Hist1h2bo (histone cluster 1 H2B family member O) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Hist1h2bo (histone cluster 1 H2B family member O) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Hist1h2bo
Name: histone cluster 1 H2B family member O
RGD ID: 1311828
Description: Predicted to enable identical protein binding activity and lipopolysaccharide binding activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide; innate immune response in mucosa; and negative regulation of tumor necrosis factor-mediated signaling pathway. Predicted to be located in extracellular space; nucleus; and plasma membrane. Predicted to be part of CENP-A containing nucleosome; INTERACTS WITH acetamide; bisphenol A; Cuprizon.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Hist1h2bm; Hist1h2bn; histone 1, H2bn; histone cluster 1, H2bm; histone cluster 1, H2bn; histone cluster 1, H2bo; LOC291157
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81747,412,176 - 47,413,789 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1747,486,657 - 47,489,207 (-)EnsemblGRCr8
mRatBN7.21742,716,433 - 42,718,046 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1742,760,219 - 42,793,359 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1742,673,067 - 42,718,095 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1744,766,061 - 44,767,675 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01749,525,153 - 49,526,767 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01744,016,124 - 44,017,738 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01744,756,557 - 44,758,170 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1744,756,555 - 44,793,927 (-)Ensemblrn6Rnor6.0
Rnor_5.01758,708,549 - 58,710,162 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41750,350,860 - 50,352,473 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1753,743,386 - 53,744,999 (+)NCBICelera
RGSC_v3.11750,387,657 - 50,390,031 (-)NCBI
Cytogenetic Map17p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
acetamide  (EXP)
bisphenol A  (EXP)
Cuprizon  (EXP)
furan  (EXP)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
extracellular space  (IBA)
nucleosome  (IBA,IEA)
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16319397   PMID:21630459  


Genomics

Variants

.
Variants in Hist1h2bo
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:63
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000047596
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173219953449497050Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 158 91 90 59 91 59 6 334 184 5 143 67 86 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000086309   ⟹   ENSRNOP00000070290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1747,486,657 - 47,489,207 (-)Ensembl
mRatBN7.2 Ensembl1742,791,589 - 42,793,359 (-)Ensembl
Rnor_6.0 Ensembl1744,756,555 - 44,793,927 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091176   ⟹   ENSRNOP00000068594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1742,760,219 - 42,793,337 (-)Ensembl
Rnor_6.0 Ensembl1744,756,557 - 44,758,170 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097329   ⟹   ENSRNOP00000094522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1742,673,067 - 42,718,095 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097860   ⟹   ENSRNOP00000092229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1742,716,421 - 42,718,095 (-)Ensembl
RefSeq Acc Id: NM_001106114   ⟹   NP_001099584
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81747,412,176 - 47,413,789 (-)NCBI
mRatBN7.21742,716,433 - 42,718,046 (-)NCBI
Rnor_6.01744,756,557 - 44,758,170 (-)NCBI
Rnor_5.01758,708,549 - 58,710,162 (+)NCBI
RGSC_v3.41750,350,860 - 50,352,473 (-)RGD
Celera1753,743,386 - 53,744,999 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099584 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL84564 (Get FASTA)   NCBI Sequence Viewer  
  EDL84568 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070290.2
  ENSRNOP00000084910.2
  ENSRNOP00000099611.1
RefSeq Acc Id: NP_001099584   ⟸   NM_001106114
- UniProtKB: A6KNA0 (UniProtKB/TrEMBL),   A0A8I6AGQ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068594   ⟸   ENSRNOT00000091176
Ensembl Acc Id: ENSRNOP00000070290   ⟸   ENSRNOT00000086309
Ensembl Acc Id: ENSRNOP00000092229   ⟸   ENSRNOT00000097860
Ensembl Acc Id: ENSRNOP00000094522   ⟸   ENSRNOT00000097329
Protein Domains
Histone H2A/H2B/H3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JXI9-F1-model_v2 AlphaFold A0A0G2JXI9 1-138 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311828 AgrOrtholog
BioCyc Gene G2FUF-9250 BioCyc
Ensembl Genes ENSRNOG00000054296 Ensembl
  ENSRNOG00000068034 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000070916 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049785.7 UniProtKB/TrEMBL
  ENSRNOT00000086309.3 UniProtKB/TrEMBL
  ENSRNOT00000122723.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
InterPro Histone-fold UniProtKB/TrEMBL
  Histone_core_D UniProtKB/TrEMBL
  Histone_H2B UniProtKB/TrEMBL
  HISTONE_H2B_site UniProtKB/TrEMBL
KEGG Report rno:291157 UniProtKB/TrEMBL
NCBI Gene 291157 ENTREZGENE
PANTHER Histone_H2B UniProtKB/TrEMBL
Pfam Histone UniProtKB/TrEMBL
PhenoGen Hist1h2bo PhenoGen
PRINTS HISTONEH2B UniProtKB/TrEMBL
PROSITE HISTONE_H2B UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054296 RatGTEx
  ENSRNOG00000068034 RatGTEx
  ENSRNOG00000070916 RatGTEx
SMART H2B UniProtKB/TrEMBL
Superfamily-SCOP Histone-fold UniProtKB/TrEMBL
UniProt A0A0G2JXI9_RAT UniProtKB/TrEMBL
  A0A8I6A2W1_RAT UniProtKB/TrEMBL
  A0A8I6AGQ8 ENTREZGENE
  A0ABK0LER6_RAT UniProtKB/TrEMBL
  A6KNA0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-12-06 Hist1h2bo  histone cluster 1 H2B family member O  Hist1h2bo  histone cluster 1 H2B family member o  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-10-12 Hist1h2bo  histone cluster 1 H2B family member o  Hist1h2bo  histone cluster 1, H2bo  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Hist1h2bo  histone cluster 1, H2bo  Hist1h2bm  histone cluster 1, H2bm  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Hist1h2bn  histone cluster 1, H2bn   Hist1h2bn_predicted  histone cluster 1, H2bn (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-07 Hist1h2bn_predicted  histone cluster 1, H2bn (predicted)    histone 1, H2bn (predicted)  Name updated 1299863 APPROVED
2005-01-12 Hist1h2bn_predicted  histone 1, H2bn (predicted)      Symbol and Name status set to approved 70820 APPROVED