Spry2 (sprouty RTK signaling antagonist 2) - Rat Genome Database

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Gene: Spry2 (sprouty RTK signaling antagonist 2) Rattus norvegicus
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Symbol: Spry2
Name: sprouty RTK signaling antagonist 2
RGD ID: 1311472
Description: Predicted to enable protein kinase binding activity; protein kinase regulator activity; and ubiquitin-protein transferase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cell differentiation; regulation of macromolecule metabolic process; and regulation of signal transduction. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; lung development; and negative regulation of signal transduction. Predicted to be located in cytoskeleton; membrane; and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2); PARTICIPATES IN fibroblast growth factor signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC306141; sprouty 2; sprouty homolog 2; sprouty homolog 2 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81589,106,809 - 89,111,926 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1589,103,731 - 89,115,074 (-)EnsemblGRCr8
mRatBN7.21582,692,291 - 82,697,408 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1582,692,143 - 82,698,009 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1586,673,206 - 86,678,322 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01587,788,634 - 87,793,751 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01584,721,558 - 84,726,674 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01590,172,769 - 90,177,823 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1590,172,975 - 90,175,802 (-)Ensemblrn6Rnor6.0
Rnor_5.01593,662,768 - 93,667,781 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41590,009,109 - 90,011,940 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1581,798,483 - 81,801,309 (-)NCBICelera
RGSC_v3.11590,024,884 - 90,027,720 (-)NCBI
Cytogenetic Map15q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
bisphenol A  (EXP,ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
diallyl trisulfide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
glucose  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
isobutanol  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
PD 0325901  (ISO)
phenobarbital  (ISO)
phorone  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
Rutecarpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium hypochlorite  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching morphogenesis of an epithelial tube  (ISO)
bud elongation involved in lung branching  (ISO)
cell fate commitment  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
establishment of mitotic spindle orientation  (ISO)
inner ear morphogenesis  (ISO)
lung development  (ISO)
lung growth  (ISO)
lung morphogenesis  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cell projection organization  (IEA,ISO)
negative regulation of epidermal growth factor receptor signaling pathway  (IBA)
negative regulation of epithelial to mesenchymal transition  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IBA,ISO)
negative regulation of fibroblast growth factor receptor signaling pathway  (IBA,ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of lens fiber cell differentiation  (IEA,ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of Ras protein signal transduction  (IBA,ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA,ISO)
negative regulation of vascular endothelial growth factor signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
regulation of signal transduction  (IEA)
respiratory system development  (ISO)
sensory perception of sound  (ISO)

Cellular Component
actin cytoskeleton  (ISO)
cytoplasm  (IEA)
cytoskeleton  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
membrane  (IEA,ISO)
microtubule cytoskeleton  (ISO)
nucleus  (IEA,ISO)
ruffle membrane  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10074434   PMID:11287183   PMID:11585837   PMID:12477932   PMID:15809037   PMID:16339969   PMID:16893902   PMID:17141539   PMID:17255109   PMID:18070883   PMID:18508928   PMID:19683577  
PMID:20029031   PMID:20439489   PMID:20489163   PMID:20736167   PMID:21536891   PMID:21764747   PMID:22236546   PMID:23982388   PMID:24177325   PMID:24210189   PMID:24469046   PMID:25822989  
PMID:29409968   PMID:33037124  


Genomics

Comparative Map Data
Spry2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81589,106,809 - 89,111,926 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1589,103,731 - 89,115,074 (-)EnsemblGRCr8
mRatBN7.21582,692,291 - 82,697,408 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1582,692,143 - 82,698,009 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1586,673,206 - 86,678,322 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01587,788,634 - 87,793,751 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01584,721,558 - 84,726,674 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01590,172,769 - 90,177,823 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1590,172,975 - 90,175,802 (-)Ensemblrn6Rnor6.0
Rnor_5.01593,662,768 - 93,667,781 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41590,009,109 - 90,011,940 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1581,798,483 - 81,801,309 (-)NCBICelera
RGSC_v3.11590,024,884 - 90,027,720 (-)NCBI
Cytogenetic Map15q22NCBI
SPRY2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381380,335,976 - 80,341,126 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1380,335,518 - 80,342,983 (-)Ensemblhg38GRCh38
GRCh371380,910,111 - 80,915,261 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361379,808,112 - 79,813,087 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341379,808,114 - 79,813,087NCBI
Celera1361,811,860 - 61,816,835 (-)NCBICelera
Cytogenetic Map13q31.1NCBI
HuRef1361,613,784 - 61,618,759 (-)NCBIHuRef
CHM1_11380,877,733 - 80,882,708 (-)NCBICHM1_1
T2T-CHM13v2.01379,564,038 - 79,569,188 (-)NCBIT2T-CHM13v2.0
Spry2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914106,129,381 - 106,134,559 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14106,129,381 - 106,134,253 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3814105,891,947 - 105,896,819 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14105,891,947 - 105,896,819 (-)Ensemblmm10GRCm38
MGSCv3714106,291,164 - 106,296,036 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3614104,778,114 - 104,782,418 (-)NCBIMGSCv36mm8
Celera14104,512,649 - 104,517,512 (-)NCBICelera
Cytogenetic Map14E2.3NCBI
cM Map1456.16NCBI
Spry2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540427,349,519 - 27,353,706 (+)Ensembl
ChiLan1.0NW_00495540427,349,286 - 27,353,706 (+)NCBIChiLan1.0ChiLan1.0
SPRY2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21481,917,809 - 81,922,593 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11380,512,191 - 80,517,659 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01361,569,658 - 61,574,817 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11380,595,679 - 80,600,670 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1380,596,346 - 80,597,408 (-)EnsemblpanPan2panpan1.1
SPRY2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12233,366,139 - 33,371,102 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2233,366,931 - 33,367,878 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2233,168,781 - 33,173,903 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02233,695,480 - 33,700,592 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2233,695,481 - 33,700,517 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12233,352,773 - 33,357,889 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02233,390,454 - 33,395,571 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02233,464,090 - 33,469,216 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spry2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945126,035,217 - 126,040,822 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365111,452,807 - 1,458,031 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365111,452,421 - 1,458,031 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPRY2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1152,153,704 - 52,159,156 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11152,153,695 - 52,158,766 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21156,943,755 - 56,948,261 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPRY2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1359,357,611 - 59,362,705 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl359,358,394 - 59,359,341 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604615,625,484 - 15,630,748 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spry2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475120,091,609 - 20,096,563 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475120,091,612 - 20,096,581 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Spry2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11218,967,047 - 18,971,935 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Spry2
32 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:354
Count of miRNA genes:211
Interacting mature miRNAs:248
Transcripts:ENSRNOT00000013342
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)1560213984105213984Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1582194914108192169Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)156244089297773284Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1574735564106469153Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1588677086104695021Rat
1358354Srcrt5Stress Responsive Cort QTL 53.38blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1582503470108192169Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)1572716871101425383Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1582714037106778197Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)1588677086104695021Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1564571127108192169Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
7411646Foco21Food consumption QTL 2123.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1584278281108192169Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1572716871101425383Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)1561710951106710951Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1575928947101425383Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1583700787108192169Rat
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1559257087104257087Rat
2313080Bss65Bone structure and strength QTL 653.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1567399137108192169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1582194914108192169Rat

Markers in Region
RH143991  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21582,692,755 - 82,692,904 (+)MAPPERmRatBN7.2
Rnor_6.01590,173,234 - 90,173,382NCBIRnor6.0
Rnor_5.01593,663,212 - 93,663,360UniSTSRnor5.0
RGSC_v3.41590,009,372 - 90,009,520UniSTSRGSC3.4
Celera1581,798,746 - 81,798,894UniSTS
RH 3.4 Map15551.19UniSTS
Cytogenetic Map15q22UniSTS
RH44769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21582,696,913 - 82,697,177 (+)MAPPERmRatBN7.2
Rnor_6.01590,177,392 - 90,177,655NCBIRnor6.0
Rnor_5.01593,667,370 - 93,667,633UniSTSRnor5.0
RGSC_v3.41590,013,530 - 90,013,793UniSTSRGSC3.4
Celera1581,802,899 - 81,803,162UniSTS
Cytogenetic Map15q22UniSTS
BQ201059  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21582,693,306 - 82,693,502 (+)MAPPERmRatBN7.2
Rnor_6.01590,173,785 - 90,173,980NCBIRnor6.0
Rnor_5.01593,663,763 - 93,663,958UniSTSRnor5.0
RGSC_v3.41590,009,923 - 90,010,118UniSTSRGSC3.4
Celera1581,799,297 - 81,799,487UniSTS
RH 3.4 Map15551.0UniSTS
Cytogenetic Map15q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013342   ⟹   ENSRNOP00000013342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1589,103,731 - 89,113,429 (-)Ensembl
mRatBN7.2 Ensembl1582,692,497 - 82,695,324 (-)Ensembl
Rnor_6.0 Ensembl1590,172,975 - 90,175,802 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097462   ⟹   ENSRNOP00000077712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1589,104,143 - 89,113,851 (-)Ensembl
mRatBN7.2 Ensembl1582,692,143 - 82,698,009 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106586   ⟹   ENSRNOP00000081271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1589,105,557 - 89,115,074 (-)Ensembl
mRatBN7.2 Ensembl1582,692,347 - 82,695,917 (-)Ensembl
RefSeq Acc Id: NM_001012046   ⟹   NP_001012046
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81589,106,809 - 89,109,842 (-)NCBI
mRatBN7.21582,692,291 - 82,695,324 (-)NCBI
Rnor_6.01590,172,971 - 90,175,802 (-)NCBI
Rnor_5.01593,662,768 - 93,667,781 (-)NCBI
RGSC_v3.41590,009,109 - 90,011,940 (-)RGD
Celera1581,798,483 - 81,801,309 (-)RGD
Sequence:
RefSeq Acc Id: NM_001393836   ⟹   NP_001380765
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81589,106,809 - 89,111,926 (-)NCBI
mRatBN7.21582,692,291 - 82,697,408 (-)NCBI
RefSeq Acc Id: XM_063274342   ⟹   XP_063130412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81589,106,830 - 89,111,328 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001012046 (Get FASTA)   NCBI Sequence Viewer  
  NP_001380765 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130412 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH89116 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013342
  ENSRNOP00000013342.3
  ENSRNOP00000077712.1
  ENSRNOP00000081271.1
RefSeq Acc Id: NP_001012046   ⟸   NM_001012046
- UniProtKB: Q5HZA2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013342   ⟸   ENSRNOT00000013342
Ensembl Acc Id: ENSRNOP00000077712   ⟸   ENSRNOT00000097462
Ensembl Acc Id: ENSRNOP00000081271   ⟸   ENSRNOT00000106586
RefSeq Acc Id: NP_001380765   ⟸   NM_001393836
- UniProtKB: Q5HZA2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130412   ⟸   XM_063274342
- Peptide Label: isoform X1
- UniProtKB: Q5HZA2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5HZA2-F1-model_v2 AlphaFold Q5HZA2 1-314 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311472 AgrOrtholog
BioCyc Gene G2FUF-12613 BioCyc
Ensembl Genes ENSRNOG00000010058 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013342 ENTREZGENE
  ENSRNOT00000013342.8 UniProtKB/TrEMBL
  ENSRNOT00000097462.2 UniProtKB/TrEMBL
  ENSRNOT00000106586.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7320532 IMAGE-MGC_LOAD
InterPro Sprouty UniProtKB/TrEMBL
  Sprouty_domain UniProtKB/TrEMBL
KEGG Report rno:306141 UniProtKB/TrEMBL
MGC_CLONE MGC:105639 IMAGE-MGC_LOAD
NCBI Gene 306141 ENTREZGENE
PANTHER PTHR12365:SF8 UniProtKB/TrEMBL
  SPROUTY UniProtKB/TrEMBL
Pfam Sprouty UniProtKB/TrEMBL
PhenoGen Spry2 PhenoGen
PROSITE SPR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010058 RatGTEx
UniProt Q5HZA2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Spry2  sprouty RTK signaling antagonist 2  Spry2  sprouty homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Spry2  sprouty homolog 2 (Drosophila)  Spry2_predicted  sprouty homolog 2 (Drosophila) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Spry2_predicted  sprouty homolog 2 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED