCC
TAGGACCTCCTTTGGCTCTTCATTAGATAGCAGTGACAGAGCCCTGGAAGGAATGGTACAGGGG
CTGAGGCAGGGAGGCGTGTCCCTCCTGGGCCAGCCACAGCCCTTGACCCATGAACAGTGGCGGA
GTTCTTTCATGCGGCGAAACCGTGACCCTCATCTCAATGAGCATGTGCACCGTGTCCGGGCACT
ACAGAGCACACTCAAGGCAAAGCTACAGGAACTGCAGGTCCTGGAGGAAGTCCTGGGTGATCCT
GAACTCACAGGAGCAAAATTTCGCCAGTGGAAGGAACAGAACCACGAGCTGTACTCAGAAGGCC
TGAGGACCTGGGGAGGGATGTGGGCCCAGACCAGCTCCCCAGACCCAAACACTGACTCCAGGGG
TCAATCCCCACAGCCTCTACCCTCTGACCCTGAAGAGCCCTCCCAGCTTTTTCCCTCGACCCCA
GAGAACAGCCTCCAACCTCCTGACCTCTGACCCTGGCTGAGGACTACTTCATCCCCAGTCTCTG
ATGTGCTTAAAACATGTCCAAGGGGTCTGTGAGAGACCGGAAGGAGCATTAGCCCTCAGCTTAC
CTCCAAACCGGTCCCTCTATGCTGGGCTTCCACACTTTCTGCTCACAAGTCCCTCATAGTGGAA
GGAAAGTTCCTCTCTTCTCTGTGAGGTAGAAATCCCTCAACCCATCCTCAGATTTGGGATGTAC
CTGCCTCCCTGGGTCATTCAAAAAGGTTTCCCAGACCTTCCTAGGTAGGTGTTTATTTTACATG
AGAGATAGTTTTCCACCAAATAAAGTTGATTTTTCTGAAGTGAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039109635 ⟹ XP_038965563

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	151,731,222 - 151,742,049 (-)	NCBI
mRatBN7.2	5	146,447,495 - 146,458,323 (-)	NCBI

RefSeq Acc Id:

XM_063287450 ⟹ XP_063143520

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	151,731,222 - 151,742,049 (-)	NCBI

RefSeq Acc Id:

XM_063287451 ⟹ XP_063143521

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	151,731,222 - 151,742,049 (-)	NCBI

RefSeq Acc Id:

XM_063287452 ⟹ XP_063143522

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	151,731,222 - 151,741,555 (-)	NCBI

RefSeq Acc Id:

XM_063287453 ⟹ XP_063143523

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	151,731,222 - 151,741,226 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001034100	(Get FASTA)	NCBI Sequence Viewer
	XP_038965563	(Get FASTA)	NCBI Sequence Viewer
	XP_063143520	(Get FASTA)	NCBI Sequence Viewer
	XP_063143521	(Get FASTA)	NCBI Sequence Viewer
	XP_063143522	(Get FASTA)	NCBI Sequence Viewer
	XP_063143523	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH99788	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000029346
	ENSRNOP00000029346.4
	ENSRNOP00000095433
	ENSRNOP00000095433.2

RefSeq Acc Id:

NP_001034100 ⟸ NM_001039011

- UniProtKB:

Q499S0 (UniProtKB/TrEMBL), A6IT10 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEPVETWTPGKVAAWLRGLDDVLQDYPFEDWELPGKYLLQLCPQNLEALTVWPLGHQELILHGV
EQLRALGSKLQTENLKSLAQGLLDRTQAFQSLVQGRLRDCAETPADVLNAAVELVREAHALLSW
LNRYLFTHLNDFSACQEIGVLCGELGQVLQEDCLEAEKESNTLRICGRVAGICHNILGCSPEEL
LEQRAVLELVQLDDPSGLEIHTTSNCLHFVSRVGVQAATGSQILPGDEIIQINEQVVVGWPHKN
MLRELLREPARVSLVLKKIPVPETPSKTPPDSPQRLSQSLPLNPPSPRVPREGLFDFKLFTDGN
PSPSPAWTDSTSLDAQPTPTPPGPPGTLPEETAEPLEASGHLDKSPTVGRKNSKGIATRLSRRR
VSCRELGLPDCDGWLLLRKVPGGFMGARWRRCWFVLKGHTLYWYRQPQDEKAEGLINISNYSLE
CGHDQKKKYVFQLTHDVYKPFIFASETLSDLSMWVRHLVTCISKYQTLGRAPSAREEDCYSETE
AEDPDEEAGSRSASPGPAQAWNDTSPSASPLQSPRTSFGSSLDSSDRALEGMVQGLRQGGVSLL
GQPQPLTHEQWRSSFMRRNRDPHLNEHVHRVRALQSTLKAKLQELQVLEEVLGDPELTGAKFRQ
WKEQNHELYSEGLRTWGGMWAQTSSPDPNTDSRGQSPQPLPSDPEEPSQLFPSTPENSLQPPDL

hide sequence

Ensembl Acc Id:

ENSRNOP00000029346 ⟸ ENSRNOT00000031225

RefSeq Acc Id:	XP_038965563 ⟸ XM_039109635
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6AI85 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000088159 ⟸ ENSRNOT00000105866

Ensembl Acc Id:

ENSRNOP00000095433 ⟸ ENSRNOT00000097555

RefSeq Acc Id:	XP_063143521 ⟸ XM_063287451
- Peptide Label:	isoform X3
- UniProtKB:	G3V8W8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063143520 ⟸ XM_063287450
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AI85 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063143522 ⟸ XM_063287452
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I6AI85 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063143523 ⟸ XM_063287453
- Peptide Label:	isoform X5
- UniProtKB:	A0A8I6AN25 (UniProtKB/TrEMBL), A6IT10 (UniProtKB/TrEMBL)

Protein Domains

CRIC PH SAM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V8W8-F1-model_v2	AlphaFold	G3V8W8	1-704	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694131

Promoter ID:

EPDNEW_R4656

Type:

initiation region

Name:

Cnksr1_1

Description:

connector enhancer of kinase suppressor of Ras 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	152,458,026 - 152,458,086	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311879	AgrOrtholog
BioCyc Gene	G2FUF-39591	BioCyc
Ensembl Genes	ENSRNOG00000022838	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000031225	ENTREZGENE
	ENSRNOT00000031225.6	UniProtKB/TrEMBL
	ENSRNOT00000097555	ENTREZGENE
	ENSRNOT00000097555.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.150.50	UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/TrEMBL
	2.30.42.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7934518	IMAGE-MGC_LOAD
InterPro	CNKSR	UniProtKB/TrEMBL
	CRIC_domain	UniProtKB/TrEMBL
	PDZ_sf	UniProtKB/TrEMBL
	PH_type	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
	SAM	UniProtKB/TrEMBL
	SAM/pointed	UniProtKB/TrEMBL
KEGG Report	rno:298545	UniProtKB/TrEMBL
MGC_CLONE	MGC:124829	IMAGE-MGC_LOAD
NCBI Gene	298545	ENTREZGENE
PANTHER	CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS	UniProtKB/TrEMBL
	CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 1	UniProtKB/TrEMBL
Pfam	CRIC_ras_sig	UniProtKB/TrEMBL
	PF00169	UniProtKB/TrEMBL
PhenoGen	Cnksr1	PhenoGen
PROSITE	CRIC	UniProtKB/TrEMBL
	PH_DOMAIN	UniProtKB/TrEMBL
	SAM_DOMAIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000022838	RatGTEx
SMART	SAM	UniProtKB/TrEMBL
	SM00233	UniProtKB/TrEMBL
Superfamily-SCOP	PDZ	UniProtKB/TrEMBL
	PH domain-like	UniProtKB/TrEMBL
	SAM_homology	UniProtKB/TrEMBL
UniProt	A0A8I6AI85	ENTREZGENE
	A0A8I6AN25	ENTREZGENE, UniProtKB/TrEMBL
	A6IT10	ENTREZGENE, UniProtKB/TrEMBL
	G3V8W8	ENTREZGENE, UniProtKB/TrEMBL
	Q499S0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Cnksr1	connector enhancer of kinase suppressor of Ras 1	Cnksr1_predicted	connector enhancer of kinase suppressor of Ras 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Cnksr1_predicted	connector enhancer of kinase suppressor of Ras 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)