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Gene: Rragc (Ras-related GTP binding C) Rattus norvegicus

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Symbol:

Rragc

Name:

Ras-related GTP binding C

RGD ID:

1311760

Description:

Predicted to enable several functions, including GTPase binding activity; guanyl ribonucleotide binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Predicted to act upstream of or within several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of translational initiation; and vacuole organization. Predicted to be located in cytoplasm. Predicted to be part of FNIP-folliculin RagC/D GAP and Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosomal membrane and nucleus. Orthologous to human RRAGC (Ras related GTP binding C); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC298514; ras-related GTP-binding protein C

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RRAGC (Ras related GTP binding C)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Rragc (Ras-related GTP binding C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rragc (Ras related GTP binding C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RRAGC (Ras related GTP binding C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RRAGC (Ras related GTP binding C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rragc (Ras related GTP binding C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RRAGC (Ras related GTP binding C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RRAGC (Ras related GTP binding C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rragc (Ras related GTP binding C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rragc (Ras related GTP binding C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	HS3ST2 (heparan sulfate-glucosamine 3-sulfotransferase 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	RRAGC (Ras related GTP binding C)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rragc (Ras-related GTP binding C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rragca (Ras-related GTP binding Ca)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rragcb (Ras-related GTP binding Cb)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	GTR2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	RagC-D	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ragc-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rragc	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	rragc	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	141,433,014 - 141,452,546 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	141,433,040 - 141,452,548 (+)	Ensembl				GRCr8
mRatBN7.2	5	136,148,239 - 136,167,773 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	136,148,276 - 136,167,767 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	138,854,327 - 138,873,812 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	140,624,336 - 140,643,825 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	140,631,486 - 140,650,971 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	141,572,536 - 141,590,784 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	141,572,536 - 141,590,781 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	145,361,045 - 145,379,293 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	143,208,628 - 143,228,470 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	134,682,625 - 134,702,090 (+)	NCBI		Celera
RGSC_v3.1	5	143,218,614 - 143,238,463 (+)	NCBI
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

follicular lymphoma (ISO)

genetic disease (ISO)

LONG-OLSEN-DISTELMAIER SYNDROME (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

capsaicin (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

DDE (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

Enterolactone (ISO)

ethyl methanesulfonate (ISO)

finasteride (EXP)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

gentamycin (EXP)

GSK-J4 (ISO)

indometacin (ISO)

L-methionine (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

N(4)-hydroxycytidine (ISO)

nefazodone (EXP)

paracetamol (ISO)

perfluorononanoic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chloride (ISO)

propiconazole (EXP)

rac-lactic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sulindac (EXP)

sunitinib (ISO)

temozolomide (ISO)

testosterone (ISO)

thiram (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cellular response to amino acid starvation (ISO)

cellular response to amino acid stimulus (IEA)

cellular response to nutrient levels (ISO)

positive regulation of TOR signaling (IEA)

positive regulation of TORC1 signaling (ISO)

protein localization to lysosome (ISO)

protein localization to membrane (ISO)

regulation of TOR signaling (ISO)

regulation of TORC1 signaling (ISO)

response to amino acid (ISO)

Cellular Component

cytoplasm (ISO)

FNIP-folliculin RagC/D GAP (ISO)

Gtr1-Gtr2 GTPase complex (ISO)

lysosomal membrane (ISO)

lysosome (IEA,ISO)

nucleoplasm (ISO)

nucleus (ISO)

Molecular Function

enzyme-substrate adaptor activity (ISO)

GDP binding (ISO)

GTP binding (IEA,ISO)

GTPase activity (ISO)

GTPase binding (ISO)

molecular adaptor activity (ISO)

protein binding (ISO)

protein heterodimerization activity (ISO)

protein-membrane adaptor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of mTORC1 by amino acids.	Bar-Peled L and Sabatini DM, Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Molecular mechanisms of mTOR-mediated translational control.	Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:11073942	PMID:12477932	PMID:20381137	PMID:22424946	PMID:23723238	PMID:27222292	PMID:31505169

Genomics

Comparative Map Data

Rragc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	141,433,014 - 141,452,546 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	141,433,040 - 141,452,548 (+)	Ensembl				GRCr8
mRatBN7.2	5	136,148,239 - 136,167,773 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	136,148,276 - 136,167,767 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	138,854,327 - 138,873,812 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	140,624,336 - 140,643,825 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	140,631,486 - 140,650,971 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	141,572,536 - 141,590,784 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	141,572,536 - 141,590,781 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	145,361,045 - 145,379,293 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	143,208,628 - 143,228,470 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	134,682,625 - 134,702,090 (+)	NCBI		Celera
RGSC_v3.1	5	143,218,614 - 143,238,463 (+)	NCBI
Cytogenetic Map	5	q36	NCBI

RRAGC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	38,838,198 - 38,859,772 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	38,838,198 - 38,859,772 (-)	Ensembl			hg38	GRCh38
GRCh37	1	39,303,870 - 39,325,444 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	39,077,592 - 39,097,927 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	38,974,113 - 38,994,433	NCBI
Celera	1	37,583,632 - 37,603,970 (-)	NCBI		Celera
Cytogenetic Map	1	p34.3	NCBI
HuRef	1	37,422,097 - 37,443,680 (-)	NCBI		HuRef
CHM1_1	1	39,419,225 - 39,440,860 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	38,705,423 - 38,727,008 (-)	NCBI		T2T-CHM13v2.0

Rragc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	123,811,226 - 123,830,790 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	123,811,239 - 123,830,790 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	123,917,433 - 123,936,997 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	123,917,446 - 123,936,997 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	123,594,676 - 123,614,240 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	123,419,814 - 123,439,293 (+)	NCBI		MGSCv36	mm8
MGSCv36	4	121,230,175 - 121,249,757 (+)	NCBI		MGSCv36	mm8
Celera	4	122,247,234 - 122,266,540 (+)	NCBI		Celera
Cytogenetic Map	4	D2.2	NCBI
cM Map	4	57.42	NCBI

Rragc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	16,466,453 - 16,486,336 (-)	Ensembl
ChiLan1.0	NW_004955452	16,469,426 - 16,486,336 (-)	NCBI	ChiLan1.0	ChiLan1.0

RRAGC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	187,980,082 - 188,001,688 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	187,110,319 - 187,131,908 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	38,110,578 - 38,132,179 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	39,456,768 - 39,478,244 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	39,456,768 - 39,478,244 (-)	Ensembl			panPan2	panpan1.1

RRAGC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	3,875,193 - 3,892,501 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	3,874,116 - 3,892,504 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	4,112,508 - 4,129,837 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	3,996,679 - 4,014,000 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	3,996,645 - 4,014,000 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	3,864,728 - 3,882,049 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	3,931,395 - 3,948,869 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	3,947,223 - 3,964,552 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rragc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	55,011,205 - 55,035,099 (-)	NCBI		HiC_Itri_2

RRAGC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	94,785,910 - 94,802,988 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	94,785,906 - 94,803,017 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	87,834,978 - 87,852,095 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RRAGC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	94,030,875 - 94,051,776 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	94,030,961 - 94,053,653 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	22,777,618 - 22,798,157 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rragc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	21,460,666 - 21,475,439 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624764	21,460,669 - 21,475,470 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rragc
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	34,373,682 - 34,392,655 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rragc
190 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	148
Count of miRNA genes:	120
Interacting mature miRNAs:	128
Transcripts:	ENSRNOT00000023514
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
2303586	Gluco52	Glucose level QTL 52	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	100826632	145826632	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
1300122	Wbc1	White blood cell count QTL 1	2.75		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	5	130678987	145274255	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134369218	156289444	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	98972960	143972960	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
2303618	Vencon1	Ventilatory control QTL 1	3.8		respiration trait (VT:0001943)	oxygen consumption (CMO:0002169)	5	100826632	145826632	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat
7411722	Strs6	Sensitivity to stroke QTL 6	3.9		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	5	140258140	143398122	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

RH142363

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	136,167,464 - 136,167,614 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	141,590,476 - 141,590,625	NCBI	Rnor6.0
Rnor_5.0	5	145,378,985 - 145,379,134	UniSTS	Rnor5.0
RGSC_v3.4	5	143,228,162 - 143,228,311	UniSTS	RGSC3.4
Celera	5	134,701,782 - 134,701,931	UniSTS
RH 3.4 Map	5	890.7	UniSTS
Cytogenetic Map	5	q36	UniSTS

RH128431

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	5	141,451,726 - 141,452,409 (+)	Marker Load Pipeline
mRatBN7.2	5	136,166,953 - 136,167,636 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	141,589,965 - 141,590,647	NCBI	Rnor6.0
Rnor_5.0	5	145,378,474 - 145,379,156	UniSTS	Rnor5.0
RGSC_v3.4	5	143,227,651 - 143,228,333	UniSTS	RGSC3.4
Celera	5	134,701,271 - 134,701,953	UniSTS
RH 3.4 Map	5	890.3	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001048184	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC091356	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC105622	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213693	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023514 ⟹ ENSRNOP00000023514

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	141,433,040 - 141,452,548 (+)	Ensembl
mRatBN7.2 Ensembl	5	136,148,276 - 136,167,767 (+)	Ensembl
Rnor_6.0 Ensembl	5	141,572,536 - 141,590,781 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000135032 ⟹ ENSRNOP00000100881

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	141,433,157 - 141,452,543 (+)	Ensembl

RefSeq Acc Id:

NM_001048184 ⟹ NP_001041649

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	141,433,075 - 141,452,546 (+)	NCBI
mRatBN7.2	5	136,148,300 - 136,167,773 (+)	NCBI
Rnor_6.0	5	141,572,536 - 141,590,784 (+)	NCBI
Rnor_5.0	5	145,361,045 - 145,379,293 (+)	NCBI
RGSC_v3.4	5	143,208,628 - 143,228,470 (+)	RGD
Celera	5	134,682,625 - 134,702,090 (+)	RGD

Sequence:

show sequence

CTGGCCTGGCCTGTCAGGGCGCGGGCGGTGGTGGTCCAGCACCATGTCCCTGCAATACGGGGCG
GAGGAGACGCCCCTGGCCGGCAGTTACGGCGCAGCCGACTCATTCCCCAAGGACTTCGGCTACG
GCGTGGAGGAGGAGGAAGAAGAGGCAGCGGCGGGTGGCGGCGGAGGCGCGGGGGCCGGCGGCGG
CTGCGGCCCGGGAGGCGGTGACAGCTCCAAGCCAAGGATCTTGCTTATGGGACTACGGCGCAGC
GGCAAGTCCTCCATTCAGAAGGTGGTGTTTCATAAGATGTCACCCAATGAGACTCTCTTTTTGG
AAAGTACCAACAAGATTTATAAAGATGACATTTCCAACAGCTCCTTTGTCAACTTCCAGATTTG
GGATTTTCCTGGGCAGATGGACTTCTTCGACCCAACCTTTGACTATGAAATGATCTTCAGGGGG
ACAGGAGCATTGATATATGTCATTGATGCACAGGATGACTACATGGAGGCTTTAACTCGACTTC
ACATCACTGTATCTAAGGCCTACAAAGTGAACCCAGACATGAACTTTGAGGTTTTTATTCACAA
AGTTGATGGTCTGTCTGATGATCACAAGATAGAAACACAGAGGGACATTCATCAAAGGGCCAAT
GATGACCTGGCAGATGCTGGGCTGGAAAAGCTCCATCTTAGCTTTTATTTGACTAGCATCTATG
ACCACTCAATATTTGAAGCTTTCAGTAAGGTGGTACAGAAACTCATCCCGCAACTGCCCACTTT
GGAAAACCTATTAAATATCTTTATATCAAATTCAGGTATTGAAAAAGCTTTTCTCTTTGATGTT
GTCAGCAAAATCTACATTGCAACAGACAGCTCCCCTGTGGATATGCAGTCTTACGAGCTCTGCT
GTGACATGATTGATGTTGTAATTGATGTGTCCTGTATATATGGATTAAAGGAAGATGGAAGTGG
AAGTGCTTATGACAAAGAATCGATGGCCATTATCAAGCTGAACAATACAACTGTCCTTTATTTA
AAGGAAGTCACTAAATTTTTGGCACTGGTTTGCATTCTTAGGGAAGAGAGCTTTGAACGAAAAG
GTTTGATAGACTACAACTTCCACTGTTTCCGAAAAGCTATCCATGAGGTGTTTGAGGTGGGTGT
GACTTCTCACAGAAGCTGTAGTCATCAGACCAGTGCTCCAAGCCTGAAAGCCTTGGCACACAAT
GGCACACCTCGGAATGCCATCTAGTCTGAATCTCAGCAGTGGAGGCTCAGTGCTGGCTTACTCC
TCACTCCAGGGTCAGACGCCATGTGCTGCAGGACTCGAGAGCCGCTGCCCATGGGAGTTGGAGA
CGATGGTGGAGCTTCTCTCTTGATGAAGGCCCCTCAGCCAGCCATGTGCAACTGAAGCTACTCT
CTAAATAACATCGCAAAAGAATGGCAGAGACCCCAGAACTCGGTGTGTCTTTTCTTCTCTTTCG
AGTCCTACTTTAAATAGTTGGACTATTTTGGACCTGGACATGATACCAGTTATCCATCTTTACC
GGTGAATGTCGCTGTCAGTTCCAGCCTGAAACAGTAGGAAACTGAGTTTTATATGCTTCCCTAG
GCCTTCACTTGAGTAGTGTCTAAAGACTCGCTTTGCTTACGTTCTAACACTGCCTTTCAGAGCT
CAGATCTCACTGTACCTCTAGGACCTCGAAAGTGCATTAGCTTGCTGACTCAGAAGACAAAGCA
AAGGATGTTTCTATTTGTCCTGAAGAAAAGAGGAAGTTTCTGTGCGGCACTGGGGAGAGCCAGG
CTCGGCAAGGGCTGCATCAGTTCCCTGGATGTGTTGAGGAAAAAACTTTGAAACAGAAGTGATT
TTTCACACCTGGGGTTTGGGTAGCAGATGGATGTACTCTCCTCATTTGATCTTGATCATGCACA
ATGTAACAAAGGGAATTCGACAGAAGGGCTTTCCCCAGAGTCCCCACAGTGAGGGGGCAAACTC
ATTATGTCACTGAAGTACTTCGCTCACTTTTCTTTAGTCCTGGTGCCATGGCTGTCACTCTATG
CTGTGTAGGCTCTTTAAGAATTGTTTTTGACCACAGATGACCCTGAGGCTCTGGCAGACTGTCT
GTCCTCTGGGGGTTGGAGGAGGCCTGTGGTGGTACAGCGTGCTCTGCAGTCTTCTGACACCAAG
TGTCAGCTGTGGTACTTTGCTTTGCTGAGGTATGAATTCATAGCTGTTCCTGTTGTTCATGGCT
GATACCCTTTCCCCGTTGATTTAGGCTTTCACATTTTCTTTACTACACATGCCCAGTAGTCACA
TTCCAAAGCCACTGGGCCCCTTGAGTGCGTCAGTGCCGCTGGTGAGGGATGTACTCAGGTCTGT
TACCCAGCAGTGAGACTTGGAGCACTTCCTGCAGATGACTGACTGTTGAGTATTTACTTGGACC
ACGGTGATAGCCAAAGGAAAAATGCTTTTATATTTATAGATTATTTCATTGAACTATATGTAAA
ATGGGTATCAATAAATGTATTTACTCCAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039109616 ⟹ XP_038965544

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	141,433,014 - 141,452,546 (+)	NCBI
mRatBN7.2	5	136,148,239 - 136,166,510 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001041649	(Get FASTA)	NCBI Sequence Viewer
	XP_038965544	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI05623	(Get FASTA)	NCBI Sequence Viewer
	EDL80390	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023514
	ENSRNOP00000023514.5
	ENSRNOP00000100881.1

RefSeq Acc Id:

NP_001041649 ⟸ NM_001048184

- UniProtKB:

Q0D2L6 (UniProtKB/TrEMBL), A6IS39 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAGGGGGAGAGGGCGPGGGDSSKPRIL
LMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDDISNSSFVNFQIWDFPGQMDFFDPTFD
YEMIFRGTGALIYVIDAQDDYMEALTRLHITVSKAYKVNPDMNFEVFIHKVDGLSDDHKIETQR
DIHQRANDDLADAGLEKLHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIE
KAFLFDVVSKIYIATDSSPVDMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLN
NTTVLYLKEVTKFLALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCSHQTSAPS
LKALAHNGTPRNAI

hide sequence

Ensembl Acc Id:

ENSRNOP00000023514 ⟸ ENSRNOT00000023514

RefSeq Acc Id:	XP_038965544 ⟸ XM_039109616
- Peptide Label:	isoform X1
- UniProtKB:	A6IS39 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000100881 ⟸ ENSRNOT00000135032

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q0D2L6-F1-model_v2	AlphaFold	Q0D2L6	1-398	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694008

Promoter ID:

EPDNEW_R4533

Type:

initiation region

Name:

Rragc_1

Description:

Ras-related GTP binding C

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	141,572,510 - 141,572,570	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311760	AgrOrtholog
BioCyc Gene	G2FUF-39984	BioCyc
Ensembl Genes	ENSRNOG00000017426	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000023514	ENTREZGENE
	ENSRNOT00000023514.7	UniProtKB/TrEMBL
	ENSRNOT00000135032.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.450.190	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7454011	IMAGE-MGC_LOAD
InterPro	Gtr1_RagA	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	RagC/D	UniProtKB/TrEMBL
KEGG Report	rno:298514	UniProtKB/TrEMBL
MGC_CLONE	MGC:125018	IMAGE-MGC_LOAD
NCBI Gene	298514	ENTREZGENE
PANTHER	Gtr1_RagA	UniProtKB/TrEMBL
	RAS-RELATED GTP-BINDING PROTEIN C	UniProtKB/TrEMBL
Pfam	Gtr1_RagA	UniProtKB/TrEMBL
PhenoGen	Rragc	PhenoGen
RatGTEx	ENSRNOG00000017426	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0ABK0LH83_RAT	UniProtKB/TrEMBL
	A6IS39	ENTREZGENE, UniProtKB/TrEMBL
	F7FGX6_RAT	UniProtKB/TrEMBL
	Q0D2L6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Rragc	Ras-related GTP binding C	Rragc_predicted	Ras-related GTP binding C (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Rragc_predicted	Ras-related GTP binding C (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)